EPS-MEG-00027

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-MEG-00027

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	290.2	1.4E-86	23	293	271

Status

Unreviewed

Ensembl Protein

ENSMGAP00000018111

UniProt Accession

G1NCT4;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1B

Gene Synonyms/Alias

PPM1B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000010220	ENSMGAP00000018111	ENSMGAT00000019040
ENSMGAG00000010220	ENSMGAP00000010593	ENSMGAT00000011454

Organism

Meleagris gallopavo

Functional Description

Protein Length

387

Protein Sequence
(FASTA)

MGAFLDKPKT EKHNAHGAGN GLRYGLSSMQ GWRVEMEDAH TAVVGIPHGL EDWSFFAVYD 60

GHAGSRVANY CSTHLLEHIT NNEDFRAAEK PGSALEPSVE NVKSGIRTGF LKIDEYMRNF 120

SDLRNGMDRS GSTAVGVMIS PEHVYFINCG DSRAVLYRNG QVCFSTQDHK PCNPREKERI 180

QNAGGSVMIQ RVNGSLAVSR ALGDYDYKCV DGKGPTEQLV SPEPEVCEIL RAEEDEFIIL 240

ACDGIWDVMS NEELCEFVKS RLEVSDDLEK VCNWVVDTCL HKGSRDNMSI VLVCLSNAPK 300

VSDEAVKKDA ELDKHLESRV EEIMEKSGEE GMPDLAHVIR ILSAENIPNL PPGGGLAGKR 360

NIIEAVYSRL NPHRETEGGA GDLEDPW 387

Nucleotide Sequence
(FASTA)

ATGGGTGCAT TTTTGGATAA GCCAAAAACT GAAAAACATA ATGCTCATGG TGCAGGGAAT 60

GGCTTGCGTT ACGGCCTCAG CAGTATGCAG GGATGGAGAG TGGAAATGGA AGATGCTCAC 120

ACAGCTGTTG TAGGTATTCC CCATGGCTTA GAGGACTGGT CCTTTTTTGC TGTCTATGAT 180

GGTCATGCAG GATCTCGTGT TGCAAATTAT TGCTCCACAC ACTTACTAGA ACACATCACT 240

AACAATGAAG ACTTTAGGGC AGCAGAAAAA CCTGGATCTG CTCTTGAACC TTCAGTGGAA 300

AATGTCAAGA GTGGAATCAG AACTGGCTTT TTGAAAATTG ATGAGTATAT GCGCAATTTC 360

TCAGACCTCA GAAATGGGAT GGACAGAAGT GGCTCAACAG CAGTGGGAGT TATGATTTCA 420

CCTGAGCATG TGTACTTTAT CAATTGCGGT GATTCACGTG CTGTTCTCTA TAGGAATGGA 480

CAAGTCTGTT TTTCAACACA GGATCACAAA CCTTGCAACC CGAGGGAGAA AGAGCGAATC 540

CAGAATGCAG GAGGCAGTGT AATGATTCAG CGTGTCAATG GTTCATTGGC AGTTTCTCGA 600

GCTCTGGGGG ACTATGACTA CAAATGTGTT GATGGTAAAG GCCCTACAGA ACAACTTGTT 660

TCTCCAGAGC CTGAGGTTTG TGAAATTTTA AGGGCAGAAG AAGATGAGTT TATCATCTTG 720

GCTTGTGATG GAATCTGGGA TGTAATGAGC AACGAAGAGC TCTGTGAATT TGTTAAGTCT 780

AGACTTGAAG TATCAGATGA CCTGGAAAAA GTGTGCAATT GGGTAGTGGA CACTTGTTTA 840

CATAAGGGGA GTCGTGATAA CATGAGTATT GTACTAGTTT GTCTTTCAAA TGCTCCTAAG 900

GTCTCAGATG AGGCAGTGAA AAAAGATGCA GAGCTGGATA AGCACTTGGA ATCACGGGTT 960

GAAGAAATTA TGGAGAAATC AGGTGAAGAA GGAATGCCTG ATCTTGCTCA TGTTATTCGT 1020

ATTTTATCTG CGGAGAATAT TCCTAATTTA CCACCAGGAG GTGGTTTAGC TGGCAAGCGT 1080

AATATTATTG AAGCTGTGTA CAGTAGACTG AATCCACACA GAGAGACTGA GGGGGGTGCT 1140

GGAGATCTAG AAGATCCGTG G 1161

Domain Profile

S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61

         ++g++s++g+r emeda+t++ ++    + +d ++ff+vyDGh+gs+va++cs++l e++

Q: 23    RYGLSSMQGWRVEMEDAHTAVVGIPH--GLED-WSFFAVYDGHAGSRVANYCSTHLLEHI  79

         69****************98555444..4434.***************************

S: 62    aeele.........sseseerkvkkalakaFlstdeelkvleeksldidksGstavvali  112

         +++ +         + e++ ++vk+ ++++Fl++de ++++++ ++ +d+sGstav ++i

Q: 80    TNNEDfraaekpgsALEPSVENVKSGIRTGFLKIDEYMRNFSDLRNGMDRSGSTAVGVMI  139

         ***99*********99********************************************

S: 113   kdsklyvanvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdgaRvlGvL  172

         +++++y++n+GdSravL rng+++  ++dHkp +++E+eRi++aggsv+ +   Rv+G+L

Q: 140   SPEHVYFINCGDSRAVLYRNGQVCFSTQDHKPCNPREKERIQNAGGSVMIQ---RVNGSL  196

         ***************************************************...******

S: 173   avsRalGdlylk.........pyvtpePevtshrltsedefliLasDGlwdvvsneeavs  223

         avsRalGd+++k         ++v+pePev ++ + +edef+iLa+DG+wdv+snee+++

Q: 197   AVSRALGDYDYKcvdgkgpteQLVSPEPEVCEILRAEEDEFIILACDGIWDVMSNEELCE  256

         ************************************************************

S: 224   lvrdvlekkeaeqeaakkLvklalargskdnvsaivv  260

         +v+++le +++++++++ +v+++l++gs+dn+s+++v

Q: 257   FVKSRLEVSDDLEKVCNWVVDTCLHKGSRDNMSIVLV  293

         ********************************98875

Domain Sequence
(FASTA)

RYGLSSMQGW RVEMEDAHTA VVGIPHGLED WSFFAVYDGH AGSRVANYCS THLLEHITNN 60

EDFRAAEKPG SALEPSVENV KSGIRTGFLK IDEYMRNFSD LRNGMDRSGS TAVGVMISPE 120

HVYFINCGDS RAVLYRNGQV CFSTQDHKPC NPREKERIQN AGGSVMIQRV NGSLAVSRAL 180

GDYDYKCVDG KGPTEQLVSP EPEVCEILRA EEDEFIILAC DGIWDVMSNE ELCEFVKSRL 240

EVSDDLEKVC NWVVDTCLHK GSRDNMSIVL V 271

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0000287	; F:magnesium ion binding
GO:0030145	; F:manganese ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0035970	; P:peptidyl-threonine dephosphorylation

KEGG

InterPros

IPR001932	; PP2C-like.
IPR012911	; PP2C_C.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481	; PP2C; 1.
PF07830	; PP2C_C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013