EKS-MEG-00225

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MEG-00225

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	388.5	1.5E-116	206	504	299

Status

Unreviewed

Ensembl Protein

ENSMGAP00000008360

UniProt Accession

G1N7Y4;

Protein Name

Protein Synonyms/Alias

Gene Name

BMPR2

Gene Synonyms/Alias

BMPR2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000008156	ENSMGAP00000008360	ENSMGAT00000009156
ENSMGAG00000008156	ENSMGAP00000008499	ENSMGAT00000009297

Organism

Meleagris gallopavo

Functional Description

Protein Length

1006

Protein Sequence
(FASTA)

ITNSLVRVAW ILKLVTKIFL SLSKAAQSEE RLCAFKDPYQ QDHGISESRI SQENGTILCM 60

KGSTCYGLWE KTREGDIHLV KQGCWSHIGD PQECHFEECI VTTTPSLIQN GTYRFCCCST 120

DLCNVNFTEN FPPPDPTDTT PYNSSHSFHR DETIVIALAS VSVLAVLIAA LFFGYRMLAG 180

DRKQGLHSMN MMEAAASEPS LDLDNLKLLE CIGRGRYGAV YKGSLDERPV AVKVFSFANR 240

QNFVNERNIY RIPLMEHDNI ARFIVGDERF TADGRMEYLL VMEYYPNGSL CKYLSLHTSD 300

WVSSCRLAHS ITRGLAYLHT ELPRGDHYKP AISHRDLNSR NVLVKNDGTC VISDFGLSMK 360

LTGNRLVRPG EEDNAAISEV GTIRYMAPEV LEGAVNLRDC ESALKQVDMY ALGLIYWEIF 420

MRCTDLFPGE SVPEYQMAFQ TEVGNHPTFE DMQVLVSREK QRPKFPEAWK ENSLAVRSLK 480

ETIEDCWDQD AEARLTAQCA EERMAELMMI WERNKSVSPT VNPMSTAMQN ERNLSHHRRV 540

SKIRPYPDYS SSSYIEDSIH HTDSIVKNIS SEHSMSTTPL TSGEKNRNSI NYERQQAQAR 600

IPSPETSVTS LSTNTTTTNT TGLTPSTGMT TISEIPYSDE TNLHTTNVMQ PGGPTPVCLQ 660

LTEEDLETNK LDPKEVDKNL KESSDENLME HSLKQFSGPD PLSSTSSSLL YPLIKLAVEV 720

TGQQDFTQAS NGQACLIPDV PSAQVYPLPK QQNLPKRPTS LPLNTKNSTK ESRLKFGGKH 780

KSNLKQVETG VAKMNTINAA EPHVVTVTMN GVAGRTHSIN SHTGTTQYAN GAVPSGQTAS 840

SVAQRAQEML QNQFSGEDSR LNINSSPDEH EPLLRREQQV GHDEGVLDRL VDRRERQLDN 900

GRTNVNNNNS NPCPVQDTAT LTIQNVARNP GQTQTRRAQR PNSLDLSATN SLDSSSMQLG 960

DSSQDSKSGS GEKIKKRVKT PYSLKRWRPS TWVISTEPLH CEVNNN 1006

Nucleotide Sequence
(FASTA)

ATCACAAATT CATTGGTCAG AGTTGCATGG ATTTTAAAGT TAGTGACAAA AATTTTTCTT 60

TCTTTGTCTA AAGCTGCACA GAGTGAGGAG CGGCTGTGTG CATTTAAGGA CCCATATCAG 120

CAGGACCATG GAATCAGTGA GAGCAGAATC TCCCAAGAGA ATGGCACCAT TTTGTGCATG 180

AAAGGTAGTA CCTGCTATGG ACTTTGGGAA AAAACACGGG AAGGAGACAT ACATCTCGTA 240

AAGCAAGGAT GCTGGTCTCA TATAGGAGAC CCACAGGAGT GTCACTTTGA GGAGTGTATA 300

GTTACAACCA CCCCTTCCTT GATTCAGAAT GGAACATATC GGTTCTGCTG TTGTAGTACT 360

GACTTATGTA ATGTCAACTT CACTGAAAAC TTCCCACCTC CTGACCCAAC TGATACAACG 420

CCTTACAATT CTTCTCATTC TTTTCATCGG GATGAGACGA TAGTTATTGC CCTTGCATCT 480

GTGTCTGTAC TAGCTGTCTT GATTGCTGCC CTGTTCTTTG GATACAGAAT GCTTGCAGGA 540

GACCGTAAAC AAGGATTGCA TAGTATGAAC ATGATGGAGG CAGCAGCATC AGAGCCCTCA 600

TTGGATCTGG ACAATCTTAA GTTACTGGAG TGTATTGGCC GGGGACGATA TGGAGCAGTG 660

TACAAAGGCT CCCTGGATGA ACGTCCTGTT GCTGTGAAAG TATTTTCTTT TGCTAATCGT 720

CAAAACTTTG TCAATGAGAG GAATATTTAC AGGATTCCAC TGATGGAACA TGACAATATT 780

GCCCGCTTCA TTGTGGGAGA TGAGAGATTC ACTGCAGATG GGCGTATGGA ATATTTATTG 840

GTGATGGAAT ATTATCCCAA TGGTTCACTG TGCAAATATC TGAGTCTCCA TACAAGTGAC 900

TGGGTGAGCT CTTGCCGGCT GGCACATTCT ATAACCAGGG GCTTGGCGTA CCTGCACACA 960

GAGCTACCTC GAGGAGACCA TTACAAACCT GCAATATCCC ATCGTGACTT GAACAGCCGC 1020

AATGTACTGG TAAAGAATGA TGGAACGTGT GTAATTAGTG ATTTTGGGCT CTCCATGAAG 1080

TTAACTGGAA ACAGACTGGT GCGCCCAGGC GAGGAAGACA ATGCAGCCAT TAGTGAGGTC 1140

GGTACGATCC GCTATATGGC CCCAGAAGTG CTTGAAGGAG CAGTGAACTT AAGGGACTGT 1200

GAATCTGCTT TGAAACAAGT AGATATGTAT GCACTGGGCC TCATCTACTG GGAGATATTT 1260

ATGCGATGTA CAGACCTCTT CCCAGGGGAA TCTGTGCCAG AGTACCAGAT GGCTTTCCAG 1320

ACAGAAGTCG GAAACCATCC CACTTTTGAA GATATGCAAG TCTTGGTGTC CAGAGAAAAG 1380

CAAAGACCAA AATTCCCAGA AGCATGGAAA GAGAACAGCC TGGCTGTGAG GTCACTTAAA 1440

GAAACAATCG AAGACTGCTG GGATCAGGAT GCTGAAGCTC GATTAACTGC CCAATGTGCT 1500

GAGGAGAGAA TGGCAGAACT CATGATGATT TGGGAGAGAA ATAAATCAGT TAGTCCAACA 1560

GTCAATCCAA TGTCAACTGC CATGCAGAAT GAGCGGAACC TGTCACATCA TAGACGAGTG 1620

TCAAAAATAA GGCCATATCC AGATTACTCT TCTTCTTCCT ACATTGAAGA TTCAATCCAC 1680

CACACTGACA GCATAGTGAA GAACATTTCG TCTGAACATT CAATGTCCAC TACACCACTG 1740

ACTTCAGGGG AAAAGAATAG AAACTCCATT AACTATGAGC GGCAACAAGC ACAAGCTCGC 1800

ATCCCTAGTC CTGAGACAAG TGTCACCAGT TTGTCCACCA ATACTACTAC CACCAATACA 1860

ACTGGCCTCA CTCCTAGCAC TGGCATGACC ACCATATCTG AAATACCTTA TTCAGATGAA 1920

ACAAACTTAC ATACTACAAA TGTCATGCAG CCAGGTGGGC CCACACCAGT TTGTCTGCAG 1980

CTAACAGAGG AGGATCTAGA GACAAATAAA CTGGATCCAA AAGAAGTAGA TAAGAACCTG 2040

AAAGAAAGTT CTGATGAGAA TCTGATGGAA CATTCACTCA AGCAGTTTAG TGGGCCAGAT 2100

CCACTCAGCA GCACTAGTTC CAGCTTGCTT TATCCGCTGA TAAAACTTGC AGTAGAGGTG 2160

ACAGGACAAC AGGATTTCAC GCAAGCTAGC AATGGTCAAG CATGTTTGAT TCCAGATGTC 2220

CCATCTGCTC AGGTCTATCC TTTACCCAAG CAACAGAACC TTCCGAAGAG GCCTACTAGC 2280

CTTCCTCTAA ACACCAAAAA TTCAACAAAG GAGTCACGGT TAAAATTTGG TGGCAAGCAC 2340

AAATCAAACT TGAAGCAAGT TGAAACAGGC GTTGCCAAGA TGAACACTAT CAATGCTGCA 2400

GAACCTCATG TGGTGACCGT TACCATGAAT GGAGTGGCTG GTAGAACCCA CAGCATAAAC 2460

TCTCATACTG GCACGACCCA GTATGCCAAT GGGGCAGTGC CATCTGGACA GACAGCCAGT 2520

TCAGTAGCAC AAAGGGCCCA GGAAATGCTT CAGAACCAGT TCAGTGGAGA GGATAGTCGT 2580

CTGAATATTA ACTCAAGCCC TGATGAGCAT GAGCCCTTGT TGAGGCGGGA GCAACAGGTT 2640

GGCCATGATG AAGGTGTTCT GGACCGCCTA GTAGACAGGA GAGAGCGACA ACTTGATAAT 2700

GGCCGAACAA ATGTTAATAA CAATAACAGT AATCCGTGTC CAGTGCAAGA CACAGCTACA 2760

CTCACTATCC AGAACGTAGC CAGAAATCCT GGGCAGACTC AAACTAGAAG AGCACAGAGG 2820

CCTAATTCGC TGGATCTATC TGCCACAAAT AGTTTGGATA GCAGCAGTAT GCAGTTAGGT 2880

GATTCGTCAC AGGACAGCAA ATCGGGCTCA GGAGAAAAGA TCAAGAAACG TGTGAAAACT 2940

CCTTACTCAC TGAAGCGATG GCGTCCTTCG ACATGGGTCA TCTCCACTGA GCCGCTGCAC 3000

TGCGAGGTCA ACAATAAC 3018

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         lklle+ig+Gryg+V+k++l+++ vAvK+fs ++++++++E++iy+ +l++h+ni +fi+

Q: 206   LKLLECIGRGRYGAVYKGSLDERPVAVKVFSFANRQNFVNERNIYRIPLMEHDNIARFIV  265

         6899********************************************************

S: 61    adk.keedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgt  119

          d+  ++d ++e+llv+ey+++gsL++yL+ +t+d+ +++rla+s+++Gla+LH+e++

Q: 266   GDErFTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSITRGLAYLHTELPRG  325

         **98999*************************************************9766

S: 120   kgkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekee....ldlaansqvGtkR  175

          +++Kpai+HRDl+s+N+lvk+d+tc+i+D+GL++kl+ ++ +    +d+aa+s+vGt R

Q: 326   -DHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMKLTGNRLVrpgeEDNAAISEVGTIR  384

         .46**********************************9999877787999**********

S: 176   YmaPEvleealnlkdfe.afkraDvYslgLvlWEvasRcee..vdeeveeyklpfeevvg  232

         YmaPEvle+a+nl+d+e a+k++D+Y+lgL++WE+++Rc++  ++e+v+ey+++f+++vg

Q: 385   YMAPEVLEGAVNLRDCEsALKQVDMYALGLIYWEIFMRCTDlfPGESVPEYQMAFQTEVG  444

         *****************99*****************************************

S: 233   sdPsleemkevvvekklrPkipeawkkke.alkelsklleecWdadpeaRltalrvkkrl  291

         ++P++e+m+ +v ++k+rPk+peawk+++ a+++l++++e+cWd+d+eaRlta++ ++r+

Q: 445   NHPTFEDMQVLVSREKQRPKFPEAWKENSlAVRSLKETIEDCWDQDAEARLTAQCAEERM  504

         ***************************9999*************************9987

Domain Sequence
(FASTA)

LKLLECIGRG RYGAVYKGSL DERPVAVKVF SFANRQNFVN ERNIYRIPLM EHDNIARFIV 60

GDERFTADGR MEYLLVMEYY PNGSLCKYLS LHTSDWVSSC RLAHSITRGL AYLHTELPRG 120

DHYKPAISHR DLNSRNVLVK NDGTCVISDF GLSMKLTGNR LVRPGEEDNA AISEVGTIRY 180

MAPEVLEGAV NLRDCESALK QVDMYALGLI YWEIFMRCTD LFPGESVPEY QMAFQTEVGN 240

HPTFEDMQVL VSREKQRPKF PEAWKENSLA VRSLKETIED CWDQDAEARL TAQCAEERM 299

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005901	; C:caveola
GO:0009986	; C:cell surface
GO:0005887	; C:integral to plasma membrane
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0030509	; P:BMP signaling pathway
GO:0009267	; P:cellular response to starvation
GO:0030308	; P:negative regulation of cell growth
GO:2000279	; P:negative regulation of DNA biosynthetic process
GO:0045906	; P:negative regulation of vasoconstriction
GO:0030513	; P:positive regulation of BMP signaling pathway
GO:0030501	; P:positive regulation of bone mineralization
GO:0010595	; P:positive regulation of endothelial cell migration
GO:0001938	; P:positive regulation of endothelial cell proliferation
GO:0010634	; P:positive regulation of epithelial cell migration
GO:0045669	; P:positive regulation of osteoblast differentiation
GO:0010862	; P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0006366	; P:transcription from RNA polymerase II promoter
GO:0048010	; P:vascular endothelial growth factor receptor signaling pathway

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR015770	; BMPRII.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013