EKS-MEG-00249
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MEG-00249
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Alk517.07.8E-156563832270
StatusUnreviewed
Ensembl ProteinENSMGAP00000018551
UniProt AccessionG1NFE1;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NameLOC100542012
Gene Synonyms/Alias LOC100542012;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMGAG00000011216ENSMGAP00000018551ENSMGAT00000020947
ENSMGAG00000011216ENSMGAP00000011717ENSMGAT00000012598
OrganismMeleagris gallopavo
Functional Description
Protein Length1081
Protein Sequence
(FASTA)
QIQFSVHVFG NYNGTISFSV REEKNGVQVT LPMWERAGSW SDHWFLITLP MPALQNRFQL 60
QLLATWGWNS RADIAIDNIT FGMNCFVDGE VNFIFHTGLG MEREVEPISK EALRDTSVVL 120
WWFSTCGASG PHGPTQAQCD NAYRGSNVSV IVVKEGRLRG VQVWRVPATN RYRISAYGAA 180
GGKGAKNHNE RSHGVFISAT FQLEKDELLY ILVGHQGEDA CPGANPQTQK ICLGESSVIE 240
EDYKKKRNLK DWAGGGGGGG GATYIFRQKD GIFEPLLIAA GGGGKAYLKA QDNSLDDIPL 300
EQFENSTAVP GVSGRTGAAG GGGGWQDVTL LPQAGKSLLE GGEGGQACHQ ALAKLQWATS 360
GGFGGGGGAC TSGGGGGGYR GGHASNNDDI TASGQYGISF VNPIGEIFLH PLAAVENDGE 420
VEVQIYLNCS HCHSDNCKRD PDTNLPVCQC EMGAVLANDN VTCTAVPQGH IPEGHLPLPL 480
LLAVVAVIVM LGMILTGGSL SITPVYHLKK QQLEGARARL QSPEYKLSKI RTSAIMTDYN 540
PNYCFAGKAA TLSELKEIPR KNISLLRALG HGAFGEVYEG TVVGIAGDPN PLQVAIKTLP 600
EVCSEQDEMD FLMEALIISK FNHQNIVQCI GVSLQTLPRF ILLELMAGGD MKSFLRQNRP 660
RVNQPSTLTM QDLLNIARDI ACGCKYLEEN HFIHRDIAAR NCLLTCAGAG RIAKIGDFGM 720
ARDIYRASYY RKGGRAMLPV KWMPPEAFLE GIFTSKTDTW SFGVLLWEIF SLGYMPYPCK 780
TNQEVLEFVT SGGRMDPPKN CPGPVYRIMT QCWQHSPEYR PNFSTILERI KYCTQDPDVI 840
NTELPMECSP APEDEGNTVV RPNVSSGIVP LLVSPSLTPQ MTPKTLDSHR PGQKLVQCPQ 900
ELLVENLSNR AARGPSLPCL SDFSASWNNP PTHRLKNKTK NLWNPTYGSW VLENMCHLSP 960
TSKLKATPER EDSGFDGNCS SSPSSRASPA SPSRSNCPHL DIGGIELVKL QTFPCGNVNY 1020
AYDDLCYGTD HPPSVLTGVR AAVLRSSSLH TDEKPFYKTD KAARERDSGL SLSDDLSVTP 1080
V 1081
Nucleotide Sequence
(FASTA)
CAGATCCAAT TCTCAGTGCA TGTTTTTGGC AACTACAATG GTACCATCTC CTTCTCTGTC 60
AGGGAAGAAA AAAATGGAGT TCAGGTTACC TTGCCAATGT GGGAAAGAGC AGGGAGCTGG 120
AGTGATCATT GGTTTCTCAT CACTTTACCA ATGCCAGCTC TTCAGAACAG GTTTCAACTG 180
CAACTCCTGG CAACCTGGGG TTGGAATTCC CGAGCTGACA TTGCTATCGA CAATATTACA 240
TTTGGAATGA ACTGCTTTGT TGATGGGGAG GTTAATTTCA TTTTTCACAC AGGGTTGGGG 300
ATGGAGAGAG AAGTGGAGCC CATAAGTAAA GAAGCTTTAA GGGATACGTC CGTTGTTCTT 360
TGGTGGTTCT CAACATGTGG TGCCAGTGGT CCACATGGGC CAACTCAGGC TCAGTGTGAC 420
AATGCCTACA GGGGCAGCAA TGTGTCGGTG ATTGTGGTGA AGGAGGGAAG GCTCCGAGGA 480
GTGCAAGTCT GGAGAGTGCC AGCCACAAAC CGATACAGAA TTTCTGCATA TGGAGCAGCT 540
GGAGGAAAGG GAGCCAAAAA CCACAATGAG AGGTCCCACG GGGTCTTCAT CTCAGCCACC 600
TTCCAGCTGG AGAAAGATGA GCTGCTGTAC ATCTTAGTGG GGCACCAGGG GGAGGATGCC 660
TGCCCTGGGG CCAATCCTCA GACCCAGAAG ATCTGCTTAG GGGAGTCATC TGTCATTGAA 720
GAAGATTACA AAAAAAAAAG GAACCTGAAG GACTGGGCTG GAGGAGGTGG GGGTGGAGGA 780
GGAGCAACCT ACATCTTTAG ACAGAAGGAT GGGATTTTCG AACCTTTGCT CATCGCAGCA 840
GGAGGAGGAG GAAAAGCCTA TCTGAAGGCT CAGGACAACT CCCTGGATGA CATACCCCTG 900
GAGCAATTTG AGAACAGCAC TGCAGTACCG GGAGTCAGTG GAAGAACTGG GGCAGCAGGT 960
GGAGGTGGTG GCTGGCAAGA TGTGACTCTG CTTCCTCAAG CTGGGAAGTC CCTCTTGGAA 1020
GGTGGAGAAG GGGGTCAAGC TTGTCATCAA GCATTAGCCA AGCTCCAGTG GGCTACCTCT 1080
GGTGGTTTTG GTGGTGGAGG AGGAGCTTGT ACTTCTGGTG GAGGAGGTGG AGGTTACAGA 1140
GGGGGGCATG CCTCTAATAA TGATGATATC ACAGCTAGTG GGCAGTATGG CATCTCGTTT 1200
GTGAATCCCA TTGGAGAGAT CTTCTTGCAT CCCCTTGCAG CTGTGGAGAA TGATGGTGAA 1260
GTGGAGGTTC AGATCTATCT TAACTGTAGC CACTGCCACT CAGACAACTG TAAGAGAGAC 1320
CCTGACACCA ACCTGCCTGT CTGCCAATGT GAGATGGGGG CTGTGCTAGC CAATGACAAT 1380
GTCACCTGCA CTGCAGTGCC ACAGGGTCAT ATCCCAGAGG GACATCTGCC TCTCCCACTC 1440
CTCCTAGCTG TGGTGGCTGT GATTGTGATG CTCGGAATGA TCCTCACTGG TGGCAGCCTA 1500
TCTATCACCC CAGTTTATCA CCTGAAGAAG CAGCAACTGG AAGGGGCCAG AGCACGACTG 1560
CAGAGCCCGG AATATAAACT GAGTAAAATC CGCACATCAG CCATCATGAC AGATTACAAC 1620
CCCAACTACT GCTTTGCTGG GAAGGCTGCA ACTCTGAGTG AGCTGAAGGA GATCCCACGG 1680
AAGAACATCT CTCTGCTTCG GGCACTAGGA CATGGTGCGT TTGGTGAGGT TTATGAAGGA 1740
ACAGTGGTAG GCATTGCAGG GGATCCCAAT CCTCTCCAGG TGGCTATTAA GACACTGCCA 1800
GAAGTCTGCT CCGAGCAAGA TGAGATGGAT TTCCTGATGG AAGCACTGAT TATCAGTAAG 1860
TTCAATCATC AAAATATTGT GCAGTGCATT GGTGTTAGCC TGCAGACGCT GCCTCGCTTC 1920
ATTCTGCTTG AGCTCATGGC TGGAGGAGAT ATGAAGAGTT TTCTTCGACA GAATCGACCC 1980
AGAGTGAATC AGCCATCCAC ACTAACAATG CAGGACCTGC TGAACATAGC TCGGGATATC 2040
GCCTGTGGCT GTAAATATCT GGAAGAGAAT CATTTCATAC ACAGAGATAT AGCTGCACGG 2100
AATTGCCTTT TGACCTGTGC TGGAGCAGGT CGAATAGCCA AAATCGGTGA CTTTGGGATG 2160
GCCAGAGATA TCTACAGAGC AAGTTACTAT CGCAAGGGAG GAAGAGCCAT GCTTCCTGTC 2220
AAGTGGATGC CGCCAGAAGC TTTTCTAGAA GGCATTTTTA CCTCCAAAAC TGATACCTGG 2280
TCCTTTGGTG TTCTTCTCTG GGAGATTTTT TCTCTGGGCT ACATGCCCTA TCCCTGCAAA 2340
ACTAATCAGG AAGTGCTGGA ATTTGTCACC AGTGGAGGAA GAATGGACCC CCCAAAGAAC 2400
TGTCCAGGGC CTGTGTACCG CATCATGACG CAGTGCTGGC AGCACAGCCC AGAATACCGG 2460
CCAAACTTCT CTACCATCCT GGAAAGAATC AAGTACTGCA CGCAGGACCC TGATGTGATC 2520
AACACAGAGT TGCCCATGGA GTGTAGCCCA GCACCAGAGG ATGAAGGGAA CACGGTTGTG 2580
CGCCCAAATG TTTCCAGTGG GATAGTGCCC CTGTTGGTGA GCCCTTCTCT TACACCTCAG 2640
ATGACACCTA AAACCCTGGA TTCCCACCGT CCTGGGCAAA AACTCGTACA ATGTCCACAA 2700
GAGCTACTGG TGGAGAACCT CAGCAATCGG GCTGCTCGAG GGCCCAGCCT GCCATGCCTC 2760
AGCGATTTCA GCGCATCCTG GAACAATCCA CCAACCCACA GACTGAAGAA CAAAACTAAA 2820
AACCTTTGGA ATCCAACCTA TGGATCATGG GTGCTAGAGA ACATGTGTCA CTTAAGCCCC 2880
ACCTCCAAAC TGAAAGCAAC TCCAGAGCGA GAAGATTCAG GCTTTGATGG AAATTGCAGT 2940
TCTTCTCCTA GTTCTCGGGC ATCTCCAGCA TCTCCAAGTC GAAGCAACTG CCCTCACTTA 3000
GATATTGGTG GGATCGAACT GGTGAAACTC CAGACTTTCC CCTGTGGTAA TGTAAATTAT 3060
GCATATGATG ATCTGTGCTA TGGCACTGAT CACCCACCAT CAGTTTTGAC AGGGGTCAGA 3120
GCAGCTGTGC TAAGGAGCTC CAGTCTGCAT ACAGATGAGA AACCTTTTTA TAAAACAGAT 3180
AAAGCAGCAA GAGAGAGGGA CTCTGGTCTG TCTTTGTCAG ATGATCTGAG TGTTACACCA 3240
GTATAA 3246
Domain Profile
S: 1     ielvralGkGafGevyeglvsglpgdasklavavktlpesaseqdeldflkealiiskfn  60
         i l+ralG+GafGevyeg v g+ gd+ +l+va+ktlpe++seqde+dfl+ealiiskfn
Q: 563   ISLLRALGHGAFGEVYEGTVVGIAGDPNPLQVAIKTLPEVCSEQDEMDFLMEALIISKFN  622
         6799********************************************************
S: 61    henivrliGvsleklprlillellaGGdlksflresrpkpeqlsslamkdllkvaldvak  120
         h+niv++iGvsl++lpr+illel+aGGd+ksflr++rp+ +q+s+l+m+dll++a+d+a+
Q: 623   HQNIVQCIGVSLQTLPRFILLELMAGGDMKSFLRQNRPRVNQPSTLTMQDLLNIARDIAC  682
         ************************************************************
S: 121   GckyleenkfihrdiaarnillsskGpsrvakiadfGmardiyraeyyrkggrallpvkw  180
         Gckyleen+fihrdiaarn+ll+++G++r+aki+dfGmardiyra+yyrkggra+lpvkw
Q: 683   GCKYLEENHFIHRDIAARNCLLTCAGAGRIAKIGDFGMARDIYRASYYRKGGRAMLPVKW  742
         ************************************************************
S: 181   mppeafleGiftsktdvwsfGvllwevfslGvvpypgksnqevlelvveGgrldspkeip  240
         mppeafleGiftsktd+wsfGvllwe+fslG++pyp k+nqevle+v++Ggr+d+pk++p
Q: 743   MPPEAFLEGIFTSKTDTWSFGVLLWEIFSLGYMPYPCKTNQEVLEFVTSGGRMDPPKNCP  802
         ************************************************************
S: 241   gsvyrimtdcwkhepedrpkfvsilerlqa  270
         g+vyrimt+cw+h+pe rp+f +iler+++
Q: 803   GPVYRIMTQCWQHSPEYRPNFSTILERIKY  832
         ***************************986
Domain Sequence
(FASTA)
ISLLRALGHG AFGEVYEGTV VGIAGDPNPL QVAIKTLPEV CSEQDEMDFL MEALIISKFN 60
HQNIVQCIGV SLQTLPRFIL LELMAGGDMK SFLRQNRPRV NQPSTLTMQD LLNIARDIAC 120
GCKYLEENHF IHRDIAARNC LLTCAGAGRI AKIGDFGMAR DIYRASYYRK GGRAMLPVKW 180
MPPEAFLEGI FTSKTDTWSF GVLLWEIFSL GYMPYPCKTN QEVLEFVTSG GRMDPPKNCP 240
GPVYRIMTQC WQHSPEYRPN FSTILERIKY 270
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Danio rerio"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Latimeria chalumnae"; ?>Macropus eugenii"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-ANC-00293
EKS-DAR-00653
EKS-GAG-00254
EKS-GAA-00375
EKS-LAC-00314
EKS-MAE-00034
EKS-ORN-00393
EKS-ORL-00363
EKS-PAT-00291
EKS-PES-00269
EKS-PEM-00167
EKS-PTV-00067
EKS-SAH-00288
EKS-TAG-00317
EKS-TAR-00396
EKS-XET-00374
EKS-XIM-00391
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0000187; P:activation of MAPK activity
GO:0006915; P:apoptotic process
GO:0008283; P:cell proliferation
GO:0071300; P:cellular response to retinoic acid
GO:0048666; P:neuron development
GO:0014065; P:phosphatidylinositol 3-kinase cascade
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR026830; ALK.
IPR008985; ConA-like_lec_gl_sf.
IPR011009; Kinase-like_dom.
IPR000998; MAM_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR002011; Tyr_kinase_rcpt_2_CS.
Pfam
PF00629; MAM; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00219; TyrKc; 1.
Prosites
PS50060; MAM_2; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00239; RECEPTOR_TYR_KIN_II; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013