EKS-MEG-00224

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MEG-00224

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	389.9	5.5E-117	204	496	293

Status

Unreviewed

Ensembl Protein

ENSMGAP00000017881

UniProt Accession

G1NF73;

Protein Name

Protein Synonyms/Alias

Gene Name

TGFBR2

Gene Synonyms/Alias

TGFBR2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000011137	ENSMGAP00000017881	ENSMGAT00000019617
ENSMGAG00000011137	ENSMGAP00000011643	ENSMGAT00000012522

Organism

Meleagris gallopavo

Functional Description

Protein Length

526

Protein Sequence
(FASTA)

LQLPRLCKFC DIKATTCSNQ YQCKSNCNIT SICEKNNEVC AAVWRRNDEN VTLETICHDP 60

QKRLYGHMLD DSSSEQCVMK EKKDDGGLMF MCSCTGEECN DVLIFSAGYT HDPHKPEEKD 120

EISKVTIISL VPLLVISVAV IVIFYAYRTH KKRKLNKAWE KNVKPRKHKD CSDVCAIMLD 180

DDHSDISSTC ANNINHNTEL LPIELDIVVG KGRFAEVYKA KLKQNTSEQY ETVAVKIFPY 240

EEYASWKTEK DIFSDVNLKH ENILQFLTAE ERKTDLGKQY WLITAFHARG NLQEYLTRHI 300

ISWEDLWKLG GSLARGIAHL HSDHTPCGRP KTPIVHRDLK SSNILVKNDL TCCLCDFGLS 360

LRLDPSLSVD DLANSGQVGT ARYMAPEVLE SRMNLENMES FKQTDVYSMA LVLWEMTSRC 420

NGVGEVKEYE PPFGSKVREH PCVESMKDNV LRDRGRPEIP SSWLNHQGIQ MVCETLIECW 480

DHDPEARLTA QCVAERFSEF KHHDKLSGRS CSEEKIPEDG SVTTAK 526

Nucleotide Sequence
(FASTA)

CTGCAATTGC CCAGGCTGTG CAAATTCTGT GACATTAAAG CAACGACGTG CTCAAACCAG 60

TATCAGTGCA AGAGCAACTG CAACATCACT TCTATCTGTG AGAAGAATAA CGAAGTCTGT 120

GCGGCTGTAT GGAGACGGAA CGATGAAAAT GTGACATTAG AAACAATCTG CCACGATCCC 180

CAGAAAAGAC TGTATGGTCA CATGTTGGAT GACTCCAGCT CAGAGCAGTG TGTGATGAAG 240

GAGAAGAAGG ATGATGGGGG ACTGATGTTC ATGTGCTCCT GTACAGGTGA AGAGTGCAAC 300

GATGTTCTTA TTTTTTCTGC AGGATATACA CATGATCCCC ATAAGCCAGA GGAGAAAGAT 360

GAAATTTCCA AAGTCACAAT CATAAGTCTT GTCCCCTTGT TGGTGATTTC TGTTGCTGTG 420

ATTGTTATCT TTTATGCCTA CCGCACTCAT AAGAAGAGGA AGCTCAACAA GGCCTGGGAG 480

AAGAATGTTA AGCCCAGGAA ACATAAAGAC TGCAGTGATG TTTGTGCCAT TATGTTGGAT 540

GATGATCACT CAGACATCAG CTCTACCTGT GCCAACAACA TCAACCACAA CACAGAATTG 600

CTGCCCATTG AGCTGGACAT TGTTGTTGGC AAAGGAAGAT TTGCTGAAGT GTATAAAGCA 660

AAATTGAAGC AAAACACATC TGAGCAGTAT GAAACTGTGG CAGTAAAGAT CTTCCCCTAT 720

GAAGAATATG CCTCCTGGAA AACCGAGAAA GACATTTTTT CGGATGTAAA CCTTAAGCAT 780

GAGAACATCC TCCAATTCTT GACTGCAGAG GAGCGTAAGA CAGATCTTGG TAAACAGTAT 840

TGGTTGATCA CTGCCTTCCA TGCTAGGGGA AACTTGCAGG AATACCTCAC ACGGCACATT 900

ATCAGCTGGG AAGACCTCTG GAAACTGGGA GGATCCTTGG CCCGAGGGAT TGCCCATCTG 960

CACAGTGATC ACACACCCTG TGGTCGTCCT AAAACCCCTA TTGTGCACAG AGACCTAAAG 1020

AGTTCCAACA TCCTGGTGAA AAATGATTTA ACTTGCTGTC TCTGTGACTT TGGGTTATCC 1080

CTCAGGCTGG ACCCTTCTCT CTCTGTGGAT GACTTGGCCA ACAGCGGTCA GGTTGGCACA 1140

GCAAGGTACA TGGCCCCTGA GGTCCTGGAG TCCAGGATGA ACCTTGAGAA CATGGAGTCC 1200

TTTAAACAAA CAGATGTGTA CTCCATGGCT TTGGTCCTTT GGGAAATGAC ATCTCGCTGT 1260

AATGGTGTTG GAGAAGTGAA AGAGTATGAG CCTCCCTTCG GCTCTAAAGT GCGGGAACAT 1320

CCCTGCGTGG AAAGCATGAA GGACAATGTC CTAAGAGACA GAGGGCGACC TGAGATCCCC 1380

AGCTCCTGGC TTAACCATCA GGGCATCCAG ATGGTGTGTG AGACCCTTAT CGAGTGCTGG 1440

GACCACGACC CCGAGGCTCG GCTCACGGCG CAGTGCGTGG CGGAGCGCTT CAGTGAGTTC 1500

AAGCACCACG ACAAGCTCTC AGGGAGAAGC TGTTCAGAGG AGAAGATCCC CGAGGACGGC 1560

TCCGTGACCA CTGCCAAGTA G 1581

Domain Profile

S: 2     klleligkGrygeVwkaklrg......eevAvKifstedeaswkrEkeiyqtvllrheni  55

         +l  ++gkGr++eV+kakl++      e+vAvKif++e+ aswk+Ek+i++ v+l+heni

Q: 204   ELDIVVGKGRFAEVYKAKLKQntseqyETVAVKIFPYEEYASWKTEKDIFSDVNLKHENI  263

         67779***************99999999********************************

S: 56    lqfiaadkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHee  115

         lqf++a+++++d+ ++++l+t++h +g+L++yL+r+++++e+l +l  sla+G+ahLH++

Q: 264   LQFLTAEERKTDLGKQYWLITAFHARGNLQEYLTRHIISWEDLWKLGGSLARGIAHLHSD  323

         ************************************************************

S: 116   ivgtkgkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkR  175

          ++ +g+ K  i+HRDlks Nilvk+dltcc++D+GL+l+l+ + ++ dla++ qvGt R

Q: 324   -HTPCGRPKTPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPSLSVDDLANSGQVGTAR  382

         .8999*******************************************************

S: 176   YmaPEvleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdP  235

         YmaPEvle+++nl+++e+fk++DvYs++LvlWE++sRc+   +ev+ey++pf ++v+++P

Q: 383   YMAPEVLESRMNLENMESFKQTDVYSMALVLWEMTSRCNG-VGEVKEYEPPFGSKVREHP  441

         ****************************************.999****************

S: 236   sleemkevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkr  290

         ++e+mk+ v++++ rP+ip++w +++ +++++++l ecWd+dpeaRlta++v++r

Q: 442   CVESMKDNVLRDRGRPEIPSSWLNHQGIQMVCETLIECWDHDPEARLTAQCVAER  496

         ****************************************************987

Domain Sequence
(FASTA)

ELDIVVGKGR FAEVYKAKLK QNTSEQYETV AVKIFPYEEY ASWKTEKDIF SDVNLKHENI 60

LQFLTAEERK TDLGKQYWLI TAFHARGNLQ EYLTRHIISW EDLWKLGGSL ARGIAHLHSD 120

HTPCGRPKTP IVHRDLKSSN ILVKNDLTCC LCDFGLSLRL DPSLSVDDLA NSGQVGTARY 180

MAPEVLESRM NLENMESFKQ TDVYSMALVL WEMTSRCNGV GEVKEYEPPF GSKVREHPCV 240

ESMKDNVLRD RGRPEIPSSW LNHQGIQMVC ETLIECWDHD PEARLTAQCV AER 293

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005901	; C:caveola
GO:0009897	; C:external side of plasma membrane
GO:0016021	; C:integral to membrane
GO:0043235	; C:receptor complex
GO:0005524	; F:ATP binding
GO:0005539	; F:glycosaminoglycan binding
GO:0046872	; F:metal ion binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005026	; F:transforming growth factor beta receptor activity, type II
GO:0032147	; P:activation of protein kinase activity
GO:0006915	; P:apoptotic process
GO:0060389	; P:pathway-restricted SMAD protein phosphorylation
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0018107	; P:peptidyl-threonine phosphorylation
GO:0002663	; P:positive regulation of B cell tolerance induction
GO:0010634	; P:positive regulation of epithelial cell migration
GO:0002053	; P:positive regulation of mesenchymal cell proliferation
GO:0051138	; P:positive regulation of NK T cell differentiation
GO:2000379	; P:positive regulation of reactive oxygen species metabolic process
GO:0002666	; P:positive regulation of T cell tolerance induction
GO:0002651	; P:positive regulation of tolerance induction to self antigen
GO:0070723	; P:response to cholesterol
GO:0042493	; P:response to drug
GO:0023014	; P:signal transduction by phosphorylation
GO:0007224	; P:smoothened signaling pathway
GO:0007179	; P:transforming growth factor beta receptor signaling pathway

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR017194	; Transform_growth_fac-b_typ-2.
IPR015013	; Transforming_GF_b_rcpt_2_ecto.

Pfam

PF08917	; ecTbetaR2; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013