EKS-MEG-00312

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MEG-00312

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	317.9	4.0E-95	17	260	244

Status

Unreviewed

Ensembl Protein

ENSMGAP00000010210

UniProt Accession

G1NC02;

Protein Name

Protein Synonyms/Alias

Gene Name

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000009860	ENSMGAP00000010210	ENSMGAT00000011056

Organism

Meleagris gallopavo

Functional Description

Protein Length

793

Protein Sequence
(FASTA)

MSSTSASFVQ IRFDDLQFFE NCGGGSFGSV YRARWISQDK EVAVKKLLKI EKEAEILSVL 60

SHKNIIQFYG AVIEPPNYGI VTEYASAGSL FDYINSNKSE EMDMDHIMTW ATDIAKGMHY 120

LHMEAPVKVI HRDLKSRNVV IAADGVLKIC DFGASRFHSH TTHMSLVGTF PWMAPEVIQS 180

LPVSETCDTY SYGVVLWEML TREVPFKGLE GLQVAWLVVE KNERLTIPSS CPRSFAELMH 240

QCWEADSKKR PSFKQIISIL ESMSNDSNLP DQCNSFLHNK AEWRCEIEAT LERLKKLERD 300

LSFKEQELKE RERRLKMWEQ KLTEQSNTPA VVLPTFTRVA QEKNAVFFWM QQLTRKGDAS 360

GEMSAYASLF KEHHITGKRL LLLEEEDLKD MGIISRGHII HLKTAIEKLT HDYLNLFHFP 420

PLIKDSAGEA GEDVEKVVNL ELVFGYHLKL GNGPKDCKWK MYMEMDGDEI AITYIKDVTF 480

NTNLPDVEIL KMTKPPFVME KWIVGIEEHQ SVECIVTYES DVRAPKSTRH VQAISWSKVK 540

AQDEVKAVQL MIQTSLPNSE GHSRSRSDSS IDSQWMQTLR MHQIAKAISL QHGHPHSPTT 600

ISHYLPYLQS QDSYAAAVRR TRGPVSYHYT SISHSRNSSP LSHSLVRNLS NLHLNSKGSS 660

TSSTASDTAS ERDRSTGKAR NASHSGNSRS SSDGRRSGTS SPVPPRSSGR AGRTASMPLA 720

HEQRRYPRNS PQPKAIPGMP LQGESEPRRS EGEGRVSEGG WIKVQHVKKP HRQSTSKQGK 780

ERPKGNWRGR RTF 793

Nucleotide Sequence
(FASTA)

ATGTCGTCTA CCAGTGCTTC ATTTGTGCAA ATTAGATTTG ATGACTTGCA GTTTTTTGAA 60

AACTGCGGCG GAGGGAGTTT TGGGAGCGTC TATCGAGCCC GATGGATTTC TCAGGACAAG 120

GAGGTGGCTG TGAAGAAGCT GCTCAAAATA GAAAAGGAGG CAGAAATACT CAGTGTGCTC 180

AGTCACAAAA ACATCATTCA GTTCTATGGA GCTGTCATTG AACCTCCAAA TTATGGCATA 240

GTTACAGAGT ATGCTTCTGC TGGCTCACTG TTTGATTACA TTAATAGTAA CAAAAGTGAA 300

GAGATGGATA TGGATCATAT CATGACCTGG GCAACTGACA TAGCTAAAGG CATGCACTAC 360

TTACACATGG AAGCTCCAGT CAAAGTAATC CACAGAGATC TGAAGTCCAG GAACGTTGTT 420

ATAGCTGCTG ATGGCGTGTT AAAGATCTGT GATTTTGGTG CCTCAAGGTT CCATTCACAT 480

ACAACACACA TGTCGTTAGT GGGTACTTTT CCATGGATGG CCCCAGAAGT TATTCAAAGT 540

CTCCCAGTAT CTGAGACGTG TGACACGTAC TCATACGGAG TGGTTCTCTG GGAGATGCTA 600

ACAAGGGAGG TCCCCTTTAA AGGCTTGGAA GGATTACAAG TAGCTTGGCT TGTAGTGGAA 660

AAAAACGAGA GATTAACCAT TCCAAGCAGT TGTCCCAGAA GTTTTGCAGA ACTGATGCAT 720

CAATGTTGGG AAGCTGACTC AAAGAAAAGG CCATCTTTCA AGCAGATAAT TTCAATTCTG 780

GAATCCATGT CAAACGACAG CAACCTTCCA GACCAGTGCA ATTCATTCCT GCATAACAAG 840

GCGGAATGGA GATGTGAAAT TGAGGCAACC TTAGAGAGAC TGAAGAAACT GGAGCGTGAT 900

CTGAGCTTTA AAGAGCAAGA ACTAAAGGAA CGGGAGCGAC GTCTGAAGAT GTGGGAACAG 960

AAGTTAACTG AACAGTCCAA TACTCCTGCT GTTGTTCTGC CAACATTTAC TAGGGTAGCT 1020

CAAGAGAAGA ATGCAGTATT TTTCTGGATG CAACAACTTA CTAGAAAAGG CGATGCTTCT 1080

GGTGAAATGA GTGCATATGC TAGCTTGTTT AAAGAACATC ATATCACTGG AAAGCGATTG 1140

CTCCTTCTAG AAGAAGAAGA TTTAAAGGAC ATGGGAATCA TTTCCAGAGG ACACATCATC 1200

CACCTAAAGA CTGCTATTGA GAAGTTAACC CATGACTACC TAAATCTGTT TCATTTTCCA 1260

CCATTAATTA AGGACTCTGC GGGTGAAGCT GGGGAAGACG TAGAGAAAGT AGTGAATCTT 1320

GAACTCGTTT TTGGCTATCA CTTAAAGCTG GGAAATGGTC CAAAGGACTG TAAATGGAAA 1380

ATGTACATGG AGATGGACGG GGATGAAATT GCAATAACCT ACATAAAAGA TGTGACATTC 1440

AACACTAACC TACCCGATGT AGAGATTTTA AAGATGACAA AGCCACCGTT TGTCATGGAG 1500

AAGTGGATCG TGGGGATCGA AGAACATCAG TCTGTAGAAT GTATTGTTAC ATATGAGAGC 1560

GACGTTCGAG CTCCCAAATC CACCAGGCAC GTCCAAGCAA TCAGCTGGAG CAAGGTGAAA 1620

GCACAGGATG AGGTCAAAGC GGTGCAGCTT ATGATACAGA CCTCGCTCCC CAACTCAGAG 1680

GGGCATTCAC GGAGCAGGTC TGACTCCAGC ATCGACAGCC AGTGGATGCA GACGCTGCGC 1740

ATGCACCAGA TAGCCAAAGC CATTTCCCTG CAGCACGGCC ACCCGCACAG CCCCACTACC 1800

ATCTCACACT ACCTGCCCTA CCTGCAGAGC CAGGACTCCT ACGCCGCTGC CGTGAGGCGG 1860

ACACGCGGGC CCGTCAGTTA CCACTACACC TCCATCAGCC ACTCCAGGAA CTCCTCTCCC 1920

CTCTCGCACA GTTTGGTGAG AAACCTGTCG AACCTACACC TCAACTCAAA GGGCAGCAGC 1980

ACTTCCAGCA CAGCATCGGA CACGGCTTCA GAGAGGGACA GGTCCACAGG CAAGGCCAGG 2040

AACGCTTCGC ACAGCGGCAA CTCCCGCAGC TCCTCTGATG GGCGGCGCAG CGGGACGAGC 2100

TCCCCGGTGC CTCCCAGGTC CTCGGGCAGG GCCGGCAGGA CTGCCTCCAT GCCCCTGGCC 2160

CATGAGCAAC GCAGGTACCC CCGCAACTCC CCCCAGCCCA AGGCCATCCC GGGCATGCCG 2220

CTGCAGGGGG AGAGCGAGCC TAGAAGAAGC GAAGGGGAGG GCAGGGTGAG CGAGGGGGGG 2280

TGGATAAAGG TGCAGCATGT AAAGAAGCCC CACAGGCAGA GCACCAGCAA GCAGGGTAAG 2340

GAAAGGCCCA AGGGCAACTG GCGGGGCCGG AGGACGTTCT AA 2382

Domain Profile

S: 2     eleeligsgafgkvykakwrkke..vavKklreeaeekekleklereakllsklshpnii  59

         ++ e +g g+fg+vy+a+w +++  vavKkl +          +e+ea++ls lsh+nii

Q: 17    QFFENCGGGSFGSVYRARWISQDkeVAVKKLLK----------IEKEAEILSVLSHKNII  66

         67799**************665444****9987..........899**************

S: 60    ellGvcleepnlllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhseap  119

         +++G++ e+pn+++v+ey++ gsL++++++++++e+d++++++wa++iA+Gm+YLh eap

Q: 67    QFYGAVIEPPNYGIVTEYASAGSLFDYINSNKSEEMDMDHIMTWATDIAKGMHYLHMEAP  126

         ************************************************************

S: 120   kkiihrdLksknvLlseekktlkicdFGtarelskstkmsaagtlawmaPEvlkeekvse  179

         +k+ihrdLks+nv++ +++ +lkicdFG +r++s++t+ms  gt+ wmaPEv+++ +vse

Q: 127   VKVIHRDLKSRNVVI-AADGVLKICDFGASRFHSHTTHMSLVGTFPWMAPEVIQSLPVSE  185

         ***************.********************************************

S: 180   ksDvwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkLmkecwne  239

         ++D +SygvvLWe+ltrevP+k+l+ l++a+ v++k++rl+ipsscp+++++Lm++cw++

Q: 186   TCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELMHQCWEA  245

         ************************************************************

S: 240   dpekRpsfseivksl  254

         d++kRpsf++i+++l

Q: 246   DSKKRPSFKQIISIL  260

         ***********9875

Domain Sequence
(FASTA)

QFFENCGGGS FGSVYRARWI SQDKEVAVKK LLKIEKEAEI LSVLSHKNII QFYGAVIEPP 60

NYGIVTEYAS AGSLFDYINS NKSEEMDMDH IMTWATDIAK GMHYLHMEAP VKVIHRDLKS 120

RNVVIAADGV LKICDFGASR FHSHTTHMSL VGTFPWMAPE VIQSLPVSET CDTYSYGVVL 180

WEMLTREVPF KGLEGLQVAW LVVEKNERLT IPSSCPRSFA ELMHQCWEAD SKKRPSFKQI 240

ISIL 244

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004709	; F:MAP kinase kinase kinase activity
GO:0007257	; P:activation of JUN kinase activity
GO:0007050	; P:cell cycle arrest
GO:0007010	; P:cytoskeleton organization
GO:0000077	; P:DNA damage checkpoint
GO:0043065	; P:positive regulation of apoptotic process
GO:0009314	; P:response to radiation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001660	; SAM.
IPR013761	; SAM/pointed.
IPR021129	; SAM_type1.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00536	; SAM_1; 1.

SMARTs

SM00454

; SAM; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50105	; SAM_DOMAIN; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013