EKS-MEG-00384

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MEG-00384

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	342.5	1.5E-102	20	316	297

Status

Unreviewed

Ensembl Protein

ENSMGAP00000006377

UniProt Accession

G1N3Q6;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK6

Gene Synonyms/Alias

MAPK6;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000006369	ENSMGAP00000006377	ENSMGAT00000007127

Organism

Meleagris gallopavo

Functional Description

Protein Length

721

Protein Sequence
(FASTA)

MAEKFESLMN IHGFDLGSRY MDLKPLGCGG NGLVFSAVDN DCDKRVAVKK IVLTDPQSVK 60

HALREIKIIR RLDHDNIVKV FEILGPSGSQ LTDDVGSLTE LNCVYIVQEY METDLANLLE 120

QGPLLEDHAR LFMYQLLRGL KYIHSANVLH RDLKPANLFI NTEDLVLKIG DFGLARIMDP 180

HYSHKGHLSE GLVTKWYRSP RLLLSPNNYT KAIDMWAAGC IFAEMLTGKT LFAGAHELEQ 240

MQLILESIPV VHEEDRQELL NVIPVYIRND MTEPHKPLTQ LLPGISPEAL DFLEQILTFS 300

PMDRLTAEEA LSHPYMSIYS FPTDEPISSH PFHIEDEVDD ILLMDESHSH IYNWERYHES 360

QFSDHDWPIH NNYEADEVQR DPRALSDVTD EEEVQVDPRK YLDGDREKYL EDPAFDTHFS 420

TEPCWQYSDH HENKYCDLEC SHTCNYKMRS SSYLDNLVWR DSEVNHYYEP KLIIDLSNWK 480

EQSKEKSDKK GKSKCEKNGL VKAQIALEEA SQQLVEKERE KNQGFDFDSF IAETIQLSLQ 540

HEPTDVDKLN DLNSSVSQME SKGLISKSVS REKQEKGMAN LAQLGALYQT SWDSQFVSNG 600

EECFLIDQFC CEVRKDEQAE KENTYTSYLD KFFSKKEDAE MLEPEPVEEG KLGEKERGES 660

FLSNSGELLF NKQLEAIGIP QFHSPVGSPL KSIQATLTPS AMKSSPQIPH KTYSSILKHL 720

N 721

Nucleotide Sequence
(FASTA)

ATGGCAGAAA AATTTGAAAG TCTCATGAAC ATTCATGGTT TTGATCTGGG CTCTCGGTAT 60

ATGGACTTAA AACCACTGGG CTGTGGTGGA AATGGCTTAG TTTTTTCTGC TGTCGACAAT 120

GACTGTGACA AGAGAGTGGC TGTCAAGAAA ATTGTCCTTA CGGATCCCCA GAGTGTTAAA 180

CATGCTCTAC GTGAGATCAA AATTATTAGA AGACTTGACC ACGATAACAT TGTCAAAGTA 240

TTTGAAATTC TTGGTCCTAG TGGAAGCCAG CTAACAGATG ATGTGGGCTC CCTGACAGAG 300

CTGAACTGTG TTTACATTGT CCAGGAATAC ATGGAGACGG ATCTGGCTAA TCTGCTAGAG 360

CAAGGCCCTT TACTGGAAGA TCATGCCAGA CTTTTCATGT ACCAGCTGCT ACGTGGGCTC 420

AAGTATATCC ACTCTGCAAA TGTTCTGCAT AGAGATCTCA AACCAGCTAA CCTTTTCATT 480

AATACCGAAG ACTTGGTGCT GAAGATTGGG GACTTCGGTC TTGCACGAAT CATGGATCCT 540

CATTATTCCC ACAAGGGCCA TCTTTCTGAA GGATTGGTCA CTAAATGGTA CAGATCACCC 600

CGGCTTTTAC TTTCTCCTAA CAACTACACT AAAGCCATTG ACATGTGGGC TGCAGGTTGC 660

ATCTTTGCTG AAATGCTGAC TGGGAAAACC CTCTTTGCAG GTGCACATGA ACTTGAACAG 720

ATGCAGTTGA TTCTAGAATC AATTCCTGTT GTACATGAGG AGGACCGTCA GGAGCTTCTC 780

AATGTAATTC CAGTTTACAT TAGAAATGAT ATGACTGAGC CACACAAACC TTTAACTCAG 840

TTGCTTCCAG GCATCAGTCC TGAAGCACTG GACTTTCTGG AGCAAATTTT GACATTTAGT 900

CCCATGGATC GATTGACAGC AGAAGAAGCT TTGTCCCATC CTTACATGAG CATTTATTCC 960

TTTCCAACGG ATGAGCCTAT TTCGAGTCAT CCTTTTCACA TTGAAGATGA GGTTGATGAT 1020

ATTCTGCTGA TGGATGAAAG TCACAGCCAT ATTTATAATT GGGAAAGATA CCATGAAAGT 1080

CAGTTTTCAG ACCATGACTG GCCTATTCAT AATAACTATG AAGCTGATGA AGTTCAGCGT 1140

GATCCAAGGG CTCTTTCTGA TGTTACTGAT GAGGAAGAAG TGCAAGTAGA TCCTCGCAAA 1200

TATTTGGATG GAGATCGTGA AAAGTATCTG GAGGATCCTG CTTTTGACAC CCACTTCTCT 1260

ACTGAGCCTT GCTGGCAGTA TTCAGATCAC CATGAAAACA AATACTGTGA TCTGGAATGT 1320

AGTCACACTT GTAATTACAA AATGAGGTCA TCTTCATACC TAGATAATTT AGTTTGGCGA 1380

GACAGTGAAG TTAACCATTA CTATGAGCCC AAGCTTATTA TAGATCTGTC AAACTGGAAG 1440

GAGCAGAGCA AAGAAAAGTC TGATAAGAAA GGCAAGTCTA AATGTGAAAA GAATGGATTG 1500

GTGAAAGCCC AGATAGCGCT TGAGGAAGCA TCACAGCAAC TTGTTGAAAA AGAAAGGGAG 1560

AAGAATCAAG GATTTGACTT TGATTCGTTT ATAGCAGAAA CCATTCAGCT TAGTTTACAA 1620

CACGAGCCTA CTGATGTTGA TAAATTAAAT GACTTGAATA GCTCGGTGTC TCAGATGGAG 1680

TCGAAAGGAT TAATATCGAA GTCGGTAAGC AGAGAGAAGC AGGAGAAGGG AATGGCTAAC 1740

TTGGCACAGT TAGGAGCTCT GTACCAAACT TCTTGGGACA GTCAGTTTGT AAGTAACGGG 1800

GAGGAGTGCT TCCTCATAGA CCAGTTCTGT TGTGAGGTGA GGAAAGATGA ACAAGCTGAA 1860

AAAGAAAATA CTTACACCAG TTATTTGGAC AAATTTTTTA GTAAGAAAGA AGATGCTGAA 1920

ATGCTAGAAC CTGAGCCAGT AGAAGAGGGG AAGCTTGGGG AGAAGGAGAG AGGAGAGAGC 1980

TTTCTCAGTA ACAGTGGAGA ACTCCTCTTC AACAAGCAGC TTGAGGCTAT AGGTATTCCT 2040

CAGTTTCATA GCCCTGTTGG TTCGCCACTG AAATCCATAC AGGCCACGCT AACGCCTTCT 2100

GCTATGAAAT CCTCTCCCCA GATTCCCCAC AAAACATACA GCAGCATTCT GAAACATCTA 2160

AATTAA 2166

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y++lkplg G +g+v+savd+++++rva+kk++  +++ +s+k++lRE+k++++l+h+Ni

Q: 20    YMDLKPLGCGGNGLVFSAVDNDCDKRVAVKKIV--LTDPQSVKHALREIKIIRRLDHDNI  77

         7899****************************9..9************************

S: 61    iklldvftpee........eleelkdvYlvtelmetdLkkviksqklsdehiklllyqil  112

         +k+++++ p+         +l+el+ vY+v+e+metdL++++++  l ++h++l++yq+l

Q: 78    VKVFEILGPSGsqltddvgSLTELNCVYIVQEYMETDLANLLEQGPLLEDHARLFMYQLL  137

         *********998999999999***************************************

S: 113   rglkylHsanviHrDlKPsNllvnedce.lkildFGlarsadkekekk..lteyvatrwY  169

         rglky+Hsanv+HrDlKP+Nl++n++   lki dFGlar++d+++++k  l+e ++t+wY

Q: 138   RGLKYIHSANVLHRDLKPANLFINTEDLvLKIGDFGLARIMDPHYSHKghLSEGLVTKWY  197

         ************************876449**************999999**********

S: 170   raPeillslkeytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflk  229

         r+P++lls ++ytka+D+W++GCI+aE+ltgk+lf+g++e++q+++ile ++ ++ee+ +

Q: 198   RSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQ  257

         ************************************************************

S: 230   kieseearnyikslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

         ++ +  +  yi++ +++++k++++l+p  s+eald+le++L+++p++R+++eeaL+hpY+

Q: 258   ELLNV-IPVYIRNDMTEPHKPLTQLLPGISPEALDFLEQILTFSPMDRLTAEEALSHPYM  316

         ****5.*****************************************************7

Domain Sequence
(FASTA)

YMDLKPLGCG GNGLVFSAVD NDCDKRVAVK KIVLTDPQSV KHALREIKII RRLDHDNIVK 60

VFEILGPSGS QLTDDVGSLT ELNCVYIVQE YMETDLANLL EQGPLLEDHA RLFMYQLLRG 120

LKYIHSANVL HRDLKPANLF INTEDLVLKI GDFGLARIMD PHYSHKGHLS EGLVTKWYRS 180

PRLLLSPNNY TKAIDMWAAG CIFAEMLTGK TLFAGAHELE QMQLILESIP VVHEEDRQEL 240

LNVIPVYIRN DMTEPHKPLT QLLPGISPEA LDFLEQILTF SPMDRLTAEE ALSHPYM 297

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity

KEGG

mgp:100548558

;

InterPros

IPR011009	; Kinase-like_dom.
IPR008350	; MAPK_ERK3/4.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01771

; ERK3ERK4MAPK.

Created Date

20-Feb-2013