EKS-MEG-00265

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MEG-00265

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	311.7	3.1E-93	2	243	242

Status

Unreviewed

Ensembl Protein

ENSMGAP00000010998

UniProt Accession

G1NDQ2;

Protein Name

Protein Synonyms/Alias

Gene Name

SLK

Gene Synonyms/Alias

SLK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000010557	ENSMGAP00000010998	ENSMGAT00000011866

Organism

Meleagris gallopavo

Functional Description

Protein Length

1183

Protein Sequence
(FASTA)

QAQNKETKVL AAAKVIDTKS EEELEDYMVE IDILASCDHP NIVKLLDAFY YENNLWILIE 60

FCAGGAVDAV MLELERPLTE PQIKVVCRQT LEALNYLHEN KIIHRDLKAG NILFTLDGDI 120

KLADFGVSAK NTRTIQRRDS FIGTPYWMAP EVVMCETSKD RPYDYKADIW SLGITLIEMA 180

QIEPPHHELN PMRVLLKIAK SDPPTLAQPS KWSSDFKDFL KKCLEKNVDL RWSATQLLQH 240

PFVTVTSNKP IRELIAEAKA EVTEEVEDGK DEDEEEETDN SLQLPADKRA SSDLSIASSE 300

EDKLSQNASV LESLSEKTES NAIEEKSNTI FPDGKTIEDD SQDIKVRKTA ESIPDVVGGD 360

IKVQNGSVPT AEKNTESPEA TAEDAEPQKG RKELDAVTIS EIKDEHNLKT EKENDIGNEQ 420

REENELKVVP RVDDSVETGE AVSEETGEKE EEIRIDLPES ENEKVTAENI IEQKEDEDEA 480

QKETITDVTT DSVPSAEDKV SDEEKELIKH GIENIKEIGG IAETQISDGD KIPETSDKPV 540

ESQESQDKEI KVEEKLAESE NENICKISSM EEMESKDSGE DDVGQKAKQD KPEEISHKMV 600

DEQTEMDQNP EEHGAENIQE NNIRMGKEQP EVSSDKIMKN KLQDTTSKQA DDSELTPVPS 660

ISISTEENNG KVKIDNQDST ETLQQLESEN LKENDADSGT GSTADNSSID LNLSISSFLS 720

KNKETGSISL QETRRQKKTL KKTRKFVVDG VEVSVTTSKI VTENDSKSEE MRFLRRQELR 780

ELRLLQKEEQ RAQQQLSNKL LQQREQMYRR FEQEMTSKKR QYDQEIENLE KQQKQTIERL 840

EQEHTNRLRD EAKRIKAEQE KELSKFQNML KNKKKEVFCE VEKAPKELRK ELLKRKKEEL 900

AQSQHAQEQE FVQKQQQELD ASLKKIIQQQ KTELATIERD CLNSKQQLMR AREAAIWELE 960

ERHLQEKHQL LKQQLKDQYF MQRHQLLKRH EKETEQMQRY NQRLIEELKN KQTQERARLP 1020

KIQRSEAKTR MAMFKKSLRI NSLASPDQDR EKIKQFAIQE EKRQKNERLA QHQKHENQMR 1080

DLQLQCEANI RELHQLQNEK CHLLVEHETQ KLKELDEEHS QELKEWREKL RPRKKTLEEE 1140

FARKLQEQEV FFKMTGESEC LNPSTQSRIS KFYPIPSLHS TGS 1183

Nucleotide Sequence
(FASTA)

CAGGCTCAGA ACAAAGAAAC GAAAGTGCTG GCTGCTGCAA AGGTGATTGA TACAAAATCA 60

GAAGAAGAGC TTGAAGATTA CATGGTAGAG ATCGATATTT TGGCATCCTG TGACCATCCT 120

AACATTGTTA AGCTCCTAGA TGCCTTCTAC TATGAAAACA ATCTGTGGAT CCTGATCGAA 180

TTTTGTGCAG GTGGAGCAGT AGATGCAGTA ATGTTGGAGC TTGAAAGGCC ATTAACAGAG 240

CCGCAGATCA AAGTGGTGTG CAGGCAGACA CTGGAAGCGT TGAACTACTT GCATGAAAAT 300

AAGATCATCC ACAGAGATCT AAAAGCTGGC AATATTCTTT TCACATTGGA TGGAGACATT 360

AAACTAGCGG ATTTCGGAGT ATCAGCTAAG AACACAAGAA CCATACAAAG AAGAGATTCT 420

TTTATCGGAA CACCATACTG GATGGCTCCA GAAGTAGTAA TGTGTGAGAC ATCTAAAGAC 480

AGGCCTTACG ATTACAAGGC TGACATTTGG TCTCTTGGCA TTACTTTAAT TGAAATGGCT 540

CAAATAGAGC CACCTCACCA TGAATTGAAT CCAATGCGAG TGCTCCTGAA AATAGCAAAA 600

TCTGATCCAC CTACATTAGC ACAGCCTTCT AAATGGTCAT CGGATTTTAA AGACTTTCTG 660

AAGAAATGTT TGGAAAAGAA TGTAGATTTG AGGTGGAGTG CAACCCAACT CCTACAGCAT 720

CCATTTGTTA CTGTTACTTC CAATAAGCCA ATAAGAGAAT TGATTGCAGA AGCTAAGGCA 780

GAAGTTACGG AAGAAGTGGA AGATGGTAAA GATGAGGATG AAGAAGAGGA AACAGACAAT 840

TCTCTGCAGT TACCTGCAGA CAAGCGTGCA TCTTCTGACC TTAGTATTGC CAGCTCTGAA 900

GAGGATAAGC TCTCACAGAA TGCCTCTGTT CTGGAATCAC TTTCTGAGAA AACAGAAAGT 960

AATGCAATTG AGGAGAAAAG CAACACTATA TTTCCAGATG GTAAAACAAT TGAAGATGAC 1020

TCTCAGGACA TTAAAGTTAG GAAAACAGCT GAAAGCATAC CTGATGTTGT TGGTGGTGAT 1080

ATCAAAGTGC AGAATGGTTC TGTGCCAACT GCTGAAAAGA ATACAGAAAG TCCGGAAGCA 1140

ACAGCTGAAG ATGCAGAACC TCAGAAAGGA AGGAAAGAAC TTGATGCAGT AACAATATCA 1200

GAAATAAAGG ATGAACACAA CTTAAAAACG GAGAAAGAAA ATGACATAGG AAATGAACAA 1260

AGAGAGGAAA ATGAACTGAA AGTAGTTCCT AGAGTTGATG ACAGTGTAGA AACTGGAGAA 1320

GCCGTTTCTG AGGAAACTGG TGAAAAAGAA GAGGAAATCA GAATAGATCT CCCAGAGAGT 1380

GAAAATGAAA AGGTCACTGC AGAAAATATC ATAGAGCAAA AGGAAGATGA AGACGAAGCT 1440

CAGAAAGAGA CAATAACAGA TGTCACTACA GACTCTGTAC CTAGTGCTGA GGATAAAGTG 1500

TCAGATGAAG AAAAGGAACT CATAAAGCAT GGAATTGAAA ACATTAAGGA GATAGGTGGT 1560

ATTGCTGAAA CACAGATCAG CGATGGGGAT AAAATACCTG AGACGTCGGA TAAGCCAGTG 1620

GAAAGTCAGG AAAGCCAAGA TAAAGAGATC AAAGTGGAGG AGAAGCTGGC AGAAAGTGAA 1680

AATGAGAATA TCTGTAAAAT AAGTAGCATG GAGGAAATGG AGAGCAAAGA CTCTGGAGAA 1740

GATGATGTAG GCCAGAAGGC AAAACAGGAC AAGCCTGAGG AGATTTCTCA TAAAATGGTG 1800

GATGAACAGA CTGAGATGGA CCAGAATCCA GAAGAGCACG GAGCTGAGAA TATCCAGGAA 1860

AACAATATCC GAATGGGCAA AGAGCAACCA GAAGTTTCTT CTGATAAAAT AATGAAGAAC 1920

AAGCTTCAAG ACACTACCAG CAAACAAGCT GATGACTCTG AACTCACTCC AGTTCCCAGT 1980

ATTAGTATTA GCACTGAAGA AAATAATGGG AAGGTCAAAA TAGATAATCA AGACAGTACT 2040

GAAACGTTAC AGCAGCTAGA ATCTGAGAAC CTGAAGGAAA ATGATGCAGA TTCAGGCACG 2100

GGTTCTACTG CAGATAACAG CAGCATTGAT TTGAACTTGT CAATTTCTAG TTTCCTCAGT 2160

AAAAACAAGG AGACAGGATC AATATCTTTA CAGGAAACCA GGAGACAGAA GAAAACTTTA 2220

AAGAAAACTC GGAAGTTTGT TGTTGATGGA GTAGAAGTGA GTGTAACAAC ATCCAAAATA 2280

GTTACTGAAA ATGACTCCAA AAGTGAAGAA ATGAGATTTC TGCGGCGTCA GGAGCTGAGA 2340

GAACTGAGGC TTCTTCAGAA AGAGGAGCAG AGAGCCCAAC AGCAGCTCAG CAATAAGCTC 2400

CTGCAACAGC GGGAACAGAT GTACAGGCGT TTTGAACAGG AAATGACAAG TAAGAAGCGG 2460

CAGTACGACC AAGAAATAGA GAATCTGGAG AAGCAACAGA AGCAGACAAT AGAGCGCTTG 2520

GAGCAGGAGC ACACAAATCG GTTACGAGAT GAAGCGAAGC GCATCAAAGC AGAGCAGGAG 2580

AAAGAGCTGT CCAAATTCCA GAACATGCTG AAGAACAAGA AGAAGGAGGT TTTTTGTGAA 2640

GTGGAGAAAG CACCAAAAGA GCTGAGAAAA GAGCTCCTGA AACGCAAGAA AGAGGAGCTT 2700

GCACAAAGCC AGCATGCTCA GGAGCAGGAG TTTGTACAGA AGCAGCAACA AGAACTGGAT 2760

GCATCTCTGA AGAAAATTAT TCAGCAGCAA AAGACAGAAC TAGCCACTAT TGAACGAGAT 2820

TGCCTCAACA GCAAACAGCA GCTCATGAGA GCTCGCGAAG CTGCCATCTG GGAGCTGGAG 2880

GAGCGACATC TACAAGAGAA ACACCAGCTC CTCAAACAGC AACTGAAGGA TCAGTACTTC 2940

ATGCAGAGGC ATCAGCTGCT TAAGAGGCAT GAAAAGGAAA CAGAACAAAT GCAGAGATAC 3000

AACCAGCGCC TTATTGAAGA GCTAAAGAAC AAGCAAACTC AGGAAAGAGC CAGACTGCCT 3060

AAGATCCAGC GAAGTGAAGC AAAGACTCGA ATGGCTATGT TTAAGAAAAG TTTAAGAATT 3120

AATTCATTAG CCTCTCCAGA TCAAGATCGT GAAAAGATTA AGCAGTTTGC AATCCAAGAA 3180

GAAAAGAGAC AGAAAAATGA GAGACTGGCG CAGCATCAGA AACATGAAAA TCAAATGCGG 3240

GACCTTCAGT TGCAGTGTGA AGCAAACATC AGAGAACTGC ATCAGCTACA GAATGAAAAA 3300

TGCCATCTAC TGGTTGAACA CGAGACTCAG AAGCTCAAAG AACTAGATGA AGAGCACAGC 3360

CAAGAACTGA AGGAATGGAG AGAGAAACTG AGACCAAGAA AAAAGACGCT GGAAGAAGAA 3420

TTTGCCAGAA AACTGCAGGA ACAGGAAGTT TTCTTTAAAA TGACTGGAGA ATCTGAATGC 3480

CTTAACCCTT CAACACAAAG CCGGATTTCC AAATTCTACC CAATCCCCAG CCTTCACTCA 3540

ACTGGGTCGT AA 3552

Domain Profile

S: 18    arekktgelvaikkinlekqekleelqkeisvlkklkhpniveylesflkeeelwlvmey  77

         a++k+t+ l+a k+i+++++e+le+++ ei +l +++hpniv++l++f++e++lw+++e+

Q: 2     AQNKETKVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEF  61

         8999********************************************************

S: 78    lagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkviHrdikakniLlteegeV  137

         +agG+++ ++  el+++l+E qi++++r++l+aL+ylH++k+iHrd+ka+niL+t +g++

Q: 62    CAGGAVDAVML-ELERPLTEPQIKVVCRQTLEALNYLHENKIIHRDLKAGNILFTLDGDI  120

         *********99.9***********************************************

S: 138   kLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe...ekgYdekaDiwslGItaiela  194

         kL+dfgv+a+ ++t ++r++++gtpywmAPEv+ +e   ++ Yd+kaDiwslGIt+ie+a

Q: 121   KLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCEtskDRPYDYKADIWSLGITLIEMA  180

         ***********************************9998999******************

S: 195   egepPfkdleplkallkilkneppklkskkkfskefkefvekclqknpekRpsasellkh  254

         + epP+++l+p+++llki+k++pp+l +++k+s+ fk+f++kcl+kn++ R+sa++ll+h

Q: 181   QIEPPHHELNPMRVLLKIAKSDPPTLAQPSKWSSDFKDFLKKCLEKNVDLRWSATQLLQH  240

         ************************************************************

S: 255   kFl  257

+F+

Q: 241   PFV  243

**7

Domain Sequence
(FASTA)

AQNKETKVLA AAKVIDTKSE EELEDYMVEI DILASCDHPN IVKLLDAFYY ENNLWILIEF 60

CAGGAVDAVM LELERPLTEP QIKVVCRQTL EALNYLHENK IIHRDLKAGN ILFTLDGDIK 120

LADFGVSAKN TRTIQRRDSF IGTPYWMAPE VVMCETSKDR PYDYKADIWS LGITLIEMAQ 180

IEPPHHELNP MRVLLKIAKS DPPTLAQPSK WSSDFKDFLK KCLEKNVDLR WSATQLLQHP 240

FV 242

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0046777	; P:protein autophosphorylation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR022165	; PKK.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR001943	; UVR_dom.

Pfam

PF00069	; Pkinase; 1.
PF12474	; PKK; 2.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50151	; UVR; 1.

Prints

Created Date

20-Feb-2013