EKS-MEG-00059
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MEG-00059
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Musk572.81.1E-172618896279
StatusUnreviewed
Ensembl ProteinENSMGAP00000008827
UniProt AccessionG1N8Y8;
Protein Name
Protein Synonyms/Alias
Gene NameMUSK
Gene Synonyms/Alias MUSK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMGAG00000008593ENSMGAP00000019275ENSMGAT00000018757
ENSMGAG00000008593ENSMGAP00000008827ENSMGAT00000009632
OrganismMeleagris gallopavo
Functional Description
Protein Length908
Protein Sequence
(FASTA)
MRDLLVVPLG HVLTLAALSL AEMLQKAPFI STPLETVDAL VEDVAKFVCV VESYPEPEIT 60
WTRNSIPIRL FDTRYSIQRN GQLLTILSVE DSDDGVYCCT ADNGVGAAAQ SCGALQVKMR 120
PKITRPPVNV EIIEGLKAVL PCTTMGNPKP SVSWIKGETV VKENARIAVL DSGNLRIHNV 180
QREDAGQYRC VAKNSLGSAY SKPATVVVEV FARILKAPES QNITFGSMVT LRCTAAGAPV 240
PTVTWLENGK AVSAGSIAES VKDRVVDSRL QVYVTRPGLF TCLATNKHSK TFGAAKAAAT 300
ISVSGSGKLY KGDAGYCSTY RGEVCSAILS RNALVFFNSS YADPEETQEL LVHTAWTELK 360
MVSSFCQPAA ESLLCNYIFQ ECKPSGVGPA PKPICRNHSV LLFHFCSVGM WLAKDCPVAL 420
CSLDCCVFPF LLPSACTERA CCSVQCESEG LTLFCGQMWC VKWNHPACGS AASAWLCHNP 480
LLTPCLVFSQ IKKENITRSV FQEGGHSIFV EDAACTAFFS VLTGLCWLDS GCCQRMAEPS 540
RLRYRKTYPS AQVLGEQGLV VVEVMVLLNL LQESETPTLT TLPSELLLDR LHPNPMYQRM 600
PLLLNPKLLS LEYPRNNIEY VRDIGEGAFG RVFQARAPGL LPYESFTMVA VKMLKEEASA 660
DMQADFQREA ALMAEFDNPN IVKLLGVCAV GKPMCLLFEY MAYGDLNEYL RNRSPRNLCS 720
LVQGTLEARA CLSNPLALCC TSQLCIAKQV AAGMAYLSER KFVHRDLATR NCLVGENMVV 780
KIADFGLSRN MYSADYYKAN ENDAIPIRWM PPESIFYNRY TTESDVWAYG VVLWEIFSYG 840
MQPYYGMAHE EVIYYVRDGN ILSCPDNCPL ELYNLMRLCW SKLPADRPSF ASIHRILERM 900
YERAVASP 908
Nucleotide Sequence
(FASTA)
ATGAGAGATC TGCTGGTGGT GCCCCTGGGG CACGTCCTCA CCCTTGCTGC CCTCAGCCTG 60
GCCGAGATGC TTCAGAAAGC CCCCTTTATC AGCACTCCTC TGGAAACTGT GGATGCGCTG 120
GTGGAGGATG TTGCCAAATT CGTGTGTGTG GTGGAGTCAT ACCCAGAGCC GGAGATCACA 180
TGGACACGCA ACAGCATTCC CATCAGGCTG TTTGACACCC GGTACAGCAT ACAGAGGAAC 240
GGGCAGCTCC TGACCATCCT GAGTGTGGAG GACAGTGACG ATGGGGTGTA CTGCTGCACA 300
GCAGACAATG GGGTTGGTGC AGCTGCCCAG AGCTGCGGGG CTCTGCAAGT CAAAATGCGA 360
CCCAAAATAA CCCGACCACC TGTAAATGTG GAAATCATAG AAGGTTTAAA GGCCGTTCTT 420
CCATGCACTA CAATGGGGAA TCCCAAACCT TCTGTTTCAT GGATCAAAGG AGAAACAGTG 480
GTAAAGGAGA ATGCACGCAT TGCTGTTCTT GATTCAGGGA ATTTAAGGAT CCACAATGTC 540
CAGAGAGAAG ATGCAGGACA GTATCGATGT GTAGCCAAAA ACAGCCTGGG CAGTGCCTAT 600
TCAAAACCTG CAACAGTGGT CGTGGAAGTT TTTGCCAGAA TCCTGAAGGC TCCTGAATCC 660
CAAAACATCA CCTTTGGCTC CATGGTGACA CTGCGGTGCA CAGCAGCAGG TGCTCCAGTC 720
CCCACTGTCA CCTGGCTGGA AAATGGAAAA GCTGTTTCTG CAGGGTCTAT AGCAGAAAGT 780
GTGAAGGACA GAGTGGTTGA CTCCAGGCTG CAGGTGTATG TTACCCGACC TGGCTTATTC 840
ACTTGCCTTG CCACCAACAA ACACAGCAAA ACCTTCGGTG CTGCCAAAGC TGCCGCAACC 900
ATCAGTGTTT CAGGCTCTGG CAAACTGTAT AAGGGTGATG CAGGCTACTG CAGCACCTAC 960
AGAGGCGAGG TGTGCAGTGC CATCCTGTCA AGAAATGCTC TTGTTTTCTT CAACTCCTCC 1020
TATGCTGACC CCGAGGAGAC CCAAGAGCTG CTTGTTCACA CTGCCTGGAC GGAGCTGAAA 1080
ATGGTGAGTT CATTCTGCCA GCCGGCTGCC GAGTCCCTGC TGTGTAACTA CATCTTCCAG 1140
GAATGCAAGC CCTCGGGAGT GGGGCCAGCC CCAAAACCCA TATGCAGGAA TCACAGCGTG 1200
CTCCTCTTTC ACTTTTGTTC TGTAGGCATG TGGCTGGCTA AAGACTGCCC AGTAGCACTG 1260
TGCTCTCTGG ATTGCTGTGT TTTTCCCTTT CTTCTCCCTT CTGCATGCAC AGAGAGGGCC 1320
TGTTGCAGTG TTCAGTGTGA AAGTGAAGGC CTGACACTGT TCTGTGGTCA GATGTGGTGT 1380
GTGAAGTGGA ACCATCCTGC CTGTGGCTCT GCAGCTAGCG CCTGGCTGTG TCACAACCCC 1440
CTCCTTACAC CTTGTCTTGT CTTTTCACAG ATTAAGAAGG AGAATATAAC CAGATCTGTT 1500
TTTCAAGAGG GTGGGCACAG CATTTTTGTT GAAGATGCAG CTTGCACGGC GTTTTTTAGT 1560
GTTTTGACTG GTCTTTGCTG GCTTGATTCA GGCTGTTGCC AGAGAATGGC TGAACCCTCA 1620
CGTCTAAGGT ATAGGAAAAC ATATCCATCT GCACAGGTTT TAGGGGAGCA GGGGCTGGTA 1680
GTTGTTGAAG TGATGGTGCT TTTAAATCTC CTCCAAGAGT CAGAAACACC AACACTTACC 1740
ACTCTGCCCT CTGAACTCCT CCTGGACCGG CTGCACCCTA ACCCCATGTA CCAGCGGATG 1800
CCTCTTCTCC TCAATCCCAA ACTACTCAGC TTGGAGTATC CCAGGAACAA TATTGAATAT 1860
GTGAGAGATA TTGGAGAAGG AGCATTTGGG AGAGTTTTCC AAGCAAGGGC CCCAGGATTG 1920
CTGCCATATG AATCTTTCAC AATGGTGGCA GTGAAAATGC TGAAAGAGGA AGCATCTGCA 1980
GACATGCAAG CGGACTTCCA GAGGGAGGCA GCCCTCATGG CTGAATTTGA CAATCCAAAC 2040
ATTGTCAAGC TCTTAGGTGT GTGTGCTGTT GGGAAACCCA TGTGCCTGCT GTTTGAGTAC 2100
ATGGCCTACG GTGATCTCAA TGAGTACCTG CGCAACCGCT CGCCCCGCAA TCTCTGCAGT 2160
CTAGTGCAGG GTACCCTGGA GGCACGGGCC TGCCTCTCCA ATCCGCTGGC ACTATGCTGT 2220
ACCAGCCAGC TCTGCATTGC CAAGCAGGTG GCCGCAGGCA TGGCCTATCT CTCTGAGCGC 2280
AAGTTTGTTC ATCGGGACTT GGCCACCAGA AACTGCCTGG TGGGGGAGAA CATGGTGGTC 2340
AAAATTGCTG ACTTTGGCCT CTCAAGGAAC ATGTATTCAG CTGATTACTA CAAAGCCAAT 2400
GAGAATGATG CCATCCCCAT CCGCTGGATG CCCCCCGAGT CCATTTTTTA TAACCGGTAC 2460
ACCACAGAGT CTGATGTGTG GGCCTATGGA GTGGTGCTGT GGGAGATCTT CTCCTATGGC 2520
ATGCAGCCCT ACTATGGGAT GGCTCATGAG GAGGTCATCT ACTACGTGAG GGATGGGAAC 2580
ATCCTGTCGT GCCCGGACAA TTGTCCTCTG GAGCTCTACA ACCTGATGCG TCTCTGCTGG 2640
AGCAAGCTGC CAGCTGACCG GCCAAGCTTT GCCAGTATCC ACCGCATCCT AGAGCGCATG 2700
TATGAGAGGG CTGTGGCCTC CCCATAG 2727
Domain Profile
S: 1     ieyvrdlgegafgrvfqarapgllpyeefllvavkmlkeeasadmqadfereaallaefd  60
         ieyvrd+gegafgrvfqarapgllpye f++vavkmlkeeasadmqadf+reaal+aefd
Q: 618   IEYVRDIGEGAFGRVFQARAPGLLPYESFTMVAVKMLKEEASADMQADFQREAALMAEFD  677
         89**********************************************************
S: 61    npnivkllgvcavgkpmcllfeymaygdlneflrslspytvcslshsdlslraqvsspdr  120
         npnivkllgvcavgkpmcllfeymaygdlne+lr  sp   csl +  l  ra    +++
Q: 678   NPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEYLRNRSPRNLCSLVQGTLEARACL--SNP  735
         **********************************************999877665..578
S: 121   lplseaellciarqvaagmaylserkfvhrdlatrnclvgetmvvkiadfglsrkiysad  180
         l l ++ +lcia+qvaagmaylserkfvhrdlatrnclvge+mvvkiadfglsr++ysad
Q: 736   LALCCTSQLCIAKQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNMYSAD  795
         9***********************************************************
S: 181   yykadendaipirwmplesilynrytlesdvwaygvvlweifsyalqpyyglaheeviky  240
         yyka+endaipirwmp+esi+ynryt+esdvwaygvvlweifsy++qpyyg+aheevi+y
Q: 796   YYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGMQPYYGMAHEEVIYY  855
         ************************************************************
S: 241   vrdgnilacpentplelyalmrlcwsklpadrpsfasihri  281
         vrdgnil+cp+n+plely+lmrlcwsklpadrpsfasihri
Q: 856   VRDGNILSCPDNCPLELYNLMRLCWSKLPADRPSFASIHRI  896
         ***************************************98
Domain Sequence
(FASTA)
IEYVRDIGEG AFGRVFQARA PGLLPYESFT MVAVKMLKEE ASADMQADFQ REAALMAEFD 60
NPNIVKLLGV CAVGKPMCLL FEYMAYGDLN EYLRNRSPRN LCSLVQGTLE ARACLSNPLA 120
LCCTSQLCIA KQVAAGMAYL SERKFVHRDL ATRNCLVGEN MVVKIADFGL SRNMYSADYY 180
KANENDAIPI RWMPPESIFY NRYTTESDVW AYGVVLWEIF SYGMQPYYGM AHEEVIYYVR 240
DGNILSCPDN CPLELYNLMR LCWSKLPADR PSFASIHRI 279
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00073
EKS-ANC-00070
EKS-BOT-00079
EKS-CAJ-00080
EKS-CAP-00079
EKS-DAR-00333
EKS-DRM-00037
EKS-EQC-00077
EKS-FEC-00076
EKS-GAG-00063
EKS-GAA-00097
EKS-GOG-00078
EKS-HOS-00081
EKS-ICT-00074
EKS-LAC-00084
EKS-LOA-00078
EKS-MAM-00078
EKS-MOD-00079
EKS-MUM-00082
EKS-MUP-00082
EKS-MYL-00087
EKS-NOL-00075
EKS-ORN-00106
EKS-ORA-00065
EKS-ORC-00074
EKS-ORL-00098
EKS-OTG-00083
EKS-PAT-00071
EKS-PES-00069
EKS-PEM-00043
EKS-POA-00076
EKS-RAN-00075
EKS-SAH-00075
EKS-TAG-00114
EKS-TAR-00112
EKS-TEN-00104
EKS-XET-00074
EKS-XIM-00101
Gene Ontology
GO:0016021; C:integral to membrane
GO:0031594; C:neuromuscular junction
GO:0005886; C:plasma membrane
GO:0045211; C:postsynaptic membrane
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
GO:0043525; P:positive regulation of neuron apoptotic process
GO:2000541; P:positive regulation of protein geranylgeranylation
GO:0001934; P:positive regulation of protein phosphorylation
GO:0043113; P:receptor clustering
GO:0006355; P:regulation of transcription, DNA-dependent
KEGG
InterPros
IPR020067; Frizzled_dom.
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF01392; Fz; 1.
PF07679; I-set; 3.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00408; IGc2; 3.
SM00219; TyrKc; 1.
Prosites
PS50038; FZ; 1.
PS50835; IG_LIKE; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013