EPS-MEG-00070

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-MEG-00070

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
DSP/PTEN	142.5	1.4E-41	363	516	154

Status

Unreviewed

Ensembl Protein

ENSMGAP00000007309

UniProt Accession

G1N5Q6;

Protein Name

Protein Synonyms/Alias

Gene Name

GAK

Gene Synonyms/Alias

GAK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000007161	ENSMGAP00000007309	ENSMGAT00000008081

Organism

Meleagris gallopavo

Functional Description

Protein Length

982

Protein Sequence
(FASTA)

GGFAFVYEAQ DLGSGKDYAL KRLLSNEEEK NKAIIQEVCF MVSFSGYRAE MKVLPTALSR 60

VDLNKTCQRT FPYFSAQCEG QAADLLSRKH STAKLGQNLL LEITYKTAYQ HLSWRKKKIK 120

NKKNKIKQIH ISTCKTLYIL KACHISLELD LEYSAEQQCL IQKISIQKNG YMIFKNLQIQ 180

EFLYLKTVPK GEKTNHDALG CILYLLCFRQ HPFEDGAKLR IVNGKYAIPQ NDTRYSVFHD 240

LIRSTLKVNP EERLSITELV NQLQEIAAAR NVNPKSPITE LLEQNGGYGN NAQPRISVTS 300

VSQSSKPAGQ LNNIYNAGLT VAECDQTYGG FFDILRGGTE RFFTNIKDTS SKVIQSVANY 360

AKGDLDISYI TSRIAVMSFP AEGVESAIKN NIEDVRLCLD SKHPGHYAVY NLSPRTYRPS 420

RFHNRVSECG WPARRAPNLQ NLYSICKNMH LWLKQDQKNV CIVHCLDGRA ASAVVVCSFL 480

CFCRLFTTAE AAVYMFSMKR CPPGIWPSHK RYAKYLEKPV CYESSSSEFG ETLVANGVLS 540

TAELNMICRE AVVRIKIRVC CPKCKVFFLI KRVRSRNLVY CMLSFFKYVT LKSVIKKHLT 600

NCGNVRLVQS HSREILGFSF QQMASMKMFQ IQFHTGFVPR NATTVKFAKY DLDACDIQEK 660

YPDLFQVNLE VEVEPRDRPS CEQLPWDNMN IKGLNPKILF STREEQQEIL SKFGKPELPR 720

QPGSTAQYEA EASQLDLSSE SAPTETESPH SSGTDANNFF HSLDWKEGKS PESGIDDNSS 780

KNDHVQLSDE REESDPSDEE FPTFPGEERA VTVDEGDSVT PGGEMLFEAG FEAPPALLQK 840

SLTEENVDLL GLNSDTSTDQ KQPVSEINSS SNAALLNNLF VSGASQVSEE PTGDLLGQGA 900

DFFFSGQPQH PAATQKTSAA TVSSADPFDP FTMSSSSENS ALPGPDLFGD FLNPSTASTA 960

NTFPSTHSSL PPSSSSDFLN LG 982

Nucleotide Sequence
(FASTA)

GGTGGTTTTG CATTTGTCTA TGAAGCTCAA GATCTTGGAA GTGGCAAAGA TTATGCTTTA 60

AAGCGGTTGT TGTCCAATGA GGAAGAAAAG AACAAAGCTA TCATTCAGGA AGTTTGTTTT 120

ATGGTATCCT TTTCTGGATA TAGAGCTGAA ATGAAAGTAC TTCCTACAGC TCTGAGCAGA 180

GTAGATCTGA ATAAAACATG TCAAAGAACA TTTCCTTACT TCTCTGCACA ATGTGAAGGG 240

CAGGCTGCTG ACCTGCTTTC CAGAAAACAT AGCACAGCTA AACTTGGTCA AAATCTCTTG 300

CTTGAGATAA CCTACAAGAC TGCTTACCAG CACTTGTCCT GGAGGAAAAA AAAAATAAAA 360

AATAAAAAAA ATAAAATCAA ACAAATTCAC ATAAGCACAT GCAAAACACT ATACATTCTG 420

AAAGCTTGCC ATATATCATT AGAGCTGGAC TTAGAATACT CAGCAGAACA ACAATGCTTA 480

ATTCAAAAAA TTTCAATTCA AAAAAACGGA TATATGATTT TTAAAAATCT ACAAATACAA 540

GAATTCTTAT ATCTGAAAAC TGTACCGAAG GGGGAAAAAA CAAATCACGA TGCTTTGGGC 600

TGTATCCTGT ACCTGCTGTG CTTTAGACAA CATCCCTTTG AAGATGGAGC TAAACTTCGC 660

ATTGTCAATG GAAAATATGC CATTCCACAG AACGACACCC GCTACTCTGT GTTTCATGAT 720

CTCATCCGCT CCACTTTGAA GGTGAACCCA GAGGAGAGAT TGTCAATCAC TGAACTTGTG 780

AATCAGCTGC AGGAGATTGC AGCAGCTCGG AATGTGAATC CTAAATCCCC CATTACAGAG 840

CTCTTGGAAC AAAATGGAGG CTATGGAAAC AATGCTCAGC CTCGAATATC TGTGACCTCT 900

GTTTCACAGA GCTCCAAGCC TGCAGGACAG CTCAACAATA TATACAATGC AGGCCTGACC 960

GTTGCGGAAT GTGACCAGAC TTATGGAGGG TTCTTTGATA TTCTGAGGGG TGGAACAGAG 1020

CGATTTTTCA CTAATATTAA GGATACATCT TCTAAAGTTA TCCAGTCTGT GGCCAATTAT 1080

GCGAAAGGAG ACTTGGATAT ATCATACATC ACTTCAAGAA TTGCAGTGAT GTCCTTTCCA 1140

GCAGAAGGTG TAGAATCTGC CATCAAAAAT AACATAGAAG ATGTAAGGTT ATGTCTGGAC 1200

TCCAAACATC CTGGGCACTA TGCTGTGTAT AATCTTTCTC CAAGGACATA CAGACCTTCA 1260

CGATTCCATA ATAGAGTTTC TGAATGTGGC TGGCCAGCAA GACGAGCACC AAATCTTCAG 1320

AATCTTTATA GTATATGCAA GAACATGCAT TTATGGCTGA AACAGGACCA GAAAAATGTT 1380

TGCATTGTGC ACTGCCTAGA TGGAAGAGCA GCATCTGCTG TTGTAGTTTG TTCTTTTCTG 1440

TGTTTCTGTC GTCTCTTCAC TACTGCTGAG GCTGCAGTTT ATATGTTCAG TATGAAACGT 1500

TGTCCTCCTG GCATATGGCC TTCTCATAAA AGGTATGCAA AATACTTGGA AAAACCAGTG 1560

TGCTATGAAT CAAGTAGTTC TGAATTTGGT GAGACCTTAG TCGCCAATGG TGTTCTTAGC 1620

ACAGCTGAAT TAAATATGAT CTGTAGAGAG GCAGTGGTAA GAATAAAAAT AAGAGTATGC 1680

TGTCCTAAGT GTAAAGTCTT CTTCCTCATA AAAAGGGTTA GATCTAGAAA TTTGGTGTAT 1740

TGCATGTTGA GTTTCTTTAA GTATGTTACT CTGAAAAGTG TAATAAAGAA ACATTTGACA 1800

AACTGTGGCA ATGTGAGGTT GGTGCAGAGT CACTCCAGAG AAATCCTTGG CTTCAGTTTC 1860

CAACAGATGG CCTCTATGAA GATGTTTCAG ATTCAGTTCC ACACAGGTTT TGTACCCCGA 1920

AATGCCACCA CAGTGAAATT TGCAAAGTAT GATCTGGATG CCTGTGACAT TCAAGAAAAA 1980

TATCCTGATT TATTTCAAGT CAATCTGGAA GTGGAGGTAG AGCCCAGAGA TAGGCCTAGC 2040

TGTGAGCAGC TGCCATGGGA TAATATGAAT ATAAAGGGAC TGAATCCCAA GATCCTTTTC 2100

TCCACTCGAG AGGAACAACA GGAAATTTTA TCAAAATTTG GGAAACCAGA GCTACCAAGG 2160

CAGCCGGGTT CAACTGCGCA GTATGAAGCA GAAGCATCCC AACTGGATCT GTCCTCAGAA 2220

AGTGCCCCGA CTGAGACAGA ATCCCCACAC AGCAGTGGTA CTGATGCAAA TAACTTCTTT 2280

CATTCTCTGG ATTGGAAAGA AGGAAAAAGT CCAGAAAGTG GAATAGATGA TAACTCGTCT 2340

AAAAATGATC ACGTTCAACT GTCTGATGAG AGAGAAGAGA GTGATCCTTC AGATGAGGAG 2400

TTCCCTACAT TTCCAGGTGA AGAAAGGGCA GTAACTGTTG ATGAGGGAGA CTCTGTTACC 2460

CCAGGAGGAG AGATGCTTTT TGAAGCTGGT TTTGAAGCTC CACCTGCACT ATTACAAAAA 2520

TCTCTCACTG AAGAGAATGT AGATCTACTG GGACTGAATT CTGATACTTC AACAGATCAG 2580

AAACAACCTG TCTCAGAAAT AAACTCATCA AGTAATGCAG CCTTGTTGAA CAATCTTTTT 2640

GTGAGTGGTG CATCACAAGT TTCAGAAGAG CCCACTGGAG ATCTCCTTGG ACAAGGAGCA 2700

GATTTCTTTT TCAGCGGTCA GCCTCAGCAT CCAGCTGCTA CTCAGAAGAC TTCAGCAGCA 2760

ACTGTGTCTT CAGCTGATCC TTTTGACCCA TTTACAATGT CATCTAGTTC TGAGAATTCA 2820

GCGCTGCCTG GCCCAGACCT TTTTGGGGAC TTTCTTAATC CAAGCACAGC ATCTACAGCT 2880

AATACGTTTC CTTCTACACA TAGTTCACTT CCACCTTCTT CCAGTTCAGA TTTCCTAAAT 2940

TTAGGT 2946

Domain Profile

S: 8     fdldltyvteriiavsfPaeareevyrnnlrevvrlldskhrnkyklynlcserrydltk  67

          dld+ y+t ri  +sfPae+ e+  +nn+++v   ldskh ++y +ynl s r y +++

Q: 363   GDLDISYITSRIAVMSFPAEGVESAIKNNIEDVRLCLDSKHPGHYAVYNL-SPRTYRPSR  421

         59************************************************.*********

S: 68    lnakvaefgiedlnaPaleklvsickeldeWlseddenvvvlhckggkgrlGvivcayll  127

         ++++v+e g++  +aP+l++l sick+++ Wl +d++nv ++hc  g+    v+vc++l

Q: 422   FHNRVSECGWPARRAPNLQNLYSICKNMHLWLKQDQKNVCIVHCLDGRAASAVVVCSFLC  481

         ************************************************************

S: 128   aseisakadealdtfgerrtredkvagvkqPsqrryvsyf  167

         + + +++a+ a+++f+++r           Ps +ry +y

Q: 482   FCRLFTTAEAAVYMFSMKRCPPG-----IWPSHKRYAKYL  516

         ******************97644.....589999999996

Domain Sequence
(FASTA)

GDLDISYITS RIAVMSFPAE GVESAIKNNI EDVRLCLDSK HPGHYAVYNL SPRTYRPSRF 60

HNRVSECGWP ARRAPNLQNL YSICKNMHLW LKQDQKNVCI VHCLDGRAAS AVVVCSFLCF 120

CRLFTTAEAA VYMFSMKRCP PGIWPSHKRY AKYL 154

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005794	; C:Golgi apparatus
GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity

KEGG

InterPros

IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR011009	; Kinase-like_dom.
IPR014019	; Phosphatase_tensin-typ.
IPR000719	; Prot_kinase_cat_dom.
IPR014020	; Tensin_phosphatase_C2-dom.

Pfam

PF10409

; PTEN_C2; 1.

SMARTs

Prosites

PS51182	; C2_TENSIN; 1.
PS51181	; PPASE_TENSIN; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013