EKS-MEG-00336
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MEG-00336
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR545.64.3E-164570898329
StatusUnreviewed
Ensembl ProteinENSMGAP00000007026
UniProt AccessionG1N542;
Protein Name
Protein Synonyms/Alias
Gene NameCSF1R
Gene Synonyms/Alias CSF1R;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMGAG00000006864ENSMGAP00000007026ENSMGAT00000007791
OrganismMeleagris gallopavo
Functional Description
Protein Length951
Protein Sequence
(FASTA)
LEYRAMLCVT LSLFFAGSAS PVISPNISAL VVNVGDPVLL RCSGESEVKW YPEKFANHTS 60
SILSIPRTTH RDTGTYRCAY VNSSDKGVAS VHLYVQDPNN VWYVPYFRIS VTKGGNAEFP 120
CFITAPEYGS NVTLIRNDGS KLPPGTNYSF SPEKGITLYH VEHEQKGQYQ CQTVVNGKIE 180
KSSRIRLIVV EGQEKPVQVM VDPADHVRIV GEPFEVTCVV TAPSHKYDIK WVTPTNSVKS 240
NGKPDISDGN YIINDTLSIP AVTMEDSGKY TCIANNSAGF KNASTMLRVV ERGYVILTPV 300
QAMNQEAAEG DSLKLQVHIE AYPKLLHWHW EHRRPFQHPS RISHFLLPQR RSRYNNTLFL 360
DHLKGEERGL YTFYAFNSEV NSSVTFSVSV KASPRLCSVM VSASDSSKLL CTAVGYPAPH 420
IEWYQCPTHS DRYEDYMLLL NDSSPHVVNT LPFQEVEVES TFPFQDLGAN FTFCCVAVNS 480
EGSTSDILHS VLRSVMAPPN QLFSPILTTC MCTSVLLLLL LLFLLYKYNQ KPKYQVRWKI 540
IEACEGNNYI FIDPTQLPYN EKWEFPRNNL QFGKTLGAGA FGKVVEATAF GLGKEDSVLK 600
VAVKMLKSTA HTDEQEALMS ELKIMSHLGH HENIVNLLGA CTYGGPILVI TEYCRYGDLL 660
NFLRKKAEYI IIQDSALDTS LDSTADYKNI DLEKKYIRSD SGFASQGLET YVEMRPISSS 720
SSGKSSEEDE SREDLRPLNL SDLLQFSSQV AQGMAFLASK NCIHRDLAAR NVLVSDGRVA 780
KICDFGLARD IMNDSNYVVK GNARLPVKWM APESIFDCIY TVQSDVWSYG ILLWEIFSLG 840
KSPYPGMAVN SKFYSMVKRG YQMARPDFAP LEMYSIMQAC WSLEPTQRPT FDQICCFIQK 900
ELDLHKEQDY TNLPSTAEED SGCDTSGCCE ESCEQEESGQ PLLKGNNYQF C 951
Nucleotide Sequence
(FASTA)
TTAGAGTACC GGGCCATGCT CTGCGTCACT CTTTCTCTTT TCTTTGCAGG CTCAGCATCC 60
CCTGTGATCA GCCCTAATAT CTCTGCTCTG GTTGTCAATG TGGGTGATCC AGTCCTCCTG 120
CGCTGCTCAG GAGAGTCAGA AGTTAAATGG TACCCTGAAA AGTTTGCCAA CCATACCAGC 180
AGCATACTCA GTATTCCTAG GACCACTCAC AGAGACACAG GCACCTATAG GTGTGCTTAT 240
GTCAACAGCA GCGACAAGGG TGTTGCATCT GTGCATCTGT ACGTGCAAGA TCCCAATAAT 300
GTGTGGTACG TCCCATACTT CCGGATCTCT GTGACCAAAG GTGGAAATGC TGAGTTCCCC 360
TGCTTCATCA CTGCTCCCGA GTATGGATCC AATGTGACTC TGATAAGGAA TGATGGCTCT 420
AAGCTCCCAC CTGGAACCAA CTACTCTTTC AGTCCTGAGA AGGGAATAAC GCTTTATCAT 480
GTGGAACACG AGCAGAAGGG CCAATACCAA TGCCAAACAG TGGTAAATGG AAAAATAGAG 540
AAGTCATCAA GAATAAGACT GATTGTGGTT GAAGGACAAG AGAAGCCTGT ACAGGTAATG 600
GTGGACCCTG CAGACCATGT GCGAATTGTG GGTGAACCTT TTGAAGTCAC TTGTGTAGTA 660
ACTGCTCCTT CCCATAAGTA TGACATCAAA TGGGTAACAC CAACAAACAG CGTTAAGAGT 720
AATGGAAAGC CTGACATAAG TGATGGGAAC TACATCATCA ATGACACCCT GTCAATTCCA 780
GCAGTGACCA TGGAAGACAG TGGGAAATAC ACTTGCATAG CTAACAATTC AGCAGGATTC 840
AAGAATGCCT CCACAATGCT TCGGGTAGTA GAAAGAGGGT ATGTGATCCT GACCCCAGTG 900
CAAGCCATGA ACCAAGAAGC TGCTGAAGGA GACAGTTTGA AACTCCAGGT CCATATTGAG 960
GCATATCCAA AACTTCTCCA CTGGCACTGG GAGCACCGAA GACCCTTCCA GCATCCCAGT 1020
AGGATCAGCC ACTTCCTGCT TCCCCAGAGA AGGAGCAGGT ATAACAACAC GCTCTTCCTG 1080
GATCATCTGA AGGGAGAAGA GAGAGGTCTC TATACGTTTT ATGCTTTCAA CAGTGAGGTC 1140
AACTCATCAG TTACTTTCAG TGTATCTGTG AAAGCTTCTC CAAGGCTGTG CAGTGTCATG 1200
GTATCAGCTA GTGACTCCAG TAAGCTTCTC TGCACAGCCG TTGGCTACCC TGCCCCACAC 1260
ATTGAGTGGT ACCAGTGCCC CACTCACTCT GACAGATATG AGGACTATAT GCTGCTTTTG 1320
AATGACTCCA GTCCCCATGT GGTGAATACA CTACCCTTCC AAGAGGTGGA GGTGGAGAGC 1380
ACTTTCCCAT TCCAGGATCT AGGGGCCAAT TTCACCTTCT GCTGTGTGGC TGTTAACAGC 1440
GAGGGGAGCA CCTCTGACAT TCTTCACTCA GTCCTCAGGA GTGTCATGGC TCCCCCAAAC 1500
CAGCTCTTCA GTCCCATTCT CACCACCTGC ATGTGCACAT CGGTCTTGCT GCTCCTGCTG 1560
CTCCTCTTCC TCCTCTACAA GTACAACCAG AAACCTAAGT ACCAGGTGCG GTGGAAGATC 1620
ATTGAGGCCT GTGAAGGGAA TAACTACATC TTTATCGATC CCACTCAGCT GCCATACAAT 1680
GAGAAATGGG AGTTTCCCCG GAATAACCTC CAGTTTGGAA AAACTCTTGG AGCTGGAGCT 1740
TTTGGAAAAG TAGTAGAAGC CACTGCTTTT GGACTGGGAA AAGAAGATTC AGTTCTCAAA 1800
GTGGCTGTGA AGATGCTGAA ATCAACGGCA CACACAGATG AGCAGGAGGC TCTCATGTCT 1860
GAGCTGAAGA TCATGAGTCA TTTGGGACAC CATGAGAACA TTGTTAACCT GCTGGGAGCG 1920
TGTACCTATG GAGGTCCAAT TCTTGTCATC ACCGAGTACT GTCGCTATGG AGATCTGCTG 1980
AATTTCCTGC GGAAGAAGGC TGAATACATA ATTATCCAGG ACTCAGCTCT GGACACCTCT 2040
TTGGACAGCA CTGCTGATTA CAAAAACATT GACCTGGAGA AAAAATACAT CCGCAGTGAC 2100
AGTGGCTTTG CGAGCCAGGG TTTGGAAACT TATGTTGAAA TGAGGCCCAT ATCATCATCA 2160
TCTTCAGGGA AAAGCTCAGA GGAAGATGAA AGCAGAGAGG ACCTCCGGCC CCTTAACCTC 2220
TCTGATCTGC TTCAATTCTC CAGCCAGGTG GCACAGGGCA TGGCATTCCT CGCATCAAAG 2280
AATTGCATCC ACCGTGACTT AGCAGCCAGG AATGTGCTTG TATCAGATGG ACGGGTAGCC 2340
AAGATTTGTG ACTTTGGCCT GGCTCGTGAC ATCATGAATG ACTCAAACTA CGTTGTAAAA 2400
GGCAATGCCC GCCTGCCCGT GAAGTGGATG GCCCCAGAGA GCATCTTTGA CTGCATTTAT 2460
ACAGTGCAGA GTGATGTGTG GTCTTACGGC ATTCTTCTCT GGGAGATTTT CTCCCTTGGT 2520
AAAAGTCCCT ATCCTGGCAT GGCGGTGAAC AGCAAGTTCT ACAGCATGGT GAAGCGGGGC 2580
TACCAGATGG CCAGGCCTGA CTTTGCTCCT TTGGAAATGT ATAGCATCAT GCAGGCATGC 2640
TGGAGCCTGG AGCCCACACA GAGACCTACA TTTGACCAGA TCTGCTGCTT TATTCAGAAA 2700
GAACTGGATT TGCATAAGGA ACAGGACTAC ACAAACCTCC CATCCACTGC TGAGGAAGAC 2760
AGTGGCTGTG ATACCTCTGG CTGCTGTGAG GAGTCCTGTG AACAAGAGGA GAGTGGGCAG 2820
CCCCTTCTCA AAGGCAACAA CTATCAGTTC TGTTAG 2856
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l++Gk+lG+GafGkvveata+Gl+k+d+vlkvavkmlksta+++e+ealmselki+shlG
Q: 570   LQFGKTLGAGAFGKVVEATAFGLGKEDSVLKVAVKMLKSTAHTDEQEALMSELKIMSHLG  629
         79**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +henivnllGact gGpi+viteyc+yGdlln+lr+k+e ++ + +   +  ++ +d+k+
Q: 630   HHENIVNLLGACTYGGPILVITEYCRYGDLLNFLRKKAEYIIIQDSALDTSLDSTADYKN  689
         ******************************************9999999999999*****
S: 121   l.ladkslrsksslssesseeyvdlkkdvsdvssskadklasekkksalerevkaaleee  179
         + l++k++rs+s ++s++ e+yv++++    +sss++ k ++e+            ++ e
Q: 690   IdLEKKYIRSDSGFASQGLETYVEMRP----ISSSSSGKSSEED------------ESRE  733
         *999***********************....7777776666555............4568
S: 180   dsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardimk  239
         d ++l+l+dll+fs+qva+Gm+flasknc+hrdlaarnvl+++G+v+kicdfGlardim+
Q: 734   DLRPLNLSDLLQFSSQVAQGMAFLASKNCIHRDLAARNVLVSDGRVAKICDFGLARDIMN  793
         89**********************************************************
S: 240   dsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvdskf  299
         dsnyvvkGnarlpvkwmapesifd++ytv+sdvwsyGillweifslG +pypg+ v+skf
Q: 794   DSNYVVKGNARLPVKWMAPESIFDCIYTVQSDVWSYGILLWEIFSLGKSPYPGMAVNSKF  853
         ************************************************************
S: 300   yklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344
         y ++k+Gy+ma+p++a+ e+y+imq+cw  ep++rp+f q++ ++
Q: 854   YSMVKRGYQMARPDFAPLEMYSIMQACWSLEPTQRPTFDQICCFI  898
         *****************************************9876
Domain Sequence
(FASTA)
LQFGKTLGAG AFGKVVEATA FGLGKEDSVL KVAVKMLKST AHTDEQEALM SELKIMSHLG 60
HHENIVNLLG ACTYGGPILV ITEYCRYGDL LNFLRKKAEY IIIQDSALDT SLDSTADYKN 120
IDLEKKYIRS DSGFASQGLE TYVEMRPISS SSSGKSSEED ESREDLRPLN LSDLLQFSSQ 180
VAQGMAFLAS KNCIHRDLAA RNVLVSDGRV AKICDFGLAR DIMNDSNYVV KGNARLPVKW 240
MAPESIFDCI YTVQSDVWSY GILLWEIFSL GKSPYPGMAV NSKFYSMVKR GYQMARPDFA 300
PLEMYSIMQA CWSLEPTQRP TFDQICCFI 329
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00376
EKS-ANC-00391
EKS-BOT-00405
EKS-CAJ-00409
EKS-CAF-00405
EKS-CAP-00434
EKS-DAR-00788
EKS-EQC-00397
EKS-FEC-00389
EKS-GAG-00342
EKS-GAA-00492
EKS-GOG-00397
EKS-HOS-00411
EKS-ICT-00384
EKS-LAC-00420
EKS-LOA-00414
EKS-MAM-00404
EKS-MOD-00393
EKS-MUM-00437
EKS-MUP-00398
EKS-MYL-00400
EKS-ORN-00515
EKS-ORC-00380
EKS-ORL-00473
EKS-OTG-00407
EKS-PAT-00383
EKS-PES-00359
EKS-PTV-00115
EKS-RAN-00419
EKS-SAH-00375
EKS-SUS-00355
EKS-TAG-00474
EKS-TAR-00511
EKS-TEN-00512
EKS-TUT-00118
EKS-XET-00514
EKS-XIM-00507
Gene Ontology
GO:0009986; C:cell surface
GO:0016021; C:integral to membrane
GO:0005886; C:plasma membrane
GO:0043235; C:receptor complex
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0008283; P:cell proliferation
GO:0045217; P:cell-cell junction maintenance
GO:0038145; P:macrophage colony-stimulating factor signaling pathway
GO:0046488; P:phosphatidylinositol metabolic process
GO:0048015; P:phosphatidylinositol-mediated signaling
GO:0030335; P:positive regulation of cell migration
GO:0090197; P:positive regulation of chemokine secretion
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:0071902; P:positive regulation of protein serine/threonine kinase activity
GO:0061098; P:positive regulation of protein tyrosine kinase activity
GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein
GO:2000249; P:regulation of actin cytoskeleton reorganization
GO:0031529; P:ruffle organization
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
Pfam
PF07679; I-set; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 3.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
Created Date20-Feb-2013