EKS-MEG-00092

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MEG-00092

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/LRRK	356.7	5.5E-107	1804	2051	248

Status

Unreviewed

Ensembl Protein

ENSMGAP00000007280

UniProt Accession

G1N5N3;

Protein Name

Protein Synonyms/Alias

Gene Name

LRRK2

Gene Synonyms/Alias

LRRK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000007137	ENSMGAP00000007280	ENSMGAT00000008051

Organism

Meleagris gallopavo

Functional Description

Protein Length

2450

Protein Sequence
(FASTA)

ILQMGWSLLC KLIEICPSTL QNIALKDVGK DWEVLGVHQQ ILKMLTVHKG NVILSVIGLK 60

TLNLLLMSDV IAFLLLEEEV DVFSLVFNAM HTFPKNEEIQ QHGCRALCKL FEKVPEEQLT 120

EFVESKDHMI ILEVFKEFPE KEEVILPALY SLHSLAGPCN NVEVLMSGNV RCYNVIVEMM 180

KSFPNSETVQ EVCCCLLHKL TLGNFFNILV LHKVPEVIVK AVKTYSENAK LQAAALSCLA 240

LLTETIFLNR DLEERKEEEE EEKLCWLEAC YRALELHRKN TDVLEAACWA LKNLFLYQRS 300

LHEKIGDGDN QFPIDRAVML SMLMHSSSKE VFQAAASTLA ILSQQNVNIR KTLLAKGIHM 360

NVLEIMKKHP HSPEVAESAC RILNHVFEGS FPHLDIMTVA ASEVVKAMRK HEKSLSVQLE 420

ALRVLLHFMM PGKLSKNFFP NVKCVCTVKV IKSQCLLEGT HSLVLGALNR FIGNPSIQRC 480

GLKLLTSVAE CTGALEILTQ QGATDTVLHT LQMYPDEQDI QSLGLSLLLF LITRKSLCIA 540

TMHVLATVLV STLRRFKEVT EIQMHGFHAI LSILGFSPCF AKLLINESFD TVIFYQMSMC 600

FTNQRDRQFQ SLCCKCFAKI AENDDLKNMM LEKACVEYNC IMAECLLLLG ADINKKTKTS 660

SLIYQVCEKG NNPKLVELLL ANGAREQDVR SALTISIKRG DSQIISLLLK KLSLDVANSS 720

ICLGGFGIGR LEPSWLIPLF PDKLTPPRKQ NTDAGSALAR MVLKYQMKNI SEDRSRTCSD 780

LNFSEDGVDK NYDWDFISDP LVDTVFPSSD DIDSEGSEGS LFRKKKSNSI AVADLHCREL 840

AFQRGSPTLP RHSYSVGPGS DYEPLVKQRR KLLLSDEPSR ISKSSLHLRP SDSLSSLISE 900

KECIKSLDLS SNELENIDAI SQNSSLMSHL EHLDKLELHQ NALTNIPEQL CENLKCLTYL 960

DLHSNRFTSF PTYLLKMNCI AYLDISRNDI GPSFALDPHL RCPTLKQLNL SYNQLMGIPE 1020

FLANVAENLE QLLLEGNKIS CLSSPMSLKE LKILNISKNN ISSLAENVLM GCAKLELFNA 1080

RMNALEIIPD LSSSITTLKL SQNCFINVPE TILLLPHLRS VDLSQNKIIS LPGPVHWKSL 1140

NLRELLFNHN QIGVLDLSEK ACAWSRLEKL HLSNNKLKEI PPQIGFLENL TSLDVSHNPD 1200

LRFFPDEMGR LSKIWDLPLE GLHLNLDFKH VGCKARDIIR FLQQRLKKAV PYNRMKLMIV 1260

GNTGSGKTTL LQQLMKCKRT ELGCPKATVG IDVKDWIIQG KGKMKKELIL NVWDFGGQEE 1320

FYSTHPHFMT QRALYLAVYD LSKGQAEVDA MKPWLFNIKA RASTSPVILV GTHLDVSDEK 1380

QHKDCMSKIT RELLNKRGFP AIQDYHFVNA KEESDSIMRL RKIIIKESLH FKIRDQPVVG 1440

QLIPDSYLEL EKRILLERKN VPVEFPVIDQ KRLLEMVQEN KLQLDENELP HAIHFLNESG 1500

VLLHFQDPAL QLRDLYFVDP KWLCKIMAQI LTVKVEGFSK YPKGIVKRSD VEKFLLKKSK 1560

FPKIYMSQYF KLLEKFQIAL PLGEDQLLIP SSLSDHRPVI ELPHCENSEI IIRLYEMPYF 1620

PMGFWSRLIN RLLEISPYML SGRARALRPN RMYWRQGIYL NWSPEAYCLV ESAVFDNNPD 1680

SFLKITAPSC RKGCILLGQV VDHIDSLMEE WFPGLLDIDV CGEGETLLKK WALYSFEDGE 1740

EHQKILLDDL LKKAEEGDLL VNPEQPRHTI PIAQIAPDLI LADLPRNIML NTDELEFDKA 1800

PEFLLGDGGF GSVYRASYAG EEVAVKIFNK HTSLRLLRQE LAVLCHLHHP SLVSLLAAAV 1860

RPRMLVMELA LKGSLDRLLQ QDKANLTRTL QHRIALHVAD GLRYLHSAMI IYRDLKPHNV 1920

LLFTLYPNAA VIAKIADYGI AQYCCRMGIK TSEGTPGFRA PEVARGNVIY NQQADVYSFG 1980

LLLYDILTGG GRIMEGVKFP NEFDELAIQG KLPDPVKEYG CAPWPKVEHL IKKCLKENPQ 2040

ERPTSSQVYE ILNSAELICL MRYVSIPSTS TAECMVATNQ SCKKAGVWIG NGNTEKAQLS 2100

FVNLNTDGHT CEDIADSKIL SLALVTLPTE KENWIVAGTH SGSLWAVNTE DETRRHRLQK 2160

MSDSITCLYC NSLSKQSKQK NFFLVGTADG MLAVFEDRAV KCKGATPLKI LTIGNVSTPL 2220

MCLNESTYLS EKNTIWGGCG TKLIALSSDF SVQKLIETKS SQLFCHNAYS DANIISIAVD 2280

KSIYLAKKNS HFVEIWDKKT EKLSELIDCA HFLKDEVEKL NQESKHKVAY SGRVKTICLQ 2340

KNTALWVGTG GGHILLLDLS TRRPVRVIDN FCDSIRVMLT AQLEKGSLKN VVLVLGYCYK 2400

GDTEDDKYRK ELQSCVSVWD INLPHEVQNL KKHIEVRQEL AEKMKSFTLD 2450

Nucleotide Sequence
(FASTA)

ATTTTACAGA TGGGTTGGTC GCTTCTTTGC AAGTTGATTG AAATTTGTCC AAGTACTCTG 60

CAGAACATAG CTCTTAAGGA TGTTGGGAAG GACTGGGAAG TGCTGGGTGT TCACCAGCAG 120

ATTCTTAAAA TGCTCACAGT CCACAAAGGA AATGTAATTC TCTCAGTAAT AGGACTAAAA 180

ACATTAAATC TACTCCTGAT GTCAGATGTA ATTGCTTTCC TGCTCCTGGA GGAAGAAGTG 240

GATGTGTTTT CCTTGGTATT TAATGCCATG CACACCTTCC CTAAAAATGA AGAGATCCAG 300

CAACATGGAT GTAGAGCATT ATGCAAGCTT TTTGAAAAAG TTCCAGAAGA GCAGCTGACT 360

GAATTTGTTG AAAGCAAAGA TCATATGATC ATACTGGAAG TATTTAAAGA GTTTCCAGAG 420

AAAGAGGAGG TGATTCTTCC TGCACTTTAT TCATTACATT CCTTAGCTGG TCCGTGTAAC 480

AATGTTGAAG TGCTCATGTC TGGAAATGTT CGCTGCTACA ATGTTATAGT AGAAATGATG 540

AAAAGTTTCC CCAATAGTGA AACTGTTCAG GAAGTATGTT GCTGCTTGTT GCATAAGCTT 600

ACTTTGGGAA ACTTTTTCAA TATCCTTGTG TTACATAAGG TTCCAGAAGT CATCGTGAAG 660

GCTGTGAAAA CATATTCTGA AAATGCAAAG TTACAGGCTG CAGCTCTCAG TTGTTTAGCT 720

CTTCTCACTG AAACAATATT CTTAAACCGA GACTTAGAGG AAAGAAAAGA AGAGGAGGAG 780

GAAGAAAAAT TATGCTGGTT GGAAGCATGT TACAGAGCAT TGGAACTGCA CCGGAAAAAT 840

ACAGATGTAC TGGAGGCTGC ATGCTGGGCT TTGAAAAATC TGTTTCTATA TCAACGTAGT 900

CTTCATGAGA AGATTGGAGA TGGAGATAAT CAGTTCCCCA TAGATAGAGC AGTGATGCTG 960

TCCATGCTGA TGCACTCCTC TTCCAAAGAA GTGTTTCAGG CAGCAGCTAG TACCTTGGCA 1020

ATTTTGTCAC AACAGAATGT AAATATTAGG AAGACACTTT TGGCTAAAGG AATACACATG 1080

AATGTCTTGG AGATAATGAA GAAACACCCA CATTCTCCTG AAGTGGCTGA AAGCGCCTGC 1140

AGAATTCTGA ATCATGTTTT TGAAGGAAGT TTCCCTCATT TGGATATAAT GACAGTAGCT 1200

GCATCTGAAG TTGTAAAAGC CATGAGAAAA CATGAGAAAT CACTATCTGT ACAACTGGAA 1260

GCACTTCGAG TCCTTTTACA CTTTATGATG CCTGGTAAGT TGTCTAAAAA CTTTTTCCCC 1320

AATGTTAAGT GTGTGTGTAC AGTAAAAGTC ATTAAAAGCC AGTGTCTGCT GGAGGGAACT 1380

CATTCGTTGG TGCTTGGTGC TTTGAACAGG TTTATTGGAA ATCCTAGCAT TCAGAGGTGT 1440

GGATTAAAAC TACTTACTTC TGTAGCTGAG TGCACTGGTG CTTTAGAAAT TTTAACACAG 1500

CAAGGAGCCA CTGACACTGT GCTTCACACC CTGCAGATGT ATCCAGATGA ACAAGACATA 1560

CAGAGTTTGG GTTTGAGTCT TCTGCTCTTT TTGATTACAA GAAAGAGTTT GTGTATTGCA 1620

ACTATGCATG TCCTGGCAAC TGTTCTGGTT TCTACTCTGC GACGATTTAA AGAGGTCACT 1680

GAAATCCAGA TGCATGGATT TCATGCAATC TTGTCAATTC TTGGTTTTTC ACCTTGTTTT 1740

GCCAAGCTGC TGATAAATGA ATCGTTTGAC ACAGTAATCT TCTACCAAAT GTCTATGTGC 1800

TTCACCAACC AACGAGATCG ACAGTTTCAA AGCCTGTGTT GTAAATGCTT TGCTAAAATA 1860

GCTGAAAATG ATGATTTAAA AAATATGATG CTTGAAAAAG CATGTGTTGA GTACAACTGT 1920

ATTATGGCTG AATGTTTACT TCTTCTGGGA GCTGATATTA ACAAGAAGAC AAAGACAAGC 1980

TCTTTGATCT ATCAGGTTTG TGAAAAAGGA AATAATCCTA AACTGGTGGA ATTGCTATTA 2040

GCCAACGGTG CTCGAGAGCA GGATGTTCGG AGTGCTTTAA CCATCAGTAT AAAGAGAGGA 2100

GATAGCCAAA TCATCAGCTT ACTCTTAAAG AAGCTTAGCC TTGATGTTGC CAACAGCAGT 2160

ATATGTCTTG GAGGATTTGG TATTGGGAGA CTTGAGCCTT CCTGGCTCAT TCCTTTGTTC 2220

CCAGATAAGC TTACTCCTCC AAGAAAACAA AATACAGATG CAGGTTCTGC ACTGGCAAGA 2280

ATGGTGCTTA AATACCAGAT GAAGAATATT TCTGAGGATA GATCAAGAAC TTGTTCTGAT 2340

CTAAACTTCT CTGAAGACGG AGTGGATAAA AACTACGATT GGGATTTCAT TTCTGACCCA 2400

TTAGTGGACA CTGTTTTTCC TTCGAGTGAT GATATTGACA GTGAAGGAAG CGAAGGCTCA 2460

CTTTTTAGAA AAAAGAAGTC CAATTCCATT GCAGTTGCTG ATTTACATTG TAGAGAACTT 2520

GCTTTTCAAA GAGGTTCTCC TACTTTACCA CGACATTCCT ACTCTGTGGG ACCTGGCTCA 2580

GATTATGAGC CATTAGTGAA ACAAAGAAGA AAATTATTGC TTTCAGATGA ACCTTCCAGA 2640

ATCTCAAAAA GCTCACTGCA CTTAAGACCT TCAGACAGTC TTTCCTCATT GATCTCAGAG 2700

AAGGAATGTA TTAAATCACT TGATCTTTCC TCAAATGAGC TGGAGAACAT TGATGCCATC 2760

AGTCAGAACA GCAGCTTAAT GAGTCACTTG GAACATCTTG ATAAACTGGA GCTCCACCAA 2820

AATGCTCTTA CAAACATTCC GGAACAACTG TGTGAGAACT TGAAATGCTT GACTTACTTG 2880

GATTTGCACA GCAACCGATT TACTTCTTTT CCTACTTATT TGCTGAAAAT GAACTGTATT 2940

GCATATCTTG ATATCTCTCG AAATGACATT GGACCTTCCT TTGCTTTGGA TCCACATCTC 3000

AGATGTCCAA CCCTAAAGCA ACTTAATCTT TCATACAATC AGCTAATGGG CATTCCTGAG 3060

TTTCTTGCAA ATGTTGCTGA AAACCTCGAA CAGCTATTGC TGGAAGGAAA CAAAATTTCA 3120

TGCTTATCTT CACCCATGTC CTTGAAAGAG CTGAAAATTT TAAATATCAG TAAGAACAAT 3180

ATTTCATCCC TTGCTGAGAA TGTGTTAATG GGCTGTGCAA AACTGGAGCT GTTCAATGCC 3240

AGGATGAATG CACTTGAGAT AATACCTGAC TTGTCATCTA GCATAACAAC CTTAAAATTA 3300

TCCCAAAATT GCTTTATTAA TGTTCCAGAA ACAATTCTTC TTCTACCACA TTTGAGATCA 3360

GTAGATTTAA GCCAAAACAA GATCATAAGC CTGCCTGGGC CAGTGCACTG GAAATCGCTG 3420

AACTTAAGGG AGCTGTTATT TAATCATAAT CAAATAGGAG TCTTGGACTT GAGTGAAAAG 3480

GCATGTGCAT GGTCTAGGCT AGAAAAGCTA CACTTGTCCA ACAACAAGTT GAAGGAGATA 3540

CCTCCTCAGA TTGGCTTCCT AGAAAACTTG ACTTCTCTGG ATGTAAGTCA TAATCCCGAT 3600

TTGAGATTCT TTCCGGATGA AATGGGAAGG CTGTCCAAAA TTTGGGATCT TCCTTTGGAA 3660

GGACTCCATC TTAACTTGGA CTTCAAACAT GTGGGATGCA AAGCCAGAGA TATCATCAGA 3720

TTTCTTCAAC AACGACTGAA AAAGGCTGTA CCTTATAACA GAATGAAGCT AATGATTGTT 3780

GGAAACACTG GTAGTGGAAA AACTACACTG TTACAACAGC TAATGAAATG CAAACGAACT 3840

GAGCTGGGCT GTCCAAAAGC TACAGTAGGC ATTGATGTAA AAGACTGGAT CATTCAAGGG 3900

AAAGGCAAAA TGAAAAAAGA GCTTATATTA AATGTCTGGG ATTTTGGAGG ACAAGAGGAG 3960

TTCTACAGTA CCCACCCTCA CTTCATGACC CAAAGAGCTT TGTATCTTGC TGTTTATGAT 4020

CTCAGCAAAG GACAAGCAGA GGTGGATGCT ATGAAGCCAT GGCTTTTTAA CATCAAGGCA 4080

CGAGCTTCAA CATCCCCCGT CATTCTTGTG GGCACCCACT TAGATGTTTC TGATGAAAAG 4140

CAACATAAGG ACTGCATGAG TAAAATTACT AGAGAGCTGT TGAATAAGCG AGGCTTCCCA 4200

GCAATCCAGG ATTATCACTT TGTGAATGCT AAAGAAGAAT CAGATTCCAT TATGAGACTT 4260

CGGAAAATCA TAATAAAGGA GAGTCTTCAT TTCAAAATAA GAGATCAGCC AGTGGTTGGT 4320

CAGCTAATTC CTGACAGCTA TCTGGAGCTG GAGAAGAGAA TTTTGCTGGA AAGAAAAAAT 4380

GTCCCGGTTG AATTTCCTGT GATTGATCAG AAACGATTAC TAGAAATGGT ACAAGAAAAC 4440

AAGTTACAAC TGGATGAAAA TGAACTCCCT CATGCAATTC ACTTTCTGAA TGAGTCAGGT 4500

GTACTGCTTC ATTTTCAGGA CCCAGCACTA CAGCTAAGAG ACCTGTACTT TGTAGATCCT 4560

AAGTGGCTAT GTAAAATCAT GGCACAGATT TTGACTGTGA AAGTGGAAGG CTTTTCTAAA 4620

TATCCTAAGG GAATTGTAAA ACGCTCAGAT GTGGAAAAAT TCCTTTTAAA GAAGAGCAAG 4680

TTTCCTAAGA TCTACATGTC ACAATACTTC AAACTTCTGG AAAAGTTTCA GATTGCTTTG 4740

CCATTAGGAG AGGACCAGCT ACTGATCCCA AGCAGTTTGT CTGATCACAG ACCTGTTATA 4800

GAGCTTCCCC ACTGTGAAAA CTCAGAAATT ATCATCAGAC TTTATGAGAT GCCATACTTT 4860

CCTATGGGAT TTTGGTCCAG GCTGATCAAC AGGTTGCTTG AAATATCACC TTATATGCTG 4920

TCAGGAAGAG CACGAGCTCT TCGTCCTAAC AGAATGTATT GGAGACAGGG CATCTACTTG 4980

AATTGGTCTC CTGAAGCTTA TTGTCTGGTG GAATCAGCCG TATTTGACAA CAACCCAGAC 5040

AGTTTTTTGA AAATTACAGC ACCTTCTTGC AGAAAAGGTT GCATCCTTTT GGGACAAGTT 5100

GTGGATCACA TTGATTCTCT TATGGAAGAA TGGTTTCCAG GTTTGCTGGA TATAGATGTA 5160

TGTGGTGAAG GGGAAACACT GTTGAAGAAA TGGGCTCTGT ACAGTTTTGA AGATGGTGAA 5220

GAACACCAAA AAATACTACT TGATGACTTA CTTAAAAAAG CTGAAGAAGG AGATCTTTTA 5280

GTAAACCCAG AGCAGCCAAG ACATACTATT CCCATCGCTC AGATTGCTCC TGATCTGATC 5340

CTGGCTGACT TGCCTAGAAA CATTATGTTG AACACTGATG AGCTGGAATT TGACAAAGCT 5400

CCTGAATTTC TCTTGGGTGA TGGTGGGTTT GGATCAGTGT ACCGTGCTTC CTATGCTGGA 5460

GAAGAAGTTG CTGTAAAGAT TTTCAATAAA CATACTTCCC TCAGGCTCCT AAGACAAGAG 5520

CTTGCAGTGC TTTGTCACCT CCATCATCCC AGCTTAGTGT CTTTGCTGGC TGCTGCTGTC 5580

CGTCCCCGGA TGCTGGTGAT GGAATTAGCC CTTAAGGGAT CTCTTGATCG TTTGCTTCAA 5640

CAAGACAAAG CAAACTTAAC TAGAACACTT CAGCACAGGA TAGCTCTACA TGTAGCTGAC 5700

GGCTTAAGGT ACCTGCATTC AGCAATGATC ATTTACCGTG ATCTAAAGCC TCACAACGTG 5760

TTGCTCTTTA CCCTGTATCC CAACGCTGCT GTCATTGCAA AGATAGCTGA CTATGGCATT 5820

GCCCAGTATT GTTGCCGAAT GGGAATAAAA ACCTCCGAAG GCACACCAGG ATTTCGAGCA 5880

CCAGAGGTTG CCAGAGGAAA TGTTATTTAC AATCAGCAAG CTGATGTGTA TTCATTTGGC 5940

TTGCTTCTCT ATGACATTTT AACAGGAGGA GGTAGAATAA TGGAAGGTGT GAAGTTTCCA 6000

AATGAATTTG ACGAGTTAGC AATACAAGGA AAGTTACCAG ATCCTGTCAA AGAATATGGG 6060

TGCGCCCCCT GGCCTAAAGT TGAACATTTA ATTAAAAAAT GTTTGAAGGA AAATCCTCAG 6120

GAACGACCAA CATCTTCCCA GGTGTATGAG ATTTTGAATT CTGCGGAGCT TATCTGTTTG 6180

ATGAGGTATG TTTCAATACC CAGCACTTCC ACAGCAGAGT GCATGGTAGC TACCAATCAA 6240

AGCTGCAAGA AGGCAGGAGT CTGGATAGGC AATGGGAACA CAGAAAAAGC ACAGCTTTCA 6300

TTTGTTAACC TAAATACAGA TGGACATACT TGTGAGGATA TTGCGGATAG TAAAATTTTA 6360

AGTTTGGCGT TGGTGACCCT TCCTACTGAG AAAGAAAACT GGATTGTGGC AGGAACCCAT 6420

TCTGGTTCTC TGTGGGCAGT TAACACAGAA GATGAAACAA GACGGCACCG TCTGCAGAAG 6480

ATGTCTGATT CTATCACCTG TTTGTACTGT AATTCACTTT CCAAGCAAAG CAAGCAGAAG 6540

AATTTCTTTC TGGTAGGCAC AGCTGATGGT ATGCTGGCAG TGTTTGAAGA CAGAGCAGTA 6600

AAGTGTAAGG GTGCAACACC TTTGAAGATA TTAACTATAG GAAATGTTAG CACACCACTG 6660

ATGTGCTTAA ATGAATCCAC GTATTTATCT GAAAAAAATA CAATCTGGGG AGGCTGTGGA 6720

ACAAAGCTCA TAGCTTTATC TAGTGATTTC TCTGTCCAAA AGCTGATTGA AACAAAGTCA 6780

AGCCAACTGT TCTGTCACAA CGCTTACAGT GATGCAAACA TTATTTCAAT AGCAGTAGAC 6840

AAATCCATCT ACTTGGCGAA GAAAAATAGC CATTTTGTGG AAATCTGGGA CAAGAAAACA 6900

GAAAAACTTT CTGAACTAAT TGACTGTGCG CATTTTCTTA AGGATGAAGT GGAAAAACTA 6960

AACCAAGAAT CAAAACATAA AGTTGCTTAT TCTGGAAGAG TGAAGACAAT TTGCCTGCAG 7020

AAAAATACTG CATTGTGGGT AGGGACAGGA GGAGGACATA TCCTGCTGCT TGATTTATCA 7080

ACACGTCGTC CTGTACGAGT AATAGATAAC TTTTGTGACT CTATTCGAGT CATGCTAACA 7140

GCTCAGCTAG AAAAAGGGAG CCTGAAGAAC GTGGTGTTGG TTTTGGGATA CTGCTACAAG 7200

GGTGACACCG AAGATGACAA ATACCGCAAA GAATTACAAT CCTGTGTGTC AGTGTGGGAC 7260

ATTAACCTCC CCCATGAAGT GCAAAACCTG AAGAAGCATA TAGAAGTGAG ACAGGAACTA 7320

GCTGAAAAAA TGAAGAGCTT CACTTTAGAC TGA 7353

Domain Profile

S: 6     llGrGafGsvyraavkGeevavkafkiaadklkrdslelalkayselrqelsvLlalkhP  65

         llG+G+fGsvyra++ Geevavk+f+      k++sl+l       lrqel+vL++l+hP

Q: 1804  LLGDGGFGSVYRASYAGEEVAVKIFN------KHTSLRL-------LRQELAVLCHLHHP  1850

         79************************......*******.......**************

S: 66    sivsLvgisikPlalvleLaplgsLdrlLsedkksssklgrtltkkialqvargleyLhk  125

         s+vsL++++++P++lv+eLa +gsLdrlL++dk++   l+rtl+++ial+va+gl+yLh+

Q: 1851  SLVSLLAAAVRPRMLVMELALKGSLDRLLQQDKAN---LTRTLQHRIALHVADGLRYLHS  1907

         ********************************999...**********************

S: 126   kkiiyrdLksenvLvwslspkeailikladyGisrqslrsGakgveGteGfraPeivrge  185

         ++iiyrdLk++nvL+++l+p++a+++k+adyGi+++++r+G+k++eGt+GfraPe++rg+

Q: 1908  AMIIYRDLKPHNVLLFTLYPNAAVIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGN  1967

         ************************************************************

S: 186   vvydekvdvfsfGlllyell.sgkrpvegeeqlkivekl.lkGkrPvlvkeeevlptpll  243

         v+y++++dv+sfGllly++l  g r++eg ++++++++l ++Gk+P++vke++++p+p +

Q: 1968  VIYNQQADVYSFGLLLYDILtGGGRIMEGVKFPNEFDELaIQGKLPDPVKEYGCAPWPKV  2027

         ********************4468**********************************99

S: 244   d.LlveCwkekPekrPtasqvvsi  266

         + L+++C+ke+P++rPt+sqv +i

Q: 2028  EhLIKKCLKENPQERPTSSQVYEI  2051

         99*******************875

Domain Sequence
(FASTA)

LLGDGGFGSV YRASYAGEEV AVKIFNKHTS LRLLRQELAV LCHLHHPSLV SLLAAAVRPR 60

MLVMELALKG SLDRLLQQDK ANLTRTLQHR IALHVADGLR YLHSAMIIYR DLKPHNVLLF 120

TLYPNAAVIA KIADYGIAQY CCRMGIKTSE GTPGFRAPEV ARGNVIYNQQ ADVYSFGLLL 180

YDILTGGGRI MEGVKFPNEF DELAIQGKLP DPVKEYGCAP WPKVEHLIKK CLKENPQERP 240

TSSQVYEI 248

Keyword

ATP-binding; Complete proteome; GTP-binding; Leucine-rich repeat; Nucleotide-binding; Reference proteome; Repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0032839	; C:dendrite cytoplasm
GO:0032473	; C:external side of mitochondrial outer membrane
GO:0045121	; C:membrane raft
GO:0043025	; C:neuronal cell body
GO:0005886	; C:plasma membrane
GO:0008021	; C:synaptic vesicle
GO:0005802	; C:trans-Golgi network
GO:0005524	; F:ATP binding
GO:0005525	; F:GTP binding
GO:0034211	; F:GTP-dependent protein kinase activity
GO:0005096	; F:GTPase activator activity
GO:0003924	; F:GTPase activity
GO:0004708	; F:MAP kinase kinase activity
GO:0000186	; P:activation of MAPKK activity
GO:0048312	; P:intracellular distribution of mitochondria
GO:2000173	; P:negative regulation of branching morphogenesis of a nerve
GO:0034260	; P:negative regulation of GTPase activity
GO:0070997	; P:neuron death
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0018107	; P:peptidyl-threonine phosphorylation
GO:0010508	; P:positive regulation of autophagy
GO:0060161	; P:positive regulation of dopamine receptor signaling pathway
GO:0043068	; P:positive regulation of programmed cell death
GO:0032436	; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0031398	; P:positive regulation of protein ubiquitination
GO:0046777	; P:protein autophosphorylation
GO:0040012	; P:regulation of locomotion
GO:0042391	; P:regulation of membrane potential
GO:0006979	; P:response to oxidative stress
GO:0007264	; P:small GTPase mediated signal transduction

KEGG

InterPros

IPR020683	; Ankyrin_rpt-contain_dom.
IPR011989	; ARM-like.
IPR016024	; ARM-type_fold.
IPR011009	; Kinase-like_dom.
IPR001611	; Leu-rich_rpt.
IPR025875	; Leu-rich_rpt_4.
IPR003591	; Leu-rich_rpt_typical-subtyp.
IPR013684	; MIRO-like.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR020859	; ROC_GTPase.
IPR008271	; Ser/Thr_kinase_AS.
IPR005225	; Small_GTP-bd_dom.
IPR001806	; Small_GTPase.
IPR015943	; WD40/YVTN_repeat-like_dom.
IPR017986	; WD40_repeat_dom.

Pfam

PF12799	; LRR_4; 1.
PF08477	; Miro; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00369

; LRR_TYP; 1.

Prosites

PS51450	; LRR; 11.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS51424	; ROC; 1.

Prints

PR00449

; RASTRNSFRMNG.

Created Date

20-Feb-2013