EKS-MEG-00258

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MEG-00258

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	328.7	2.0E-98	457	704	248

Status

Unreviewed

Ensembl Protein

ENSMGAP00000006387

UniProt Accession

G1N3R3;

Protein Name

Protein Synonyms/Alias

Gene Name

PAK7

Gene Synonyms/Alias

PAK7;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000006360	ENSMGAP00000006387	ENSMGAT00000007137

Organism

Meleagris gallopavo

Functional Description

Protein Length

723

Protein Sequence
(FASTA)

MFGKKKKRLE ISGPSNFEHR VHTGFDHREQ KFTGLPQQWH SLLADTANRP KPMVDPSCIT 60

PIQLAPMKTI VRGNKPRKDT SINGLLEEFD NISVTRSNSL RKESPPTHHQ GNANHVPRHQ 120

EENGYITYSQ YSSESDTTTD YVMDKYRDKT LYGEELDRYY KGGYTAKQNG HMMKVTSRDI 180

YYSEMAPLKS DLSRFLPDYH AQVEAKPKPL EYGGLKLEYQ RIPSGSSLDY RDPFPYALSR 240

ASVQSECPKE RLEYSDSDWG HSPAKDDYDK RPKSSYVDPA SPQPTMRQRS RSGSGLQEPA 300

MPYGASAFKA HQQGHSYSSY TYPRLSETAA GISKVDYDRA QLVVSPPLSG SDTYPRGPVK 360

LPQSQSKVSY SSSSYQYPLV YHKASHYHQP SLQPSSPYIS TASYPSSPSI TSSAYPPPSW 420

GSSSDQQPSR VSHEQFRAAL QLVVSPGDPR EYLDSFIKIG EGSTGIVCIA TEKHTGKQVA 480

VKKMDLRKQQ RRELLFNEVV IMRDYHHENV VDMYNSYLVS DELWVVMEFL EGGALTDIVT 540

HTRMNEEQIA TVCLSVLRAL SYLHNQGVIH RDIKSDSILL TSDGRIKLSD FGFCAQVSKE 600

VPRRKSLVGT PYWMAPEVIS RMPYGTEVDI WSLGIMVIEM IDGEPPYFNE PPLQAMRRIR 660

DNLPPRVKDM HKVSSVLRGF LDLMLVREPS QRATAQELLR HPFLKLAGAP SCIVPLMRQH 720

RHR 723

Nucleotide Sequence
(FASTA)

ATGTTCGGAA AGAAAAAGAA AAGGCTTGAA ATTTCTGGGC CCTCTAACTT CGAGCATCGT 60

GTCCATACTG GCTTTGACCA CCGGGAGCAG AAGTTCACAG GACTACCTCA GCAATGGCAC 120

AGCTTGCTGG CGGACACGGC CAACAGGCCG AAGCCTATGG TGGACCCATC ATGCATCACT 180

CCCATTCAGC TCGCACCTAT GAAGACTATT GTTAGAGGAA ATAAGCCTCG GAAGGATACT 240

TCAATCAACG GCTTGCTCGA AGAGTTTGAC AATATCTCCG TGACTCGATC CAACTCCCTG 300

CGGAAGGAAA GTCCTCCCAC ACACCACCAA GGCAATGCAA ACCATGTGCC AAGGCACCAG 360

GAGGAAAATG GGTACATCAC ATATTCGCAG TACTCCAGTG AGTCAGACAC AACAACAGAC 420

TATGTCATGG ACAAGTATAG AGACAAGACT CTCTATGGGG AAGAGCTAGA CAGGTACTAC 480

AAAGGGGGCT ACACTGCCAA GCAGAATGGG CACATGATGA AAGTCACTTC CAGGGACATC 540

TATTATTCAG AAATGGCACC CCTGAAATCA GACCTCTCCA GGTTCCTCCC AGATTACCAC 600

GCACAAGTGG AGGCAAAGCC CAAACCGCTC GAATATGGAG GTCTAAAGCT GGAGTACCAG 660

AGGATTCCCA GTGGATCCTC ACTCGACTAC AGAGACCCCT TCCCTTATGC CCTGTCCCGA 720

GCGTCAGTGC AGAGCGAGTG CCCCAAGGAG AGGCTGGAGT ACAGCGACAG CGACTGGGGG 780

CACAGCCCAG CCAAGGATGA CTATGACAAG AGGCCCAAGT CATCCTACGT GGACCCGGCG 840

AGCCCTCAGC CAACCATGAG GCAGAGGTCC AGGTCGGGCT CTGGTCTGCA GGAGCCAGCC 900

ATGCCCTATG GAGCAAGTGC ATTTAAAGCA CACCAGCAGG GACACTCCTA CAGCTCCTAC 960

ACCTACCCTC GCTTGTCTGA AACTGCAGCA GGCATCTCTA AGGTGGATTA CGACCGAGCA 1020

CAGCTGGTAG TTAGCCCACC ACTCTCTGGA TCCGACACCT ACCCAAGGGG CCCAGTAAAG 1080

CTACCTCAAA GTCAAAGTAA AGTCAGCTAT TCCAGCAGCA GCTACCAGTA TCCTCTGGTC 1140

TACCACAAAG CATCCCACTA CCACCAGCCA TCACTCCAGC CGAGCTCTCC CTATATTTCC 1200

ACCGCCTCCT ACCCCAGCTC TCCAAGTATC ACATCAAGTG CTTATCCCCC ACCCAGCTGG 1260

GGCTCCTCCT CAGACCAGCA GCCCTCCAGG GTGTCCCACG AACAGTTCAG AGCTGCTCTG 1320

CAGCTGGTCG TCAGCCCTGG TGATCCCCGG GAGTACTTGG ACAGCTTCAT CAAGATCGGG 1380

GAGGGCTCCA CAGGGATAGT CTGCATTGCC ACCGAGAAGC ACACGGGGAA GCAAGTCGCT 1440

GTGAAGAAAA TGGATCTCAG GAAACAGCAG AGGAGGGAGC TGCTGTTCAA TGAGGTTGTA 1500

ATCATGAGAG ATTACCATCA CGAAAACGTG GTTGACATGT ACAACAGTTA CCTTGTCAGC 1560

GATGAGCTGT GGGTGGTGAT GGAGTTCCTA GAGGGCGGTG CTCTGACAGA CATCGTGACT 1620

CACACCAGGA TGAACGAGGA GCAGATAGCA ACTGTCTGCC TGTCTGTCCT GAGAGCTCTG 1680

TCCTACCTGC ACAACCAGGG TGTCATCCAC CGCGACATCA AAAGCGACTC CATCCTCCTC 1740

ACAAGCGATG GGCGGATCAA ATTGTCCGAC TTCGGGTTCT GTGCCCAGGT GTCCAAGGAG 1800

GTGCCGCGGA GGAAGTCGCT GGTTGGGACG CCATACTGGA TGGCACCAGA GGTGATATCA 1860

CGCATGCCCT ACGGCACTGA GGTGGACATC TGGTCGCTGG GCATCATGGT GATAGAGATG 1920

ATCGACGGCG AACCTCCCTA CTTCAATGAG CCGCCGCTGC AGGCCATGCG CCGAATCCGG 1980

GATAACTTAC CACCCCGCGT GAAGGACATG CACAAGGTCT CCTCTGTCCT CCGGGGCTTC 2040

TTGGATTTGA TGCTGGTGCG GGAACCCTCG CAGAGAGCCA CGGCGCAGGA ACTGTTGAGA 2100

CACCCATTCC TTAAGCTGGC CGGGGCCCCT TCTTGCATCG TGCCCCTCAT GAGGCAGCAC 2160

CGGCACCGCT GA 2172

Domain Profile

S: 5     eeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpniveyles  64

          +ig+G++g v++a+ek+tg++va+kk++l+kq++ e+l++e+ ++++++h+n+v++++s

Q: 457   IKIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHENVVDMYNS  516

         68**********************************************************

S: 65    flkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkviHrdi  124

         +l+++elw+vme+l+gG+l+d+v+   +++++Eeqia+++ +vl+aL+ylH+++viHrdi

Q: 517   YLVSDELWVVMEFLEGGALTDIVT---HTRMNEEQIATVCLSVLRALSYLHNQGVIHRDI  573

         ************************...9********************************

S: 125   kakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqeekgYdekaDiw  184

         k+++iLlt++g++kLsdfg++aq++k++ +rk++vgtpywmAPEvi+  +  Y +++Diw

Q: 574   KSDSILLTSDGRIKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPEVIS--RMPYGTEVDIW  631

         ***********************************************..9**********

S: 185   slGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekclqknpek  244

         slGI++ie+++gepP+++++pl+a+ +i +n pp++k+ +k+s+ ++ f++ +l ++p++

Q: 632   SLGIMVIEMIDGEPPYFNEPPLQAMRRIRDNLPPRVKDMHKVSSVLRGFLDLMLVREPSQ  691

         ************************************************************

S: 245   RpsasellkhkFl  257

         R++a+ell+h+Fl

Q: 692   RATAQELLRHPFL  704

         ************7

Domain Sequence
(FASTA)

IKIGEGSTGI VCIATEKHTG KQVAVKKMDL RKQQRRELLF NEVVIMRDYH HENVVDMYNS 60

YLVSDELWVV MEFLEGGALT DIVTHTRMNE EQIATVCLSV LRALSYLHNQ GVIHRDIKSD 120

SILLTSDGRI KLSDFGFCAQ VSKEVPRRKS LVGTPYWMAP EVISRMPYGT EVDIWSLGIM 180

VIEMIDGEPP YFNEPPLQAM RRIRDNLPPR VKDMHKVSSV LRGFLDLMLV REPSQRATAQ 240

ELLRHPFL 248

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005739	; C:mitochondrion
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000095	; PAK_box_Rho-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00786	; PBD; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00285	; PBD; 1.
SM00220	; S_TKc; 1.

Prosites

PS50108	; CRIB; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013