EKS-MEG-00175

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MEG-00175

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE7	385.5	1.0E-115	53	314	262

Status

Unreviewed

Ensembl Protein

ENSMGAP00000006696

UniProt Accession

G1N4E6;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP2K6

Gene Synonyms/Alias

MAP2K6;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000006657	ENSMGAP00000006696	ENSMGAT00000007452

Organism

Meleagris gallopavo

Functional Description

Protein Length

336

Protein Sequence
(FASTA)

MSQSRGKKRN PGLKIPKEAF EQPQTSSTPP RDLDSKACIS IGEENFEVKA DDLEPISELG 60

RGAYGVVEKM RHMPSGQIMA VKRIRATVNS QEQKRLLMDL DISMRTVDCP FTVTFYGALF 120

REGDVWICME LMDTSLDKFY KHVIDKGLTI PEDILGKIAV SIVKALEHLH SKLSVIHRDV 180

KPSNVLINTQ GQVKMCDFGI SGYLVDSVAK TMDAGCKPYM APERINPELN QKGYSVKSDI 240

WSLGITMIEL AILRFPYDSW GTPFQQLKQV VEEPSPQLPA EKFSAEFVDF TSQCLKKNSK 300

ERPTYPELMT HTYFNTLHTS PGTKDVASFV KLILGD 336

Nucleotide Sequence
(FASTA)

ATGTCTCAGT CGAGAGGCAA GAAGAGAAAC CCTGGGCTGA AAATTCCTAA AGAAGCATTT 60

GAGCAACCAC AGACGAGCTC CACGCCACCC AGGGATCTAG ACTCCAAAGC CTGCATCTCT 120

ATTGGCGAGG AGAACTTTGA GGTGAAAGCT GATGACCTGG AGCCCATCTC CGAGCTGGGA 180

CGAGGTGCAT ACGGGGTGGT GGAGAAGATG CGGCACATGC CTAGCGGGCA GATCATGGCA 240

GTGAAGCGCA TCCGAGCCAC GGTGAACAGC CAAGAGCAGA AGAGGTTATT GATGGATCTG 300

GATATCTCCA TGAGGACAGT AGATTGCCCC TTCACCGTTA CTTTCTATGG AGCACTTTTC 360

CGAGAGGGAG ATGTGTGGAT TTGCATGGAG CTGATGGATA CCTCACTGGA CAAATTCTAC 420

AAGCATGTCA TTGACAAAGG CCTGACGATT CCTGAGGACA TCTTAGGGAA AATAGCTGTC 480

TCTATTGTAA AAGCACTAGA ACATCTACAC AGTAAGCTCT CCGTGATCCA CAGAGATGTA 540

AAGCCCTCTA ACGTGTTGAT CAATACGCAG GGGCAGGTGA AAATGTGCGA TTTTGGAATT 600

AGCGGTTACC TCGTTGACTC GGTTGCTAAA ACCATGGATG CAGGATGCAA ACCCTACATG 660

GCTCCTGAAA GAATTAACCC GGAGTTGAAC CAGAAGGGGT ACAGCGTCAA ATCTGATATC 720

TGGAGCCTGG GGATCACAAT GATCGAGCTG GCCATCCTGC GCTTTCCCTA TGACTCCTGG 780

GGGACGCCCT TCCAGCAGCT CAAGCAGGTG GTGGAGGAGC CATCGCCGCA GCTCCCAGCG 840

GAAAAGTTCT CAGCAGAGTT CGTCGATTTT ACCTCGCAAT GCTTGAAGAA GAATTCCAAA 900

GAGCGGCCAA CATACCCAGA GCTTATGACA CATACATATT TTAACACTCT CCATACAAGC 960

CCTGGTACAA AAGACGTCGC CTCTTTTGTC AAACTCATCC TGGGAGACTG A 1011

Domain Profile

S: 1     lekleelGaGnggvVekvlhkksgkilavKtirleikkeeqkqilrelevlkkssnspyi  60

         le ++elG+G++gvVek++h +sg+i+avK+ir++++++eqk++l++l++ +++ ++p++

Q: 53    LEPISELGRGAYGVVEKMRHMPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFT  112

         67899*******************************************************

S: 61    vkfyGafvsegdvsicmelmdgtsldkvlkkvlekkkripekvlgkiavavvkaleylke  120

         v+fyGa+++egdv+icmelmd tsldk++k+v++k  +ipe++lgkiav++vkale+l++

Q: 113   VTFYGALFREGDVWICMELMD-TSLDKFYKHVIDKGLTIPEDILGKIAVSIVKALEHLHS  171

         *********************.**************************************

S: 121   klkiiHRDvKPsNiLvnskGevKlCDFGvsgqlvdsiAksa.vGtksYmaPErieg...k  176

         kl++iHRDvKPsN+L+n++G+vK+CDFG+sg+lvds+Ak++ +G+k+YmaPEri++   +

Q: 172   KLSVIHRDVKPSNVLINTQGQVKMCDFGISGYLVDSVAKTMdAGCKPYMAPERINPelnQ  231

         ********************************************************9999

S: 177   kkYsvksdvWslGltlvelatgrypyeklkeilellkaivneeppklpeeefseefqefv  236

         k Ysvksd+WslG+t++ela+ r+py+++ +++++lk++v+e++p+lp+e+fs ef++f

Q: 232   KGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPAEKFSAEFVDFT  291

         9***********************************************************

S: 237   skClkkdekeRpklkellkhafi  259

         s+Clkk++keRp++ el++h+++

Q: 292   SQCLKKNSKERPTYPELMTHTYF  314

         ********************985

Domain Sequence
(FASTA)

LEPISELGRG AYGVVEKMRH MPSGQIMAVK RIRATVNSQE QKRLLMDLDI SMRTVDCPFT 60

VTFYGALFRE GDVWICMELM DTSLDKFYKH VIDKGLTIPE DILGKIAVSI VKALEHLHSK 120

LSVIHRDVKP SNVLINTQGQ VKMCDFGISG YLVDSVAKTM DAGCKPYMAP ERINPELNQK 180

GYSVKSDIWS LGITMIELAI LRFPYDSWGT PFQQLKQVVE EPSPQLPAEK FSAEFVDFTS 240

QCLKKNSKER PTYPELMTHT YF 262

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0000187	; P:activation of MAPK activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013