EKS-MEG-00041

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MEG-00041

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/RAF	385.6	1.1E-115	492	755	264

Status

Unreviewed

Ensembl Protein

ENSMGAP00000008711

UniProt Accession

G1N8P4;

Protein Name

Protein Synonyms/Alias

Gene Name

KSR1

Gene Synonyms/Alias

KSR1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000008476	ENSMGAP00000008711	ENSMGAT00000009513

Organism

Meleagris gallopavo

Functional Description

Protein Length

801

Protein Sequence
(FASTA)

QVKLIDYIHR QRQCKLSVPL NDRTAELNSY PRFNDWLDIV NVRKEVVQRI PEELTLDALL 60

EMNESKVKET MKRCGARDEE CSRLNGALSC LRKVTGSGIA RRENSSTNTT ECPCSSAPTW 120

THSAMNLPKG NGPQARSVSV STISSSDSLA SSHGPSIYAD NLLDPFAFPA HGGKLTPRTP 180

HSITITPPTT PQAKRRHKLK PPRTPPPPCR KVFQLLPNFP TLTRSKSHES QLGNRIDDVP 240

PIKFELSQGS PQMVRRDFGL AVTHRFSTKS WLSQICQVCQ KSMFGVKCKY CRLKCHNKCT 300

KEAPACRISF FPITKIRRTE SVPSDINNPV DRPTEPQFGT LPKAVTKKEH PPAINHLDSS 360

SNPSSTTSST PSSPAPFQSS NPPSATPPPN LSPMGQRDGR FNFPEIPSPA QIAQPPETTA 420

DTNAKEPPDM EGVKHEAEVE EPESNKSEPE DDEDEVEDLP NRRPHLQGMI YRKPSQTSVY 480

LQEWDIPFEQ IELGDPIGQG RWGKVHKGKW HGEVAIRLLE IDGNNQDHLK LFKKEVMNYR 540

QTRHENVVLF MGACMNPPHL AIITSFCKGR TLYSFVRDPK ISLDINKTRQ IAQEIIKGMG 600

YLHAKGIVHK DLKSKNVFYD NGKVVITDFG LFGISGVVQE GRRENELKLP HDWLCYLAPE 660

IVREMAPGKD EDKLPFSKAA DIYAFGTVWY ELQAREWPFK NQPAEALIWQ IGSGEGVKQI 720

LATISLGKEI NEILSACWSF DLSERPSFTV LMDMLEKLPK LNRRLSHPGH FWKSADINSS 780

KVVLRFERFG LGILEPSNQK I 801

Nucleotide Sequence
(FASTA)

CAGGTGAAAC TGATTGACTA CATCCACCGA CAGCGGCAGT GCAAGCTGAG TGTGCCCCTG 60

AATGACAGGA CAGCAGAGCT CAACAGCTAC CCGAGATTCA ATGACTGGTT AGACATTGTC 120

AATGTGAGGA AAGAAGTTGT ACAGAGAATA CCAGAGGAGC TAACCTTAGA TGCCTTACTT 180

GAAATGAATG AATCAAAGGT GAAAGAAACA ATGAAGAGAT GTGGCGCCAG AGATGAGGAG 240

TGCTCCAGAC TCAATGGGGC ACTGAGCTGT TTAAGGAAGG TGACTGGATC AGGTATAGCA 300

CGCCGAGAGA ACAGCTCTAC CAACACGACT GAGTGCCCTT GCTCCTCTGC GCCCACGTGG 360

ACTCACAGTG CAATGAACCT TCCCAAGGGC AACGGCCCGC AGGCACGATC GGTGTCGGTA 420

TCTACAATCT CATCTTCAGA TTCTCTTGCC TCGAGTCACG GACCTTCTAT CTATGCAGAT 480

AACCTCCTGG ACCCTTTTGC CTTCCCTGCA CACGGTGGAA AGTTAACACC AAGGACTCCT 540

CATAGCATCA CCATCACTCC CCCAACCACT CCTCAAGCCA AGAGACGGCA CAAGTTGAAG 600

CCACCACGGA CTCCTCCTCC TCCTTGCCGG AAAGTTTTTC AGCTGCTACC TAATTTTCCA 660

ACCCTCACAA GGAGCAAGTC CCATGAATCA CAGCTGGGAA ACAGGATAGA TGATGTTCCT 720

CCAATCAAGT TCGAACTCTC CCAAGGATCC CCTCAAATGG TACGAAGAGA CTTTGGCTTA 780

GCTGTAACAC ACAGGTTCTC TACAAAGTCT TGGTTATCTC AGATTTGCCA AGTTTGCCAG 840

AAAAGCATGT TTGGGGTGAA GTGTAAGTAC TGCAGATTGA AATGTCACAA CAAGTGTACT 900

AAAGAGGCAC CTGCTTGTAG AATATCATTC TTTCCCATTA CCAAAATAAG GAGAACAGAG 960

TCTGTCCCTT CTGATATCAA CAATCCAGTA GACAGACCAA CAGAACCACA GTTTGGAACT 1020

CTTCCCAAAG CAGTCACTAA AAAGGAGCAC CCACCAGCAA TAAATCATCT GGATTCCAGC 1080

AGTAATCCCT CTTCTACAAC CTCTTCCACG CCATCTTCTC CAGCACCTTT CCAGTCTTCC 1140

AACCCTCCCA GTGCAACACC TCCCCCAAAC TTATCTCCTA TGGGCCAGAG AGATGGACGA 1200

TTTAACTTCC CAGAAATTCC CAGTCCTGCA CAAATAGCAC AGCCTCCAGA AACCACTGCA 1260

GACACAAATG CTAAAGAACC ACCAGATATG GAGGGAGTTA AACATGAAGC AGAGGTGGAA 1320

GAACCTGAGA GTAATAAATC AGAACCTGAG GATGATGAGG ACGAAGTGGA AGATTTGCCA 1380

AACAGAAGGC CGCACTTGCA AGGGATGATT TATCGCAAAC CCAGCCAGAC CAGCGTCTAC 1440

CTGCAGGAAT GGGACATTCC CTTTGAGCAG ATCGAACTGG GGGATCCCAT TGGCCAAGGA 1500

CGATGGGGAA AGGTTCACAA GGGAAAATGG CATGGGGAAG TGGCCATCAG GCTGCTGGAG 1560

ATAGATGGGA ACAATCAGGA TCATCTCAAG CTCTTTAAAA AGGAGGTGAT GAATTACAGA 1620

CAGACCCGGC ATGAGAACGT GGTGCTTTTC ATGGGAGCGT GCATGAACCC TCCTCACTTA 1680

GCAATCATTA CCAGCTTCTG CAAAGGAAGG ACACTTTATT CGTTTGTAAG GGACCCCAAG 1740

ATATCCCTGG ATATTAACAA AACCAGGCAG ATAGCACAGG AGATCATTAA GGGTATGGGC 1800

TACCTTCACG CAAAGGGGAT TGTACACAAG GATCTGAAAT CCAAGAATGT TTTTTATGAC 1860

AATGGGAAAG TAGTGATCAC TGACTTTGGA CTATTTGGAA TTTCGGGTGT GGTTCAGGAA 1920

GGAAGGAGAG AGAATGAATT GAAGCTGCCT CATGACTGGT TATGCTACCT GGCCCCTGAA 1980

ATTGTTCGTG AGATGGCCCC TGGGAAAGAT GAAGACAAGC TGCCTTTCTC CAAAGCTGCA 2040

GATATCTATG CCTTTGGGAC TGTGTGGTAT GAGCTCCAAG CAAGAGAATG GCCCTTCAAG 2100

AACCAGCCTG CCGAGGCACT CATCTGGCAG ATTGGAAGTG GTGAAGGAGT GAAACAGATC 2160

CTTGCAACTA TTAGTTTGGG GAAAGAAATC AATGAAATTC TCTCAGCATG CTGGTCATTT 2220

GATCTCAGTG AGAGACCTAG CTTCACTGTC CTCATGGATA TGCTTGAAAA ACTGCCAAAA 2280

CTGAATCGTC GGCTCTCACA CCCAGGGCAC TTCTGGAAGT CTGCTGACAT TAACAGTAGC 2340

AAAGTTGTCC TGCGTTTCGA GAGATTTGGC TTGGGAATCC TGGAACCAAG TAATCAAAAG 2400

ATATAG 2406

Domain Profile

S: 2     elaekiGsGrfGtvyrgkwhGdvavkllnveelseeqleaFkkevaaykktRhenivLFm  61

         el++ iG+Gr+G+v++gkwhG+va++ll+++ +++++l+ Fkkev++y++tRhen+vLFm

Q: 492   ELGDPIGQGRWGKVHKGKWHGEVAIRLLEIDGNNQDHLKLFKKEVMNYRQTRHENVVLFM  551

         78899*******************************************************

S: 62    G.yvskpelaivtslckgssLykllheqetkldlaklidiarqiaqgmdYLhakkilhkD  120

         G ++++p+lai+ts+ckg++Ly+++++ + +ld++k+++ia++i++gm+YLhak+i+hkD

Q: 552   GaCMNPPHLAIITSFCKGRTLYSFVRDPKISLDINKTRQIAQEIIKGMGYLHAKGIVHKD  611

         ************************************************************

S: 121   lksknilleeglkvvitDFgllsvkrllsg.rrekqleipkgwilylapeviralsidle  179

         lkskn+++++g kvvitDFgl+ ++ ++++ rre++l++p++w++ylape++r++ ++++

Q: 612   LKSKNVFYDNG-KVVITDFGLFGISGVVQEgRRENELKLPHDWLCYLAPEIVREMAPGKD  670

         ***********.***************9977*****************************

S: 180   qdelpfskesDvyafGivlyellarelpykeesadqilfavgrG..lkpdlskvksklpk  237

         +d+lpfsk++D+yafG+v+yel+are+p+k+++a++ ++++g+G  +k+ l+ +  +l+k

Q: 671   EDKLPFSKAADIYAFGTVWYELQAREWPFKNQPAEALIWQIGSGegVKQILATI--SLGK  728

         *****************************************99988********..****

S: 238   elkellleClkfekeeRPlftqilkkl  264

         e++e+l++C++f+  eRP+ft ++++l

Q: 729   EINEILSACWSFDLSERPSFTVLMDML  755

         ***********************9985

Domain Sequence
(FASTA)

ELGDPIGQGR WGKVHKGKWH GEVAIRLLEI DGNNQDHLKL FKKEVMNYRQ TRHENVVLFM 60

GACMNPPHLA IITSFCKGRT LYSFVRDPKI SLDINKTRQI AQEIIKGMGY LHAKGIVHKD 120

LKSKNVFYDN GKVVITDFGL FGISGVVQEG RRENELKLPH DWLCYLAPEI VREMAPGKDE 180

DKLPFSKAAD IYAFGTVWYE LQAREWPFKN QPAEALIWQI GSGEGVKQIL ATISLGKEIN 240

EILSACWSFD LSERPSFTVL MDML 264

Keyword

Complete proteome; Metal-binding; Reference proteome; Zinc.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0035556	; P:intracellular signal transduction
GO:0043410	; P:positive regulation of MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR025561	; KSR_SAM-like_dom.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF13543	; KSR1-SAM; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00109

; C1; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

Created Date

20-Feb-2013