EKS-MEG-00093

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MEG-00093

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Met	476.6	1.5E-143	1079	1339	261

Status

Unreviewed

Ensembl Protein

ENSMGAP00000009217

UniProt Accession

G1N9U2;

Protein Name

Protein Synonyms/Alias

Gene Name

MET

Gene Synonyms/Alias

MET;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000008925	ENSMGAP00000009217	ENSMGAT00000010034

Organism

Meleagris gallopavo

Functional Description

Protein Length

1382

Protein Sequence
(FASTA)

MKPVTAYPSG IILFLFALLQ RSHGQCKEAA KKSEMNLNVK YDLPNFITET PIQNVVLYKH 60

HVYIGAVNKI YVLNETLQNI SVYKTGPILE SPGCAPCEDC KDKANLSNSI WKDNVNMALL 120

LETYYDDQLI SCGSMSGGVC HRHIIPPDNP ADIESEVHCM YSPQVDGETE NCPDCVVSTL 180

GTKVLVTEKD RFVNFFVGNT VTSAFQPPHV LHSISVRRLK ETQDGFEFLT DQSYIDILPQ 240

FRDSYPVKYV HAFEHDHFVY FLTVQRESLD SQTFHTRIIR FCTLDSEMRS YMEMPLECIF 300

TEKRRKRSIR KEVFNILQAA YVSKPGAALA HEMGLGLNDD ILYGVFAQSK PDSSEPTNRS 360

AVCAVSVRTI NEFFNKIVDK QNMKCLQHFY GKDSKYCLNR AFSRNASYCR AQDDEYRLEV 420

TTPLQRVDLF MGQFNNILLT SISVFTKGNL TIANLGTSEG RFMQIVVSRS ESTAPHVSFQ 480

LDSHPVSPQV VVEQSAAADG YTLVVTGKKI TKVPLNGPGC HHFQSCSQCL LAPAFMRCGW 540

CGQRCLRASE CGGGTWTQES CLPRVYEILP SSAPLEGGTK LTLCGWDFGF SKNNRFELRN 600

TVVHIGGQIC ALEAKSSNKN KLECTAPAAK SASFNISSSV SVGHGKTLFN TFSYVNPIIT 660

SISPTYGPKS GGTLLTIAGK YLNSGKSRRI FVGEKPCSLK STSESTVECY TPAQGIPQEY 720

RVRVGIDGAI RDAKGYFTYR EDPVVLKIHP AKSFLSGGST ITAQGINLNS VCFPRMVITV 780

PKLGMNFSVA CNHRSSSEII CCTTPSLKAF NLQPPFVTKV FFIFDGVSSL YFDFDYVNNP 840

VFKHFEKPVF ISRSNPNVLE IKGNYIDSEA VKGEVLKVGN KSCENLLLQS ETILCTVPSD 900

LLKSNSELNI EWKQEVLSTV IGKVLIRQDQ NFTGLIAGVV STSVLIFIFL VFFLWRRKKK 960

QIKDLGSELV RYDGRVHTPH LDRLVSARSV SPTTEMVSSE SVDYRSTFLE DQFPSMSQNG 1020

SCRPAQYPHS DLSPILSSGD SDLASPLLQT NVHIDISALN PDLVKEVQHV VIGADSLIVH 1080

FSEVIGRGHF GCVYHGTLLD NDGRKIHCAV KSLNRITDLE EVAQFLKEGI IMKDFTHPNV 1140

LSLLGICLPN EGSPLVVLPY MKHGDLRNFI RNETHNPTVK DLIGFGLQVA KGMKYLASKK 1200

FVHRDLAARN CMLDEKFTVK VADFGLARDV YDKEYYSVHN KTGAKLPVKW MALESLQTQK 1260

FTTKSDVWSF GVLLWELMTR GAPPYPDVNS FDITVYLLQG RRLLQPEYCP DPLYEVMLKC 1320

WHPKPEMRPA FSELVSKIST IFSTFIGEHY VHVNATYVNV KCVAPYPSLL STQDNTDMDV 1380

DT 1382

Nucleotide Sequence
(FASTA)

ATGAAGCCTG TTACTGCCTA TCCTTCTGGG ATTATCCTAT TCCTGTTTGC GTTGCTGCAA 60

AGGAGTCATG GACAATGCAA AGAAGCAGCT AAAAAATCAG AGATGAACTT GAATGTAAAA 120

TATGATCTTC CTAACTTCAT CACAGAGACG CCAATTCAGA ATGTAGTTTT ATACAAGCAT 180

CATGTTTATA TTGGAGCAGT CAACAAGATT TATGTACTAA ATGAGACTCT CCAAAACATT 240

TCTGTCTACA AGACTGGGCC TATTTTGGAG AGTCCTGGCT GCGCACCATG TGAAGACTGC 300

AAAGATAAAG CTAATTTATC TAACAGCATA TGGAAGGATA ATGTCAACAT GGCGCTGCTC 360

TTAGAAACCT ATTACGATGA TCAGCTCATC AGCTGTGGTA GCATGTCTGG AGGTGTCTGT 420

CATCGTCACA TCATTCCCCC TGACAACCCT GCTGACATAG AAAGTGAGGT GCACTGCATG 480

TATTCACCGC AGGTAGACGG AGAGACAGAA AATTGTCCTG ACTGTGTTGT AAGCACTTTA 540

GGAACCAAAG TTTTGGTGAC TGAAAAGGAC AGGTTTGTCA ACTTCTTTGT TGGAAACACC 600

GTGACATCTG CATTTCAACC TCCCCATGTA CTGCATTCAA TATCAGTTAG AAGGTTGAAA 660

GAAACACAGG ATGGGTTTGA ATTTCTTACA GATCAGTCTT ACATAGATAT CCTCCCTCAG 720

TTCCGTGATT CGTATCCCGT TAAGTATGTC CATGCCTTTG AGCATGACCA CTTTGTCTAT 780

TTTCTGACTG TCCAGAGAGA ATCTCTTGAC TCCCAGACTT TTCACACCAG AATTATCCGC 840

TTCTGCACTT TAGATTCAGA GATGCGTTCT TACATGGAAA TGCCTCTTGA GTGTATTTTT 900

ACTGAAAAGC GGAGGAAGAG GTCCATTAGA AAGGAGGTAT TCAACATTTT GCAAGCTGCA 960

TATGTAAGCA AACCCGGTGC AGCTCTAGCC CATGAAATGG GCCTTGGATT GAATGATGAT 1020

ATTCTCTATG GCGTTTTTGC ACAAAGCAAA CCAGATTCCT CAGAACCAAC AAACAGATCT 1080

GCTGTCTGTG CTGTCTCTGT GCGAACAATC AATGAGTTCT TCAACAAGAT TGTTGACAAG 1140

CAGAACATGA AATGTCTTCA GCACTTTTAT GGGAAGGATA GCAAATACTG CTTGAACAGG 1200

GCTTTTTCAA GAAATGCTTC ATACTGCAGA GCACAAGATG ATGAATACCG CTTAGAAGTT 1260

ACGACTCCTT TGCAGAGGGT TGACTTGTTC ATGGGCCAGT TCAACAACAT CCTGTTAACT 1320

TCGATATCTG TCTTCACCAA AGGGAACCTT ACCATTGCCA ATCTGGGAAC TTCAGAGGGA 1380

CGCTTCATGC AGATAGTGGT TTCCCGCTCC GAGTCCACAG CTCCACACGT CAGCTTTCAG 1440

CTGGACTCCC ACCCCGTCTC TCCCCAGGTT GTTGTTGAGC AGTCGGCAGC AGCAGATGGC 1500

TATACTCTGG TAGTGACTGG AAAAAAGATA ACCAAGGTGC CACTGAATGG GCCGGGCTGC 1560

CACCACTTCC AGTCCTGCAG CCAGTGCCTG CTGGCACCTG CCTTCATGCG CTGCGGCTGG 1620

TGTGGCCAGC GGTGCCTGAG GGCTTCTGAG TGCGGCGGAG GGACGTGGAC CCAGGAGTCC 1680

TGCTTGCCAA GAGTTTATGA GATTCTCCCA AGCAGTGCTC CTTTAGAAGG TGGGACAAAA 1740

CTGACACTGT GTGGATGGGA CTTCGGATTC AGCAAAAATA ATAGATTTGA ATTAAGAAAT 1800

ACAGTAGTCC ATATCGGAGG ACAAATCTGT GCTCTGGAAG CAAAATCTAG CAACAAAAAC 1860

AAGCTGGAAT GCACAGCTCC TGCTGCAAAA AGTGCAAGTT TTAATATATC CAGTAGTGTT 1920

TCTGTTGGAC ATGGAAAAAC ATTATTCAAT ACATTTTCAT ATGTGAATCC TATAATAACA 1980

AGTATCTCCC CCACCTATGG CCCCAAATCT GGAGGAACAT TGCTAACAAT AGCTGGCAAA 2040

TACCTAAACA GTGGAAAATC CAGAAGGATT TTTGTTGGTG AGAAACCATG CAGCTTGAAA 2100

AGCACATCGG AAAGCACTGT GGAGTGCTAC ACTCCAGCAC AAGGAATCCC ACAGGAATAC 2160

CGCGTGAGGG TGGGAATCGA TGGAGCTATC AGAGATGCAA AAGGTTATTT CACCTACAGA 2220

GAAGACCCCG TTGTTTTAAA AATTCATCCA GCCAAATCTT TTCTTAGTGG TGGAAGTACA 2280

ATTACAGCTC AGGGAATCAA CTTGAATTCA GTGTGCTTTC CTCGGATGGT GATTACTGTA 2340

CCTAAACTGG GAATGAACTT CTCTGTGGCA TGTAACCACC GCTCTAGTTC AGAGATAATC 2400

TGCTGTACAA CTCCTTCCCT AAAAGCTTTC AATCTTCAAC CACCGTTTGT AACCAAAGTA 2460

TTCTTTATTT TTGATGGTGT CAGCTCTCTG TACTTTGATT TTGACTATGT AAATAATCCT 2520

GTATTTAAAC ATTTTGAAAA GCCAGTGTTC ATCTCAAGGA GCAACCCAAA CGTTCTGGAA 2580

ATTAAGGGAA ATTATATTGA TTCAGAAGCT GTTAAAGGAG AGGTGCTAAA AGTTGGAAAT 2640

AAAAGCTGTG AAAACCTTCT CTTGCAGTCA GAAACAATTT TGTGCACAGT TCCGAGCGAT 2700

CTCCTGAAAT CCAACAGTGA GCTAAATATA GAGTGGAAGC AAGAAGTTTT GTCAACAGTT 2760

ATTGGGAAAG TGCTGATCCG GCAAGATCAG AATTTCACAG GACTGATTGC TGGAGTTGTT 2820

TCAACATCTG TTTTAATTTT TATCTTTTTG GTATTTTTTC TCTGGAGAAG GAAGAAGAAA 2880

CAGATTAAAG ATCTGGGAAG TGAGCTGGTG CGCTATGATG GCAGAGTGCA CACTCCTCAC 2940

CTGGACAGGC TGGTGAGTGC AAGGAGTGTC AGTCCAACAA CAGAAATGGT CTCCAGCGAA 3000

TCTGTAGATT ACAGGTCAAC ATTCCTAGAA GATCAGTTCC CAAGCATGTC TCAGAATGGA 3060

TCGTGCAGAC CTGCCCAATA TCCTCACTCT GACCTCTCCC CAATTCTGTC CAGTGGGGAC 3120

TCAGATTTAG CCAGTCCTCT TCTTCAAACT AACGTCCACA TCGATATCAG TGCCTTAAAT 3180

CCTGACCTGG TCAAAGAAGT CCAGCACGTT GTTATTGGTG CTGATAGCCT GATAGTACAT 3240

TTCAGTGAAG TAATAGGAAG AGGTCATTTT GGGTGTGTGT ACCATGGAAC ACTGCTGGAT 3300

AACGATGGCA GGAAAATTCA CTGTGCTGTG AAGTCACTGA ACAGAATTAC GGACCTGGAA 3360

GAAGTAGCTC AGTTTCTGAA AGAAGGAATA ATCATGAAAG ATTTCACTCA TCCCAACGTT 3420

CTGTCACTTC TGGGAATCTG TTTACCCAAT GAAGGATCCC CCTTAGTGGT TCTTCCATAT 3480

ATGAAACATG GAGACCTTCG AAACTTCATT AGGAATGAGA CTCATAATCC AACAGTTAAA 3540

GATTTAATTG GATTTGGTCT TCAGGTTGCA AAAGGGATGA AATACCTTGC AAGCAAAAAG 3600

TTTGTCCACA GAGACTTGGC AGCAAGAAAC TGTATGTTGG ATGAAAAATT CACTGTCAAG 3660

GTAGCTGATT TTGGTCTTGC TAGAGATGTC TATGATAAAG AGTACTACAG TGTGCACAAT 3720

AAAACAGGAG CTAAACTGCC AGTGAAATGG ATGGCTTTAG AAAGTTTACA AACTCAGAAG 3780

TTCACAACAA AGTCAGATGT GTGGTCCTTT GGTGTTTTGT TATGGGAACT TATGACAAGA 3840

GGGGCACCAC CTTATCCTGA TGTAAATTCT TTCGATATAA CTGTTTACTT ATTACAAGGA 3900

AGAAGGCTGC TACAACCTGA ATACTGCCCT GACCCACTGT ATGAAGTCAT GCTGAAATGT 3960

TGGCATCCAA AACCTGAGAT GCGTCCAGCA TTTTCTGAAC TTGTTTCAAA AATATCAACA 4020

ATCTTCTCCA CTTTTATTGG GGAACACTAT GTTCACGTCA ATGCTACTTA CGTCAACGTG 4080

AAGTGCGTTG CTCCCTATCC TTCTCTTTTA TCAACACAAG ACAATACAGA CATGGATGTA 4140

GACACATGA 4149

Domain Profile

S: 1     vdkeeviGkGhfGvvykgelsdsaskkikvavksleritdiekveeflreglvmkeldhp  60

         v+++eviG+GhfG+vy+g+l+d++++ki++avksl+ritd+e+v +fl+eg++mk++ hp

Q: 1079  VHFSEVIGRGHFGCVYHGTLLDNDGRKIHCAVKSLNRITDLEEVAQFLKEGIIMKDFTHP  1138

         7999********************************************************

S: 61    nvlsllGialddeglplvvlpymkkGdlksfirneernltvkdllefalqvakgmeylas  120

         nvlsllGi+l++eg+plvvlpymk+Gdl++firne++n+tvkdl++f+lqvakgm+ylas

Q: 1139  NVLSLLGICLPNEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLAS  1198

         ************************************************************

S: 121   kkfvhrdlaarnclldekltvkvadfGlardvldkelyvveeerdarlpvkwlaleslqt  180

         kkfvhrdlaarnc+ldek+tvkvadfGlardv+dke+y+v+++++a+lpvkw+aleslqt

Q: 1199  KKFVHRDLAARNCMLDEKFTVKVADFGLARDVYDKEYYSVHNKTGAKLPVKWMALESLQT  1258

         ************************************************************

S: 181   fkqfttksdvwsfGvllwelltrgatpysevasfdltlylkegrrlrkpeycpdklydvm  240

         +k fttksdvwsfGvllwel+trga+py++v+sfd+t+yl +grrl +peycpd ly+vm

Q: 1259  QK-FTTKSDVWSFGVLLWELMTRGAPPYPDVNSFDITVYLLQGRRLLQPEYCPDPLYEVM  1317

         **.*********************************************************

S: 241   lkcwkakpaerpqfsdlvsiis  262

         lkcw++kp++rp fs+lvs+is

Q: 1318  LKCWHPKPEMRPAFSELVSKIS  1339

         *******************997

Domain Sequence
(FASTA)

VHFSEVIGRG HFGCVYHGTL LDNDGRKIHC AVKSLNRITD LEEVAQFLKE GIIMKDFTHP 60

NVLSLLGICL PNEGSPLVVL PYMKHGDLRN FIRNETHNPT VKDLIGFGLQ VAKGMKYLAS 120

KKFVHRDLAA RNCMLDEKFT VKVADFGLAR DVYDKEYYSV HNKTGAKLPV KWMALESLQT 180

QKFTTKSDVW SFGVLLWELM TRGAPPYPDV NSFDITVYLL QGRRLLQPEY CPDPLYEVML 240

KCWHPKPEMR PAFSELVSKI S 261

Keyword

ATP-binding; Complete proteome; Disulfide bond; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0009925	; C:basal plasma membrane
GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0005008	; F:hepatocyte growth factor-activated receptor activity
GO:0000187	; P:activation of MAPK activity
GO:0042593	; P:glucose homeostasis
GO:0007275	; P:multicellular organismal development
GO:0014812	; P:muscle cell migration
GO:0051450	; P:myoblast proliferation
GO:0010828	; P:positive regulation of glucose transport
GO:0046777	; P:protein autophosphorylation
GO:0060665	; P:regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling

KEGG

mgp:100544894

;

InterPros

IPR013783	; Ig-like_fold.
IPR014756	; Ig_E-set.
IPR002909	; IPT_TIG_rcpt.
IPR011009	; Kinase-like_dom.
IPR003659	; Plexin-like.
IPR016201	; Plexin-like_fold.
IPR002165	; Plexin_repeat.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001627	; Semaphorin/CD100_Ag.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016244	; Tyr_kinase_HGF/MSP_rcpt.
IPR015943	; WD40/YVTN_repeat-like_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF01437	; PSI; 1.
PF01403	; Sema; 1.
PF01833	; TIG; 2.

SMARTs

SM00429	; IPT; 4.
SM00423	; PSI; 1.
SM00630	; Sema; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS51004	; SEMA; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013