EKS-MEG-00131

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MEG-00131

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKG	483.5	1.0E-145	446	704	259

Status

Unreviewed

Ensembl Protein

ENSMGAP00000007584

UniProt Accession

G1N6A5;

Protein Name

cGMP-dependent protein kinase

Protein Synonyms/Alias

Gene Name

PRKG2

Gene Synonyms/Alias

PRKG2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000007424	ENSMGAP00000007584	ENSMGAT00000008362

Organism

Meleagris gallopavo

Functional Description

Protein Length

755

Protein Sequence
(FASTA)

MGNASMKPKH LRQPDRHIAN LALGCASNRV LELEKELKRK DEELQEGQSL VAELQDQLSV 60

QTKVIAELTK ELQSKCIQLN KLQDVINTQG EHSLQPSPYR VTPKHQVSAD RRKGAKEGVS 120

AEPTTQLYDS GKQARFSFEK SRVRKDSSEK KLITDALNKN QFLKRLEPQQ IREMVECMYE 180

RTFQQGSYVI RQGEPGNHIF VLKEGRLEVF QQNKLLSSIP VWTAFGELAI LYNCTRTASV 240

KAITNVKTWA LDREVFQNIM RVTAQTRQEQ YRNFLRSVSL LKNLPEDKLT KIMDCLEVEY 300

YDKGDYVIRE GEEGNTFFII AKGKVKVTQS TADHSQPQLI KNLHKGDYFG EKALISDDVR 360

SANVIADEYD VECLVIDRET FNQTVGTYEE LQTYLEGYVA NLARADEKRH AKRRSFCGQS 420

TKEVSLEMIQ LKEKVAQFPS SPFQNLEVVT TLGVGGFGRV ELVKVKNENM AFAMKCIKKK 480

HVVDTKQQEH IYSEKKILEQ ICSPFIVKLY RTFKDSKYVY MLLEACLGGE LWSLLRDRGS 540

FDEPTTKFCV GCVTEALDYL HHIGIVYRDL KPENLILDAE GYIKLVDFGF AKKIGSGQKT 600

WTFCGTPEYV APEVILSKGH DFSVDFWSLG ILVYELLTGS PPFSGADQMT TYNLILKGIE 660

KLDFPRTITR RPEDLIRRLC RQNPTERLGN LRNGINDIKK HRWLNGFNWD GLKLRKLASP 720

LKRELSGPTD YSYFDSYPPE EGMPPDELSG WDKDF 755

Nucleotide Sequence
(FASTA)

ATGGGGAATG CATCAATGAA ACCCAAACAT CTGAGGCAGC CGGACAGACA CATAGCAAAC 60

CTAGCTCTTG GTTGTGCTAG CAACAGAGTG CTTGAACTGG AAAAGGAGCT GAAAAGAAAA 120

GATGAAGAGT TGCAAGAGGG TCAAAGCCTT GTTGCTGAGC TTCAGGATCA GCTGTCTGTG 180

CAGACTAAAG TCATAGCAGA ACTCACCAAG GAACTTCAGA GCAAGTGCAT ACAGCTGAAC 240

AAGCTGCAGG ATGTTATTAA CACTCAAGGA GAACACTCTC TCCAGCCTTC TCCATATAGA 300

GTGACTCCAA AGCATCAAGT CTCTGCTGAC AGAAGGAAAG GAGCTAAGGA GGGTGTATCT 360

GCAGAGCCAA CAACACAGCT CTACGATTCC GGCAAACAAG CTAGATTTTC CTTTGAAAAA 420

TCAAGAGTCC GAAAGGATTC CAGTGAGAAG AAGCTCATCA CAGATGCCCT GAACAAAAAT 480

CAGTTCTTGA AGAGACTGGA GCCTCAGCAG ATCCGAGAGA TGGTGGAATG TATGTACGAG 540

AGGACTTTCC AGCAGGGGAG CTATGTCATC AGACAAGGAG AGCCTGGCAA TCACATTTTT 600

GTCCTCAAAG AGGGCAGACT GGAAGTCTTC CAGCAGAATA AACTGCTCTC CTCCATACCT 660

GTGTGGACGG CATTTGGTGA ACTGGCCATT TTATACAACT GCACGCGGAC GGCTTCCGTG 720

AAAGCAATCA CCAATGTTAA AACATGGGCA CTGGACAGAG AAGTGTTTCA AAACATCATG 780

AGAGTGACAG CACAGACAAG ACAAGAACAG TACAGAAACT TTCTTAGAAG TGTGTCCCTC 840

TTAAAAAACT TACCAGAAGA TAAATTGACC AAAATCATGG ACTGCCTGGA GGTGGAGTAC 900

TATGACAAAG GAGATTATGT TATTCGGGAA GGAGAAGAAG GAAATACCTT CTTTATAATA 960

GCAAAAGGAA AGGTAAAGGT TACCCAGAGT ACTGCAGATC ACTCACAGCC TCAGCTGATT 1020

AAAAATCTGC ATAAAGGAGA TTACTTTGGA GAAAAGGCCC TCATTAGTGA TGACGTCAGA 1080

TCAGCAAACG TTATTGCGGA TGAATATGAC GTGGAGTGCC TTGTAATAGA TAGAGAGACA 1140

TTTAATCAAA CTGTTGGAAC TTATGAGGAG TTACAAACCT ATCTTGAAGG TTATGTGGCC 1200

AACCTGGCCC GAGCTGACGA AAAGCGACAT GCCAAAAGAA GATCCTTCTG TGGACAGTCA 1260

ACCAAAGAGG TGTCTTTGGA GATGATACAA CTGAAGGAGA AAGTAGCCCA GTTCCCTTCT 1320

TCCCCATTCC AGAATTTAGA AGTTGTCACA ACTCTCGGTG TTGGTGGGTT CGGAAGGGTT 1380

GAGCTTGTTA AGGTAAAAAA TGAGAACATG GCATTTGCTA TGAAGTGTAT AAAGAAGAAA 1440

CATGTAGTGG ACACCAAACA ACAAGAGCAT ATATATTCTG AAAAGAAAAT CCTTGAGCAG 1500

ATATGTTCTC CTTTCATTGT AAAACTGTAT CGCACATTTA AGGATAGTAA GTACGTGTAC 1560

ATGCTGCTGG AGGCTTGCCT TGGTGGGGAG TTGTGGAGCT TGCTGAGAGA CAGAGGCAGC 1620

TTTGATGAAC CCACTACAAA GTTCTGTGTT GGATGTGTGA CAGAGGCTTT GGACTATCTA 1680

CATCACATAG GAATTGTCTA CAGAGACTTG AAGCCAGAAA ACTTAATTTT GGATGCTGAA 1740

GGATATATAA AATTGGTTGA TTTTGGATTT GCAAAAAAGA TCGGATCAGG GCAGAAAACC 1800

TGGACGTTCT GTGGAACCCC TGAGTATGTT GCTCCAGAAG TCATTCTGAG TAAGGGCCAT 1860

GACTTCAGTG TGGATTTTTG GTCCCTTGGG ATTCTTGTGT ATGAGCTCCT TACTGGCAGC 1920

CCACCATTCT CTGGGGCTGA TCAGATGACA ACATATAATT TGATTCTAAA AGGCATTGAA 1980

AAACTGGATT TTCCTAGAAC AATAACAAGG CGGCCTGAGG ATTTGATCCG CAGACTCTGC 2040

AGGCAGAACC CGACAGAAAG ATTAGGCAAT CTGAGGAATG GGATTAATGA CATTAAGAAG 2100

CACAGGTGGT TGAATGGTTT TAACTGGGAT GGTCTGAAAT TGAGGAAATT AGCATCACCT 2160

TTAAAAAGAG AGTTATCCGG ACCAACTGAT TACAGCTACT TTGACAGCTA TCCACCTGAA 2220

GAGGGAATGC CTCCAGATGA ACTTTCTGGC TGGGACAAGG ATTTCTGA 2268

Domain Profile

S: 1     lkviatlgvggfgrvelvkvksdeskafalkilkkkhivdtkqqehvlsekrileeaksd  60

         l+v++tlgvggfgrvelvkvk+ e+ afa+k++kkkh+vdtkqqeh++sek+ile+++s+

Q: 446   LEVVTTLGVGGFGRVELVKVKN-ENMAFAMKCIKKKHVVDTKQQEHIYSEKKILEQICSP  504

         689******************9.999**********************************

S: 61    fivklyrtfkdekyvyllleaclggelwtilrdrgsfddktakfivacvvealeylhskn  120

         fivklyrtfkd+kyvy+lleaclggelw++lrdrgsfd+ t+kf+v+cv+eal+ylh+ +

Q: 505   FIVKLYRTFKDSKYVYMLLEACLGGELWSLLRDRGSFDEPTTKFCVGCVTEALDYLHHIG  564

         ************************************************************

S: 121   iiyrdlkpenllldeegylklvdfgfakklksgkktwtfcgtpeyvapeiilnkghdlsv  180

         i+yrdlkpenl+ld+egy+klvdfgfakk++sg+ktwtfcgtpeyvape+il kghd+sv

Q: 565   IVYRDLKPENLILDAEGYIKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILSKGHDFSV  624

         ************************************************************

S: 181   dywalgilvyelltgkppfsgvdplktynlilkgidklelprkitkeaedlikklcrdnp  240

         d+w+lgilvyelltg+ppfsg+d+++tynlilkgi+kl++pr+it+++edli++lcr+np

Q: 625   DFWSLGILVYELLTGSPPFSGADQMTTYNLILKGIEKLDFPRTITRRPEDLIRRLCRQNP  684

         ************************************************************

S: 241   aerlgylkggikdikkhkwf  260

         +erlg+l++gi+dikkh+w+

Q: 685   TERLGNLRNGINDIKKHRWL  704

         *******************7

Domain Sequence
(FASTA)

LEVVTTLGVG GFGRVELVKV KNENMAFAMK CIKKKHVVDT KQQEHIYSEK KILEQICSPF 60

IVKLYRTFKD SKYVYMLLEA CLGGELWSLL RDRGSFDEPT TKFCVGCVTE ALDYLHHIGI 120

VYRDLKPENL ILDAEGYIKL VDFGFAKKIG SGQKTWTFCG TPEYVAPEVI LSKGHDFSVD 180

FWSLGILVYE LLTGSPPFSG ADQMTTYNLI LKGIEKLDFP RTITRRPEDL IRRLCRQNPT 240

ERLGNLRNGI NDIKKHRWL 259

Keyword

ATP-binding; cGMP; cGMP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0030553	; F:cGMP binding
GO:0004692	; F:cGMP-dependent protein kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR016232	; cGMP-dependent_protein_kinase.
IPR002374	; cGMP_dep_kinase.
IPR018490	; cNMP-bd-like.
IPR018488	; cNMP-bd_CS.
IPR000595	; cNMP-bd_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR014710	; RmlC-like_jellyroll.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00027	; cNMP_binding; 2.
PF00069	; Pkinase; 1.

SMARTs

SM00100	; cNMP; 2.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00888	; CNMP_BINDING_1; 2.
PS00889	; CNMP_BINDING_2; 2.
PS50042	; CNMP_BINDING_3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00104

; CGMPKINASE.

Created Date

20-Feb-2013