EKS-MEG-00034

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MEG-00034

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CK1/VRK	287.1	8.9E-86	9	220	212

Status

Unreviewed

Ensembl Protein

ENSMGAP00000010516

UniProt Accession

G1NCM8;

Protein Name

Protein Synonyms/Alias

Gene Name

VRK3

Gene Synonyms/Alias

VRK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000010151	ENSMGAP00000010516	ENSMGAT00000011375

Organism

Meleagris gallopavo

Functional Description

Protein Length

234

Protein Sequence
(FASTA)

STAQSASGTC PQKQRFSLKL DVKDSKIYNE QNFFQRAAKK DRVEKWKKLH SLPLLGIPSC 60

LGFGLHADKY RFLVFSDLGR SLQSILNDNL HLNEKAAFQI AVRLLDCLEY LHENEYVHGD 120

ITADNIYVNP ADLTQVTLAG YYFAFRYCPE GKHVARREGS RTPHEGTIEF ISQDSHKGAA 180

PSRRSDLESL GYCLLKWLCG FLPWSKELDK VETVMEKKEI LFLLSKTGCF SACS 234

Nucleotide Sequence
(FASTA)

TCCACAGCAC AGTCAGCATC TGGAACCTGC CCTCAAAAGC AAAGATTCTC CCTCAAACTT 60

GATGTCAAAG ACAGTAAGAT CTACAATGAA CAGAACTTTT TCCAGCGAGC TGCAAAGAAA 120

GACAGAGTGG AGAAGTGGAA GAAGCTGCAC TCTTTGCCCC TGCTGGGCAT CCCCAGCTGT 180

CTTGGCTTTG GACTGCATGC AGATAAATAC AGGTTTTTGG TGTTCTCTGA TTTAGGGCGA 240

TCTCTTCAGT CCATTCTGAA TGACAACTTA CACCTGAATG AGAAGGCAGC TTTTCAGATT 300

GCAGTCCGGC TGCTGGACTG CCTGGAGTAC CTTCATGAAA ATGAGTATGT GCATGGGGAC 360

ATCACAGCTG ACAACATCTA TGTGAACCCA GCAGACCTCA CGCAGGTGAC CCTAGCAGGC 420

TACTACTTCG CCTTCCGTTA CTGCCCAGAA GGGAAGCATG TGGCTAGGCG TGAAGGCAGC 480

AGGACTCCTC ATGAGGGCAC GATAGAGTTT ATCAGCCAGG ACAGCCACAA GGGAGCAGCA 540

CCATCTCGAC GGAGTGACTT GGAATCTCTG GGCTACTGTC TTCTGAAATG GCTCTGCGGC 600

TTCTTGCCTT GGTCTAAGGA GCTGGACAAA GTAGAAACTG TGATGGAAAA GAAAGAAATT 660

TTGTTCTTGT TGTCAAAGAC AGGATGCTTC AGTGCCTGCT CC 702

Domain Profile

S: 23    keekdaklvvkvepkenGpLfvelkfyqraakkeqikkwkkkkklkllgiPtliasGlhe  82

         + ++++++++k++ k+  ++++e++f+qraakk+ ++kwkk ++l+llgiP+++++Glh

Q: 9     TCPQKQRFSLKLDVKD-SKIYNEQNFFQRAAKKDRVEKWKKLHSLPLLGIPSCLGFGLHA  67

         56789**********9.9*****************************************9

S: 83    fegekyRflvlprlgrdLqklleqngkrlsektvlqlavrlldvleylHeneYvHgdikA  142

            +kyRflv+  lgr+Lq++l++n  +l+ek+ +q+avrlld leylHeneYvHgdi+A

Q: 68    ---DKYRFLVFSDLGRSLQSILNDNL-HLNEKAAFQIAVRLLDCLEYLHENEYVHGDITA  123

         ...**********************9.7********************************

S: 143   anllleeeeasqvyLvdyGlayrycpegkhkeykedkrraHdGtleftslDaHkGvapsr  202

         +n+ +++ +  qv+L++y +a+rycpegkh++ +e++r +H+Gt+ef+s D HkG+apsr

Q: 124   DNIYVNPADLTQVTLAGYYFAFRYCPEGKHVARREGSRTPHEGTIEFISQDSHKGAAPSR  183

         ************************************************************

S: 203   RsDleiLgYcllkWltgkLPWeallkdpekvqkakek  239

         RsDle+LgYcllkWl+g+LPW ++l++ e+v+++ke

Q: 184   RSDLESLGYCLLKWLCGFLPWSKELDKVETVMEKKEI  220

         *********************************9985

Domain Sequence
(FASTA)

TCPQKQRFSL KLDVKDSKIY NEQNFFQRAA KKDRVEKWKK LHSLPLLGIP SCLGFGLHAD 60

KYRFLVFSDL GRSLQSILND NLHLNEKAAF QIAVRLLDCL EYLHENEYVH GDITADNIYV 120

NPADLTQVTL AGYYFAFRYC PEGKHVARRE GSRTPHEGTI EFISQDSHKG AAPSRRSDLE 180

SLGYCLLKWL CGFLPWSKEL DKVETVMEKK EI 212

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity
GO:0070373	; P:negative regulation of ERK1 and ERK2 cascade
GO:0032516	; P:positive regulation of phosphoprotein phosphatase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

Created Date

20-Feb-2013