EKS-MEG-00307

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MEG-00307

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	386.6	3.7E-116	238	486	249

Status

Unreviewed

Ensembl Protein

ENSMGAP00000006490

UniProt Accession

G1N3Z8;

Protein Name

Protein Synonyms/Alias

Gene Name

SRMS

Gene Synonyms/Alias

SRMS;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000006462	ENSMGAP00000006490	ENSMGAT00000007243

Organism

Meleagris gallopavo

Functional Description

Protein Length

498

Protein Sequence
(FASTA)

QTLHPPGMEQ FVRKRLTFLT SFWNKLWPRS GPDSCSLGYF GSDSVSLHSE PSCVSFIPKS 60

SLCIALYAFT ARSADELTVN AGDKLRVLRE EGDYVLARRL LGEPATGYVP AAYVANLSQG 120

TSAHRPWYFS KISRSEAEQL LLSPPNQHGS FLVRDSESSR GEYSLSVRNH TKVSHFRICK 180

SPSGSLYIQR GHPFPDMEEL LAFYTENWKV IQSPLLQPCS PTTPPERDGW ERPRWEFTLR 240

RKLGEGYFGE VWEGLWRNTV PVAIKIIKAD MKAEDFTKEI QNLKRLRHEK LIQLHAVCSL 300

DEPVYIITEL MRKGNLHSYL NSPEGKSLGT SHLLNIACQV ADGMRYLEEK HIVHRDLAAR 360

NILVGEELTC KIADFGLARL LKDDIYSTSS STKIPVKWTA PEAANYRTYS LKSDVWSYGI 420

LLYEVFTYGQ IPYEGMTNQE TIRQITRGYR LPRPSSCPPE IYSIMLECWS GNTEERPTFL 480

ALREKLGFIY RRLLNTLS 498

Nucleotide Sequence
(FASTA)

CAGACGCTGC ATCCTCCAGG GATGGAGCAG TTCGTCCGCA AGCGTTTGAC CTTCTTGACA 60

TCCTTCTGGA ACAAGCTGTG GCCCCGCTCA GGCCCGGATA GCTGCTCGCT GGGGTACTTT 120

GGTTCCGATT CTGTTTCGCT GCACTCGGAG CCCAGCTGCG TTTCCTTCAT TCCAAAGTCC 180

TCTCTCTGTA TCGCTTTATA CGCTTTCACA GCCCGCAGTG CAGATGAACT GACTGTAAAT 240

GCAGGGGACA AACTGCGTGT CCTCAGAGAA GAAGGGGACT ATGTCTTAGC CAGGAGGCTG 300

CTGGGGGAAC CGGCCACGGG ATACGTCCCT GCTGCATATG TGGCCAACCT CAGCCAGGGC 360

ACCTCTGCTC ACCGACCGTG GTATTTCAGC AAGATCAGCC GCAGTGAGGC CGAGCAGCTG 420

CTCCTCTCGC CTCCAAACCA GCATGGCTCC TTCCTTGTCC GGGACAGTGA GAGCAGCAGG 480

GGCGAGTACT CTCTCTCAGT GCGCAACCAC ACCAAAGTCA GCCATTTCCG CATCTGCAAG 540

AGCCCTTCAG GCAGCCTCTA CATCCAGAGG GGTCATCCCT TCCCCGACAT GGAGGAGCTG 600

CTTGCCTTCT ACACCGAGAA CTGGAAGGTC ATCCAGAGCC CCTTACTGCA GCCCTGCAGC 660

CCCACGACCC CCCCGGAGAG GGATGGCTGG GAGCGCCCGC GCTGGGAATT CACCCTGCGG 720

AGGAAGCTGG GCGAGGGCTA CTTCGGAGAA GTGTGGGAAG GACTGTGGAG GAACACAGTG 780

CCCGTGGCCA TCAAGATCAT CAAAGCTGAC ATGAAGGCAG AAGACTTCAC CAAGGAGATT 840

CAAAACCTGA AGCGCTTGAG GCATGAGAAG CTGATCCAAC TGCACGCTGT CTGCTCGCTG 900

GATGAGCCTG TGTACATCAT CACCGAGCTC ATGCGGAAAG GCAACCTGCA CAGCTACCTC 960

AACAGTCCTG AAGGAAAGTC CCTGGGCACC TCCCACCTGC TCAACATCGC CTGCCAGGTG 1020

GCAGATGGGA TGAGGTACCT GGAGGAGAAG CACATCGTCC ACCGGGACTT GGCGGCCAGA 1080

AACATCCTGG TGGGAGAGGA GCTCACCTGC AAAATTGCTG ACTTTGGACT GGCCCGGCTC 1140

CTCAAGGATG ACATTTATTC CACCAGCAGC AGCACCAAAA TCCCGGTGAA ATGGACAGCC 1200

CCTGAGGCAG CCAACTACCG CACCTACTCT CTCAAATCCG ATGTCTGGTC CTATGGCATT 1260

CTGCTCTATG AAGTCTTCAC ATACGGGCAG ATCCCATATG AAGGAATGAC AAACCAAGAA 1320

ACCATACGAC AAATCACCAG GGGCTACCGC CTTCCCCGGC CCAGCTCCTG CCCTCCTGAG 1380

ATTTACAGCA TCATGTTGGA GTGCTGGAGT GGCAACACGG AGGAGCGGCC CACCTTCCTG 1440

GCACTGCGGG AGAAATTGGG CTTCATCTAC AGGCGGCTGC TCAACACCCT GTCCTGA 1497

Domain Profile

S: 2     klvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvklya  61

         +l +klGeG+fGevw+g+w+++v+va+k +k  +++ e+f++e+q lk+lrhekl++l+a

Q: 238   TLRRKLGEGYFGEVWEGLWRNTVPVAIKIIKA-DMKAEDFTKEIQNLKRLRHEKLIQLHA  296

         689***************************97.59*************************

S: 62    vvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihrd  121

         v+s +eP+yi+telm+kG+l ++l++ egk+l  ++l+++a+qva+Gm yleek+++hrd

Q: 297   VCSLDEPVYIITELMRKGNLHSYLNSPEGKSLGTSHLLNIACQVADGMRYLEEKHIVHRD  356

         ************************************************************

S: 122   laarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdvW  181

         laarn+lvge+l++k+adfGlarl++dd+y++++++k+P+kWtaPea++++++++ksdvW

Q: 357   LAARNILVGEELTCKIADFGLARLLKDDIYSTSSSTKIPVKWTAPEAANYRTYSLKSDVW  416

         ************************************************************

S: 182   sfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpeer  241

         s+Gill+e++t+G++Py+Gmtn+e+++q++rgyrlprp++cp e+y+++lecw+ + eer

Q: 417   SYGILLYEVFTYGQIPYEGMTNQETIRQITRGYRLPRPSSCPPEIYSIMLECWSGNTEER  476

         ************************************************************

S: 242   Ptfetlqevl  251

         Ptf +l+e+l

Q: 477   PTFLALREKL  486

         ****999875

Domain Sequence
(FASTA)

TLRRKLGEGY FGEVWEGLWR NTVPVAIKII KADMKAEDFT KEIQNLKRLR HEKLIQLHAV 60

CSLDEPVYII TELMRKGNLH SYLNSPEGKS LGTSHLLNIA CQVADGMRYL EEKHIVHRDL 120

AARNILVGEE LTCKIADFGL ARLLKDDIYS TSSSTKIPVK WTAPEAANYR TYSLKSDVWS 180

YGILLYEVFT YGQIPYEGMT NQETIRQITR GYRLPRPSSC PPEIYSIMLE CWSGNTEERP 240

TFLALREKL 249

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013