EPS-MEG-00034

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-MEG-00034

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	190.9	2.8E-56	39	292	254

Status

Unreviewed

Ensembl Protein

ENSMGAP00000007199

UniProt Accession

G1N5H1;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1E

Gene Synonyms/Alias

PPM1E;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000007109	ENSMGAP00000007199	ENSMGAT00000007967

Organism

Meleagris gallopavo

Functional Description

Protein Length

565

Protein Sequence
(FASTA)

EIETVKLARL VFSKLHEICS NWVKEFPLQP KPHRYYETSI HAIKNMRRKM EDKHVCIPDF 60

NMLFNLEDQE EQAYFAVFDG HGGVDAAIYA SIHLHVNMVH QEMFQHDPAE ALCRAFRVTD 120

ERFVQKAARE SLRCGTTGVV TFIRGNMLHV AWLGDSQVML VRRGQAVELM KPHKPDREDE 180

KKRIEALGGC VVWFGAWRVN GSLSVSRAIG DAEHKPYICG DADSASTVLD GSEDYLILAC 240

DGFYDTVNPD EAVKVVADHL KENNGDSSMV AHKLVASARD AGSSDNITVI VVFLRDMNAA 300

VSVSEESDWT ENSFQGGQED NGEDKENHGE CKRPWPQHQC SAPADLGYEG RVDSFTDRTS 360

LSIGSGINPF DDQGYLDLTK TETSTPNSAK CLPPIQVFSP GIPKNASLIN GLTVKNESPE 420

STSSICGQSN PREYSAPLGL HAAEQSIYRV KGLTPIFFGL EDELFKSLGK RVAFFHFRFC 480

NGKRRRGARL KPKFHTPLLA REPSHREGSG LPLPVRSRGS TRLLVRHSPW WRLPSPNAYS 540

ESMFLMRRQS HCIPDAYLHQ CYELE 565

Nucleotide Sequence
(FASTA)

GAGATTGAGA CAGTGAAACT AGCCCGCTTA GTTTTTAGCA AACTCCACGA GATCTGCAGC 60

AACTGGGTGA AAGAATTCCC ACTCCAGCCG AAGCCACACC GCTATTATGA GACGTCCATC 120

CACGCCATCA AGAATATGCG GAGGAAAATG GAAGACAAGC ATGTCTGCAT TCCAGACTTC 180

AACATGCTCT TCAACCTTGA GGACCAAGAA GAGCAAGCCT ACTTTGCGGT GTTTGATGGC 240

CACGGGGGAG TGGATGCTGC CATCTATGCC TCCATCCATC TCCATGTGAA CATGGTCCAT 300

CAGGAGATGT TTCAGCACGA CCCGGCCGAG GCGCTGTGCC GAGCTTTCCG GGTGACGGAT 360

GAGCGCTTTG TCCAGAAGGC AGCCAGAGAG AGCCTGCGTT GTGGAACCAC CGGGGTGGTG 420

ACTTTCATCC GAGGGAATAT GTTACATGTG GCTTGGCTTG GGGACTCTCA GGTTATGCTT 480

GTGAGGAGAG GCCAAGCTGT GGAACTGATG AAACCCCACA AACCAGATCG AGAGGATGAG 540

AAGAAACGCA TCGAGGCGCT TGGTGGCTGT GTGGTCTGGT TTGGAGCCTG GAGGGTGAAT 600

GGGAGCCTGT CAGTCTCCAG AGCTATTGGG GACGCTGAGC ACAAGCCATA CATCTGTGGG 660

GATGCAGACT CTGCCTCCAC TGTACTAGAT GGCTCTGAAG ACTACCTCAT TTTAGCCTGC 720

GATGGTTTCT ATGACACGGT CAATCCCGAT GAGGCAGTCA AAGTGGTGGC TGACCATCTA 780

AAGGAAAATA ATGGTGACAG CAGCATGGTA GCACATAAAT TAGTGGCATC TGCTCGGGAT 840

GCCGGTTCCA GCGACAACAT TACTGTCATT GTGGTATTTC TCAGGGACAT GAATGCAGCA 900

GTCAGCGTTA GTGAGGAGTC AGACTGGACA GAGAACTCTT TTCAAGGTGG GCAAGAAGAC 960

AATGGGGAGG ATAAGGAAAA CCACGGAGAA TGCAAGCGAC CGTGGCCCCA GCACCAGTGC 1020

TCAGCACCTG CTGACCTAGG CTATGAAGGA CGAGTGGATT CCTTCACTGA TAGAACTAGC 1080

TTAAGCATAG GGTCCGGCAT TAACCCATTT GATGATCAAG GTTATTTAGA CCTGACAAAA 1140

ACAGAAACTA GTACGCCTAA TAGTGCCAAA TGCCTGCCAC CAATTCAAGT GTTTAGTCCT 1200

GGTATACCAA AGAATGCAAG TTTGATTAAT GGTTTAACAG TGAAGAATGA ATCGCCGGAG 1260

AGCACATCAT CCATCTGTGG ACAGAGCAAC CCCAGGGAGT ACAGTGCTCC TCTCGGTTTG 1320

CATGCTGCAG AGCAGAGCAT CTACAGGGTG AAGGGTTTAA CCCCCATCTT CTTTGGGCTG 1380

GAAGATGAAC TGTTCAAGTC CTTGGGAAAA CGAGTTGCGT TCTTTCATTT CCGATTCTGT 1440

AATGGGAAGA GGCGACGAGG AGCCAGGCTC AAACCAAAGT TTCACACGCC GCTCTTGGCT 1500

CGTGAGCCTT CCCACAGAGA GGGGTCGGGT CTGCCCTTGC CTGTCCGAAG CCGTGGTAGC 1560

ACGAGGCTGT TGGTAAGACA CTCCCCGTGG TGGAGGCTGC CCAGTCCTAA CGCTTACAGT 1620

GAGAGCATGT TTTTGATGCG AAGACAAAGT CATTGTATAC CAGATGCATA CCTTCATCAA 1680

TGCTATGAAT TAGAA 1695

Domain Profile

S: 4     gvvsvngrrnemedavtsspnflkspekkdr..laffgvyDGhggsevakfcseklheil  61

         ++ +++++r++med++   p+f    + +d+   a+f+v+DGhgg ++a ++s +lh  +

Q: 39    SIHAIKNMRRKMEDKHVCIPDFNMLFNLEDQeeQAYFAVFDGHGGVDAAIYASIHLHVNM  98

         567899**************99766555544459***********************888

S: 62    aeelesseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikdsklyvan  121

           +       + +  +al +aF  tde++  ++++  ++ ++G+t vv  i+++ l+va

Q: 99    VHQEM----FQHDPAEALCRAFRVTDERF--VQKAARESLRCGTTGVVTFIRGNMLHVAW  152

         88855....5777888999**********..7777788888*******************

S: 122   vGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdga.RvlGvLavsRalGd  180

         +GdS+++L r g+avel + Hkp+redE++Rie+ gg v+ + ga Rv+G+L vsRa+Gd

Q: 153   LGDSQVMLVRRGQAVELMKPHKPDREDEKKRIEALGGCVV-WFGAwRVNGSLSVSRAIGD  211

         *************************************999.55899**************

S: 181   lylkpyvtpePevtshrltsedefliLasDGlwdvvsneeavslvrdvle.kkeaeqeaa  239

          + kpy+  + +  s+ l+ ++++liLa+DG +d+v++ eav++v d+l+ ++ + + +a

Q: 212   AEHKPYICGDADSASTVLDGSEDYLILACDGFYDTVNPDEAVKVVADHLKeNNGDSSMVA  271

         ************************************************9966778899**

S: 240   kkLvklalargskdnvsaivv  260

         +kLv+ a++ gs+dn+++ivv

Q: 272   HKLVASARDAGSSDNITVIVV  292

         *****************9997

Domain Sequence
(FASTA)

SIHAIKNMRR KMEDKHVCIP DFNMLFNLED QEEQAYFAVF DGHGGVDAAI YASIHLHVNM 60

VHQEMFQHDP AEALCRAFRV TDERFVQKAA RESLRCGTTG VVTFIRGNML HVAWLGDSQV 120

MLVRRGQAVE LMKPHKPDRE DEKKRIEALG GCVVWFGAWR VNGSLSVSRA IGDAEHKPYI 180

CGDADSASTV LDGSEDYLIL ACDGFYDTVN PDEAVKVVAD HLKENNGDSS MVAHKLVASA 240

RDAGSSDNIT VIVV 254

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005730	; C:nucleolus
GO:0043234	; C:protein complex
GO:0046872	; F:metal ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0035690	; P:cellular response to drug
GO:0006469	; P:negative regulation of protein kinase activity
GO:0035970	; P:peptidyl-threonine dephosphorylation
GO:0051496	; P:positive regulation of stress fiber assembly

KEGG

InterPros

IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013