EKS-MEG-00004
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MEG-00004
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph515.41.6E-155629888260
StatusUnreviewed
Ensembl ProteinENSMGAP00000006439
UniProt AccessionG1N3W0;
Protein Name
Protein Synonyms/Alias
Gene NameEPHB2
Gene Synonyms/Alias EPHB2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMGAG00000006426ENSMGAP00000006439ENSMGAT00000007192
OrganismMeleagris gallopavo
Functional Description
Protein Length994
Protein Sequence
(FASTA)
LILLPLLSAF SETLMDSTTA TAELGWMVHP PSGWEEVSGY DENMNTIRTY QVCNVFESSQ 60
NNWLRTKYIR RRGAHRIHVE MKFSVRDCSS IPNVPGSCKE TFNLYYYESD FDSATKTFPN 120
WMENPWMKVD TIAADESFSQ VDLGGRVMKI NTEVRSFGPV SKNGFYLAFQ DYGGCMSLIA 180
VRVFYRKCPR VIQNGAVFQE TLSGAESTSL VAARGTCISN AEEVDVPIKL YCNGDGEWLV 240
PIGRCMCRPG YESVENGTVC RGCPSGTFKA SQGDEGCVHC PINSRTTSEG ATNCVCRNGY 300
YRADADPVDM PCTTIPSAPQ AVISSVNETS LMLEWTPPRD SGGREDLVYN IICKSCGSGR 360
GACTRCGDNV QFAPRQLGLT EPRIYISDLL AHTQYTFEIQ AVNGVTDQSP FSPQFASVNI 420
TTNQAAPSAV SIMHQVSRTV DSITLSWSQP DQPNGVILDY ELQYYEKNLS ELNSTAVKSP 480
TNTVTVQNLK AGTIYVFQVR ARTVAGYGRY SGKMYFQTMT EAEYQTSVQE KLPLIIGSSA 540
AGLVFLIAVV VIIIVCNRRR GFERADSEYT DKLQHYTSGH STYRGPPPGL GVRSLFVTPG 600
MKIYIDPFTY EDPNEAVREF AKEIDISCVK IEQVIGAGEF GEVCSGHLKL PGKREIFVAI 660
KTLKSGYTEK QRRDFLSEAS IMGQFDHPNV IHLEGVVTKS SPVMIITEFM ENGSLDSFLR 720
QNDGQFTVIQ LVGMLRGIAA GMKYLADMNY VHRDLAARNI LVNSNLVCKV SDFGLSRFLE 780
DDTSDPTYTS ALGGKIPIRW TAPEAIQYRK FTSASDVWSY GIVMWEVMSY GERPYWDMTN 840
QDVINAIEQD YRLPPPMDCP NALHQLMLDC WQKDRNHRPK FGQIVNTLDK MIRNPNSLKA 900
MAPLSSGVNL PLLDRTIPDY TSFNTVDEWL DAIKMSQYKE SFASAGFTTF DIVSQMTVED 960
ILRVGVTLAG HQKKILNSIQ VMRAQMNQIQ SVEV 994
Nucleotide Sequence
(FASTA)
CTGATCCTTC TGCCTCTTCT GTCTGCCTTT TCAGAGACAC TGATGGACTC CACAACAGCC 60
ACGGCAGAGC TGGGCTGGAT GGTGCATCCT CCCTCAGGGT GGGAAGAGGT GAGTGGATAC 120
GATGAGAACA TGAACACCAT CCGCACCTAC CAGGTGTGCA ACGTCTTTGA ATCCAGCCAA 180
AACAACTGGC TGCGGACCAA GTACATCCGG AGGCGAGGAG CGCACCGCAT CCACGTGGAG 240
ATGAAATTCT CCGTTCGGGA CTGCAGCAGC ATCCCCAACG TCCCGGGTTC CTGTAAGGAG 300
ACTTTTAATC TCTATTACTA CGAATCAGAC TTTGACTCTG CCACCAAGAC TTTTCCTAAC 360
TGGATGGAAA ACCCTTGGAT GAAGGTAGAT ACAATTGCTG CCGACGAGAG CTTCTCGCAG 420
GTGGACCTTG GTGGGCGGGT GATGAAGATT AACACCGAGG TGCGCAGTTT TGGGCCTGTC 480
TCCAAAAATG GTTTCTACCT GGCCTTCCAG GACTATGGGG GCTGCATGTC CTTGATTGCG 540
GTCCGTGTCT TTTACCGCAA GTGTCCCCGT GTGATCCAGA ACGGGGCGGT CTTCCAGGAA 600
ACCCTTTCGG GAGCGGAGAG CACATCTCTG GTGGCAGCCC GGGGGACGTG CATCAGCAAT 660
GCAGAGGAGG TGGATGTGCC AATCAAGCTG TACTGCAATG GGGATGGAGA GTGGCTGGTG 720
CCCATCGGCC GCTGCATGTG CAGGCCAGGC TACGAGTCGG TGGAGAATGG GACCGTCTGC 780
AGAGGCTGCC CATCAGGGAC CTTCAAGGCC AGCCAAGGAG ATGAAGGATG CGTCCATTGT 840
CCAATTAACA GCCGGACGAC TTCGGAAGGG GCCACGAACT GCGTGTGCCG AAACGGATAT 900
TATCGGGCAG ATGCTGACCC TGTCGACATG CCATGCACCA CCATCCCATC TGCCCCCCAG 960
GCTGTGATCT CCAGCGTGAA CGAAACCTCC CTGATGCTGG AGTGGACCCC ACCACGAGAC 1020
TCAGGGGGCC GGGAGGATCT GGTGTACAAC ATCATCTGCA AGAGCTGCGG GTCGGGACGC 1080
GGGGCGTGCA CACGCTGTGG GGACAACGTG CAGTTTGCCC CACGCCAGCT GGGTCTGACA 1140
GAGCCTCGCA TCTACATCAG CGACCTGCTG GCCCACACGC AGTACACCTT CGAGATCCAG 1200
GCTGTGAATG GGGTCACTGA CCAAAGCCCC TTTTCCCCGC AGTTTGCATC AGTGAATATC 1260
ACCACCAACC AGGCTGCTCC TTCAGCTGTG TCCATCATGC ACCAGGTCAG CCGCACTGTG 1320
GACAGCATTA CTCTCTCGTG GTCTCAACCT GACCAGCCCA ATGGAGTCAT CCTGGATTAT 1380
GAGCTGCAAT ATTATGAGAA GAACCTGAGT GAGTTAAATT CAACAGCAGT GAAGAGCCCC 1440
ACCAACACTG TGACAGTGCA AAACCTCAAA GCTGGCACGA TCTACGTCTT CCAAGTGCGA 1500
GCACGTACCG TGGCTGGGTA CGGCCGGTAT AGTGGCAAGA TGTACTTCCA GACCATGACT 1560
GAAGCCGAGT ACCAGACCAG TGTCCAGGAG AAGCTGCCAC TCATCATTGG CTCCTCTGCA 1620
GCAGGACTGG TGTTTCTCAT TGCTGTTGTT GTCATCATTA TTGTGTGCAA CAGAAGACGG 1680
GGCTTTGAAC GCGCCGACTC TGAGTACACT GACAAGCTGC AGCACTATAC CAGTGGCCAC 1740
AGTACGTACC GTGGTCCCCC GCCAGGCCTG GGGGTCCGCT CTCTCTTCGT GACTCCAGGG 1800
ATGAAGATTT ATATTGATCC GTTTACCTAC GAGGATCCCA ATGAGGCTGT CAGGGAATTT 1860
GCAAAAGAAA TTGATATCTC CTGTGTGAAA ATCGAGCAGG TGATTGGGGC AGGGGAGTTT 1920
GGTGAGGTGT GCAGTGGGCA TCTCAAGCTT CCTGGCAAAA GAGAGATCTT TGTGGCCATC 1980
AAGACCCTGA AATCTGGTTA CACAGAGAAG CAGAGACGGG ACTTCCTGAG TGAAGCCAGC 2040
ATCATGGGGC AGTTTGACCA CCCCAATGTA ATCCACCTGG AGGGAGTGGT GACCAAGAGT 2100
TCCCCAGTCA TGATCATTAC AGAGTTCATG GAGAATGGCT CGTTGGACTC CTTCTTGAGG 2160
CAAAATGATG GGCAGTTCAC GGTGATCCAG CTGGTGGGCA TGTTGCGTGG CATTGCAGCA 2220
GGCATGAAGT ACCTGGCTGA TATGAACTAC GTGCACCGGG ACCTGGCTGC CCGCAACATC 2280
CTGGTCAACA GCAACCTGGT CTGCAAAGTG TCCGACTTCG GCCTCTCCCG TTTCCTGGAG 2340
GATGACACCT CTGATCCCAC TTACACCAGT GCACTGGGTG GAAAGATCCC AATACGGTGG 2400
ACAGCACCTG AAGCAATTCA ATACCGAAAA TTCACATCAG CCAGTGATGT GTGGAGCTAT 2460
GGAATAGTCA TGTGGGAGGT GATGTCGTAC GGCGAGCGGC CTTACTGGGA TATGACCAAT 2520
CAAGATGTGA TAAATGCTAT TGAGCAGGAC TATCGGCTGC CACCCCCTAT GGATTGTCCA 2580
AATGCCCTGC ACCAGCTAAT GCTTGACTGT TGGCAGAAGG ATCGAAACCA CAGACCCAAA 2640
TTTGGACAGA TTGTCAACAC TTTAGACAAA ATGATCCGAA ATCCTAATAG TCTGAAAGCC 2700
ATGGCACCTC TCTCCTCTGG GGTTAACCTC CCTCTACTTG ACCGCACAAT CCCAGATTAT 2760
ACCAGCTTCA ACACTGTGGA TGAATGGCTG GATGCCATCA AGATGAGCCA GTACAAGGAG 2820
AGCTTTGCCA GTGCTGGCTT CACCACCTTT GATATAGTAT CTCAGATGAC TGTAGAGGAC 2880
ATTCTACGAG TTGGGGTCAC TTTAGCAGGA CACCAGAAGA AAATTCTGAA CAGTATCCAG 2940
GTGATGAGAG CACAGATGAA CCAAATTCAG TCTGTGGAGG TTTGA 2985
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         vkie+viGaGefGevcsG+lklpgkrei vaiktlk+g+tekqrrdflseasi+Gqfdhp
Q: 629   VKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHP  688
         79**********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         n+i+leGvvtks+pvmi+te+meng+ldsflr++dgqftviqlvgmlrGia+gmkyl+dm
Q: 689   NVIHLEGVVTKSSPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLADM  748
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvledds.eaaytts.ggkipirwtapeaiay  178
         +yvhrdlaarnilvnsnlvckvsdfGlsr+ledd+ +++yt++ ggkipirwtapeai+y
Q: 749   NYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTsDPTYTSAlGGKIPIRWTAPEAIQY  808
         **********************************99*****999****************
S: 179   rkftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlml  238
         rkftsasdvwsyGiv+wev+syGerpywdm+nqdvi+aie++yrlpppmdcp+al+qlml
Q: 809   RKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPNALHQLML  868
         ************************************************************
S: 239   dcwqkdraerpkfeqivsil  258
         dcwqkdr++rpkf qiv++l
Q: 869   DCWQKDRNHRPKFGQIVNTL  888
         *****************975
Domain Sequence
(FASTA)
VKIEQVIGAG EFGEVCSGHL KLPGKREIFV AIKTLKSGYT EKQRRDFLSE ASIMGQFDHP 60
NVIHLEGVVT KSSPVMIITE FMENGSLDSF LRQNDGQFTV IQLVGMLRGI AAGMKYLADM 120
NYVHRDLAAR NILVNSNLVC KVSDFGLSRF LEDDTSDPTY TSALGGKIPI RWTAPEAIQY 180
RKFTSASDVW SYGIVMWEVM SYGERPYWDM TNQDVINAIE QDYRLPPPMD CPNALHQLML 240
DCWQKDRNHR PKFGQIVNTL 260
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>
EKS-CAF-00005
EKS-CAP-00004
EKS-DAR-00002
EKS-DRM-00001
EKS-EQC-00005
EKS-GAG-00005
EKS-GAA-00006
EKS-GOG-00004
EKS-HOS-00006
EKS-ICT-00004
EKS-LOA-00005
EKS-MOD-00005
EKS-MUM-00005
EKS-MUP-00004
EKS-MYL-00005
EKS-ORN-00004
EKS-ORC-00004
EKS-ORL-00005
EKS-OTG-00003
EKS-PAT-00005
EKS-PES-00010
EKS-PEM-00001
EKS-POA-00013
EKS-PTV-00003
EKS-RAN-00005
EKS-SAH-00004
EKS-SUS-00004
EKS-TAG-00009
EKS-TAR-00006
EKS-TEN-00005
EKS-TUT-00002
EKS-XIM-00002
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0043025; C:neuronal cell body
GO:0005524; F:ATP binding
GO:0008046; F:axon guidance receptor activity
GO:0005003; F:ephrin receptor activity
GO:0007411; P:axon guidance
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0048168; P:regulation of neuronal synaptic plasticity
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR009030; Growth_fac_rcpt.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07699; GCC2_GCC3; 1.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013