EKS-MEG-00148

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MEG-00148

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/LISK	470.6	1.1E-141	326	595	270

Status

Unreviewed

Ensembl Protein

ENSMGAP00000008722

UniProt Accession

G5E7H1;

Protein Name

Protein Synonyms/Alias

Gene Name

LIMK2

Gene Synonyms/Alias

LIMK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000008461	ENSMGAP00000017807	ENSMGAT00000019157
ENSMGAG00000008461	ENSMGAP00000008722	ENSMGAT00000009525

Organism

Meleagris gallopavo

Functional Description

Protein Length

637

Protein Sequence
(FASTA)

GEEVWRCLGC GDLIAAGQRL YRTVNEAWHV SCFRCSECQD PLTNWYYEKD GKLYCHKDYW 60

GKFGESCHGC SLLMTGPVMV AGEYKYHPEC FACMSCKVII EDGDTYALVQ HSTLYCGKCH 120

NQIVLTPMIE KHSSESLREQ LPYTLTLISM PAATDGKRGF SVSVEGGCSS YATGVQVKEV 180

NRMHISPDVR NAIHPADRIL EINGAPIRTL QVEEVEDLIR KTSQTLQLLI EHDPVSQRLD 240

RLRLDSRLPT HIKSPISPHS ISPLDIKENL EGTLRRRSLR RSNSISKSPG PSSPKEPLLL 300

SRDISRSESL RSSSSCSQQI FRPCDLIHGE VLGKGFFGQA IKVTHKATGK VMVMKELIRC 360

DEETQKTFLT EVKVMRSLDH PNVLKFIGVL YKDKKLNLLT EYIEGGTLKD FLRNADPFPW 420

QQKVSFAKGI ASGMAYLHSM CIIHRDLNSH NCLIKLDKTV VVADFGLSRL IVEERKKPTL 480

EKPSAKKRTL RKSDRKKRYT VVGNPYWMAP EMLNGQSYDE TVDIFSFGIV LCEIIGQVYA 540

DPDCLPRTLD FGLNVKLFWE KFVPADCPPA FFPLAAICCR LEPESRPPFS KLEDSFEALS 600

LYLGELAIPL PSELEELDHN VSVQYGLNRD KLPENTT 637

Nucleotide Sequence
(FASTA)

GGTGAAGAAG TCTGGAGATG CCTGGGATGT GGGGACCTCA TTGCTGCTGG TCAGCGCCTC 60

TATAGGACAG TTAATGAAGC TTGGCATGTT TCCTGTTTCC GGTGTTCTGA ATGCCAGGAT 120

CCCCTCACTA ACTGGTACTA TGAGAAAGAT GGGAAGCTGT ATTGCCACAA AGACTACTGG 180

GGGAAGTTTG GGGAATCTTG CCATGGCTGC TCTCTGCTGA TGACTGGACC TGTGATGGTG 240

GCTGGAGAAT ACAAGTATCA CCCTGAGTGC TTTGCTTGTA TGAGCTGCAA AGTGATCATT 300

GAGGATGGGG ACACTTATGC ACTGGTGCAG CATTCCACTC TCTACTGTGG AAAATGCCAT 360

AACCAGATTG TGCTGACACC GATGATAGAA AAACATTCCA GTGAGTCTCT GCGTGAGCAG 420

CTGCCTTATA CATTGACACT CATCTCCATG CCAGCAGCTA CTGATGGCAA AAGGGGCTTC 480

TCCGTGTCTG TTGAGGGTGG CTGCTCCAGT TATGCCACTG GCGTCCAAGT GAAGGAAGTT 540

AACAGGATGC ACATCAGCCC AGATGTCCGA AATGCCATCC ACCCTGCAGA TCGTATCCTG 600

GAAATTAATG GAGCTCCCAT TCGTACGTTA CAGGTGGAGG AGGTGGAGGA CTTGATTCGC 660

AAGACAAGCC AGACGCTTCA GCTGCTGATA GAGCATGACC CTGTCTCACA GCGCTTAGAC 720

AGGCTTCGGT TGGACTCCCG GCTTCCCACC CACATAAAGT CACCCATCTC TCCCCACTCC 780

ATCTCTCCAC TGGACATCAA GGAGAATCTG GAAGGAACGC TCCGCCGACG ATCCCTCAGG 840

CGAAGTAACA GCATTTCTAA GTCTCCTGGC CCCAGTTCTC CAAAGGAACC CCTCCTTCTG 900

AGCCGTGACA TCAGTCGCTC TGAATCTCTA CGTTCCTCTT CTAGCTGCTC CCAGCAAATC 960

TTCCGGCCAT GTGATCTCAT TCATGGAGAA GTACTAGGAA AAGGATTTTT TGGACAAGCA 1020

ATCAAGGTGA CTCACAAAGC AACAGGAAAG GTGATGGTGA TGAAGGAGCT GATTCGCTGT 1080

GATGAGGAAA CACAGAAGAC TTTTTTGACA GAGGTGAAAG TGATGCGCAG CCTGGATCAC 1140

CCCAATGTGC TGAAGTTCAT TGGTGTACTT TACAAGGACA AGAAGCTCAA TCTCCTCACT 1200

GAGTACATCG AGGGAGGCAC TCTGAAGGAC TTCCTCCGCA ATGCGGACCC ATTTCCCTGG 1260

CAGCAGAAGG TCAGCTTTGC CAAAGGAATT GCCTCTGGAA TGGCTTACCT GCATTCCATG 1320

TGCATCATTC ACAGAGACCT GAATTCACAT AACTGCTTAA TCAAGTTGGA TAAGACAGTG 1380

GTGGTGGCTG ACTTTGGACT GTCTCGGCTG ATTGTGGAGG AAAGAAAAAA GCCCACTCTG 1440

GAGAAGCCAT CTGCCAAGAA ACGAACCCTG CGGAAGAGTG ACAGGAAGAA GCGCTACACA 1500

GTGGTTGGCA ACCCGTACTG GATGGCCCCA GAGATGCTAA ATGGACAGAG CTATGATGAG 1560

ACAGTGGACA TCTTTTCATT TGGGATAGTT CTTTGTGAGA TCATAGGCCA GGTTTATGCT 1620

GACCCAGACT GTCTTCCACG CACACTGGAT TTTGGCCTTA ATGTTAAGCT GTTCTGGGAA 1680

AAATTTGTTC CTGCTGACTG TCCTCCAGCC TTTTTCCCTC TGGCTGCCAT TTGCTGTAGA 1740

CTGGAACCAG AGAGCAGGCC CCCTTTTTCC AAGCTGGAAG ATTCCTTTGA AGCTCTCTCC 1800

CTCTACTTGG GAGAACTTGC CATCCCCCTC CCGTCTGAGC TGGAAGAGCT GGACCACAAC 1860

GTGAGTGTGC AGTACGGACT GAACCGTGAC AAGTTACCTG AAAACACAAC C 1911

Domain Profile

S: 1     livgeklGkGffsevfkvthrasGevmvlkeliradeenrknllkevkllrklehpnvlk  60

         li+ge+lGkGff++++kvth+a+G+vmv+kelir+dee++k++l+evk++r+l+hpnvlk

Q: 326   LIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLK  385

         689*********************************************************

S: 61    fiGvlvkdkklhllteyiegGtlkellkskeslpwtqrvrlakdiasGlsylhskgiihr  120

         fiGvl+kdkkl+llteyiegGtlk++l++ +++pw+q+v++ak+iasG++ylhs++iihr

Q: 386   FIGVLYKDKKLNLLTEYIEGGTLKDFLRNADPFPWQQKVSFAKGIASGMAYLHSMCIIHR  445

         ************************************************************

S: 121   dlnsknclvredksvvvadfGlarlvveerkks......eklrslkkkdrkkrltvvGsP  174

         dlns+ncl++ dk+vvvadfGl+rl+veerkk+      +k+r+l+k+drkkr+tvvG+P

Q: 446   DLNSHNCLIKLDKTVVVADFGLSRLIVEERKKPtlekpsAKKRTLRKSDRKKRYTVVGNP  505

         *******************************999999999********************

S: 175   ywmaPevlkgksydekvdvfsfGivlceiiarveadPdylPrtedfgldvkafreklvae  234

         ywmaPe+l+g+syde+vd+fsfGivlceii++v+adPd+lPrt dfgl+vk f+ek+v++

Q: 506   YWMAPEMLNGQSYDETVDIFSFGIVLCEIIGQVYADPDCLPRTLDFGLNVKLFWEKFVPA  565

         ************************************************************

S: 235   dcPeaflklavvccdldpesrpsfeelekk  264

         dcP+af++la++cc+l+pesrp+f++le++

Q: 566   DCPPAFFPLAAICCRLEPESRPPFSKLEDS  595

         ***************************986

Domain Sequence
(FASTA)

LIHGEVLGKG FFGQAIKVTH KATGKVMVMK ELIRCDEETQ KTFLTEVKVM RSLDHPNVLK 60

FIGVLYKDKK LNLLTEYIEG GTLKDFLRNA DPFPWQQKVS FAKGIASGMA YLHSMCIIHR 120

DLNSHNCLIK LDKTVVVADF GLSRLIVEER KKPTLEKPSA KKRTLRKSDR KKRYTVVGNP 180

YWMAPEMLNG QSYDETVDIF SFGIVLCEII GQVYADPDCL PRTLDFGLNV KLFWEKFVPA 240

DCPPAFFPLA AICCRLEPES RPPFSKLEDS 270

Keyword

Complete proteome; LIM domain; Metal-binding; Reference proteome; Zinc.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005801	; C:cis-Golgi network
GO:0005739	; C:mitochondrion
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0008270	; F:zinc ion binding

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR001478	; PDZ.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR001781	; Znf_LIM.

Pfam

PF00412	; LIM; 2.
PF00595	; PDZ; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00132	; LIM; 2.
SM00228	; PDZ; 1.

Prosites

PS00478	; LIM_DOMAIN_1; 1.
PS50023	; LIM_DOMAIN_2; 1.
PS50106	; PDZ; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013