EKS-MEG-00141

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MEG-00141

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKA	483.7	9.3E-146	35	289	255

Status

Unreviewed

Ensembl Protein

ENSMGAP00000006437

UniProt Accession

G1N3V9;

Protein Name

Protein Synonyms/Alias

Gene Name

PRKACB

Gene Synonyms/Alias

PRKACB;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000006417	ENSMGAP00000006437	ENSMGAT00000007190

Organism

Meleagris gallopavo

Functional Description

Protein Length

342

Protein Sequence
(FASTA)

VLCVFSVKEF LAKAKEDFLR KWESPPQNTA GLDDFERQKT LGTGSFGRVM MVKHKATEQY 60

YAMKILDKQK VVKLKQIEHT LNEKRILQAV NFPFLVKLEY SFKDNSNLYM VMEYVPGGEM 120

FSHLRRIGRF SEPHARFYAA QIVLTFEYLH SLDLIYRDLK PENLLIDQQG YIQVTDFGFA 180

KRVKGRTWTL CGTPEYLAPE IILSKGYNKA VDWWALGVLI YEMAAGYPPF FADQPIQIYE 240

KIVSGKVRFP SHFSSDLKDL LRNLLQVDLT KRYGNLKNGV NDIKNHKWFA TTDWIAIYQR 300

KVEAPFIPKC RGPGDTSNFD DYEEEDIRAS LTEKCAKEFA DF 342

Nucleotide Sequence
(FASTA)

GTTTTGTGTG TGTTTTCAGT GAAAGAGTTC CTAGCCAAAG CCAAAGAAGA CTTTTTAAGA 60

AAATGGGAAA GCCCACCTCA GAATACTGCT GGCCTAGATG ATTTTGAGAG GCAAAAAACT 120

CTTGGAACAG GATCATTTGG GAGAGTTATG ATGGTGAAGC ATAAAGCCAC AGAACAGTAT 180

TATGCCATGA AGATACTGGA CAAACAAAAG GTTGTCAAGC TGAAGCAGAT AGAACACACA 240

CTGAATGAAA AGAGAATATT ACAAGCAGTG AACTTTCCTT TCCTTGTAAA ACTGGAGTAT 300

TCTTTTAAGG ACAATTCTAA TTTATACATG GTAATGGAGT ATGTTCCTGG TGGTGAAATG 360

TTCTCACATC TAAGAAGAAT CGGAAGGTTC AGTGAACCAC ACGCACGGTT TTACGCAGCT 420

CAGATAGTGC TAACATTTGA GTACCTCCAT TCATTAGACC TCATCTACAG AGATCTAAAG 480

CCTGAAAATC TTTTAATTGA TCAGCAAGGA TACATCCAGG TCACGGACTT TGGCTTTGCA 540

AAAAGAGTAA AAGGAAGAAC TTGGACATTA TGTGGGACTC CAGAATACCT GGCACCTGAA 600

ATAATTCTCA GCAAGGGTTA CAACAAGGCA GTGGATTGGT GGGCATTAGG AGTGTTAATC 660

TATGAAATGG CAGCTGGATA TCCCCCATTC TTTGCAGATC AACCCATTCA AATTTATGAG 720

AAGATTGTGT CTGGCAAGGT AAGGTTCCCA TCACACTTCA GTTCAGATCT AAAGGATCTT 780

CTAAGAAATT TACTCCAGGT AGATTTGACC AAACGATATG GAAATCTCAA GAATGGTGTA 840

AATGACATAA AGAACCACAA GTGGTTTGCG ACTACAGATT GGATTGCCAT TTATCAGAGA 900

AAGGTAGAAG CTCCATTCAT ACCAAAGTGC AGAGGCCCTG GAGATACCAG CAACTTTGAT 960

GACTATGAAG AAGAAGATAT TCGTGCGTCT CTAACAGAAA AATGTGCAAA AGAATTTGCT 1020

GATTTTTAG 1029

Domain Profile

S: 1     ferlktlGtGsfGrvelvrekeskkyyalkvlskekvvklkqvehvknekrvlkavefpf  60

         fer+ktlGtGsfGrv++v++k++++yya+k+l+k+kvvklkq+eh+ nekr+l+av+fpf

Q: 35    FERQKTLGTGSFGRVMMVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPF  94

         7899********************************************************

S: 61    lvkllasfkdesnlylvleyveGGelfsylrkvrrfsekaarfyaaeivlaleylhsldl  120

         lvkl++sfkd+snly+v+eyv+GGe+fs+lr+++rfse++arfyaa+ivl++eylhsldl

Q: 95    LVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDL  154

         ************************************************************

S: 121   iyrdlkpenllldkeGyikvtdfGfakkvkdrtwtlcGtpeylapeiiqskgynkavdww  180

         iyrdlkpenll+d++Gyi+vtdfGfak+vk+rtwtlcGtpeylapeii skgynkavdww

Q: 155   IYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWW  214

         ************************************************************

S: 181   alGvliyellaGyppffddqpikiyekivsgklkfpsklssdlkdllkkllqvdltkrlg  240

         alGvliye++aGyppff+dqpi+iyekivsgk++fps++ssdlkdll++llqvdltkr+g

Q: 215   ALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRYG  274

         ************************************************************

S: 241   nlkngvedikehkwf  255

         nlkngv+dik+hkwf

Q: 275   NLKNGVNDIKNHKWF  289

         **************9

Domain Sequence
(FASTA)

FERQKTLGTG SFGRVMMVKH KATEQYYAMK ILDKQKVVKL KQIEHTLNEK RILQAVNFPF 60

LVKLEYSFKD NSNLYMVMEY VPGGEMFSHL RRIGRFSEPH ARFYAAQIVL TFEYLHSLDL 120

IYRDLKPENL LIDQQGYIQV TDFGFAKRVK GRTWTLCGTP EYLAPEIILS KGYNKAVDWW 180

ALGVLIYEMA AGYPPFFADQ PIQIYEKIVS GKVRFPSHFS SDLKDLLRNL LQVDLTKRYG 240

NLKNGVNDIK NHKWF 255

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005813	; C:centrosome
GO:0005524	; F:ATP binding
GO:0004691	; F:cAMP-dependent protein kinase activity
GO:0000287	; F:magnesium ion binding

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013