EKS-MEG-00050

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MEG-00050

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	372.3	1.2E-111	47	331	285

Status

Unreviewed

Ensembl Protein

ENSMGAP00000008339

UniProt Accession

G1N7X1;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK10

Gene Synonyms/Alias

CDK10;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000008128	ENSMGAP00000008339	ENSMGAT00000009135

Organism

Meleagris gallopavo

Functional Description

Protein Length

370

Protein Sequence
(FASTA)

MADGDRAEGA PAESEAEPLR FQRLWGEGYF EVPASERLGK CRSVKEFEKL NRIGEGTYGI 60

VYRARDTVTD ETVALKKVRM DNEKEGMPIS SLREITLLLE LQHPNIVELK EVVVGNHLES 120

IFLVMGYCEQ DLASLLENMQ TPFSEAQVKC IILQVLKGLQ YLHERYIIHR DLKVSNLLMT 180

DKGCVKIADF GLARTYGMPP QPMTPKVVTL WYRAPELLLG VTTQTTSIDM WAVGCILAEL 240

LAHKPLLPGT SEIHQIDLIV QLLGTPNENI WPGFSKLPLV SQYTLRKQPY NNLKHKFPWL 300

SEAGLRLLNF LFMYDPKKRA TAKDSLDSSY FKEKPLPCEP ELMPTFPHHR NKRAASTSTG 360

TETQAKRAKP 370

Nucleotide Sequence
(FASTA)

ATGGCGGACG GAGACCGCGC TGAGGGAGCT CCGGCCGAGA GTGAGGCGGA ACCGCTGCGG 60

TTCCAGCGGC TGTGGGGAGA GGGCTACTTC GAGGTGCCGG CGTCCGAGCG GCTGGGGAAA 120

TGCCGGAGCG TGAAGGAGTT TGAGAAGCTG AATCGGATCG GAGAGGGCAC TTATGGCATA 180

GTGTACCGTG CCCGGGACAC TGTGACAGAT GAGACTGTGG CACTGAAGAA GGTGCGGATG 240

GACAATGAGA AGGAAGGAAT GCCCATCAGC AGCCTGCGGG AGATCACACT GCTCCTGGAG 300

CTCCAGCATC CCAACATCGT GGAGCTGAAG GAGGTGGTTG TGGGGAACCA TCTGGAGAGT 360

ATTTTCCTGG TGATGGGTTA CTGTGAGCAG GACCTTGCCA GCCTTCTCGA GAACATGCAG 420

ACACCTTTTT CAGAGGCTCA GGTGAAATGC ATCATCTTGC AAGTCCTCAA GGGTCTGCAG 480

TACCTTCATG AGAGGTACAT CATCCACAGG GATCTGAAGG TGTCCAACCT GCTCATGACT 540

GACAAAGGCT GTGTGAAGAT AGCGGATTTT GGTCTGGCAC GTACATATGG GATGCCACCA 600

CAACCCATGA CCCCCAAAGT CGTCACGCTG TGGTACCGAG CACCTGAGCT GCTGCTAGGA 660

GTGACAACGC AGACCACCAG CATTGACATG TGGGCCGTGG GCTGCATCCT TGCTGAGCTG 720

TTGGCTCACA AGCCACTGCT GCCAGGCACC TCTGAAATCC ACCAAATAGA CCTCATCGTG 780

CAGCTCCTGG GGACACCGAA TGAAAACATC TGGCCGGGTT TCTCCAAGTT GCCCCTGGTG 840

AGTCAGTACA CGCTGCGGAA ACAGCCTTAC AACAACCTCA AGCACAAGTT CCCCTGGCTC 900

TCAGAGGCCG GGCTGCGTCT GCTCAACTTC CTCTTCATGT ATGATCCCAA GAAGCGGGCA 960

ACAGCAAAAG ACAGCCTGGA TAGTTCATAC TTCAAGGAAA AGCCCCTGCC CTGCGAGCCA 1020

GAGCTCATGC CCACCTTCCC CCACCATCGC AACAAGCGGG CAGCCAGCAC CAGCACAGGG 1080

ACTGAGACCC AGGCAAAGCG TGCCAAGCCC TGA 1113

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         +ekl++igeGtyg vy+a+d+ t+e+vAlKk+r+++ekeg+pi++lrEi+ll el+h+ni

Q: 47    FEKLNRIGEGTYGIVYRARDTVTDETVALKKVRMDNEKEGMPISSLREITLLLELQHPNI  106

         89**********************************************************

S: 61    vkLlevvakdk.kklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylHsn  119

         v+L+evv+ ++ ++++Lv+ ++eqdL++ll+++++  +s+++vk ++lq+l+gl+ylH++

Q: 107   VELKEVVVGNHlESIFLVMGYCEQDLASLLENMQT-PFSEAQVKCIILQVLKGLQYLHER  165

         ********5555**********************9.************************

S: 120   kilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgakeYs  179

          i+HRDlK +NlL++++g++k+aDfGlar++++p + +t++vvTlwYraPelLlg ++ +

Q: 166   YIIHRDLKVSNLLMTDKGCVKIADFGLARTYGMPPQPMTPKVVTLWYRAPELLLGVTTQT  225

         ************************************************************

S: 180   tavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeyk.ksf  238

         t++D+W+vgcilaell++kpl++g+sei+q++ i++llgtp+e++wp++sklp ++ +++

Q: 226   TSIDMWAVGCILAELLAHKPLLPGTSEIHQIDLIVQLLGTPNENIWPGFSKLPLVSqYTL  285

         ********************************************************8899

S: 239   pkkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         +k+++++lk+k++ l+e++l+ll+ l+++dpkkR +ak+ l+++yf

Q: 286   RKQPYNNLKHKFPWLSEAGLRLLNFLFMYDPKKRATAKDSLDSSYF  331

         999999**************************************98

Domain Sequence
(FASTA)

FEKLNRIGEG TYGIVYRARD TVTDETVALK KVRMDNEKEG MPISSLREIT LLLELQHPNI 60

VELKEVVVGN HLESIFLVMG YCEQDLASLL ENMQTPFSEA QVKCIILQVL KGLQYLHERY 120

IIHRDLKVSN LLMTDKGCVK IADFGLARTY GMPPQPMTPK VVTLWYRAPE LLLGVTTQTT 180

SIDMWAVGCI LAELLAHKPL LPGTSEIHQI DLIVQLLGTP NENIWPGFSK LPLVSQYTLR 240

KQPYNNLKHK FPWLSEAGLR LLNFLFMYDP KKRATAKDSL DSSYF 285

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

mgp:100542237

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013