EKS-MEG-00396

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MEG-00396

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/TBCK	385.2	8.9E-116	18	272	255

Status

Unreviewed

Ensembl Protein

ENSMGAP00000005942

UniProt Accession

G1N2Q7;

Protein Name

Protein Synonyms/Alias

Gene Name

TBCK

Gene Synonyms/Alias

TBCK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000005932	ENSMGAP00000005942	ENSMGAT00000006687

Organism

Meleagris gallopavo

Functional Description

Protein Length

895

Protein Sequence
(FASTA)

MFPLRDTEMG ASTFFASALP HDVCGSNGLP LTPNSIKILG RFQILKTITH PRLCQYVDIT 60

RGKHERLVVA AEHCENSLED LLREGKPVSS SRILCIAYEV LQGLQYMNKH GMVHRALSPR 120

NILLDRKGHV KLAKFGLYHM TAQGVDVDFP IGYPSYLAPE VIAQGIVKPR DHTQCEKPLP 180

SGPKSDLWSL GIILFELCVG RKLFQALEIA ERLKFVITLG YVDDIVTVLA EEHGCLDIIK 240

DLSENVVTLL KKCLTFQPSM RPTPEELMRD CLFSEVSLAY PPFLKPAGLF SSSPRCADLT 300

LPEDISQLCK DEDNDYLAER SIEEVYYLWC LAGGDLEKEL VNKEIIRSKP PVCTLPNFVL 360

EDGESFGQGR DRSSLLDDTT VTLSLCQLRN RLKDVGGEAF YPLLEDDQST LPHSNSSSEL 420

SAAANLPLII RERDTEYQLN RIVLFDRLLK AYPYKKNQIW KEARVDIPPL LRGMTWAALL 480

GVEGAIQAKY DAIDKDTPIP TDRQIEVDIP RCHQYDELLS SPEGHAKFRR VLKAWVVSHP 540

DLVYWQGLDS LCAPFLYLNF NNEALAYACM SAFIPKYLYN FFLKDNSHVI QEYLTVFSQM 600

IAFHDPELSN HLNEIGFIPD LYAIPWFLTM FTHVFPLHKI FHLWDTLLLG NSSFPFCIGV 660

AILQQLRDRL LANGFNECIL LFSDLPGPEI DIERCVRESI NLFRWTPKSA TYRQYAQPPR 720

QASESNSTRS SMSCFSVDYQ EAPRGDLSRD SIKLDDLKAE VSPRISAEDL IDLCELTGPS 780

HSKTPVKKTK SSKPKLLVVD IRNSEDFNRG HISGSINIPF ASAFTAEGDL IQCPATAMLQ 840

SFKGRVVVIV GNAAKNTATF SAHLVKSKYP RVCILDGGIN KIKPTGLLTV SSPQI 895

Nucleotide Sequence
(FASTA)

ATGTTTCCTT TAAGAGATAC TGAGATGGGT GCTTCCACCT TCTTTGCCTC AGCTCTTCCA 60

CATGATGTTT GTGGAAGTAA TGGCCTTCCT CTGACACCCA ATTCCATCAA AATTTTAGGA 120

AGGTTTCAAA TCCTTAAAAC AATCACCCAT CCTAGGCTTT GCCAGTATGT TGATATTACC 180

AGAGGTAAAC ATGAGAGACT GGTTGTGGCT GCTGAACACT GTGAAAATAG TCTGGAAGAT 240

TTGCTACGAG AGGGAAAACC AGTCAGTTCC TCAAGAATTT TATGCATTGC ATATGAAGTC 300

TTGCAAGGTT TGCAATATAT GAACAAACAT GGGATGGTCC ACCGAGCTCT CTCCCCTCGC 360

AATATTCTTT TGGATCGAAA GGGACATGTC AAGTTGGCTA AATTTGGACT TTACCATATG 420

ACTGCTCAAG GTGTTGATGT TGATTTTCCT ATAGGGTACC CGTCTTATCT GGCGCCTGAA 480

GTAATTGCAC AGGGAATAGT CAAACCACGT GATCATACTC AGTGTGAGAA GCCTCTGCCT 540

TCTGGCCCTA AATCAGATCT CTGGTCTCTT GGCATAATAC TATTTGAGCT TTGTGTGGGG 600

AGAAAATTGT TCCAGGCTTT GGAGATAGCA GAAAGATTAA AATTTGTAAT TACACTAGGC 660

TATGTAGATG ATATTGTAAC TGTATTAGCT GAAGAACATG GTTGCCTTGA TATTATTAAG 720

GATCTTTCTG AAAATGTCGT AACTCTGCTG AAAAAATGCC TTACATTCCA ACCTTCTATG 780

AGGCCAACTC CGGAGGAATT GATGCGTGAC TGTTTATTCA GTGAAGTATC TTTGGCATAC 840

CCTCCCTTTC TCAAACCTGC TGGACTGTTC TCGTCCTCTC CAAGGTGTGC TGACTTAACG 900

CTGCCTGAAG ACATAAGTCA GTTATGCAAA GATGAAGATA ATGATTACCT TGCAGAAAGA 960

TCAATTGAAG AGGTTTATTA TCTCTGGTGT CTGGCTGGAG GAGACTTAGA GAAAGAACTT 1020

GTCAACAAGG AAATCATTCG ATCAAAACCT CCTGTCTGCA CACTTCCCAA CTTTGTGTTA 1080

GAAGATGGTG AAAGCTTTGG GCAAGGACGA GATAGAAGTT CCCTTCTAGA TGACACAACT 1140

GTGACTTTGT CTCTGTGCCA GCTCCGAAAT AGACTGAAAG ATGTTGGTGG GGAAGCATTT 1200

TATCCATTAC TTGAAGATGA CCAGTCAACT TTACCTCATT CAAATAGTAG TAGTGAGCTG 1260

TCTGCAGCTG CCAATCTACC TCTGATCATC CGGGAGAGGG ACACAGAGTA TCAGCTAAAC 1320

AGAATTGTTC TGTTTGACAG ACTGCTGAAG GCCTACCCAT ATAAGAAAAA CCAAATCTGG 1380

AAAGAAGCCA GAGTTGACAT CCCTCCTCTC CTGAGAGGCA TGACCTGGGC TGCTCTGTTG 1440

GGTGTTGAGG GTGCCATTCA AGCAAAATAT GATGCCATTG ATAAAGACAC ACCGATTCCT 1500

ACAGACAGAC AAATTGAAGT TGATATTCCT CGTTGCCATC AGTATGATGA ATTGCTGTCA 1560

TCACCAGAGG GTCATGCAAA GTTTAGACGT GTATTGAAGG CCTGGGTTGT TTCCCATCCT 1620

GATTTGGTAT ACTGGCAAGG TCTCGATTCT CTTTGTGCAC CATTCCTATA CTTGAATTTT 1680

AACAATGAAG CTCTGGCATA TGCTTGCATG TCTGCTTTTA TACCCAAGTA TTTGTATAAC 1740

TTCTTTCTGA AGGATAATTC TCATGTTATC CAAGAGTACC TAACGGTGTT TTCTCAGATG 1800

ATTGCATTCC ATGATCCAGA GCTGAGCAAC CACCTTAATG AAATTGGTTT CATTCCTGAT 1860

CTCTATGCTA TTCCGTGGTT TCTTACAATG TTCACACATG TCTTTCCTTT GCATAAAATT 1920

TTTCACTTGT GGGATACATT ATTGCTTGGA AATTCCTCCT TCCCATTCTG CATAGGGGTG 1980

GCTATACTTC AACAACTGAG GGATCGTCTT CTCGCAAATG GGTTCAACGA ATGCATTCTC 2040

CTTTTCTCAG ACTTACCAGG ACCAGAGATT GACATTGAGC GTTGTGTTCG TGAGTCAATC 2100

AACCTGTTTC GCTGGACCCC AAAGAGTGCT ACGTACAGGC AATATGCACA GCCTCCTCGG 2160

CAAGCCAGTG AGAGCAATAG CACAAGAAGT TCAATGTCCT GCTTTTCTGT AGATTATCAG 2220

GAAGCACCTA GAGGTGACCT GTCTAGGGAT TCTATCAAGT TGGATGACCT GAAGGCAGAG 2280

GTGTCACCAA GGATTTCAGC AGAAGATCTG ATTGATCTCT GTGAACTGAC AGGACCAAGT 2340

CATTCCAAAA CACCTGTAAA GAAAACAAAG TCTAGCAAGC CAAAGTTGCT GGTGGTGGAC 2400

ATCCGTAACA GTGAAGACTT TAACCGTGGC CACATCTCTG GCAGCATCAA CATCCCATTT 2460

GCGTCAGCAT TTACTGCAGA AGGAGATCTC ATCCAGTGCC CAGCAACTGC CATGCTCCAG 2520

AGCTTTAAAG GAAGAGTTGT AGTGATTGTA GGAAATGCAG CAAAGAACAC AGCTACTTTT 2580

TCAGCTCATC TGGTGAAGAG CAAGTACCCA CGGGTCTGCA TCTTAGATGG CGGAATCAAC 2640

AAGATCAAAC CAACTGGTCT CCTCACTGTT TCTTCTCCAC AAATATAA 2688

Domain Profile

S: 1     llaqdkdGsnGlplasnakkilGrfqiLkelqhdrLcqYldisrgkhervivvaehlels  60

         +l++d++GsnGlpl++n++kilGrfqiLk+++h+rLcqY+di+rgkher++v aeh+e s

Q: 18    ALPHDVCGSNGLPLTPNSIKILGRFQILKTITHPRLCQYVDITRGKHERLVVAAEHCENS  77

         589*********************************************************

S: 61    LeDllkerkpvseslvlriayevlsgldylnkhnivhralepksilldrkgqkvkLakyG  120

         LeDll+e+kpvs s +l+iayevl+gl+y+nkh++vhral+p++illdrkg+ vkLak+G

Q: 78    LEDLLREGKPVSSSRILCIAYEVLQGLQYMNKHGMVHRALSPRNILLDRKGH-VKLAKFG  136

         ****************************************************.*******

S: 121   LyhltayGkdvdfpigygsylaPerilqd.........edkllaatvksDvWsLglille  171

         Lyh+ta+G dvdfpigy+sylaPe+i+q+          +k+l++++ksD WsLg+il+e

Q: 137   LYHMTAQGVDVDFPIGYPSYLAPEVIAQGivkprdhtqCEKPLPSGPKSDLWSLGIILFE  196

         ************************************999*********************

S: 172   lilgikLfaeldlserlkillklstvdetliklaeekkcldiikklderleallkkCLtl  231

         l++g+kLf+ l+++erlk++ +l+ vd+ + +laee++cldiik+l e++  llkkCLt+

Q: 197   LCVGRKLFQALEIAERLKFVITLGYVDDIVTVLAEEHGCLDIIKDLSENVVTLLKKCLTF  256

         ************************************************************

S: 232   lpskRpspdellkekv  247

          ps Rp+p+el+++

Q: 257   QPSMRPTPEELMRDCL  272

         ************9976

Domain Sequence
(FASTA)

ALPHDVCGSN GLPLTPNSIK ILGRFQILKT ITHPRLCQYV DITRGKHERL VVAAEHCENS 60

LEDLLREGKP VSSSRILCIA YEVLQGLQYM NKHGMVHRAL SPRNILLDRK GHVKLAKFGL 120

YHMTAQGVDV DFPIGYPSYL APEVIAQGIV KPRDHTQCEK PLPSGPKSDL WSLGIILFEL 180

CVGRKLFQAL EIAERLKFVI TLGYVDDIVT VLAEEHGCLD IIKDLSENVV TLLKKCLTFQ 240

PSMRPTPEEL MRDCL 255

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0005097	; F:Rab GTPase activator activity
GO:0032851	; P:positive regulation of Rab GTPase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR000195	; Rab-GTPase-TBC_dom.
IPR001763	; Rhodanese-like_dom.

Pfam

PF00069	; Pkinase; 1.
PF00566	; RabGAP-TBC; 1.
PF00581	; Rhodanese; 1.

SMARTs

SM00450	; RHOD; 1.
SM00164	; TBC; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS50206	; RHODANESE_3; 1.
PS50086	; TBC_RABGAP; 1.

Prints

Created Date

20-Feb-2013