EPS-MEG-00036

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-MEG-00036

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	179.4	8.9E-53	769	1013	245

Status

Unreviewed

Ensembl Protein

ENSMGAP00000009227

UniProt Accession

G1N9U7;

Protein Name

Protein Synonyms/Alias

Gene Name

PHLPP2

Gene Synonyms/Alias

PHLPP2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000008937	ENSMGAP00000009227	ENSMGAT00000010044

Organism

Meleagris gallopavo

Functional Description

Protein Length

1300

Protein Sequence
(FASTA)

AKRNGSRSCL NRSRFGSRER DWLREDVGRG CVYVYRGDSA AALSDLRLVL CTVDTPASEI 60

CDGEERKNLF VQLHGDLVRR LEPTEKPLQI VYDYLAGLGF DDPVRMQEEA ANSDLSCMIR 120

FYSEKPCQME QLDRILLSGI YNVRKGKTQL HKWAERLVIL CGTCLIVSSV KDSHAGKMHI 180

LPLVGGKVEE MKRRQYTLAF TSVGAQAQTY HVSFETLAEC QRWHRQASTV VSMRLNMVDL 240

SCYSLEEVPE HLFYSQDITY LNLRHNFMRS SGAGSLGSLC RFSQLKSLNL SHNRLGEFPV 300

SLCEISTLTE LNMSCNGLYH LPNQIGKLLN LQSFWLDGNF LTSLPEELGS LQQLSCLGLS 360

FNNFCELPAI CEKLTFLDKI AMAGNLLENL DLTVLNRMSH IKSVDLRLNN LKRAAADTLE 420

GNKSVIYMDL RDNQLTYLDV SSLGSLEQLH CERNKLKELT LSGFSLRALY ANNNCLTSVN 480

VYPVPSQLTC LELAHNQLQC VPDWACEAKK LEILDMSYNL LVELPSRILS SLSLRKLTVG 540

HNNLQSLPPL LEHVPMEVLD LQHNLLTKLP EMLFIKALNL RCLNASANSL ESLPSACTGE 600

ESLSMLQMLY LTNNNLTDQC IPVLVGHPNL RILHLANNHL QAFPASKLSK LEHLEELNLS 660

GNKLKTIPTT VANCKLLHTL IAHSNDISIF PEILHLPHIQ IVDLSCNELN EILIPEALPA 720

TLQELDLTGN ANLVLEHKTL DIFSHITTLK IDAKLSLTTD STLTSTFWSH GVAEMAGQRN 780

KLCVSSLALG SFAEGMEAVY GMFDGDKNEE LPRLLQCTMA DVLLEEVQQS DTVFMSNTFL 840

VSHRKLGMAG QKLGSSAVLC YIHHDMADPA STFSLTVANV GTCQAVLCRS GKPLLLSKVF 900

SLEQCTEEAK RIKEQKAIIT EDNKVNGVTC CTRMLGCTYL HPWILPKPHV SSIPLTVQDE 960

LLLLGNKALW EHLSYTEAVS AVRHLHDPLA AAKKLCTLAQ SYGCQDNVGA MVVYLNISED 1020

NCTCEMHGLS LPGPGGFSST TAKTATSSSS SGIASEFGSE LSASEVSSEV GSTASDEHSA 1080

VGLDGSLLPR QERRCSLHPL LPSSIFQRQP SSATFSSNQS DNGLDSDDEQ PVEGVMSNGS 1140

KVEVEVDIHC CKGKGLEFEP LALEYSSSAP GVEDDSELVL IVQRQNGINS TAARGGVKEK 1200

SELQKSPSTC CLYGKKLSNG SIVPLEESLN LIEVATEVPK KKTGYFAAPS QMEPEDQFVV 1260

PPDLEEEVKE QMKQHQENGA NEEQKEEPAV ALTEEFDTAL 1300

Nucleotide Sequence
(FASTA)

GCGAAGCGCA ACGGGAGCAG GAGCTGTCTG AACAGGAGCC GGTTCGGTTC CCGTGAGAGG 60

GACTGGCTGA GAGAGGACGT CGGACGAGGC TGCGTGTATG TTTATAGAGG AGATTCTGCT 120

GCTGCTTTGT CTGACCTGCG CTTAGTCCTC TGTACGGTGG ATACCCCGGC ATCTGAGATC 180

TGCGATGGGG AAGAGAGGAA AAACCTCTTC GTGCAGCTTC ATGGAGACCT GGTCAGGAGG 240

CTGGAACCCA CCGAAAAGCC CCTTCAGATT GTGTATGACT ACTTGGCTGG GTTGGGTTTT 300

GATGACCCTG TCAGAATGCA GGAGGAGGCA GCAAACTCTG ACCTCAGCTG TATGATTCGC 360

TTTTACAGCG AAAAGCCTTG CCAGATGGAA CAGTTAGATC GCATCCTGCT CTCTGGAATC 420

TATAATGTAC GCAAAGGGAA GACTCAGTTG CACAAATGGG CAGAACGCCT AGTAATTCTC 480

TGTGGTACCT GTCTCATTGT GTCCTCTGTT AAAGATAGCC ATGCAGGGAA GATGCATATC 540

TTGCCTCTTG TTGGAGGAAA GGTTGAAGAA ATGAAACGCC GGCAGTACAC GCTTGCTTTC 600

ACATCAGTGG GAGCACAAGC CCAAACGTAC CACGTTTCCT TCGAAACGCT GGCTGAGTGC 660

CAACGGTGGC ACCGACAGGC ATCCACGGTT GTGTCTATGC GACTTAACAT GGTTGATCTT 720

TCGTGCTACA GTCTTGAGGA AGTACCTGAG CATCTCTTCT ACAGTCAAGA CATCACCTAC 780

CTCAACCTAC GACACAATTT TATGAGATCA AGTGGAGCAG GGAGTCTTGG TTCTCTTTGC 840

AGGTTTTCTC AGTTGAAGAG CTTGAATCTG TCTCATAACA GACTGGGGGA ATTTCCTGTA 900

TCGCTGTGTG AGATCTCTAC TCTGACCGAA CTCAATATGT CCTGTAATGG ACTTTATCAC 960

TTGCCAAACC AGATCGGCAA GCTGCTGAAT CTCCAAAGCT TCTGGCTTGA TGGGAATTTC 1020

CTCACATCCT TACCAGAAGA GCTTGGAAGT CTGCAGCAGC TCAGCTGTCT TGGGCTTTCC 1080

TTCAATAACT TCTGTGAGCT GCCAGCAATT TGTGAGAAAC TCACCTTTTT AGACAAAATA 1140

GCCATGGCAG GGAACTTGCT AGAGAACCTG GACCTTACAG TGCTGAACCG CATGAGTCAC 1200

ATCAAAAGCG TGGACCTGAG GCTGAACAAC CTGAAGAGAG CAGCAGCTGA CACTCTGGAG 1260

GGGAATAAAT CCGTGATTTA CATGGATTTG CGAGACAATC AGCTGACATA CCTGGATGTG 1320

AGCTCATTGG GTAGCCTGGA GCAGCTGCAC TGTGAGCGGA ATAAGCTGAA AGAGTTGACG 1380

CTGAGTGGTT TCTCCCTTCG GGCTCTGTAT GCCAACAACA ACTGTCTCAC ATCTGTCAAT 1440

GTTTATCCGG TTCCTAGTCA ACTGACATGT CTAGAACTTG CCCACAATCA GCTGCAGTGT 1500

GTTCCAGATT GGGCCTGTGA AGCAAAGAAA CTGGAAATTT TAGACATGAG CTACAACCTC 1560

CTTGTGGAAC TCCCATCAAG GATCCTCAGC AGCTTGAGCC TTCGGAAATT GACAGTGGGG 1620

CACAATAATC TTCAGAGCCT TCCACCTCTT CTAGAGCATG TTCCAATGGA GGTGCTGGAC 1680

CTTCAACACA ACCTGTTGAC TAAACTCCCT GAGATGCTCT TTATCAAGGC TCTGAACCTC 1740

AGGTGCCTGA ATGCATCTGC AAATAGCCTG GAGTCCTTGC CCTCTGCATG TACAGGGGAG 1800

GAGAGTCTGA GCATGCTGCA GATGCTTTAC TTAACCAATA ACAACCTCAC AGATCAATGC 1860

ATCCCTGTCT TGGTGGGACA CCCAAACCTA CGGATCCTGC ATCTGGCAAA CAACCACCTT 1920

CAGGCTTTCC CTGCAAGCAA ACTCAGTAAG CTAGAACACT TGGAAGAGCT GAATCTGAGC 1980

GGCAACAAAC TGAAAACAAT TCCCACAACT GTGGCAAACT GCAAGCTACT TCATACACTT 2040

ATTGCACACT CTAATGACAT CAGCATCTTT CCAGAGATCC TGCATTTACC TCATATACAG 2100

ATTGTGGACT TGAGTTGCAA TGAATTAAAT GAAATCCTAA TCCCTGAGGC GCTGCCAGCT 2160

ACTTTGCAAG AGCTAGACCT GACTGGAAAT GCAAACCTGG TGCTAGAACA CAAGACACTG 2220

GATATCTTCA GTCATATTAC CACACTGAAG ATTGATGCTA AGCTCTCCCT CACAACAGAT 2280

TCAACACTCA CTTCTACTTT TTGGAGTCAT GGAGTAGCTG AGATGGCAGG GCAAAGAAAT 2340

AAGCTGTGTG TGTCGTCCCT GGCACTGGGA AGCTTTGCAG AAGGGATGGA GGCTGTGTAT 2400

GGCATGTTTG ATGGTGACAA GAACGAGGAG CTGCCACGCC TGCTGCAGTG CACTATGGCT 2460

GATGTGCTCC TGGAGGAGGT ACAGCAGTCG GACACAGTGT TCATGTCCAA CACCTTCTTG 2520

GTCTCCCACA GGAAGCTGGG TATGGCTGGG CAGAAGCTTG GTTCCTCTGC TGTCCTTTGC 2580

TATATTCATC ACGATATGGC TGATCCAGCG AGCACCTTTT CTCTGACTGT GGCCAATGTG 2640

GGAACGTGCC AAGCTGTTCT GTGCCGAAGT GGAAAACCAC TGCTTCTCTC CAAAGTCTTC 2700

AGTCTTGAGC AGTGTACTGA AGAGGCCAAG AGAATCAAGG AGCAAAAAGC AATTATAACA 2760

GAGGACAATA AGGTAAATGG TGTGACTTGC TGCACTCGGA TGCTAGGCTG CACATACTTG 2820

CACCCTTGGA TCCTGCCCAA GCCACATGTC AGTTCCATTC CACTGACTGT ACAAGATGAG 2880

CTGCTGCTTC TAGGGAATAA AGCACTGTGG GAACACCTTT CTTACACGGA GGCTGTCTCA 2940

GCTGTGCGCC ATCTACATGA CCCTCTAGCT GCTGCAAAGA AACTCTGCAC ATTAGCCCAA 3000

AGCTACGGTT GCCAGGACAA TGTAGGTGCA ATGGTGGTGT ATCTGAACAT CAGTGAGGAC 3060

AACTGCACAT GTGAGATGCA TGGTCTCTCT TTACCAGGCC CTGGGGGATT TAGTTCCACC 3120

ACTGCCAAGA CAGCAACATC TTCGTCTAGC AGCGGAATTG CTTCAGAGTT CGGTAGTGAG 3180

CTGTCTGCTT CTGAGGTTAG CAGTGAGGTG GGCTCTACTG CTTCAGATGA ACACAGTGCT 3240

GTTGGTCTTG ATGGCAGCTT GCTACCACGA CAAGAGCGAC GTTGCAGCCT ACATCCTCTG 3300

CTCCCCTCAA GCATCTTTCA GCGCCAACCT TCCAGTGCCA CCTTCTCCAG TAACCAGTCT 3360

GACAATGGCC TGGATAGTGA CGATGAACAG CCTGTGGAAG GTGTGATGTC AAATGGCAGT 3420

AAAGTGGAGG TAGAGGTGGA CATACACTGC TGTAAAGGCA AGGGTCTGGA GTTTGAACCT 3480

CTTGCTTTAG AGTACAGCTC CTCTGCTCCA GGGGTAGAGG ATGACTCTGA ACTTGTCCTC 3540

ATCGTTCAGA GACAGAACGG CATAAATAGC ACAGCTGCAC GTGGAGGGGT CAAGGAAAAG 3600

AGTGAACTGC AGAAATCTCC TTCCACGTGC TGTCTCTATG GAAAGAAGCT TTCCAACGGC 3660

TCCATAGTGC CCTTGGAGGA GAGCCTTAAC CTCATTGAAG TAGCTACAGA GGTACCCAAG 3720

AAGAAGACAG GTTATTTTGC TGCTCCATCT CAGATGGAGC CAGAGGATCA ATTTGTGGTG 3780

CCACCTGATC TGGAGGAGGA AGTGAAGGAA CAAATGAAGC AGCACCAGGA GAATGGAGCA 3840

AATGAGGAGC AGAAAGAAGA GCCTGCAGTA GCTCTGACAG AGGAGTTTGA CACAGCTTTG 3900

TAA 3903

Domain Profile

S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61

         ++gv+++ g+rn+++ ++ + ++f++  e     a++g++DG++++e  + +++++ ++l

Q: 769   SHGVAEMAGQRNKLCVSSLALGSFAEGME-----AVYGMFDGDKNEELPRLLQCTMADVL  823

         789*********************99866.....59************************

S: 62    aeelesseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikds......  115

          ee++      +  + ++ ++Fl  +++l       ++ +k Gs+av+++i ++

Q: 824   LEEVQ------QSDTVFMSNTFLVSHRKL------GMAGQKLGSSAVLCYIHHDmadpas  871

         ***88......555668************......89***************999*****

S: 116   ..klyvanvGdSravLcrngkavelssdHkpsre.dEleRieeaggsvilkdgaRvlGvL  172

           +l+vanvG ++avLcr+gk++ ls+ ++ ++  +E +Ri+e+++ +++++  +v+Gv+

Q: 872   tfSLTVANVGTCQAVLCRSGKPLLLSKVFSLEQCtEEAKRIKEQKAIITEDN--KVNGVT  929

         ******************************986449*********9999998..******

S: 173   avsRalGdlylkpyvtpePevtshrltsedefliLasDGlwdvvsneeavslvrdvlekk  232

         +++R+lG++yl+p++ p+P+v+s++lt +de l L+ + lw+++s  eavs+vr+ ++

Q: 930   CCTRMLGCTYLHPWILPKPHVSSIPLTVQDELLLLGNKALWEHLSYTEAVSAVRHLHD--  987

         **********************************************************..

S: 233   eaeqeaakkLvklalargskdnvsaivv  260

           + +aakkL++la+++g++dnv a+vv

Q: 988   --PLAAAKKLCTLAQSYGCQDNVGAMVV  1013

         ..************************97

Domain Sequence
(FASTA)

SHGVAEMAGQ RNKLCVSSLA LGSFAEGMEA VYGMFDGDKN EELPRLLQCT MADVLLEEVQ 60

QSDTVFMSNT FLVSHRKLGM AGQKLGSSAV LCYIHHDMAD PASTFSLTVA NVGTCQAVLC 120

RSGKPLLLSK VFSLEQCTEE AKRIKEQKAI ITEDNKVNGV TCCTRMLGCT YLHPWILPKP 180

HVSSIPLTVQ DELLLLGNKA LWEHLSYTEA VSAVRHLHDP LAAAKKLCTL AQSYGCQDNV 240

GAMVV 245

Keyword

Complete proteome; Leucine-rich repeat; Reference proteome; Repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0003824	; F:catalytic activity
GO:0005543	; F:phospholipid binding
GO:0008152	; P:metabolic process

KEGG

InterPros

IPR001611	; Leu-rich_rpt.
IPR025875	; Leu-rich_rpt_4.
IPR003591	; Leu-rich_rpt_typical-subtyp.
IPR011993	; PH_like_dom.
IPR001849	; Pleckstrin_homology.
IPR001932	; PP2C-like.

Pfam

PF00560	; LRR_1; 2.
PF12799	; LRR_4; 1.
PF00481	; PP2C; 1.

SMARTs

SM00369	; LRR_TYP; 1.
SM00233	; PH; 1.
SM00332	; PP2Cc; 1.

Prosites

PS51450

; LRR; 16.

Prints

Created Date

20-Feb-2013