EKS-MEG-00310

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MEG-00310

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	348.2	2.3E-104	11	267	257

Status

Unreviewed

Ensembl Protein

ENSMGAP00000012346

UniProt Accession

G1NGV0;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K9

Gene Synonyms/Alias

MAP3K9;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000011771	ENSMGAP00000012346	ENSMGAT00000013236

Organism

Meleagris gallopavo

Functional Description

Protein Length

951

Protein Sequence
(FASTA)

VLEIDFSELV LEEIIGIGGF GKVYRAVWIG DEVAVKAARY DPDEDISQTI ENVRQEAKLF 60

AMLKHPNIIA LRGVCLKEPN LCLIMEFARG GSLNRVLSGK RIPPDILVNW AVQIAKGMNY 120

LHEEAIVPII HRDLKSSNIL ILEKVENGDL SNKILKITDF GLAREWHKTT KMSAAGTYAW 180

MAPEVIRSSM FSKGSDVWSY GVLLWELLTG EVPFRGIDGL AVAYGVAMNK LALPIPSTCP 240

EPFAKLMEDC WNPDPHSRPS FASILGHLTA IEESGFFEMP KDSFHSLQED WKQEIQEMFD 300

QLRAKEKELR TWEEELTRAA VEQKNHEELL RRREQELAER EIDILERELN IIIHQLCQEK 360

PRVKKRMGKF KKSRLKLKDG NNISLPSVTD FQHKFTVQAS PTMDKRKSLI SSCSSPPASP 420

TIIPRLRAIQ LTPAESSKTW GRNSVLPKEE GEEEEKRGQK KKGRTWGPSS LCHKELGAGE 480

DSLKALVEGY KQWSSSAPNL GKIQRTAPAF PGFTSLAEMD DEDSECLNGE GKVHPSPGHN 540

QSYLCIPFQK NDDWDGPSSD ANDESTPVNS ATSTPQLTPT NSLKRSGSHH KRCEVALLGC 600

GAVLAAAGLG FDLLEAGKCQ LLIEEDPEPP KEEKKKRDSI FQRAGRPRRS TSPPSRKIFK 660

KDEPMLLLGE PSTSLTLLSL SSISECNSTR SLLRSDSDEI VVYEMPVSPV TVKAPLPAIN 720

NPLVNVQIER FKQDPNQSLT PTHVTVSSHT QQGGHRRTPS DGAIKGTGLV VNGCPTSGCP 780

SSSCLTGALG AGVLKTPSPS RDPNEVPRLP DPNLVFPPTP RRWNAQQDPT LERPKTLEFL 840

PRPRPAASRQ RLDPWWFVSP SNAKGESSAN SSSTDTPSNL DSCFASSSST VEERPGLPAL 900

LPFQGSHPVE ERTLLDIDAE GQSQDSTIPL CRSELNTQKA TAYELKQEFW S 951

Nucleotide Sequence
(FASTA)

GTCTTGGAGA TCGACTTCTC AGAACTTGTT CTGGAGGAAA TCATTGGCAT AGGGGGCTTC 60

GGAAAAGTAT ATCGAGCTGT GTGGATAGGA GATGAGGTTG CTGTCAAGGC AGCTCGCTAT 120

GACCCTGATG AGGACATCAG CCAGACCATT GAGAATGTCC GCCAAGAAGC CAAGCTTTTT 180

GCGATGTTAA AGCATCCCAA CATCATTGCC CTCAGGGGCG TATGTTTGAA GGAACCTAAT 240

CTTTGCTTGA TCATGGAGTT TGCCCGTGGA GGATCATTAA ATAGAGTGTT GTCTGGTAAA 300

AGGATACCTC CTGACATTTT AGTGAACTGG GCAGTACAGA TTGCAAAGGG AATGAACTAC 360

TTGCATGAGG AAGCAATTGT TCCTATAATT CACCGTGACC TGAAGTCCAG CAACATACTG 420

ATACTCGAAA AGGTGGAAAA TGGAGATCTG AGCAACAAGA TACTGAAGAT CACGGATTTC 480

GGCTTGGCCA GGGAATGGCA TAAAACTACC AAAATGAGTG CAGCTGGGAC ATATGCCTGG 540

ATGGCTCCTG AGGTCATCCG CTCCTCCATG TTCTCCAAAG GCAGCGATGT GTGGAGTTAT 600

GGCGTGCTGC TTTGGGAGCT GCTAACAGGG GAAGTGCCAT TCCGAGGAAT TGATGGTCTT 660

GCAGTAGCCT ACGGTGTTGC CATGAATAAA CTTGCTCTTC CAATCCCTTC CACGTGTCCA 720

GAGCCTTTTG CCAAACTAAT GGAAGATTGT TGGAACCCTG ACCCACACTC ACGACCTTCC 780

TTTGCCAGTA TCCTAGGCCA TCTCACCGCT ATAGAAGAGT CTGGTTTCTT TGAAATGCCC 840

AAAGATTCCT TCCATTCCCT TCAGGAAGAC TGGAAACAAG AGATCCAAGA GATGTTTGAT 900

CAGCTCAGAG CCAAAGAAAA GGAGCTTCGC ACGTGGGAAG AAGAGCTGAC TCGTGCTGCT 960

GTTGAACAGA AGAACCACGA GGAGTTGCTC CGAAGGCGGG AACAGGAGCT GGCAGAACGT 1020

GAGATTGACA TCCTGGAAAG AGAGCTCAAC ATCATCATCC ACCAGCTGTG TCAGGAGAAG 1080

CCTCGTGTGA AGAAACGTAT GGGGAAGTTC AAGAAGAGTC GGCTCAAGTT AAAAGATGGC 1140

AATAATATCA GCCTGCCTTC AGTAACAGAT TTCCAACATA AATTCACTGT GCAGGCTTCT 1200

CCAACAATGG ATAAAAGGAA GAGCTTGATC AGTAGCTGCT CCAGCCCTCC TGCAAGTCCC 1260

ACCATTATTC CCAGACTCAG GGCCATACAG TTGACTCCTG CTGAAAGCAG TAAAACATGG 1320

GGACGAAACT CAGTCCTTCC AAAGGAGGAA GGAGAGGAAG AAGAGAAGAG AGGCCAGAAG 1380

AAAAAAGGAC GCACCTGGGG ACCAAGCTCA CTTTGTCACA AGGAGCTAGG TGCAGGAGAG 1440

GACAGTCTGA AAGCTCTGGT AGAAGGATAC AAACAGTGGT CATCCAGTGC ACCAAACTTA 1500

GGGAAGATTC AGAGAACTGC GCCTGCTTTT CCAGGATTCA CCAGCTTAGC AGAGATGGAT 1560

GATGAAGACA GTGAATGTCT TAATGGGGAG GGCAAAGTGC ACCCTTCACC TGGGCACAAC 1620

CAGTCATACC TCTGCATCCC ATTTCAGAAG AATGATGACT GGGATGGGCC TTCTAGTGAT 1680

GCCAATGATG AATCCACTCC TGTGAACTCT GCTACAAGCA CTCCACAGCT TACACCCACC 1740

AACAGCCTCA AACGTAGTGG CTCCCACCAC AAACGGTGCG AGGTTGCCTT GCTTGGCTGT 1800

GGAGCGGTTC TGGCTGCTGC AGGCCTGGGG TTTGATCTCC TAGAAGCGGG GAAGTGTCAG 1860

CTACTGATTG AAGAGGATCC AGAGCCACCC AAGGAAGAGA AGAAAAAACG TGACAGCATT 1920

TTCCAGCGAG CTGGACGCCC ACGCAGGAGC ACTAGCCCTC CTTCTCGAAA AATCTTCAAG 1980

AAAGATGAGC CCATGTTGTT GCTTGGCGAG CCATCCACAT CCCTCACCCT TCTTTCCCTG 2040

TCTTCCATTT CCGAATGTAA TTCCACCCGA TCCCTGCTGC GCTCAGACAG TGATGAGATT 2100

GTGGTATACG AAATGCCTGT CAGCCCTGTG ACAGTCAAGG CTCCCTTGCC AGCCATTAAT 2160

AACCCACTAG TTAATGTCCA GATTGAGAGA TTCAAACAAG ACCCCAACCA GTCCCTCACT 2220

CCCACACATG TGACGGTCTC TTCCCACACC CAGCAAGGCG GGCACAGGCG CACACCTTCT 2280

GATGGGGCCA TCAAAGGGAC TGGACTAGTT GTCAATGGGT GCCCAACCAG TGGATGCCCT 2340

TCCAGTAGCT GTTTAACTGG AGCACTGGGA GCAGGTGTAT TAAAAACACC TAGTCCAAGT 2400

AGAGATCCAA ATGAGGTCCC TCGCCTGCCA GATCCCAACC TTGTTTTTCC TCCAACCCCG 2460

AGACGATGGA ATGCACAGCA GGACCCCACG CTGGAAAGAC CCAAGACGCT GGAGTTCCTG 2520

CCTCGGCCTC GGCCCGCAGC CAGCCGGCAG CGGCTTGATC CCTGGTGGTT TGTGTCACCC 2580

AGCAATGCCA AGGGTGAATC TTCTGCCAAC AGTTCAAGTA CTGACACTCC AAGCAATCTG 2640

GACTCTTGTT TTGCTAGTAG CAGCAGCACT GTAGAAGAGA GACCTGGACT TCCTGCACTG 2700

CTTCCTTTCC AGGGGAGTCA TCCTGTAGAG GAGCGGACAC TGTTGGACAT AGATGCTGAG 2760

GGACAGAGCC AAGACAGCAC CATTCCGCTA TGCAGAAGTG AACTTAACAC ACAAAAAGCT 2820

ACAGCATATG AACTCAAGCA AGAATTCTGG TCTTAG 2856

Domain Profile

S: 3     leeligsgafgkvykakwrkkevavKklreeaee..kekleklereakllsklshpniie  60

         lee+ig g fgkvy+a w ++evavK++r +  e  ++++e++++eakl+++l+hpnii+

Q: 11    LEEIIGIGGFGKVYRAVWIGDEVAVKAARYDPDEdiSQTIENVRQEAKLFAMLKHPNIIA  70

         589***************************99998999**********************

S: 61    llGvcleepnlllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhseapk  120

         l+Gvcl+epnl+l+me+++ggsL++vl++   ++i+++ lv+wa+qiA+Gm+YLh+ea +

Q: 71    LRGVCLKEPNLCLIMEFARGGSLNRVLSG---KRIPPDILVNWAVQIAKGMNYLHEEAIV  127

         *****************************...99**************************

S: 121   kiihrdLksknvLl.......seekktlkicdFGtarelskstkmsaagtlawmaPEvlk  173

         +iihrdLks+n+L+       + ++k lki+dFG are++k+tkmsaagt+awmaPEv++

Q: 128   PIIHRDLKSSNILIlekvengDLSNKILKITDFGLAREWHKTTKMSAAGTYAWMAPEVIR  187

         *******************99999************************************

S: 174   eekvseksDvwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkLm  233

         ++ +s+ sDvwSygv+LWellt+evP+++++ la+ay+va+++l lpips+cpe+++kLm

Q: 188   SSMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLM  247

         ************************************************************

S: 234   kecwnedpekRpsfseivks  253

         ++cwn dp++Rpsf++i+ +

Q: 248   EDCWNPDPHSRPSFASILGH  267

         ****************9876

Domain Sequence
(FASTA)

LEEIIGIGGF GKVYRAVWIG DEVAVKAARY DPDEDISQTI ENVRQEAKLF AMLKHPNIIA 60

LRGVCLKEPN LCLIMEFARG GSLNRVLSGK RIPPDILVNW AVQIAKGMNY LHEEAIVPII 120

HRDLKSSNIL ILEKVENGDL SNKILKITDF GLAREWHKTT KMSAAGTYAW MAPEVIRSSM 180

FSKGSDVWSY GVLLWELLTG EVPFRGIDGL AVAYGVAMNK LALPIPSTCP EPFAKLMEDC 240

WNPDPHSRPS FASILGH 257

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004709	; F:MAP kinase kinase kinase activity
GO:0004713	; F:protein tyrosine kinase activity
GO:0000186	; P:activation of MAPKK activity
GO:0000165	; P:MAPK cascade
GO:0046777	; P:protein autophosphorylation
GO:0038032	; P:termination of G-protein coupled receptor signaling pathway

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR016231	; MAPKKK9/10/11.
IPR015785	; MAPKKK9/10/11-like.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016137	; Regulat_G_prot_signal_superfam.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00219

; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013