EKS-MEG-00190

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MEG-00190

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	322.7	1.1E-96	13	265	253

Status

Unreviewed

Ensembl Protein

ENSMGAP00000009434

UniProt Accession

G1NAA7;

Protein Name

Protein Synonyms/Alias

Gene Name

MELK

Gene Synonyms/Alias

MELK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000009123	ENSMGAP00000009434	ENSMGAT00000010256

Organism

Meleagris gallopavo

Functional Description

Protein Length

657

Protein Sequence
(FASTA)

MSASDYQEIL KYYELHETIG TGGFAKVKLG RHLLTGEKVA IKIMDKFALG DDLPRVKTEI 60

DAMKNLSHQH VCRLYHVIET SKKIFMVLEY CPGGELFDYI VSKDRLSEEE ARVFFRQIVS 120

AIAYVHSQGY AHRDLKPENL LIDEKHNLKL IDFGLCAKPK GGLDYRLNTC CGSPAYAAPE 180

LIQGKAYIGS EADIWSMGVL LYALLCGFLP FDDDNVMALY RRITRGKYTI PKWLSPSSTL 240

LLNQLLQVDP KKRITVKHLL SHPWLMQGYS DAVQWQSKYP LGHLDEDCIT ELSVFHNQSR 300

ESISALISEW NYDQMSATYL LLQSKKVRGK RIHLRIPSQT AHASATQSAS LGSEKAVTSE 360

DAPDCSDVPD AFGSMEFSDA ASLSEECPLE EFILNTCGTK QQSRHDTQPG GTEFTLSTPV 420

TRKVASKKHA NKENVGAESA LRDELPFALP APKASFSKSE TDKQVQGTLF QAPTPKESQF 480

TTVTPVKKPK IPTNTYELTA TEVLPERRCH SVDLDLNIAH VDSSQKKRKA KLFGSLERGL 540

DKVITMLTPG KKKRFSRHGP RKLKAHYNVT MTQLLNPDQL LSEIISVLSK KQVEYTKKGY 600

TLKCQTKPDF GKESMKFELE VCRLSKNEAV GIRRQRLRGD AWVYKRLVED ILSSCQV 657

Nucleotide Sequence
(FASTA)

ATGTCTGCCA GCGACTACCA GGAAATTCTC AAGTACTATG AATTACATGA AACAATTGGA 60

ACGGGTGGTT TTGCAAAGGT AAAACTCGGA CGGCATCTTC TTACTGGTGA AAAAGTTGCA 120

ATAAAGATCA TGGACAAATT TGCTTTAGGG GATGACTTGC CTCGTGTTAA AACAGAAATT 180

GATGCCATGA AGAACTTAAG TCATCAACAT GTTTGCCGAT TGTATCATGT AATAGAGACA 240

TCAAAGAAAA TATTCATGGT CTTAGAGTAT TGTCCTGGAG GGGAGCTGTT TGATTACATT 300

GTTTCTAAGG ACCGCCTTTC AGAAGAGGAA GCTCGAGTCT TTTTTCGACA GATTGTTTCA 360

GCAATTGCTT ACGTTCACAG TCAGGGTTAT GCCCACAGAG ACCTCAAACC AGAAAATCTG 420

CTGATTGATG AGAAACATAA TTTGAAGCTG ATAGACTTTG GGCTCTGTGC AAAGCCAAAG 480

GGAGGCCTCG ATTACCGCCT GAACACATGC TGTGGAAGCC CAGCGTATGC AGCACCAGAG 540

CTAATCCAGG GCAAAGCGTA TATTGGCTCA GAGGCAGATA TTTGGAGCAT GGGTGTACTG 600

CTGTATGCTC TGTTGTGTGG GTTTCTTCCT TTTGATGATG ACAATGTGAT GGCACTCTAC 660

AGGAGGATAA CAAGAGGAAA ATACACCATT CCAAAATGGC TTTCACCTAG CAGTACACTG 720

CTACTTAACC AACTGCTACA GGTAGACCCT AAGAAGAGGA TTACAGTTAA ACACCTGCTA 780

AGTCACCCTT GGCTCATGCA AGGTTATTCT GATGCTGTTC AGTGGCAAAG TAAATACCCA 840

CTGGGGCACC TTGATGAGGA CTGTATAACA GAGCTTTCTG TGTTTCACAA CCAGAGCAGA 900

GAGAGTATAT CGGCATTGAT ATCAGAGTGG AATTATGACC AGATGTCAGC AACCTATCTC 960

TTGCTTCAAT CCAAGAAGGT TCGTGGCAAG CGCATCCACT TACGAATTCC ATCACAAACA 1020

GCACATGCCA GTGCAACACA GTCAGCAAGC CTGGGGTCTG AAAAGGCTGT GACATCTGAA 1080

GATGCGCCAG ATTGCAGCGA TGTGCCAGAT GCGTTTGGAT CCATGGAATT TTCTGATGCA 1140

GCTTCATTGT CTGAAGAATG TCCACTGGAA GAGTTTATTC TGAATACTTG TGGAACAAAG 1200

CAGCAGTCAA GGCACGACAC TCAGCCGGGT GGCACGGAAT TCACACTGTC AACTCCAGTG 1260

ACAAGGAAAG TGGCATCTAA GAAGCACGCA AACAAAGAGA ATGTTGGTGC AGAGTCAGCG 1320

TTAAGAGATG AGCTGCCCTT TGCACTTCCT GCTCCAAAGG CCTCCTTTTC AAAGAGTGAG 1380

ACAGACAAGC AAGTACAAGG CACACTCTTT CAGGCACCTA CTCCCAAAGA GAGCCAGTTC 1440

ACAACAGTCA CCCCAGTTAA GAAGCCCAAA ATACCAACAA ATACGTATGA ACTGACAGCA 1500

ACTGAGGTTC TTCCTGAGAG GAGGTGTCAT TCTGTGGATT TAGATCTCAA CATAGCTCAT 1560

GTGGATAGCA GCCAAAAGAA GAGAAAGGCC AAACTATTTG GAAGTCTTGA AAGAGGCCTA 1620

GATAAAGTGA TAACAATGCT TACACCAGGC AAAAAGAAGC GATTCAGTAG ACACGGACCA 1680

AGAAAACTTA AGGCACACTA TAATGTTACC ATGACTCAAC TACTGAATCC AGACCAACTG 1740

CTGAGTGAAA TAATCTCTGT CCTTTCAAAG AAGCAAGTGG AATACACTAA GAAGGGCTAC 1800

ACCCTGAAAT GCCAAACAAA GCCAGACTTT GGCAAAGAAT CCATGAAGTT TGAGTTAGAA 1860

GTGTGTCGGC TCAGTAAGAA TGAAGCAGTT GGCATCAGGA GACAGAGGCT CAGAGGGGAT 1920

GCTTGGGTCT ACAAGAGGCT GGTGGAAGAC ATTTTATCCA GCTGCCAAGT GTGA 1974

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y+l++t+G+g f+kVkl +h +t+ekva+Ki++k +l +  l ++k+Ei+++k+l+h+++

Q: 13    YELHETIGTGGFAKVKLGRHLLTGEKVAIKIMDKFALGD-DLPRVKTEIDAMKNLSHQHV  71

         99********************************88875.589*****************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         ++l++viet+kk+++vley+ ggeLfdyi++k rl+e+ear +f+q+vsa+ Y+hs+g +

Q: 72    CRLYHVIETSKKIFMVLEYCPGGELFDYIVSKDRLSEEEARVFFRQIVSAIAYVHSQGYA  131

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkeg..klletfcGsppYaaPellkgkkYegpk  178

         HrDlKpeNll+d+k+n+k++DFGl+++ k g    l+t+cGsp+YaaPel++gk Y g++

Q: 132   HRDLKPENLLIDEKHNLKLIDFGLCAKPKGGldYRLNTCCGSPAYAAPELIQGKAYIGSE  191

         **************************999887799*************************

S: 179   vDvWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpe  238

         +D+Ws+Gv+Lyal++g lPfd++n+ +l+++i++gk++ipk+ls++ + Ll++lL+vdp+

Q: 192   ADIWSMGVLLYALLCGFLPFDDDNVMALYRRITRGKYTIPKWLSPSSTLLLNQLLQVDPK  251

         ************************************************************

S: 239   kRatieeilkhewl  252

         kR+t++++l+h+wl

Q: 252   KRITVKHLLSHPWL  265

         *************7

Domain Sequence
(FASTA)

YELHETIGTG GFAKVKLGRH LLTGEKVAIK IMDKFALGDD LPRVKTEIDA MKNLSHQHVC 60

RLYHVIETSK KIFMVLEYCP GGELFDYIVS KDRLSEEEAR VFFRQIVSAI AYVHSQGYAH 120

RDLKPENLLI DEKHNLKLID FGLCAKPKGG LDYRLNTCCG SPAYAAPELI QGKAYIGSEA 180

DIWSMGVLLY ALLCGFLPFD DDNVMALYRR ITRGKYTIPK WLSPSSTLLL NQLLQVDPKK 240

RITVKHLLSH PWL 253

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005938	; C:cell cortex
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0005509	; F:calcium ion binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006915	; P:apoptotic process
GO:0061351	; P:neural precursor cell proliferation
GO:0043065	; P:positive regulation of apoptotic process
GO:0046777	; P:protein autophosphorylation

KEGG

mgp:100549393

;

InterPros

IPR001772	; Kinase-assoc_KA1.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF02149	; KA1; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50032	; KA1; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013