EPS-MEG-00073

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-MEG-00073

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPP/PP2B	428.0	3.9E-129	67	267	201

Status

Unreviewed

Ensembl Protein

ENSMGAP00000018420

UniProt Accession

G1N4D9;

Protein Name

Serine/threonine-protein phosphatase

Protein Synonyms/Alias

Gene Name

PPP3CB

Gene Synonyms/Alias

PPP3CB;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000006623	ENSMGAP00000018420	ENSMGAT00000018720
ENSMGAG00000006623	ENSMGAP00000006685	ENSMGAT00000007441

Organism

Meleagris gallopavo

Functional Description

Protein Length

489

Protein Sequence
(FASTA)

ILAVPFPPTH RLTSEEVFDT DGKPRVDILK NHLIKEGRVD EEIALRIINE GAAILRREKT 60

MIEVEAPITV CGDIHGQFFD LMKLFEVGGS PANTRYLFLG DYVDRGYFSI ECVLYLWVLK 120

ILYPSTLFLL RGNHECRHLT EYFTFKQECK IKYSERVYDA CMEAFDCLPL AALLNQQFLC 180

VHGGLSPEIN TLDDIRRLDR FKEPPAFGPM CDLLWSDPSE DFGNESSPEH FSHNTVRGCS 240

YFYSYPAVCE FLQNNNLLSI IRAHEAQDAG YRMYRKSQTT GFPSLITIFS APNYLDVYNN 300

KAAVLKYENN VMNIRQFNCS PHPYWLPNFM DVFTWSLPFV GEKVTEMLVN VLSICSDDEL 360

MTEGEDQFDV GTAAARKEII RNKIRAIGKM ARVFSVLREE SESVLTLKGL TPTGMLPSGV 420

LAGGRQTLQS AIRGFSPQHK ICSFEEAKGL DRINERMPPR KDALQQDGIN TINTTNANGN 480

NGTGNNNAQ 489

Nucleotide Sequence
(FASTA)

ATTTTAGCTG TCCCTTTTCC ACCAACGCAT CGTTTGACAT CTGAAGAAGT GTTTGACACA 60

GATGGAAAAC CCAGGGTTGA CATTTTGAAG AACCACTTGA TAAAGGAAGG TCGAGTGGAT 120

GAAGAAATTG CACTTAGAAT CATCAATGAG GGTGCTGCAA TATTACGGAG GGAAAAAACT 180

ATGATAGAAG TTGAAGCTCC AATTACAGTG TGTGGTGATA TACATGGCCA GTTCTTTGAT 240

CTAATGAAGC TGTTTGAAGT GGGAGGATCA CCTGCTAACA CAAGATACCT CTTCCTCGGT 300

GACTATGTAG ACAGAGGTTA TTTTAGTATA GAGTGTGTGC TGTATTTATG GGTCCTGAAA 360

ATTCTCTATC CAAGCACGTT ATTTCTTTTG AGAGGCAACC ATGAATGCAG ACACCTAACA 420

GAGTATTTTA CCTTTAAACA AGAATGTAAA ATAAAATACT CTGAAAGAGT CTATGATGCT 480

TGCATGGAAG CTTTTGATTG CCTTCCTCTT GCTGCTCTCT TAAATCAACA GTTTCTTTGT 540

GTTCATGGTG GACTTTCACC AGAAATTAAT ACACTAGATG ACATTAGGAG ATTAGATAGA 600

TTCAAAGAAC CTCCAGCATT TGGACCAATG TGTGACTTAC TGTGGTCAGA TCCTTCAGAA 660

GATTTTGGAA ATGAAAGTTC ACCAGAGCAC TTCAGTCACA ATACAGTCAG AGGATGCTCA 720

TACTTTTATA GCTATCCAGC AGTTTGTGAA TTTTTGCAAA ATAATAATTT GTTGTCAATC 780

ATTAGAGCAC ACGAAGCACA AGATGCAGGT TATAGAATGT ACAGGAAAAG TCAAACTACA 840

GGGTTTCCAT CATTAATAAC AATTTTTTCA GCACCTAATT ACCTGGATGT CTACAATAAT 900

AAAGCTGCTG TTTTAAAATA TGAAAACAAT GTGATGAATA TTCGTCAATT CAATTGTTCT 960

CCTCATCCTT ACTGGCTACC AAATTTTATG GATGTTTTTA CATGGTCCTT GCCATTTGTT 1020

GGAGAAAAAG TAACTGAAAT GTTGGTGAAT GTTTTGAGCA TTTGTTCTGA TGATGAACTG 1080

ATGACAGAGG GAGAAGATCA ATTTGACGTA GGTACAGCTG CTGCACGGAA AGAAATAATC 1140

AGGAACAAAA TTCGTGCAAT TGGCAAGATG GCAAGAGTCT TCTCTGTTCT CAGGGAGGAG 1200

AGTGAAAGTG TGCTGACACT CAAGGGTTTG ACTCCCACTG GAATGTTACC TAGTGGAGTG 1260

TTGGCTGGAG GACGACAGAC CCTGCAAAGT GCAATACGAG GATTCTCTCC GCAACATAAA 1320

ATCTGCAGTT TTGAAGAAGC AAAAGGTTTG GATAGGATCA ATGAGAGAAT GCCACCAAGA 1380

AAAGATGCTC TTCAGCAAGA TGGTATTAAT ACTATAAACA CAACAAATGC CAATGGAAAC 1440

AATGGAACTG GCAACAACAA TGCACAGTGA 1470

Domain Profile

S: 1     pvtvcgdihgqffdllklfevggspantrylflgdyvdrgyfsiecvlylyalkilypkt  60

         p+tvcgdihgqffdl+klfevggspantrylflgdyvdrgyfsiecvlyl++lkilyp+t

Q: 67    PITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPST  126

         9***********************************************************

S: 61    lfllrgnhecrhlteyftfkqelkikyservydacleafdalplaallnqqflcvhggls  120

         lfllrgnhecrhlteyftfkqe+kikyservydac+eafd+lplaallnqqflcvhggls

Q: 127   LFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMEAFDCLPLAALLNQQFLCVHGGLS  186

         ************************************************************

S: 121   pelktlddirkldrfkeppayglmcdllwsdpledfgnekseeefvhnsvrgcsyfysyk  180

         pe++tlddir+ldrfkeppa+g+mcdllwsdp edfgne s e+f+hn+vrgcsyfysy+

Q: 187   PEINTLDDIRRLDRFKEPPAFGPMCDLLWSDPSEDFGNESSPEHFSHNTVRGCSYFYSYP  246

         ************************************************************

S: 181   avceflqennllsiiraheaq  201

         avceflq+nnllsiiraheaq

Q: 247   AVCEFLQNNNLLSIIRAHEAQ  267

         ********************8

Domain Sequence
(FASTA)

PITVCGDIHG QFFDLMKLFE VGGSPANTRY LFLGDYVDRG YFSIECVLYL WVLKILYPST 60

LFLLRGNHEC RHLTEYFTFK QECKIKYSER VYDACMEAFD CLPLAALLNQ QFLCVHGGLS 120

PEINTLDDIR RLDRFKEPPA FGPMCDLLWS DPSEDFGNES SPEHFSHNTV RGCSYFYSYP 180

AVCEFLQNNN LLSIIRAHEA Q 201

Keyword

Complete proteome; Hydrolase; Iron; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>

Gene Ontology

GO:0005955	; C:calcineurin complex
GO:0005886	; C:plasma membrane
GO:0005509	; F:calcium ion binding
GO:0005516	; F:calmodulin binding
GO:0033192	; F:calmodulin-dependent protein phosphatase activity
GO:0008144	; F:drug binding
GO:0030346	; F:protein phosphatase 2B binding
GO:0017156	; P:calcium ion-dependent exocytosis
GO:0035690	; P:cellular response to drug
GO:0001915	; P:negative regulation of T cell mediated cytotoxicity
GO:0035774	; P:positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0006470	; P:protein dephosphorylation
GO:0006468	; P:protein phosphorylation
GO:0010468	; P:regulation of gene expression
GO:0034097	; P:response to cytokine stimulus
GO:0043029	; P:T cell homeostasis

KEGG

InterPros

IPR004843	; Metallo_PEstase_dom.
IPR006186	; Ser/Thr-sp_prot-phosphatase.

Pfam

PF00149

; Metallophos; 1.

SMARTs

SM00156

; PP2Ac; 1.

Prosites

PS00125

; SER_THR_PHOSPHATASE; 1.

Prints

PR00114

; STPHPHTASE.

Created Date

20-Feb-2013