EKS-MEG-00192

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MEG-00192

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	319.3	1.2E-95	3	237	235

Status

Unreviewed

Ensembl Protein

ENSMGAP00000012006

UniProt Accession

A1E4B7;

Protein Name

Protein Synonyms/Alias

5'-AMP-activated protein kinase alpha-2 catalytic subunit;

Gene Name

PRKAA2

Gene Synonyms/Alias

PRKAA2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000011473	ENSMGAP00000012006	ENSMGAT00000012892

Organism

Meleagris gallopavo

Functional Description

Protein Length

520

Protein Sequence
(FASTA)

VGEHQLTGHK VAVKILNRQK IRSLDVVGKI KREIQNLKLF RHPHIIKLYQ VISTPTDFFM 60

VMEYVSGGEL FDYICKHGRV EEAEARRLFQ QILSAVDYCH RHMVVHRDLK PENVLLDAHM 120

NAKIADFGLS NMMSDGEFLR TSCGSPNYAA PEVISGRLYA GPEVDIWSCG VILYALLCGT 180

LPFDDEHVPT LFKKIRGGVF YIPEYLNRSV ATLLMHMLQV DPLKRATIKD IREHEWFKEE 240

LPSYLFPEDP SYDATVIDDD AVREVCEKFE CTESEVMNSL YSGDPQDQLA VAYHLVIDNR 300

RIMNQASEFY LASSPPTGSF MDDTMHIPPG VKPHPERMPP LVADSPKARC PLDALNTTKP 360

KPLTVKKAKW HLGIRSQSKP YDIMAEVYRA MKQLDFEWKV VNSYHLRVRR KNPVTGNYVK 420

MSLQLYQVDN RSYLLDFKSI DDEVMEQRSG SSTPQRSCSA AGLHRPRLSI DAAAATECQS 480

LMGSLSGSFV GSISSVPPRL GSHTMDFFEM CASLIMALAR 520

Nucleotide Sequence
(FASTA)

GTTGGCGAAC ACCAGTTGAC GGGGCACAAA GTAGCAGTAA AAATCCTAAA CAGACAGAAA 60

ATACGCAGCC TGGATGTGGT TGGGAAGATC AAACGAGAAA TTCAAAACCT AAAACTCTTC 120

CGGCACCCTC ATATTATCAA ACTGTACCAG GTCATCAGCA CGCCAACGGA CTTCTTCATG 180

GTCATGGAAT ATGTATCCGG TGGTGAATTA TTTGATTACA TCTGTAAGCA TGGACGTGTT 240

GAAGAGGCGG AGGCTCGACG CCTTTTCCAG CAGATTCTCT CCGCAGTGGA TTACTGTCAC 300

CGACACATGG TTGTCCACAG GGACCTGAAA CCAGAGAACG TGCTGCTGGA CGCACACATG 360

AATGCGAAGA TAGCCGATTT TGGATTGTCC AACATGATGT CTGATGGTGA ATTTCTACGC 420

ACCAGCTGCG GTTCCCCAAA TTATGCGGCC CCTGAAGTCA TTTCTGGAAG GCTGTATGCT 480

GGCCCAGAGG TGGACATCTG GAGCTGCGGC GTCATCCTCT ATGCCCTCCT CTGTGGCACT 540

TTGCCCTTTG ATGATGAGCA TGTGCCCACC CTCTTCAAGA AGATCCGTGG AGGTGTGTTT 600

TACATCCCTG AGTACCTCAA CCGCTCCGTT GCCACTCTGC TCATGCACAT GCTGCAGGTT 660

GACCCTCTCA AGCGCGCAAC CATCAAGGAC ATCAGGGAAC ACGAGTGGTT TAAGGAGGAG 720

CTGCCCAGCT ACCTCTTCCC AGAGGACCCT TCCTACGATG CCACCGTCAT CGATGACGAC 780

GCTGTTCGGG AGGTCTGTGA GAAGTTTGAG TGCACCGAGT CAGAAGTGAT GAACAGTCTG 840

TACAGCGGTG ACCCCCAGGA CCAACTCGCG GTCGCCTACC ACCTTGTCAT CGACAACCGG 900

AGGATCATGA ACCAAGCCAG CGAGTTCTAC CTAGCCTCCA GCCCCCCAAC TGGCTCCTTC 960

ATGGACGACA CCATGCACAT CCCTCCCGGT GTGAAGCCTC ACCCCGAGCG GATGCCACCC 1020

TTGGTAGCAG ACAGCCCCAA GGCACGTTGC CCTTTGGATG CACTCAACAC CACCAAGCCC 1080

AAACCTCTGA CTGTCAAAAA GGCCAAGTGG CACCTGGGGA TCCGCAGCCA GAGCAAGCCC 1140

TATGACATTA TGGCCGAGGT GTACCGAGCT ATGAAGCAGT TGGATTTTGA GTGGAAGGTG 1200

GTGAACTCCT ACCATCTCAG AGTGCGTCGG AAGAACCCGG TGACGGGCAA TTATGTGAAA 1260

ATGAGTCTGC AACTGTACCA GGTGGACAAC CGCAGCTACC TCCTGGACTT CAAAAGCATT 1320

GACGACGAGG TGATGGAGCA GAGGTCCGGC TCATCCACCC CGCAGCGCTC GTGCTCAGCA 1380

GCTGGCTTGC ACCGGCCAAG ATTGAGCATT GATGCTGCAG CAGCCACTGA GTGCCAGTCA 1440

CTGATGGGGT CCCTGAGCGG CTCCTTCGTG GGCAGCATCT CCTCAGTGCC CCCACGCCTG 1500

GGCAGCCACA CCATGGACTT CTTCGAGATG TGTGCCAGTT TGATCATGGC TCTGGCTCGC 1560

TGA 1563

Domain Profile

S: 19    khketkekvavKiikkkkl.seeslekikrEieilkklkhpniikllevietkkklylvl  77

         +h++t++kvavKi++++k+ s + + kikrEi+ lk ++hp+iikl++vi+t +++++v+

Q: 3     EHQLTGHKVAVKILNRQKIrSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVM  62

         799***************96667788**********************************

S: 78    eyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgivHrDlKpeNllldkkeni  137

         ey+sggeLfdyi ++gr++e ear+lf+q++sav+Y+h++ +vHrDlKpeN+lld+++n

Q: 63    EYVSGGELFDYICKHGRVEEAEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNA  122

         ************************************************************

S: 138   kiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkvDvWslGvvLyalvtgklP  197

         kiaDFGl+n++++g+ l+t+cGsp+YaaPe+++g+ Y gp+vD+Ws+Gv+Lyal++g+lP

Q: 123   KIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLP  182

         ************************************************************

S: 198   fdeenlkellekilkgkleipkklskelesLlrklLvvdpekRatieeilkhewl  252

         fd+e++ +l++ki  g + ip++l++++++Ll ++L+vdp kRati++i++hew+

Q: 183   FDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWF  237

         ******************************************************7

Domain Sequence
(FASTA)

EHQLTGHKVA VKILNRQKIR SLDVVGKIKR EIQNLKLFRH PHIIKLYQVI STPTDFFMVM 60

EYVSGGELFD YICKHGRVEE AEARRLFQQI LSAVDYCHRH MVVHRDLKPE NVLLDAHMNA 120

KIADFGLSNM MSDGEFLRTS CGSPNYAAPE VISGRLYAGP EVDIWSCGVI LYALLCGTLP 180

FDDEHVPTLF KKIRGGVFYI PEYLNRSVAT LLMHMLQVDP LKRATIKDIR EHEWF 235

Keyword

ATP-binding; Kinase; Nucleotide-binding; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0004679	; F:AMP-activated protein kinase activity
GO:0005524	; F:ATP binding
GO:0003682	; F:chromatin binding
GO:0035174	; F:histone serine kinase activity
GO:0042149	; P:cellular response to glucose starvation
GO:0042593	; P:glucose homeostasis
GO:0008610	; P:lipid biosynthetic process
GO:0043066	; P:negative regulation of apoptotic process
GO:0032007	; P:negative regulation of TOR signaling cascade
GO:0010508	; P:positive regulation of autophagy
GO:0042752	; P:regulation of circadian rhythm

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013