EKS-MEG-00111

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MEG-00111

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/CDC7	511.0	8.8E-154	53	554	502

Status

Unreviewed

Ensembl Protein

ENSMGAP00000008638

UniProt Accession

G1N8J4;

Protein Name

Protein Synonyms/Alias

Gene Name

CDC7

Gene Synonyms/Alias

CDC7;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000008404	ENSMGAP00000008638	ENSMGAT00000009438

Organism

Meleagris gallopavo

Functional Description

Protein Length

559

Protein Sequence
(FASTA)

VMETESKSHC DEQHPHQAED TSRKLAQSSK LSAGIKKDIE KLYEAVPQLV NVFKIKEKIG 60

EGTFSSVYLA TAQLQTGCEE KMALKHLIPT SHPLRIAAEL QCLTVAGGQD NVMGVKYCFR 120

KNDHVVIVMP YLEHESFLDI LNSLSFEEVK EYMFNLFKAL RRIHHFGIVH RDVKPSNFLY 180

NRRLKQYALV DFGLAQGTPD TKIELLKTAH SEGQQGSYSQ SNPSIALGNG ASVAVTAPKQ 240

IPQQLASRAS DKSSHSKIQI KQGRGGKEDS VHHSAQRSVF GERNFNIYCS TYQENSNTKL 300

IKQSKMIDVS SRKLVTKKKI ISTKAVSRKA ASGCPSNLTC DCYATDRVCS VCLSRTRCQQ 360

VAPRAGTPGF RAPEVLTKCP TQTTAIDMWS AGIVFLSLLS GRYPFYKASD DLTALAQIMT 420

VRGSRETIQA AKTFGKSVLC TQVVPAQNLR TLCEKLRGTN SSCNRSQGDV PSKSGDNTAL 480

PVEVDKQCAP ETIREEIQHL KSCQEDDGAS EIKVTDMKGW DQVPDEAYDL LDKLLDLNPA 540

TRITAKDALL HPFFKDMRL 559

Nucleotide Sequence
(FASTA)

GTGATGGAGA CAGAGTCCAA GTCTCACTGT GATGAGCAGC ACCCTCATCA GGCTGAAGAC 60

ACAAGCAGAA AGCTTGCACA GAGCAGTAAG CTTTCAGCAG GAATAAAAAA AGATATTGAA 120

AAACTTTATG AAGCAGTGCC GCAGCTTGTA AACGTGTTCA AAATTAAGGA AAAAATTGGA 180

GAAGGTACTT TTAGTTCTGT TTACTTGGCC ACAGCGCAAC TGCAAACAGG ATGTGAAGAA 240

AAAATGGCTC TGAAGCACTT GATTCCAACC AGTCACCCTC TGCGAATTGC TGCTGAACTT 300

CAGTGCCTCA CAGTAGCAGG GGGACAAGAT AACGTTATGG GAGTTAAATA TTGCTTTAGG 360

AAAAATGATC ACGTGGTTAT TGTTATGCCA TATCTGGAAC ATGAATCCTT CTTGGACATT 420

CTGAATTCTC TTTCCTTTGA AGAAGTGAAA GAATACATGT TTAATCTGTT TAAAGCATTG 480

AGGCGCATTC ACCACTTTGG TATTGTTCAT CGTGACGTCA AACCCAGTAA CTTTCTCTAC 540

AACAGGAGGC TGAAGCAGTA CGCCTTGGTA GATTTTGGCT TGGCGCAAGG AACTCCTGAT 600

ACAAAAATTG AACTTCTCAA AACTGCCCAT TCTGAAGGCC AGCAGGGAAG TTACTCGCAA 660

AGCAATCCCA GCATAGCTTT GGGAAATGGG GCTTCTGTCG CTGTCACAGC ACCTAAACAG 720

ATTCCTCAAC AGTTAGCATC AAGAGCATCT GATAAAAGCT CACACTCAAA AATACAGATT 780

AAACAAGGAA GAGGAGGAAA GGAGGATTCT GTGCACCATT CTGCCCAACG CTCTGTCTTT 840

GGAGAGAGGA ATTTCAACAT CTATTGTTCC ACATACCAGG AGAACTCAAA TACAAAACTC 900

ATTAAACAAT CGAAGATGAT AGATGTTTCA TCTAGAAAGT TAGTAACAAA GAAGAAGATT 960

ATTTCTACCA AAGCAGTGAG CAGGAAAGCT GCCAGTGGTT GTCCGTCAAA CCTGACCTGT 1020

GACTGTTACG CAACGGACAG AGTTTGCAGT GTTTGCCTTT CAAGAACAAG ATGTCAACAA 1080

GTTGCTCCCA GAGCAGGAAC ACCTGGATTC AGAGCACCAG AAGTACTGAC AAAGTGCCCC 1140

ACTCAGACAA CAGCAATTGA CATGTGGTCT GCAGGAATTG TATTCCTTTC TCTGCTCAGT 1200

GGACGGTATC CATTTTACAA AGCAAGCGAT GATTTAACTG CTTTGGCACA AATCATGACA 1260

GTTCGTGGAT CTCGAGAAAC CATTCAGGCT GCTAAAACTT TTGGTAAATC AGTTCTGTGT 1320

ACCCAAGTTG TCCCCGCACA AAACTTACGA ACCCTCTGTG AGAAGCTGAG AGGAACAAAT 1380

AGCAGCTGTA ACAGATCCCA AGGTGACGTA CCCAGCAAAT CTGGAGACAA CACAGCTTTG 1440

CCAGTTGAAG TAGACAAACA GTGTGCTCCT GAGACAATCA GAGAAGAAAT TCAGCACTTA 1500

AAGAGCTGTC AGGAAGATGA TGGTGCTTCA GAAATTAAGG TGACAGACAT GAAAGGATGG 1560

GATCAGGTTC CTGATGAAGC ATACGACCTA CTTGATAAGC TACTAGACTT AAACCCTGCA 1620

ACAAGAATAA CTGCAAAAGA TGCTTTGCTG CATCCCTTTT TTAAAGACAT GAGACTATGA 1680

Domain Profile

S: 1     fkikdkiGeGtfssvylataqleegleekialkhliptshPeriaaeLelltvlgGqenv  60

         fkik+kiGeGtfssvylataql++g eek+alkhliptshP riaaeL++ltv+gGq+nv

Q: 53    FKIKEKIGEGTFSSVYLATAQLQTGCEEKMALKHLIPTSHPLRIAAELQCLTVAGGQDNV  112

         9***********************************************************

S: 61    vglkecfrkndsvvivlpylehesfldllrslsfqevreYlrnLlvalkrvhkfgivhrD  120

         +g+k+cfrknd+vviv+pylehesfld+l+slsf+ev+eY++nL++al+r+h+fgivhrD

Q: 113   MGVKYCFRKNDHVVIVMPYLEHESFLDILNSLSFEEVKEYMFNLFKALRRIHHFGIVHRD  172

         ************************************************************

S: 121   vkpsnfLynrrlkkfaLvDfGLaq..............seaqkeecsrn...........  155

         vkpsnfLynrrlk++aLvDfGLaq              se q+ + s++

Q: 173   VKPSNFLYNRRLKQYALVDFGLAQgtpdtkiellktahSEGQQGSYSQSnpsialgngas  232

         *************************************99999999999988888887775

S: 156   ........llsaavekevd.........................................  166

Q: 233   vavtapkqI---------Pqqlasrasdksshskiqikqgrggkedsvhhsaqrsvfger  283

         555444440.........24455666666666****************************

S: 167   .......................................................tcdcy  171

                                                                tcdcy

Q: 284   nfniycstyqensntklikqskmidvssrklvtkkkiistkavsrkaasgcpsnlTCDCY  343

         ************************************************************

S: 172   gtdkvcsvclsr..rqqvanraGtpGfraPevLlkipdqttaiDiwsaGvilLsllsgry  229

         +td+vcsvclsr   qqva+raGtpGfraPevL+k+p+qttaiD+wsaG+++Lsllsgry

Q: 344   ATDRVCSVCLSRtrCQQVAPRAGTPGFRAPEVLTKCPTQTTAIDMWSAGIVFLSLLSGRY  403

         **********9974589*******************************************

S: 230   PffkasddlealaeivtilGsreiikaakafgksvllskevp..................  271

         Pf+kasddl+ala+i+t++Gsre+i+aak+fgksvl+++ vp

Q: 404   PFYKASDDLTALAQIMTVRGSRETIQAAKTFGKSVLCTQVVPaqnlrtlceklrgtnssc  463

         ***********************************************************9

S: 272   .................................................dsdsye.....  277

Q: 464   nrsqgdvpsksgdntalpvevdkqcapetireeiqhlkscqeddgaseiK----Vtdmkg  519

         99999999999999999999999999999999888888887666555550....055555

S: 278   ....PdeaydlldkllelnPakritaeealkhpff  308

             Pdeaydlldkll+lnPa rita++al+hpff

Q: 520   wdqvPDEAYDLLDKLLDLNPATRITAKDALLHPFF  554

         6777******************************8

Domain Sequence
(FASTA)

FKIKEKIGEG TFSSVYLATA QLQTGCEEKM ALKHLIPTSH PLRIAAELQC LTVAGGQDNV 60

MGVKYCFRKN DHVVIVMPYL EHESFLDILN SLSFEEVKEY MFNLFKALRR IHHFGIVHRD 120

VKPSNFLYNR RLKQYALVDF GLAQGTPDTK IELLKTAHSE GQQGSYSQSN PSIALGNGAS 180

VAVTAPKQIP QQLASRASDK SSHSKIQIKQ GRGGKEDSVH HSAQRSVFGE RNFNIYCSTY 240

QENSNTKLIK QSKMIDVSSR KLVTKKKIIS TKAVSRKAAS GCPSNLTCDC YATDRVCSVC 300

LSRTRCQQVA PRAGTPGFRA PEVLTKCPTQ TTAIDMWSAG IVFLSLLSGR YPFYKASDDL 360

TALAQIMTVR GSRETIQAAK TFGKSVLCTQ VVPAQNLRTL CEKLRGTNSS CNRSQGDVPS 420

KSGDNTALPV EVDKQCAPET IREEIQHLKS CQEDDGASEI KVTDMKGWDQ VPDEAYDLLD 480

KLLDLNPATR ITAKDALLHP FF 502

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0008284	; P:positive regulation of cell proliferation
GO:0033261	; P:regulation of S phase

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 2.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013