EKS-MEG-00380
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MEG-00380
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/MAPK413.92.4E-12426321296
StatusUnreviewed
Ensembl ProteinENSMGAP00000008218
UniProt AccessionG1N7L8;
Protein Name
Protein Synonyms/Alias
Gene NameMAPK8
Gene Synonyms/Alias MAPK8;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMGAG00000008028ENSMGAP00000008218ENSMGAT00000009008
OrganismMeleagris gallopavo
Functional Description
Protein Length427
Protein Sequence
(FASTA)
MSRSKRDNNF YSVEIGDSTF TVLKRYQNLK PIGSGAQGIV CAAYDAILER NVAIKKLSRP 60
FQNQTHAKRA YRELVLMKCV NHKNIIGLLN VFTPQKSLEE FQDVYIVMEL MDANLCQVIQ 120
MELDHERMSY LLYQMLCGIK HLHSAGIIHR DLKPSNIVVK SDCTLKILDF GLARTAGTSF 180
MMTPYVVTRY YRAPEVILGM GYKENVDIWS VGCIMGEMIK GGVLFPGTDH IDQWNKVIEQ 240
LGTPCPEFMK KLQPTVRTYV ENRPKYAGYS FEKLFPDVLF PADSEHNKLK ASQARDLLSK 300
MLVIDASKRI SVDEALQHPY INVWYDPSEA EAPPPKIPDK QLDEREHTIE EWKELIYKEV 360
MDLEERTKNG VIRGQPAPLG AAVINGSQHP SSSSSVNDVS SMSTDPTLAS DTDSSLETSA 420
GPLGCCR 427
Nucleotide Sequence
(FASTA)
ATGAGCAGAA GCAAGCGTGA CAACAATTTC TACAGTGTTG AAATTGGAGA TTCAACGTTC 60
ACTGTATTGA AACGATATCA AAACTTAAAA CCAATAGGAT CAGGAGCGCA AGGAATAGTA 120
TGTGCAGCCT ATGATGCCAT CCTTGAGCGA AACGTTGCAA TCAAGAAACT AAGCCGACCA 180
TTTCAGAATC AGACCCATGC TAAAAGAGCT TACAGGGAGC TCGTTCTTAT GAAGTGCGTT 240
AATCACAAAA ATATAATCGG CTTACTGAAT GTGTTCACAC CACAGAAATC CCTAGAAGAA 300
TTTCAAGATG TCTACATAGT AATGGAGCTC ATGGATGCAA ATCTCTGCCA AGTAATTCAG 360
ATGGAGCTAG ACCATGAACG AATGTCCTAT CTCCTTTATC AGATGCTGTG TGGTATCAAA 420
CATCTTCACT CAGCTGGAAT TATACATAGG GACTTAAAGC CCAGTAATAT AGTAGTAAAG 480
TCAGACTGCA CTTTGAAGAT TCTTGACTTT GGACTGGCCA GAACTGCAGG AACTAGTTTT 540
ATGATGACGC CTTATGTAGT GACTCGTTAC TACAGAGCAC CAGAGGTCAT CCTAGGGATG 600
GGATACAAAG AAAACGTTGA CATTTGGTCA GTTGGGTGCA TCATGGGAGA AATGATCAAA 660
GGTGGTGTTT TATTTCCTGG TACAGATCAT ATTGATCAAT GGAATAAAGT TATAGAGCAG 720
CTAGGAACAC CGTGCCCCGA ATTTATGAAG AAATTACAGC CCACAGTTCG AACTTACGTG 780
GAGAACAGAC CCAAGTATGC TGGATATAGC TTTGAGAAAC TCTTTCCAGA TGTCCTTTTC 840
CCAGCTGATT CTGAACACAA CAAACTTAAA GCAAGTCAAG CAAGGGATTT GTTATCAAAA 900
ATGCTGGTTA TAGATGCCTC GAAAAGAATT TCTGTGGATG AAGCCCTCCA GCACCCATAC 960
ATCAATGTTT GGTATGATCC ATCAGAAGCC GAAGCTCCTC CACCAAAGAT ACCAGATAAG 1020
CAGTTAGATG AGAGGGAGCA CACAATAGAA GAATGGAAAG AATTGATATA CAAGGAAGTC 1080
ATGGACCTGG AGGAAAGAAC CAAGAATGGG GTTATACGTG GGCAGCCAGC CCCTTTAGGT 1140
GCAGCAGTGA TCAATGGCTC TCAGCATCCA TCTTCGTCGT CATCTGTCAA TGATGTGTCT 1200
TCAATGTCAA CAGATCCAAC ATTGGCCTCT GATACAGACA GCAGTCTAGA AACCTCAGCT 1260
GGACCTCTGG GTTGCTGTAG ATGA 1284
Domain Profile
S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60
         y++lkp+g+Ga+g+v++a+d+  e++vaikklsrpfq++t+akr++REl l+k+++h+Ni
Q: 26    YQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI  85
         899*********************************************************
S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120
         i ll+vftp+++lee++dvY+v+elm+++L++vi+++ l++e++++llyq+l+g+k+lHs
Q: 86    IGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQME-LDHERMSYLLYQMLCGIKHLHS  144
         ************************************9.**********************
S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslke  180
         a++iHrDlKPsN++v++dc+lkildFGlar+a ++ +  +t+yv+tr+YraPe++l  + 
Q: 145   AGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFM--MTPYVVTRYYRAPEVILG-MG  201
         **********************************976..*****************9.99
S: 181   ytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyi  240
         y+++vDiWsvGCI++E+++g +lfpg+d+idq++k++e+lgtp  ef+kk++  ++r+y+
Q: 202   YKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQP-TVRTYV  260
         *****************************************************.5*****
S: 241   kslpkkkkkdfeelfpk............aseealdLleklLvldpdkRisveeaLehpY  288
         +++pk++  +fe+lfp+            + ++a+dLl+k+Lv+d++kRisv+eaL+hpY
Q: 261   ENRPKYAGYSFEKLFPDvlfpadsehnklKASQARDLLSKMLVIDASKRISVDEALQHPY  320
         *****************************99*****************************
S: 289   l  289
         +
Q: 321   I  321
         7
Domain Sequence
(FASTA)
YQNLKPIGSG AQGIVCAAYD AILERNVAIK KLSRPFQNQT HAKRAYRELV LMKCVNHKNI 60
IGLLNVFTPQ KSLEEFQDVY IVMELMDANL CQVIQMELDH ERMSYLLYQM LCGIKHLHSA 120
GIIHRDLKPS NIVVKSDCTL KILDFGLART AGTSFMMTPY VVTRYYRAPE VILGMGYKEN 180
VDIWSVGCIM GEMIKGGVLF PGTDHIDQWN KVIEQLGTPC PEFMKKLQPT VRTYVENRPK 240
YAGYSFEKLF PDVLFPADSE HNKLKASQAR DLLSKMLVID ASKRISVDEA LQHPYI 296
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tupaia belangeri"; ?>Vicugna pacos"; ?>
EKS-AIM-00433
EKS-ANC-00452
EKS-BOT-00465
EKS-CAE-00386
EKS-CAJ-00470
EKS-CAF-00466
EKS-CAP-00497
EKS-CIS-00222
EKS-DAR-00873
EKS-DRM-00223
EKS-EQC-00453
EKS-FEC-00443
EKS-GAM-00270
EKS-GAG-00388
EKS-GOG-00455
EKS-HOS-00474
EKS-ICT-00440
EKS-LAC-00476
EKS-LOA-00470
EKS-MAM-00462
EKS-MOD-00457
EKS-MUM-00498
EKS-MUP-00455
EKS-MYL-00456
EKS-NOL-00422
EKS-ORC-00439
EKS-OTG-00472
EKS-PAT-00438
EKS-PES-00409
EKS-POA-00453
EKS-SAH-00433
EKS-TAG-00527
EKS-TAS-00066
EKS-TUB-00050
EKS-VIP-00088
Gene Ontology
GO:0005829; C:cytosol
GO:0005739; C:mitochondrion
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0035033; F:histone deacetylase regulator activity
GO:0004705; F:JUN kinase activity
GO:0071260; P:cellular response to mechanical stimulus
GO:0043066; P:negative regulation of apoptotic process
GO:0032091; P:negative regulation of protein binding
GO:0018105; P:peptidyl-serine phosphorylation
GO:0018107; P:peptidyl-threonine phosphorylation
GO:0090045; P:positive regulation of deacetylase activity
GO:2000017; P:positive regulation of determination of dorsal identity
GO:0010628; P:positive regulation of gene expression
GO:0032880; P:regulation of protein localization
GO:0046686; P:response to cadmium ion
GO:0009411; P:response to UV
KEGG
mgp:100547737;
InterPros
IPR011009; Kinase-like_dom.
IPR003527; MAP_kinase_CS.
IPR008351; MAPK_JNK.
IPR000719; Prot_kinase_cat_dom.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS01351; MAPK; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
PR01772; JNKMAPKINASE.
Created Date20-Feb-2013