EKS-MEG-00334
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MEG-00334
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR576.02.5E-173602960359
StatusUnreviewed
Ensembl ProteinENSMGAP00000006912
UniProt AccessionG1N4V8;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NamePDGFRB
Gene Synonyms/Alias PDGFRB;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMGAG00000006856ENSMGAP00000006912ENSMGAT00000007675
OrganismMeleagris gallopavo
Functional Description
Protein Length1097
Protein Sequence
(FASTA)
WAVEPTMLCP SLKASLQLFI LTGLLDVTSG GSRLHIEPED AELVLRLHST FSLVCYGDRA 60
LVWERDGQPL TALLEHRDGV FVSNLTLKNV TGRHTGEYAC FYSPDQAPER AERKALYIYV 120
PDPSLVFLPA ITSEEFFIFI TGYTEAIIPC RVTNPELQVT LYEKKVENPI PAAYDPQQGF 180
KGFFEDKTYY CQAIVDDQEV DSDTFYVYRI QVSSVNVSIS AVQTVVRQGE NVTLMCTVSG 240
NELVNFNWDY PRKQAGKAVE PVTDFLPGST HDIRSILIIQ NAELEDSGTY VCNVSEGYHE 300
KTDRKDITVQ VIERGFVRFH THLASTVYAE VHKSHIIQVD VEAYPQPNIV WLKNNKTLTM 360
ESSSEFTITN RNLSETRYQT SLVLVRVKQE EGGYYTIRAS NEDDAQELSF HLQINVPAKV 420
VDLKENSSAS SGEQTVTCSA EGMPQPEISW STCSNIKWCG NQGQPTQLLG NNSAEIGLHT 480
NATYHAELQV YRVNSTLQLH RVDEPLLLRC TVQNFLGSNS QDITLVPNAL PFKVVIISVI 540
LALLVLTVIS LIILIVLWQK KPRYEIRWKV IESVSSDGHE YIYVDPMQLP YDSSWEVPRD 600
KLVLGRTLGS GAFGRVVEAT AHGLSHSQST MKVAVKMLKS TARSSEKQAL MSELKIMSHL 660
GPHLNIVNLL GACTKGGPIY IITEYCRYGD LVDYLHRNKH TFLQSYGEKA RREAELYGNT 720
IKVSLSPSSH LSLSVESDGG YMDMSKDESL DYVPMSDMKG EVKYADIESS NYGTPYELDS 780
YSPSAPERTD RATLINESPL LSYMDLVGFS FQVANGMEFL ASKNCVHRDL AARNVLICEG 840
KLVKICDFGL ARDIMRDSNY ISKGSTFLPL KWMAPESIFN NLYTTLSDVW SFGILLWEIF 900
TLGGTPYPEL PMNEQFYNAI KRGYRMSKPT HASDEIYDIM QKCWEEKFEI RPSFSQLVVL 960
MGNLLVDCYR KRYQQVDEEF MKSDHPAVVR TRPTIPGLNN ARLPPSSPTL YTAVHQNGGE 1020
NDYIIPLPDP KPEAVCDLPQ EASISRASSM LNEANTSSTI SCDSPLGPQQ DEEPECDLQL 1080
GCQELAPGHH EVEESFL 1097
Nucleotide Sequence
(FASTA)
TGGGCCGTGG AGCCCACCAT GCTCTGTCCC TCTCTGAAGG CATCACTGCA GCTCTTCATT 60
CTCACTGGTC TGCTGGATGT AACGTCTGGG GGCAGCAGGC TGCACATCGA ACCTGAAGAT 120
GCTGAGCTCG TCCTTAGGCT TCACAGCACC TTTTCCCTTG TGTGCTATGG GGACAGAGCG 180
CTAGTCTGGG AGCGGGATGG TCAGCCTCTC ACTGCCTTGC TGGAGCACAG GGATGGGGTC 240
TTTGTCAGCA ACCTCACCCT CAAGAATGTG ACAGGCCGTC ACACAGGGGA GTATGCGTGC 300
TTCTACAGCC CTGACCAGGC TCCAGAGCGA GCAGAGAGGA AAGCCCTTTA CATCTATGTT 360
CCAGATCCCT CCTTAGTTTT CCTCCCCGCA ATCACTTCTG AAGAGTTCTT CATCTTCATC 420
ACGGGCTACA CAGAGGCCAT CATCCCATGC CGTGTGACCA ACCCAGAGCT GCAGGTGACC 480
CTCTATGAAA AGAAAGTGGA GAATCCCATT CCAGCTGCTT ATGACCCACA ACAGGGTTTC 540
AAAGGTTTCT TTGAGGACAA GACCTACTAC TGCCAGGCAA TCGTGGATGA CCAAGAGGTG 600
GATTCTGACA CCTTCTATGT CTACAGGATC CAGGTCTCAT CTGTGAATGT CTCCATCAGC 660
GCGGTGCAGA CTGTAGTGCG TCAGGGAGAA AATGTTACCC TGATGTGCAC TGTCAGCGGC 720
AATGAGCTGG TCAACTTCAA CTGGGATTAT CCACGCAAGC AGGCTGGGAA GGCTGTGGAG 780
CCAGTGACCG ACTTCCTGCC TGGATCCACC CATGACATCC GTTCCATCCT CATCATCCAG 840
AATGCAGAGC TAGAGGACAG TGGGACCTAC GTCTGCAATG TCTCTGAGGG CTACCATGAG 900
AAAACAGACC GGAAAGACAT CACGGTCCAA GTGATCGAGC GTGGCTTTGT GCGCTTCCAC 960
ACCCACCTGG CCAGCACAGT GTATGCTGAG GTCCACAAGA GCCACATCAT CCAGGTGGAT 1020
GTGGAGGCCT ACCCACAGCC GAACATTGTG TGGCTAAAGA ACAACAAGAC ATTGACCATG 1080
GAGAGCAGCA GCGAGTTCAC CATCACCAAC AGGAACCTGT CAGAAACCAG GTACCAGACG 1140
TCTCTGGTCC TGGTGCGGGT GAAGCAGGAG GAAGGAGGAT ATTACACCAT CCGAGCTTCC 1200
AATGAGGACG ATGCACAAGA GCTGTCCTTC CATCTGCAAA TAAATGTACC AGCCAAAGTG 1260
GTGGATCTCA AGGAAAACAG CAGTGCCAGC AGCGGGGAGC AGACTGTAAC ATGCTCTGCT 1320
GAAGGGATGC CCCAGCCAGA GATCAGTTGG TCCACTTGCA GCAACATCAA ATGGTGTGGC 1380
AACCAGGGGC AGCCCACCCA GCTGCTGGGG AACAACTCTG CAGAGATCGG CCTGCACACC 1440
AACGCCACGT ACCATGCAGA GCTGCAGGTG TACCGCGTGA ACAGCACCCT GCAGCTGCAC 1500
AGGGTGGATG AACCCCTGCT CCTGAGATGC ACTGTGCAAA ACTTCCTGGG CTCCAACTCC 1560
CAAGACATCA CTCTGGTCCC AAATGCCTTG CCGTTCAAAG TGGTCATCAT CTCCGTCATC 1620
CTGGCTCTGC TGGTCCTCAC TGTCATCTCC CTGATCATCT TGATCGTCCT GTGGCAGAAG 1680
AAACCTCGCT ATGAAATCCG CTGGAAGGTG ATCGAGTCAG TGAGCTCTGA TGGGCACGAG 1740
TACATCTATG TGGATCCCAT GCAGCTCCCT TATGACTCCA GCTGGGAGGT GCCCAGGGAC 1800
AAGCTGGTGT TAGGACGCAC TCTTGGCTCC GGTGCCTTTG GACGTGTGGT GGAGGCAACG 1860
GCACATGGCC TGAGCCATTC ACAGTCCACC ATGAAAGTTG CAGTCAAGAT GCTCAAGTCC 1920
ACTGCCCGGA GCAGTGAGAA GCAAGCCCTC ATGTCTGAGC TGAAGATCAT GAGCCACCTG 1980
GGACCTCACC TCAACATTGT CAACTTGCTG GGGGCCTGCA CCAAAGGAGG GCCCATCTAT 2040
ATCATCACCG AGTACTGCCG TTACGGGGAC CTGGTGGACT ACCTGCACCG CAACAAGCAC 2100
ACCTTCCTGC AGTCCTATGG CGAGAAGGCC CGCCGGGAGG CAGAGCTGTA TGGGAACACC 2160
ATCAAAGTCT CTCTTTCCCC CTCCAGTCAC CTTTCCTTGT CTGTTGAGAG TGATGGGGGC 2220
TATATGGACA TGAGCAAGGA TGAGTCTCTG GATTATGTGC CCATGTCTGA CATGAAGGGT 2280
GAAGTCAAGT ACGCTGACAT CGAGTCCTCT AACTACGGCA CCCCATACGA GCTGGACAGC 2340
TATTCCCCAT CAGCTCCTGA AAGAACAGAC CGGGCGACAC TGATAAATGA ATCTCCACTC 2400
CTCAGCTACA TGGACTTGGT GGGCTTCAGC TTCCAAGTGG CCAATGGGAT GGAATTCCTG 2460
GCTTCTAAAA ATTGTGTGCA TCGTGACCTG GCTGCCAGGA ACGTCCTCAT CTGCGAGGGA 2520
AAGCTGGTGA AGATCTGTGA CTTTGGTCTG GCAAGAGACA TCATGAGGGA TTCCAACTAC 2580
ATTTCCAAAG GAAGTACTTT CTTGCCCCTT AAGTGGATGG CTCCTGAGAG CATCTTCAAC 2640
AACCTCTACA CCACCTTAAG TGATGTGTGG TCCTTTGGGA TTCTTCTCTG GGAAATATTC 2700
ACTCTAGGAG GGACTCCCTA CCCTGAACTG CCTATGAATG AACAGTTCTA CAATGCCATC 2760
AAACGTGGCT ATCGGATGTC CAAACCCACC CATGCTTCTG ATGAAATCTA TGATATTATG 2820
CAGAAGTGCT GGGAGGAGAA GTTTGAGATC AGACCATCCT TCTCACAGCT GGTGGTGCTT 2880
ATGGGAAACC TCTTGGTGGA TTGCTACAGA AAGAGGTACC AGCAGGTGGA TGAAGAGTTC 2940
ATGAAGAGCG ACCACCCCGC TGTTGTACGC ACAAGACCCA CCATCCCTGG GCTGAACAAC 3000
GCCAGGCTCC CTCCCAGCTC CCCAACCCTC TACACGGCTG TGCACCAGAA CGGGGGAGAG 3060
AATGACTACA TCATCCCTCT TCCTGACCCC AAGCCTGAGG CAGTCTGTGA CCTCCCTCAG 3120
GAGGCCTCCA TCAGCCGTGC CAGCTCTATG CTGAATGAAG CCAACACATC ATCTACAATA 3180
TCCTGTGACA GCCCTCTGGG CCCCCAGCAG GACGAGGAGC CGGAATGTGA CCTGCAGCTG 3240
GGCTGCCAGG AGCTGGCCCC AGGGCACCAC GAGGTGGAGG AGAGCTTCCT GTAG 3294
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l+lG++lGsGafG+vveata+Gls+s++++kvavkmlkstarssek+almselki+shlG
Q: 602   LVLGRTLGSGAFGRVVEATAHGLSHSQSTMKVAVKMLKSTARSSEKQALMSELKIMSHLG  661
         78**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +h+nivnllGactkgGpiy+iteyc+yGdl++yl+r++++fl+++ ek   +e+el+ ++
Q: 662   PHLNIVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQSYGEK-ARREAELYGNT  720
         ******************************************999999.6678999****
S: 121   lladkslrsksslssesseeyvdlkkd................vsdvssskadklas..e  162
         ++++ s  s+ sls+es++ y+d++kd                ++d++ss++ ++++  +
Q: 721   IKVSLSPSSHLSLSVESDGGYMDMSKDesldyvpmsdmkgevkYADIESSNYGTPYEldS  780
         ****************************************************99986115
S: 163   kkksalerevkaaleeedsevleledllsfsyqvakGmeflaskncvhrdlaarnvllte  222
         +  sa er+ +a+l++e s  l+++dl+ fs+qva+Gmeflaskncvhrdlaarnvl++e
Q: 781   YSPSAPERTDRATLINE-SPLLSYMDLVGFSFQVANGMEFLASKNCVHRDLAARNVLICE  839
         568899*********99.99****************************************
S: 223   GkvvkicdfGlardimkdsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillwei  282
         Gk+vkicdfGlardim+dsny++kG+++lp+kwmapesif++lyt+ sdvws+Gillwei
Q: 840   GKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNNLYTTLSDVWSFGILLWEI  899
         ************************************************************
S: 283   fslGstpypgllvdskfyklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlve  342
         f+lG+tpyp+l+++++fy++ik+Gyrm++p++a++eiy+imqkcwe+++e rpsf+qlv 
Q: 900   FTLGGTPYPELPMNEQFYNAIKRGYRMSKPTHASDEIYDIMQKCWEEKFEIRPSFSQLVV  959
         **********************************************************98
S: 343   l  343
         l
Q: 960   L  960
         7
Domain Sequence
(FASTA)
LVLGRTLGSG AFGRVVEATA HGLSHSQSTM KVAVKMLKST ARSSEKQALM SELKIMSHLG 60
PHLNIVNLLG ACTKGGPIYI ITEYCRYGDL VDYLHRNKHT FLQSYGEKAR REAELYGNTI 120
KVSLSPSSHL SLSVESDGGY MDMSKDESLD YVPMSDMKGE VKYADIESSN YGTPYELDSY 180
SPSAPERTDR ATLINESPLL SYMDLVGFSF QVANGMEFLA SKNCVHRDLA ARNVLICEGK 240
LVKICDFGLA RDIMRDSNYI SKGSTFLPLK WMAPESIFNN LYTTLSDVWS FGILLWEIFT 300
LGGTPYPELP MNEQFYNAIK RGYRMSKPTH ASDEIYDIMQ KCWEEKFEIR PSFSQLVVL 359
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00377
EKS-ANC-00390
EKS-BOT-00403
EKS-CAJ-00406
EKS-CAF-00403
EKS-CAP-00431
EKS-DAR-00792
EKS-EQC-00395
EKS-FEC-00387
EKS-GAG-00340
EKS-GAA-00491
EKS-GOG-00395
EKS-HOS-00408
EKS-ICT-00382
EKS-LAC-00418
EKS-LOA-00411
EKS-MAM-00401
EKS-MOD-00394
EKS-MUM-00434
EKS-MUP-00396
EKS-MYL-00398
EKS-NOL-00367
EKS-OCP-00083
EKS-ORN-00513
EKS-ORA-00353
EKS-ORC-00377
EKS-ORL-00471
EKS-OTG-00404
EKS-PES-00358
EKS-POA-00393
EKS-RAN-00417
EKS-SAH-00371
EKS-SUS-00358
EKS-TAG-00472
EKS-TAR-00509
EKS-TEN-00510
EKS-XET-00513
EKS-XIM-00505
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005019; F:platelet-derived growth factor beta-receptor activity
GO:0005021; F:vascular endothelial growth factor-activated receptor activity
GO:0060326; P:cell chemotaxis
GO:0006807; P:nitrogen compound metabolic process
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0046488; P:phosphatidylinositol metabolic process
GO:0048015; P:phosphatidylinositol-mediated signaling
GO:0030335; P:positive regulation of cell migration
GO:0038091; P:positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0010863; P:positive regulation of phospholipase C activity
GO:0032516; P:positive regulation of phosphoprotein phosphatase activity
GO:0046777; P:protein autophosphorylation
GO:0050730; P:regulation of peptidyl-tyrosine phosphorylation
GO:0048010; P:vascular endothelial growth factor receptor signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
IPR009134; Tyr_kinase_VEGFR_rcpt_N.
Pfam
PF07679; I-set; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 2.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 4.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
PR01832; VEGFRECEPTOR.
Created Date20-Feb-2013