EKS-MEG-00306
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MEG-00306
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src401.31.2E-120187435249
StatusUnreviewed
Ensembl ProteinENSMGAP00000007465
UniProt AccessionG1N615;
Protein Name
Protein Synonyms/Alias
Gene NameHCK
Gene Synonyms/Alias HCK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMGAG00000007338ENSMGAP00000007465ENSMGAT00000008239
OrganismMeleagris gallopavo
Functional Description
Protein Length450
Protein Sequence
(FASTA)
AGSGDNVVLA LYDYEAMHSG DLSFQKGEQL QVLEQLGEWW QARSLVTGRK GFIPSNFVAR 60
ANSLEAEEWF FKGISRKDAE RQLLSPGNTL GSFMIRDSET TKGCYSLSVR DGDGLHGGSI 120
KHYRIRTLDS GGFYISSRSS FDTLQELVEH YKGQSDGLCQ RLTYPCSVPK PQKPWEKDAW 180
EIPRESLKLE KKLGAGQFGE VWMATYNKHT KVAVKTMKPG SMSVSAFLEE ANLMKSLQHD 240
KLVRLHAVVT REDQAERHAM PSGSLLDFLK SEEGNKQPLP KLIDFSAQIA EGMAFIEKRN 300
YIHRDLRAAN ILVSAMLVCK IADFGLARII EDNEYVAREG AKFPIKWTAP EAINYGSFTI 360
KSDVWSFGIL LTEIVTYGRI PYPGMSSAEV IRALEHGYRM PRTESCPEEL YDVMMRCWKT 420
KPEDRPTFEY MQSILEDFFT ATEGQYQQQA 450
Nucleotide Sequence
(FASTA)
GCAGGCTCAG GGGACAACGT GGTGCTGGCA CTGTATGACT ATGAGGCGAT GCACTCTGGG 60
GACCTGAGCT TCCAGAAAGG GGAACAGCTG CAGGTCCTGG AGCAGCTGGG AGAGTGGTGG 120
CAGGCACGGT CGCTGGTGAC AGGGCGCAAG GGCTTCATCC CCAGCAACTT CGTCGCCCGA 180
GCTAACTCAC TGGAGGCAGA AGAGTGGTTC TTCAAGGGTA TCAGCCGGAA GGATGCGGAG 240
CGGCAGCTGC TCAGCCCCGG GAACACATTG GGATCCTTCA TGATTCGGGA CAGTGAGACG 300
ACCAAAGGTT GCTACTCCTT GTCGGTGCGG GATGGGGACG GCCTGCATGG AGGCAGCATC 360
AAGCACTACA GGATCCGGAC ACTGGATAGT GGTGGCTTCT ACATCTCTTC ACGCAGCAGT 420
TTTGACACAC TGCAGGAGCT GGTGGAGCAC TATAAGGGGC AGAGTGATGG GCTGTGCCAG 480
AGGCTCACCT ACCCCTGCAG TGTGCCCAAA CCCCAGAAGC CCTGGGAGAA GGATGCCTGG 540
GAAATTCCTC GGGAGTCGCT GAAGCTGGAG AAGAAGCTGG GAGCCGGGCA GTTTGGAGAA 600
GTGTGGATGG CAACCTACAA CAAGCACACC AAGGTGGCAG TGAAGACAAT GAAACCCGGC 660
AGCATGTCTG TGAGTGCCTT CCTGGAGGAG GCAAACCTCA TGAAGAGCCT GCAGCACGAC 720
AAGCTGGTGA GGCTGCACGC TGTGGTCACC AGGGAGGACC AAGCTGAGCG CCATGCTATG 780
CCTTCAGGGA GCCTGCTAGA CTTCCTGAAG AGTGAGGAGG GCAACAAGCA GCCACTGCCA 840
AAGCTGATTG ACTTCTCTGC GCAGATTGCA GAAGGAATGG CTTTTATTGA GAAGAGGAAC 900
TACATTCACA GAGACTTGAG AGCTGCCAAC ATTCTTGTGT CAGCGATGTT GGTCTGCAAG 960
ATTGCAGACT TTGGGCTGGC CAGGATCATT GAAGACAATG AGTACGTAGC TCGGGAAGGT 1020
GCCAAATTTC CCATTAAATG GACTGCACCA GAAGCAATCA ACTATGGATC TTTCACTATA 1080
AAATCTGACG TCTGGTCCTT TGGGATCCTC CTGACCGAGA TCGTTACCTA CGGGCGCATC 1140
CCATACCCAG GGATGTCGAG CGCGGAGGTG ATCAGAGCTC TGGAGCACGG CTACCGCATG 1200
CCCCGCACAG AAAGCTGTCC TGAGGAGCTC TACGATGTCA TGATGAGATG CTGGAAAACC 1260
AAACCAGAGG ACCGTCCCAC CTTTGAGTAC ATGCAGAGCA TTTTGGAGGA TTTCTTTACT 1320
GCGACAGAGG GCCAGTACCA GCAGCAGGCA TAG 1353
Domain Profile
S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60
         lkl+kklG+GqfGevw++++++++kvavkt+k+g++s +afleea+++k+l+h+klv+l+
Q: 187   LKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVSAFLEEANLMKSLQHDKLVRLH  246
         689*********************************************************
S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120
         avv++e+        m  Gslldflk+eeg+k++lpkl+d++aq+aeGma++e++n+ihr
Q: 247   AVVTREDQA--ERHAMPSGSLLDFLKSEEGNKQPLPKLIDFSAQIAEGMAFIEKRNYIHR  304
         *****9976..4789*********************************************
S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180
         dl+a+n+lv+  lv+k+adfGlar+ied+ey+a+egak+PikWtaPeai++g+ftiksdv
Q: 305   DLRAANILVSAMLVCKIADFGLARIIEDNEYVAREGAKFPIKWTAPEAINYGSFTIKSDV  364
         ************************************************************
S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240
         WsfGillteivt+G++PypGm+++ev++++e+gyr+pr+e+cpeely+++++cwk++pe+
Q: 365   WSFGILLTEIVTYGRIPYPGMSSAEVIRALEHGYRMPRTESCPEELYDVMMRCWKTKPED  424
         ************************************************************
S: 241   rPtfetlqevl  251
         rPtfe++q++l
Q: 425   RPTFEYMQSIL  435
         *******9875
Domain Sequence
(FASTA)
LKLEKKLGAG QFGEVWMATY NKHTKVAVKT MKPGSMSVSA FLEEANLMKS LQHDKLVRLH 60
AVVTREDQAE RHAMPSGSLL DFLKSEEGNK QPLPKLIDFS AQIAEGMAFI EKRNYIHRDL 120
RAANILVSAM LVCKIADFGL ARIIEDNEYV AREGAKFPIK WTAPEAINYG SFTIKSDVWS 180
FGILLTEIVT YGRIPYPGMS SAEVIRALEH GYRMPRTESC PEELYDVMMR CWKTKPEDRP 240
TFEYMQSIL 249
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00343
EKS-ANC-00359
EKS-BOT-00369
EKS-CAJ-00373
EKS-CAF-00370
EKS-CAP-00404
EKS-DAR-00749
EKS-EQC-00360
EKS-FEC-00356
EKS-GAG-00313
EKS-GAA-00451
EKS-GOG-00360
EKS-HOS-00375
EKS-ICT-00350
EKS-LAC-00384
EKS-LOA-00378
EKS-MAM-00369
EKS-MOD-00358
EKS-MUM-00401
EKS-MUP-00363
EKS-MYL-00369
EKS-NOL-00337
EKS-OCP-00073
EKS-ORN-00478
EKS-ORC-00347
EKS-ORL-00440
EKS-OTG-00371
EKS-PAT-00354
EKS-PES-00327
EKS-POA-00358
EKS-PTV-00094
EKS-RAN-00383
EKS-SAH-00339
EKS-TAG-00442
EKS-TAR-00474
EKS-TAS-00040
EKS-XIM-00467
Gene Ontology
GO:0005884; C:actin filament
GO:0005901; C:caveola
GO:0031234; C:extrinsic to internal side of plasma membrane
GO:0005925; C:focal adhesion
GO:0005764; C:lysosome
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
GO:0043066; P:negative regulation of apoptotic process
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0006909; P:phagocytosis
GO:2000251; P:positive regulation of actin cytoskeleton reorganization
GO:0008284; P:positive regulation of cell proliferation
GO:0046777; P:protein autophosphorylation
GO:0008360; P:regulation of cell shape
GO:0050764; P:regulation of phagocytosis
GO:0071801; P:regulation of podosome assembly
GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013