EKS-MEG-00115
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MEG-00115
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/FGFR557.04.7E-168169445277
StatusUnreviewed
Ensembl ProteinENSMGAP00000019139
UniProt AccessionG1NG34;
Protein NameFibroblast growth factor receptor
Protein Synonyms/Alias
Gene NameFGFR2
Gene Synonyms/Alias FGFR2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMGAG00000011456ENSMGAP00000012017ENSMGAT00000012903
ENSMGAG00000011456ENSMGAP00000019139ENSMGAT00000020901
OrganismMeleagris gallopavo
Functional Description
Protein Length509
Protein Sequence
(FASTA)
HSGINSSNAE VLTLYNVTEA DAGEYICKVS NYIGEANQSA WLSVLPSLQA PEKEKEYPTS 60
PDYLEIAIYC IGVFLIACMV LTVILCRMKN TTKKPDFSSQ PAVHKLTKRI PLRRQVTVSA 120
DSSSSMNSNT PLVRITTRLS STADAPMLAG VSEYELPEDP KWEFPRDKLT LGKPLGEGCF 180
GQVVMAEAVG IDKDRPKEAV TVAVKMLKDD ATEKDLSDLV SEMEMMKMIG KHKNIINLLG 240
ACTQDGPLYV IVEYASKGNL REYLRARRPP GMEYSFDINR VPEEQMTFKD LVSCTYQLAR 300
GMEYLASQKC IHRDLAARNV LVTENNVMKI ADFGLARDIN NIDYYKKTTN GRLPVKWMAP 360
EALFDRVYTH QSDVWSFGVL MWEIFTLGGS PYPGIPVEEL FKLLKEGHRM DKPANCTNEL 420
YMMMRDCWQA VPSQRPTFKQ LVEDLDRILI LTTNEEYLDL SGPLEQYSPS YPDTRSSCSS 480
GDDSVFSPDP MPYEPCLPKY QHMNGSVKT 509
Nucleotide Sequence
(FASTA)
CATTCGGGGA TAAATAGTTC CAATGCTGAA GTGCTGACAC TGTACAATGT GACAGAGGCG 60
GATGCTGGAG AATATATTTG TAAGGTCTCC AATTATATAG GGGAGGCCAA CCAGTCTGCC 120
TGGCTCTCTG TTCTGCCGAG TTTACAAGCT CCTGAAAAGG AAAAGGAATA TCCAACATCT 180
CCAGACTACC TGGAAATAGC AATTTACTGC ATAGGGGTCT TCCTGATCGC CTGCATGGTG 240
CTGACGGTCA TCCTGTGCCG CATGAAGAAC ACCACCAAGA AGCCTGACTT CAGCAGCCAG 300
CCTGCTGTCC ACAAGCTGAC AAAGCGAATC CCTCTGCGCA GACAGGTAAC AGTGTCGGCT 360
GACTCGAGCT CCTCCATGAA CTCCAACACG CCCCTGGTGA GGATAACTAC TCGTCTCTCC 420
TCCACTGCTG ATGCCCCAAT GCTGGCAGGG GTCTCGGAAT ATGAACTACC AGAGGACCCG 480
AAATGGGAGT TTCCAAGAGA TAAGCTGACG CTGGGTAAAC CCCTGGGGGA AGGTTGCTTT 540
GGGCAAGTGG TGATGGCCGA AGCGGTGGGA ATTGACAAAG ACCGGCCCAA AGAAGCAGTG 600
ACTGTGGCAG TGAAGATGCT GAAAGATGAT GCTACAGAAA AGGATCTATC CGACCTGGTG 660
TCAGAGATGG AGATGATGAA GATGATTGGG AAACATAAAA ATATCATCAA TCTTCTTGGA 720
GCCTGTACCC AGGATGGTCC ACTGTATGTG ATTGTAGAAT ATGCTTCCAA AGGAAATCTG 780
CGTGAGTACC TGCGAGCACG CCGGCCTCCT GGGATGGAGT ACTCCTTTGA TATTAACAGG 840
GTCCCAGAGG AGCAGATGAC ATTCAAGGAC TTGGTATCCT GCACGTACCA GTTGGCAAGA 900
GGCATGGAGT ACTTGGCTTC ACAAAAATGT ATCCACCGAG ACCTAGCTGC AAGAAATGTT 960
TTGGTAACTG AAAATAATGT CATGAAAATA GCAGACTTCG GTTTAGCCAG AGACATCAAC 1020
AATATAGATT ATTATAAAAA GACTACTAAT GGACGGCTTC CAGTTAAGTG GATGGCTCCA 1080
GAAGCTCTGT TTGACAGAGT TTACACACAC CAAAGCGACG TATGGTCGTT TGGTGTGCTA 1140
ATGTGGGAGA TCTTCACCTT AGGAGGATCG CCCTACCCAG GAATCCCAGT GGAGGAACTT 1200
TTTAAGCTGC TTAAAGAAGG GCACCGAATG GATAAACCTG CCAACTGCAC CAATGAACTC 1260
TATATGATGA TGAGAGATTG CTGGCAGGCT GTGCCTTCAC AAAGACCAAC TTTTAAACAG 1320
TTGGTAGAAG ACTTGGATCG GATCCTTATT CTCACAACTA ATGAGGAGTA TCTGGACCTC 1380
AGCGGACCTC TGGAGCAGTA TTCACCTAGC TACCCTGACA CCAGGAGTTC GTGTTCTTCA 1440
GGTGATGACT CTGTTTTTTC TCCTGATCCA ATGCCTTATG AACCTTGTCT TCCCAAGTAC 1500
CAACACATGA ATGGAAGCGT TAAAACA 1527
Domain Profile
S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60
         l+lgk+lGeG+fGqvv+aea+g+dkd++k++vtvavkmlk+dat+kdl+dlvseme++k+
Q: 169   LTLGKPLGEGCFGQVVMAEAVGIDKDRPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKM  228
         79**********************************************************
S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120
         iGkhkniinllGactq+Gplyviveya+kGnlre+lrarrp+g+e+s d ++++eeq+t+
Q: 229   IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSFDINRVPEEQMTF  288
         ************************************************************
S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180
         kdlvs++yq+arGmeylas+kcihrdlaarnvlvte+nv+kiadfGlard+++idyykkt
Q: 289   KDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKT  348
         ************************************************************
S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240
         tnGrlpvkwmapealfdrvyt+qsdvwsfGvl+wei+tlGgspypgi+veelfkllkeGh
Q: 349   TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH  408
         ************************************************************
S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277
         rm+kpa+ct+ely++mr+cw+a++s+rptfkqlvedl
Q: 409   RMDKPANCTNELYMMMRDCWQAVPSQRPTFKQLVEDL  445
         ***********************************97
Domain Sequence
(FASTA)
LTLGKPLGEG CFGQVVMAEA VGIDKDRPKE AVTVAVKMLK DDATEKDLSD LVSEMEMMKM 60
IGKHKNIINL LGACTQDGPL YVIVEYASKG NLREYLRARR PPGMEYSFDI NRVPEEQMTF 120
KDLVSCTYQL ARGMEYLASQ KCIHRDLAAR NVLVTENNVM KIADFGLARD INNIDYYKKT 180
TNGRLPVKWM APEALFDRVY THQSDVWSFG VLMWEIFTLG GSPYPGIPVE ELFKLLKEGH 240
RMDKPANCTN ELYMMMRDCW QAVPSQRPTF KQLVEDL 277
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Cavia porcellus"; ?>Ciona savignyi"; ?>Mus musculus"; ?>
EKS-CAP-00147
EKS-CIS-00182
EKS-MUM-00151
Gene Ontology
GO:0005938; C:cell cortex
GO:0009986; C:cell surface
GO:0031012; C:extracellular matrix
GO:0005887; C:integral to plasma membrane
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0005007; F:fibroblast growth factor-activated receptor activity
GO:0045165; P:cell fate commitment
GO:0007267; P:cell-cell signaling
GO:0050673; P:epithelial cell proliferation
GO:0008285; P:negative regulation of cell proliferation
GO:0045839; P:negative regulation of mitosis
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter
GO:0035265; P:organ growth
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0090263; P:positive regulation of canonical Wnt receptor signaling pathway
GO:0060045; P:positive regulation of cardiac muscle cell proliferation
GO:0051781; P:positive regulation of cell division
GO:0060501; P:positive regulation of epithelial cell proliferation involved in lung morphogenesis
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:0002053; P:positive regulation of mesenchymal cell proliferation
GO:0010518; P:positive regulation of phospholipase activity
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
GO:0046777; P:protein autophosphorylation
GO:0060687; P:regulation of branching involved in prostate gland morphogenesis
GO:0010453; P:regulation of cell fate commitment
GO:0040036; P:regulation of fibroblast growth factor receptor signaling pathway
GO:0040014; P:regulation of multicellular organism growth
GO:0051150; P:regulation of smooth muscle cell differentiation
GO:0008589; P:regulation of smoothened signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016248; Tyr_kinase_fibroblast_GF_rcpt.
Pfam
PF07679; I-set; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 1.
SM00408; IGc2; 2.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013