EKS-MEG-00083
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MEG-00083
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Tec473.51.1E-142292542251
StatusUnreviewed
Ensembl ProteinENSMGAP00000009784
UniProt AccessionG1NB26;
Protein Name
Protein Synonyms/Alias
Gene NameBTK
Gene Synonyms/Alias BTK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMGAG00000009438ENSMGAP00000009784ENSMGAT00000010619
OrganismMeleagris gallopavo
Functional Description
Protein Length549
Protein Sequence
(FASTA)
PLYVFSPTEE LRKRWIHQLK SVIRYNSDLV QKYHPCFWID GQYLCCSQTA KNAMGCKILE 60
SRNGSLKAGR SHRKTKKPLP PTPEEDMMVM KPLPPEPAPS AAGEMKKVVA LYNYVPMNVQ 120
DLQLQKGEEY LILEESHLPW WKARDKNGRE GYIPSNYVTE TSNSLEIYEW YSKNITRSQA 180
EQLLKQEGKE GGFIVRDSTS KTGKYTVSVY AKSAVDPQGM IRHYVVCCTP QNQYYLAEKH 240
LFNTIPELIT YHQHNSAGLI SRLKYPVSRH QKSAPSTAGL GYGSWEIDPK DLTFLKELGT 300
GQFGVVKYGK WRGQYNVAIK MIREGSMSED EFIDEAKVMM NLSHEKLVQL YGVCTKQRPI 360
FIITEYMANG CLLNFLRETQ RRFQPAELLE MCKDVCEAME YLESKQFLHR DLAARNCLVN 420
DQGIVKVSDF GLSRYVLDDE YTSSMGSKFP VRWSPPEVLL YSKFSSKSDV WSFGVLMWEV 480
YSLGKMPYER FNNSETTEHV IQGLRLYRPQ QASERVYAIM YSCWHEKAEE RPTFTALLGS 540
IVDITDEEP 549
Nucleotide Sequence
(FASTA)
CCCCTCTATG TCTTCTCCCC GACAGAGGAG CTGCGCAAAC GCTGGATCCA TCAGCTGAAG 60
AGCGTGATCC GATACAACAG CGACCTGGTG CAGAAGTACC ACCCCTGCTT CTGGATTGAT 120
GGCCAGTACC TGTGCTGCTC CCAGACAGCC AAGAATGCCA TGGGCTGCAA GATCTTGGAG 180
AGCAGGAATG GCAGTTTAAA AGCTGGGCGG TCACATCGCA AAACAAAGAA GCCTCTTCCC 240
CCCACGCCTG AGGAGGACAT GATGGTGATG AAGCCCCTGC CCCCTGAACC AGCCCCCAGT 300
GCAGCAGGAG AAATGAAGAA GGTGGTGGCC CTGTACAACT ACGTGCCAAT GAATGTGCAG 360
GACCTGCAGC TGCAGAAGGG TGAGGAGTAC CTCATCCTGG AGGAAAGCCA CCTGCCCTGG 420
TGGAAAGCCC GTGACAAGAA TGGAAGGGAA GGATACATCC CCAGCAACTA TGTCACCGAA 480
ACCAGCAATT CCCTGGAGAT TTATGAGTGG TACTCAAAGA ATATCACTCG GAGCCAAGCA 540
GAACAACTCC TGAAGCAGGA GGGTAAGGAA GGAGGTTTCA TTGTCCGAGA CTCTACCAGC 600
AAGACAGGGA AATACACTGT CTCTGTTTAT GCCAAGTCTG CTGTAGACCC CCAAGGGATG 660
ATTCGCCATT ACGTTGTATG CTGCACCCCT CAGAATCAGT ATTACCTGGC AGAAAAACAC 720
CTGTTCAACA CCATCCCAGA GCTCATCACG TACCATCAGC ACAACTCTGC CGGGCTTATA 780
TCCAGATTGA AGTATCCCGT GTCCCGACAC CAGAAAAGTG CCCCTTCCAC AGCTGGCCTG 840
GGCTATGGGT CGTGGGAGAT TGACCCGAAG GATCTGACCT TCCTGAAGGA ACTGGGGACG 900
GGACAGTTTG GCGTGGTGAA GTATGGGAAA TGGAGAGGCC AATACAACGT TGCCATCAAG 960
ATGATCAGGG AGGGCTCCAT GTCGGAGGAC GAGTTTATTG ATGAAGCCAA AGTCATGATG 1020
AACCTATCTC ATGAGAAGCT GGTGCAGCTC TACGGGGTCT GCACAAAGCA GCGTCCCATC 1080
TTCATCATCA CTGAGTACAT GGCCAACGGC TGTCTCTTGA ACTTCCTGAG GGAAACTCAG 1140
CGGCGGTTCC AGCCTGCTGA GCTGCTGGAA ATGTGCAAAG ATGTCTGTGA AGCTATGGAG 1200
TACCTGGAAT CCAAGCAGTT TCTGCACCGA GACCTGGCTG CTCGCAACTG TTTGGTGAAT 1260
GACCAAGGGA TTGTGAAAGT CTCAGATTTT GGCCTTTCCA GATACGTTCT GGATGATGAG 1320
TACACAAGCT CCATGGGGTC AAAGTTTCCA GTTCGGTGGT CTCCTCCTGA AGTTCTCCTG 1380
TACAGCAAGT TCAGCAGCAA ATCTGACGTG TGGTCGTTTG GCGTGCTGAT GTGGGAGGTT 1440
TACTCTCTGG GAAAGATGCC TTACGAGAGG TTTAACAACA GCGAGACCAC AGAGCACGTC 1500
ATCCAAGGCC TGCGTCTCTA CCGGCCTCAG CAGGCCTCGG AGCGGGTCTA CGCCATCATG 1560
TACAGCTGCT GGCACGAGAA GGCCGAGGAG CGCCCCACCT TCACCGCGCT GCTGGGCAGC 1620
ATCGTGGACA TCACAGACGA AGAGCCGTGA 1650
Domain Profile
S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60
         lt+lkelg+gqfgvvk+gkwr++++vaik+i+eg+mse++fi+eakvmm+lsh+klvqly
Q: 292   LTFLKELGTGQFGVVKYGKWRGQYNVAIKMIREGSMSEDEFIDEAKVMMNLSHEKLVQLY  351
         79**********************************************************
S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120
         gvc+kq+pi+i+tey++ngclln+lre++++++ + llemckdvce+meyle+k+f+hrd
Q: 352   GVCTKQRPIFIITEYMANGCLLNFLRETQRRFQPAELLEMCKDVCEAMEYLESKQFLHRD  411
         ************************************************************
S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180
         laarnclv+++ +vkvsdfgl+ryvldd+y+ss+g+kfpv+wsppevl ysk+ssksdvw
Q: 412   LAARNCLVNDQGIVKVSDFGLSRYVLDDEYTSSMGSKFPVRWSPPEVLLYSKFSSKSDVW  471
         ************************************************************
S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeer  240
         +fgvlmwev+s+gk+pye+++nse+ e+v +glrlyrp+ as++vy +m+scw+ek+eer
Q: 472   SFGVLMWEVYSLGKMPYERFNNSETTEHVIQGLRLYRPQQASERVYAIMYSCWHEKAEER  531
         ************************************************************
S: 241   ptfkellsale  251
         ptf+ ll +++
Q: 532   PTFTALLGSIV  542
         *******9885
Domain Sequence
(FASTA)
LTFLKELGTG QFGVVKYGKW RGQYNVAIKM IREGSMSEDE FIDEAKVMMN LSHEKLVQLY 60
GVCTKQRPIF IITEYMANGC LLNFLRETQR RFQPAELLEM CKDVCEAMEY LESKQFLHRD 120
LAARNCLVND QGIVKVSDFG LSRYVLDDEY TSSMGSKFPV RWSPPEVLLY SKFSSKSDVW 180
SFGVLMWEVY SLGKMPYERF NNSETTEHVI QGLRLYRPQQ ASERVYAIMY SCWHEKAEER 240
PTFTALLGSI V 251
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00098
EKS-ANC-00100
EKS-BOT-00108
EKS-CAJ-00109
EKS-CAF-00109
EKS-CAP-00103
EKS-DAR-00355
EKS-EQC-00104
EKS-FEC-00102
EKS-GAM-00052
EKS-GAG-00088
EKS-GAA-00127
EKS-GOG-00108
EKS-HOS-00110
EKS-ICT-00102
EKS-LAC-00112
EKS-LOA-00102
EKS-MAM-00103
EKS-MOD-00109
EKS-MUM-00109
EKS-MUP-00110
EKS-MYL-00121
EKS-NOL-00100
EKS-ORN-00132
EKS-ORA-00087
EKS-ORC-00099
EKS-ORL-00124
EKS-OTG-00109
EKS-PAT-00098
EKS-PES-00092
EKS-PEM-00054
EKS-POA-00100
EKS-PTV-00097
EKS-RAN-00109
EKS-SAH-00100
EKS-SOA-00057
EKS-SUS-00094
EKS-TAR-00136
EKS-TEN-00126
EKS-XET-00090
EKS-XIM-00130
Gene Ontology
GO:0031410; C:cytoplasmic vesicle
GO:0005829; C:cytosol
GO:0045121; C:membrane raft
GO:0005634; C:nucleus
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding
GO:0004713; F:protein tyrosine kinase activity
GO:0007249; P:I-kappaB kinase/NF-kappaB cascade
GO:0018108; P:peptidyl-tyrosine phosphorylation
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR001849; Pleckstrin_homology.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR001562; Znf_Btk_motif.
Pfam
PF00779; BTK; 1.
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00107; BTK; 1.
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS50003; PH_DOMAIN; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
PS51113; ZF_BTK; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00402; TECBTKDOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013