EPS-MEG-00072

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-MEG-00072

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPP/PP2B	436.1	1.4E-131	65	265	201

Status

Unreviewed

Ensembl Protein

ENSMGAP00000019807

UniProt Accession

G1NFJ1;

Protein Name

Serine/threonine-protein phosphatase

Protein Synonyms/Alias

Gene Name

PPP3CA

Gene Synonyms/Alias

PPP3CA;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000011269	ENSMGAP00000019807	ENSMGAT00000018469
ENSMGAG00000011269	ENSMGAP00000011783	ENSMGAT00000012664

Organism

Meleagris gallopavo

Functional Description

Protein Length

491

Protein Sequence
(FASTA)

AVPFPPSHRL TAKEVFDNDG KPRVDILKAH LMKEGRLEES VALRIITEGA SILRQEKNLL 60

DIDAPVTVCG DIHGQFFDLM KLFEVGGSPA NTRYLFLGDY VDRGYFSIEC VLYLWALKIL 120

YPKTLFLLRG NHECRHLTEY FTFKQECKIK YSERVYDACM DAFDCLPLAA LMNQQFLCVH 180

GGLSPEINTL DDIRKLDRFK EPPAYGPMCD ILWSDPLEDF GNEKTQEHFT HNTVRGCSYF 240

YSYPAVCEFL QHNNLLSILR AHEAQDAGYR MYRKSQTTGF PSLITIFSAP NYLDVYNNKA 300

AVLKYENNVM NIRQFNCSPH PYWLPNFMDV FTWSLPFVGE KVTEMLVNVL NICSDDELGT 360

EEDGFDGATA AARKEVIRNK IRAIGKMARV FSVLREESES VLTLKGLTPT GMLPSGVLSG 420

GKQTLQSAIK GFSPQHKITS FEEAKGLDRI NERMPPRRDV PSDANLNSIN KAISTETNGT 480

DSNGSNSSNI Q 491

Nucleotide Sequence
(FASTA)

GCTGTCCCAT TTCCTCCAAG TCACCGGCTC ACAGCTAAGG AAGTGTTTGA TAATGATGGC 60

AAGCCACGTG TGGATATCTT AAAGGCACAC CTTATGAAAG AAGGGAGACT GGAAGAAAGT 120

GTGGCATTGA GAATAATAAC AGAGGGAGCT TCAATTCTTC GTCAAGAAAA AAATTTGCTG 180

GACATAGATG CACCAGTCAC AGTTTGTGGA GACATCCATG GCCAATTCTT TGACTTGATG 240

AAACTGTTTG AAGTGGGAGG TTCTCCTGCC AATACACGGT ATCTCTTCCT GGGGGACTAC 300

GTGGATAGAG GGTACTTCAG CATTGAATGT GTGCTGTACT TGTGGGCCTT GAAAATCCTT 360

TACCCCAAAA CACTGTTTTT ACTTCGTGGG AATCATGAAT GTAGACATTT AACAGAGTAT 420

TTCACATTTA AGCAAGAATG TAAAATCAAA TATTCAGAAC GAGTATATGA TGCCTGCATG 480

GATGCCTTTG ACTGCCTTCC CTTGGCAGCT CTGATGAATC AACAGTTCCT GTGTGTACAT 540

GGTGGCTTGT CTCCAGAGAT CAACACCCTA GATGACATCA GAAAATTAGA TCGATTCAAG 600

GAACCACCTG CATATGGACC TATGTGTGAC ATCCTCTGGT CAGATCCATT GGAGGACTTT 660

GGAAATGAGA AGACTCAGGA ACACTTCACT CACAACACAG TCAGGGGATG CTCGTACTTC 720

TACAGTTACC CTGCTGTGTG TGAATTCCTA CAGCACAATA ACTTGTTATC TATACTTCGA 780

GCTCATGAAG CCCAGGATGC TGGGTATCGC ATGTACAGGA AAAGCCAAAC AACAGGCTTC 840

CCTTCACTAA TCACAATTTT TTCAGCACCA AACTATCTAG ATGTATACAA TAACAAAGCT 900

GCAGTATTGA AATATGAGAA CAACGTTATG AATATCAGGC AGTTCAACTG CTCCCCTCAT 960

CCTTACTGGC TTCCAAATTT CATGGATGTG TTTACCTGGT CCTTGCCATT TGTGGGTGAG 1020

AAGGTGACAG AGATGCTGGT GAATGTGCTG AACATCTGCT CGGATGATGA ATTAGGAACA 1080

GAAGAAGATG GTTTTGATGG AGCAACAGCT GCTGCTCGAA AGGAGGTTAT AAGAAACAAG 1140

ATAAGAGCAA TAGGAAAAAT GGCTAGAGTT TTCTCAGTGC TAAGGGAGGA GAGTGAAAGT 1200

GTGCTGACAC TGAAAGGGCT GACTCCCACA GGAATGCTGC CCAGTGGTGT GCTTTCTGGA 1260

GGAAAACAAA CACTGCAAAG CGCTATCAAA GGATTTTCAC CCCAGCATAA GATCACTAGC 1320

TTCGAAGAGG CCAAAGGCTT AGATCGAATT AATGAGCGAA TGCCTCCGCG CAGAGATGTG 1380

CCATCTGATG CCAACCTTAA CTCCATCAAC AAGGCAATCT CCACAGAGAC TAATGGCACT 1440

GACAGCAACG GCAGTAATAG CAGCAATATT CAGTGA 1476

Domain Profile

S: 1     pvtvcgdihgqffdllklfevggspantrylflgdyvdrgyfsiecvlylyalkilypkt  60

         pvtvcgdihgqffdl+klfevggspantrylflgdyvdrgyfsiecvlyl+alkilypkt

Q: 65    PVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWALKILYPKT  124

         9***********************************************************

S: 61    lfllrgnhecrhlteyftfkqelkikyservydacleafdalplaallnqqflcvhggls  120

         lfllrgnhecrhlteyftfkqe+kikyservydac++afd+lplaal+nqqflcvhggls

Q: 125   LFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLS  184

         ************************************************************

S: 121   pelktlddirkldrfkeppayglmcdllwsdpledfgnekseeefvhnsvrgcsyfysyk  180

         pe++tlddirkldrfkeppayg+mcd+lwsdpledfgnek++e+f+hn+vrgcsyfysy+

Q: 185   PEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFGNEKTQEHFTHNTVRGCSYFYSYP  244

         ************************************************************

S: 181   avceflqennllsiiraheaq  201

         avceflq+nnllsi+raheaq

Q: 245   AVCEFLQHNNLLSILRAHEAQ  265

         ********************8

Domain Sequence
(FASTA)

PVTVCGDIHG QFFDLMKLFE VGGSPANTRY LFLGDYVDRG YFSIECVLYL WALKILYPKT 60

LFLLRGNHEC RHLTEYFTFK QECKIKYSER VYDACMDAFD CLPLAALMNQ QFLCVHGGLS 120

PEINTLDDIR KLDRFKEPPA YGPMCDILWS DPLEDFGNEK TQEHFTHNTV RGCSYFYSYP 180

AVCEFLQHNN LLSILRAHEA Q 201

Keyword

Complete proteome; Hydrolase; Iron; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005955	; C:calcineurin complex
GO:0005829	; C:cytosol
GO:0005739	; C:mitochondrion
GO:0005634	; C:nucleus
GO:0030018	; C:Z disc
GO:0033192	; F:calmodulin-dependent protein phosphatase activity
GO:0008144	; F:drug binding
GO:0033173	; P:calcineurin-NFAT signaling cascade
GO:0006816	; P:calcium ion transport
GO:0035690	; P:cellular response to drug
GO:0000082	; P:G1/S transition of mitotic cell cycle
GO:0045944	; P:positive regulation of transcription from RNA polymerase II promoter
GO:0006470	; P:protein dephosphorylation
GO:0006606	; P:protein import into nucleus
GO:0050804	; P:regulation of synaptic transmission
GO:0051592	; P:response to calcium ion
GO:0006950	; P:response to stress
GO:0014883	; P:transition between fast and slow fiber

KEGG

InterPros

IPR004843	; Metallo_PEstase_dom.
IPR006186	; Ser/Thr-sp_prot-phosphatase.

Pfam

PF00149

; Metallophos; 1.

SMARTs

SM00156

; PP2Ac; 1.

Prosites

PS00125

; SER_THR_PHOSPHATASE; 1.

Prints

PR00114

; STPHPHTASE.

Created Date

20-Feb-2013