EKS-MEG-00338

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MEG-00338

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/IRAK	332.4	1.9E-99	143	409	267

Status

Unreviewed

Ensembl Protein

ENSMGAP00000009823

UniProt Accession

G1NB62;

Protein Name

Protein Synonyms/Alias

Gene Name

IRAK4

Gene Synonyms/Alias

IRAK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000009511	ENSMGAP00000009823	ENSMGAT00000010659

Organism

Meleagris gallopavo

Functional Description

Protein Length

415

Protein Sequence
(FASTA)

FFLRRFEAFV QMGKSPTCEL LYDWGTTNCT VGDLVDLLIR NQFLAPASLL LPEAVGMAQE 60

VTLPLSSQET LPVHEKQQPI QEKEVTSVKP VLSQNTEKQP SVPPCLSEEN SSTQSSNTDF 120

HNFCFRDLEN VTNNFDERPE SAGGNKLGEG GFGIVFKGYI NGRNVAVKKL AAVVDVSAQD 180

LKQQFDQEIE IMAKCKHENL VELLGFSSDG AQPCLVYEYM PNGSLLDRLA CLDGTPPISW 240

NTRCEIAQGT ASGINFLHDN NHIHRDIKSA NILLTDKYVP KISDFGLARA SVTFTRTIMT 300

DRVVGTAAYM APEALRGEIT PKSDIFSFGV VLLEVITGLP PVDENREPQL LLSIKDEIED 360

EEATVEDYVD VKMSDWDATS VHKMYSLADR CLNEKKNRRP NIQMVQQYLQ ELTGH 415

Nucleotide Sequence
(FASTA)

TTCTTTTTAA GGAGATTTGA AGCATTTGTG CAAATGGGAA AGAGTCCCAC GTGTGAATTG 60

CTTTATGACT GGGGAACAAC AAATTGTACG GTTGGTGACC TTGTGGATCT GCTGATTAGG 120

AACCAGTTTC TGGCACCAGC AAGTCTTTTG CTTCCAGAAG CTGTCGGGAT GGCACAAGAA 180

GTTACATTAC CTCTTTCTTC ACAGGAAACT TTGCCTGTGC ATGAGAAACA ACAGCCTATA 240

CAGGAAAAAG AAGTGACATC TGTAAAGCCT GTTTTGTCTC AGAACACAGA GAAGCAACCT 300

TCAGTCCCTC CATGTTTAAG TGAAGAAAAC AGCAGCACAC AGTCTAGTAA TACAGATTTC 360

CACAATTTTT GCTTTCGTGA CTTGGAAAAT GTTACAAATA ATTTTGATGA ACGGCCAGAA 420

TCAGCTGGAG GAAATAAGCT GGGGGAAGGT GGCTTTGGCA TTGTGTTCAA AGGCTACATC 480

AATGGCAGAA ATGTGGCTGT CAAGAAACTT GCTGCTGTGG TTGATGTTAG TGCACAGGAT 540

TTGAAACAGC AATTTGATCA AGAAATAGAA ATTATGGCAA AGTGCAAACA TGAAAATCTA 600

GTAGAATTGC TTGGTTTCTC AAGTGATGGT GCTCAGCCCT GTTTGGTGTA TGAATACATG 660

CCCAATGGTT CGCTGCTTGA CAGACTTGCT TGTCTGGATG GCACTCCACC AATTTCTTGG 720

AATACAAGGT GTGAAATTGC TCAAGGTACT GCGAGTGGCA TCAACTTTTT GCATGACAAT 780

AATCATATTC ACAGAGATAT TAAAAGTGCA AATATTTTAT TGACTGATAA GTATGTGCCC 840

AAAATTTCGG ACTTTGGACT TGCAAGAGCA TCAGTAACGT TCACACGAAC CATCATGACA 900

GATAGAGTTG TGGGAACAGC AGCCTATATG GCACCTGAAG CTCTGCGAGG AGAAATAACT 960

CCTAAATCTG ATATCTTCAG CTTTGGGGTA GTCTTACTAG AAGTAATAAC AGGTTTGCCA 1020

CCTGTAGATG AAAACCGGGA GCCACAGTTA CTGTTAAGTA TCAAGGATGA AATTGAGGAT 1080

GAGGAGGCGA CAGTAGAGGA TTATGTTGAT GTAAAGATGA GTGACTGGGA TGCAACTTCA 1140

GTTCATAAAA TGTATTCACT TGCTGATCGG TGTCTGAATG AGAAAAAAAA CAGGAGGCCG 1200

AACATTCAGA TGGTCCAGCA GTATTTACAA GAGTTAACTG GGCAC 1245

Domain Profile

S: 3     ednrigeGgfgevyrgelkntavavkklkeeadlslkelkqsfltElkvlarfrHdnile  62

          +n++geGgfg v++g +++ +vavkkl++ +d+s + lkq+f++E++++a+++H+n++e

Q: 143   GGNKLGEGGFGIVFKGYINGRNVAVKKLAAVVDVSAQDLKQQFDQEIEIMAKCKHENLVE  202

         579*********************************************************

S: 63    llgysaeseklcLvYqymknGsLedrLqcqkgsepLsWpqRlsillGtaraiefLHeasp  122

         llg+s+++ ++cLvY+ym+nGsL drL c +g++p+sW++R++i++Gta +i+fLH++

Q: 203   LLGFSSDGAQPCLVYEYMPNGSLLDRLACLDGTPPISWNTRCEIAQGTASGINFLHDN--  260

         **********************************************************..

S: 123   slihgdiksaNiLLDekltpKlgDfglarfapesekqsstvlrtskvrgtlaYlpeefir  182

         ++ih+diksaNiLL +k  pK++Dfglar   +s   ++t++ t++v+gt+aY+++e++r

Q: 261   NHIHRDIKSANILLTDKYVPKISDFGLAR---ASVTFTRTIM-TDRVVGTAAYMAPEALR  316

         *****************************...8888999999.*****************

S: 183   vgqltvkvDvySfGiVllEvltGlravdedrktkyLkdllkeeieeekveilekfldkka  242

          g++t k+D++SfG+VllEv+tGl+ vde+r+++ L+ + k+eie+e+  ++e+++d k+

Q: 317   -GEITPKSDIFSFGVVLLEVITGLPPVDENREPQLLLSI-KDEIEDEE-ATVEDYVDVKM  373

         .************************************99.********.899********

S: 243   gkleeellealielalaclaekakkrPtmsqvlell  278

         ++ + ++++++++la +cl+ek+++rP+++ v+++l

Q: 374   SDWDATSVHKMYSLADRCLNEKKNRRPNIQMVQQYL  409

         *********************************987

Domain Sequence
(FASTA)

GGNKLGEGGF GIVFKGYING RNVAVKKLAA VVDVSAQDLK QQFDQEIEIM AKCKHENLVE 60

LLGFSSDGAQ PCLVYEYMPN GSLLDRLACL DGTPPISWNT RCEIAQGTAS GINFLHDNNH 120

IHRDIKSANI LLTDKYVPKI SDFGLARASV TFTRTIMTDR VVGTAAYMAP EALRGEITPK 180

SDIFSFGVVL LEVITGLPPV DENREPQLLL SIKDEIEDEE ATVEDYVDVK MSDWDATSVH 240

KMYSLADRCL NEKKNRRPNI QMVQQYL 267

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0019221	; P:cytokine-mediated signaling pathway

KEGG

InterPros

IPR011029	; DEATH-like.
IPR017428	; Interleukin-1_rcpt-assoc_kin4.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013