EKS-MEG-00335
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MEG-00335
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR574.28.8E-173553892340
StatusUnreviewed
Ensembl ProteinENSMGAP00000012432
UniProt AccessionG1NH11;
Protein Name
Protein Synonyms/Alias
Gene NameKIT
Gene Synonyms/Alias KIT;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMGAG00000011800ENSMGAP00000012432ENSMGAT00000013323
ENSMGAG00000011800ENSMGAP00000017546ENSMGAT00000020836
OrganismMeleagris gallopavo
Functional Description
Protein Length943
Protein Sequence
(FASTA)
ESSLVVNKGE ELRLKCNEDG PVTWNFQNSD PSAKTRISNE KEWHTKNATI RDIGRYECKS 60
KGSIVNSFYV FVKDPNVLFL VDSLIYGKED SDILLVCPLT DPDVLNFTLR KCDGKPLPRN 120
MTFIPNPQKG IIIKNVQRSF KGCYQCLAKH NGVEKISEHI FLNVRPVHKA LPVITLSKSY 180
ELLKEGEEFE VTCIIMDVDS SVQASWISYK SGTGVIVTSK SRNVGDYGYE RKLTLNIRSV 240
GVNDSGEFTC QAENPFGKTN ATVTLKALAK GFVRLFATMN TTIDINAGQN GNLTVEYEAY 300
PKPKEEVWMY MNETLQNSSD HYVKFKTVGN NSYTSELHLT RLKGTEGGIY TFFVSNSDAS 360
SSVTFNVYVK TKPEILTLDI LSNGILQCVA AGFPAPTIYW YFCPGTEQRC FDSPTISPMD 420
VKVSYTNSSV PSFERILVES TVNASMFRST GTICCEASSN GDKSSAFFNF AIKGNVWKQI 480
RTHTLFTPLL IAFGVAAGLM CIIVMILVYI YLQKPKYEVQ WKVVEEINGN NYVYIDPTQL 540
PYDHKWEFPR NRLSFGKTLG AGAFGKVVEA TAYGLFKSDA AMTVAVKMLK PSAHLTEREA 600
LMSELKVLSY LGNHINIVNL LGACTIGGPT LVITEYCCYG DLLNFLRRKR DSFICPKHEE 660
HTEAAVYENL LHQAEPTACC LCRDAVNEYM DMKPGVSYAV PPKADKKRPV KSGSYTDQDV 720
TLSMLEDDEL ALDVEDLLSF SYQVAKGMSF LASKNCIHRD LAARNILLTH GRITKICDFG 780
LARDIRNDSN YVVKGNARLP VKWMAPESIF NCVYTFESDV WSYGILLWEL FSLGSSPYPG 840
MPVDSKFYKM IKEGYRMFSP ECSPPEMYDI MKSCWDADPL QRPTFKQIVQ LIEQQLSDNA 900
PRVYANFSTP PSSQGNATDH SVRINSVGSS ASSTQPLLVR EDV 943
Nucleotide Sequence
(FASTA)
GAATCCTCAC TGGTTGTGAA TAAGGGAGAG GAATTAAGGC TGAAGTGCAA TGAGGACGGA 60
CCCGTGACTT GGAATTTCCA GAACTCGGAT CCATCAGCAA AAACAAGGAT TTCCAATGAG 120
AAAGAGTGGC ACACCAAAAA TGCAACGATC AGAGACATAG GCAGATATGA GTGCAAAAGC 180
AAAGGGAGTA TTGTCAACTC TTTTTATGTT TTTGTTAAAG ATCCGAATGT GCTCTTCCTT 240
GTTGATTCTC TGATCTATGG GAAAGAAGAC AGTGACATCC TGCTGGTGTG CCCACTAACA 300
GATCCAGATG TTTTAAATTT CACCCTGAGA AAATGTGATG GCAAACCTCT CCCCAGAAAC 360
ATGACATTCA TTCCCAATCC ACAGAAGGGT ATTATTATAA AGAATGTACA GAGGTCATTC 420
AAGGGCTGCT ACCAATGCTT GGCAAAGCAT AATGGAGTTG AGAAAATATC AGAGCACATT 480
TTCCTGAATG TGAGACCAGT TCACAAAGCT CTTCCAGTCA TTACCTTATC GAAAAGCTAT 540
GAGCTTCTCA AAGAAGGGGA AGAATTTGAA GTTACATGCA TAATCATGGA TGTGGATAGC 600
AGCGTACAAG CTAGTTGGAT TTCTTACAAA AGTGGGACTG GTGTGATTGT TACAAGCAAA 660
AGCAGAAATG TGGGTGATTA CGGATACGAA AGGAAATTAA CATTGAACAT CCGTTCAGTG 720
GGAGTTAATG ATTCTGGAGA ATTCACTTGC CAAGCAGAGA ACCCTTTTGG AAAAACCAAT 780
GCCACAGTAA CCTTGAAAGC ACTAGCTAAA GGATTTGTCC GTTTGTTTGC AACAATGAAT 840
ACCACAATTG ACATAAATGC AGGACAAAAT GGAAATTTAA CAGTTGAATA TGAGGCGTAT 900
CCAAAACCGA AGGAAGAAGT CTGGATGTAC ATGAACGAAA CATTACAGAA TTCGTCAGAC 960
CATTATGTCA AGTTCAAGAC TGTGGGCAAT AACAGTTATA CTAGCGAACT TCACCTTACC 1020
CGATTAAAAG GAACAGAGGG AGGCATTTAC ACATTTTTTG TGTCCAACTC AGATGCCAGC 1080
TCCTCTGTAA CATTTAATGT CTATGTGAAA ACAAAACCGG AGATCCTTAC CTTGGATATA 1140
CTCAGCAATG GCATTCTTCA GTGTGTGGCA GCTGGATTCC CAGCCCCTAC CATTTACTGG 1200
TATTTTTGCC CAGGAACTGA ACAGAGGTGC TTTGACTCAC CAACGATATC CCCCATGGAT 1260
GTGAAAGTCA GTTACACAAA TTCATCGGTG CCATCCTTTG AGCGGATCCT GGTTGAGAGC 1320
ACTGTTAATG CCAGCATGTT CAGGAGCACT GGTACCATCT GCTGTGAGGC ATCCAGCAAT 1380
GGTGACAAGA GCTCTGCTTT CTTCAACTTT GCTATTAAAG GTAATGTCTG GAAGCAAATC 1440
CGTACCCACA CCCTTTTCAC ACCTTTACTA ATTGCGTTTG GGGTCGCCGC TGGACTGATG 1500
TGCATCATAG TCATGATCCT GGTGTACATA TATTTGCAGA AACCCAAATA CGAAGTCCAG 1560
TGGAAAGTTG TTGAAGAAAT AAATGGAAAC AACTATGTTT ACATAGACCC AACGCAACTT 1620
CCTTATGATC ACAAATGGGA GTTTCCTAGA AACCGGTTGA GTTTTGGTAA AACCCTTGGT 1680
GCTGGAGCTT TTGGAAAGGT TGTTGAAGCC ACTGCTTATG GCCTATTTAA ATCTGATGCC 1740
GCTATGACAG TAGCAGTGAA AATGTTGAAA CCAAGCGCCC ATTTAACTGA AAGAGAAGCC 1800
TTGATGTCAG AGCTGAAAGT TCTCAGTTAC CTTGGTAACC ACATTAATAT TGTGAATCTA 1860
CTTGGAGCTT GCACTATCGG AGGGCCCACA CTGGTCATTA CAGAATATTG CTGCTATGGT 1920
GATCTCTTAA ATTTTCTGAG GCGGAAGCGA GATTCATTCA TTTGTCCAAA GCATGAAGAG 1980
CACACAGAAG CAGCCGTTTA TGAGAACCTT TTGCACCAGG CAGAGCCCAC AGCCTGCTGC 2040
CTCTGCAGGG ATGCTGTCAA TGAGTACATG GACATGAAAC CAGGAGTGTC ATATGCAGTT 2100
CCCCCAAAAG CTGATAAAAA AAGGCCAGTG AAATCTGGAT CCTATACCGA TCAGGATGTT 2160
ACCCTTTCCA TGTTGGAAGA TGACGAACTT GCTCTAGACG TTGAAGATCT ATTAAGCTTC 2220
TCTTACCAGG TGGCAAAGGG CATGAGCTTC CTTGCCTCTA AAAACTGCAT TCATAGGGAT 2280
CTGGCAGCAA GAAATATTCT TCTCACTCAT GGTCGAATAA CAAAAATCTG TGACTTTGGC 2340
CTGGCAAGAG ATATAAGGAA TGACTCAAAT TACGTGGTTA AAGGCAATGC CCGTCTCCCT 2400
GTGAAGTGGA TGGCACCTGA AAGCATTTTC AACTGCGTTT ACACCTTCGA GAGTGATGTC 2460
TGGTCTTATG GAATATTGCT TTGGGAACTC TTCTCTTTAG GAAGCAGCCC TTACCCAGGG 2520
ATGCCCGTGG ACTCCAAGTT CTATAAAATG ATCAAGGAGG GATATCGGAT GTTCAGCCCC 2580
GAATGCTCAC CCCCCGAAAT GTATGACATA ATGAAGAGTT GCTGGGATGC TGATCCCTTG 2640
CAGAGACCCA CATTCAAACA AATCGTGCAG CTGATAGAAC AGCAGCTTTC AGATAATGCC 2700
CCCCGGGTGT ATGCAAACTT TTCCACTCCG CCTTCCAGTC AAGGCAATGC TACAGATCAT 2760
TCAGTGAGGA TTAACTCAGT GGGTAGCAGC GCTTCATCTA CTCAGCCCCT CCTGGTACGT 2820
GAAGATGTTT GA 2832
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l++Gk+lG+GafGkvveatayGl ksda+++vavkmlk++a+ +e+ealmselk+ls+lG
Q: 553   LSFGKTLGAGAFGKVVEATAYGLFKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLG  612
         79**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +h nivnllGact gGp++viteyccyGdlln+lrrkr+sf+   + k++e++e++ +++
Q: 613   NHINIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFI---CPKHEEHTEAAVYEN  669
         ******************************************...677788999999999
S: 121   lladkslrsksslssesseeyvdlkkdvsdvssskadklasekkksalerevkaaleeed  180
         ll  ++  +   l+ ++ +ey+d+k++vs+  + kadk++  k  s+++++v+ ++ e+d
Q: 670   LLH-QAEPTACCLCRDAVNEYMDMKPGVSYAVPPKADKKRPVKSGSYTDQDVTLSMLEDD  728
         954.55678899************************************************
S: 181   sevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardimkd  240
         + +l++edllsfsyqvakGm flasknc+hrdlaarn+llt+G+++kicdfGlardi++d
Q: 729   ELALDVEDLLSFSYQVAKGMSFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIRND  788
         ************************************************************
S: 241   snyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvdskfy  300
         snyvvkGnarlpvkwmapesif+++yt++sdvwsyGillwe+fslGs+pypg++vdskfy
Q: 789   SNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGILLWELFSLGSSPYPGMPVDSKFY  848
         ************************************************************
S: 301   klikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344
         k+ikeGyrm +p+ ++ e+y+im++cw+a+p +rp+fkq+v+l+
Q: 849   KMIKEGYRMFSPECSPPEMYDIMKSCWDADPLQRPTFKQIVQLI  892
         *****************************************996
Domain Sequence
(FASTA)
LSFGKTLGAG AFGKVVEATA YGLFKSDAAM TVAVKMLKPS AHLTEREALM SELKVLSYLG 60
NHINIVNLLG ACTIGGPTLV ITEYCCYGDL LNFLRRKRDS FICPKHEEHT EAAVYENLLH 120
QAEPTACCLC RDAVNEYMDM KPGVSYAVPP KADKKRPVKS GSYTDQDVTL SMLEDDELAL 180
DVEDLLSFSY QVAKGMSFLA SKNCIHRDLA ARNILLTHGR ITKICDFGLA RDIRNDSNYV 240
VKGNARLPVK WMAPESIFNC VYTFESDVWS YGILLWELFS LGSSPYPGMP VDSKFYKMIK 300
EGYRMFSPEC SPPEMYDIMK SCWDADPLQR PTFKQIVQLI 340
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00374
EKS-ANC-00389
EKS-BOT-00402
EKS-CAJ-00407
EKS-CAF-00402
EKS-CAP-00432
EKS-DAR-00787
EKS-EQC-00394
EKS-FEC-00386
EKS-GAG-00341
EKS-GAA-00515
EKS-GOG-00394
EKS-HOS-00409
EKS-ICT-00381
EKS-LAC-00419
EKS-LOA-00412
EKS-MAM-00402
EKS-MOD-00391
EKS-MUM-00435
EKS-MUP-00399
EKS-MYL-00397
EKS-NOL-00368
EKS-ORN-00514
EKS-ORA-00347
EKS-ORC-00378
EKS-ORL-00472
EKS-OTG-00405
EKS-PAT-00381
EKS-PES-00357
EKS-POA-00394
EKS-PTV-00114
EKS-RAN-00418
EKS-SAH-00372
EKS-SUS-00353
EKS-TAG-00473
EKS-TAR-00510
EKS-TEN-00511
EKS-XET-00515
EKS-XIM-00506
Gene Ontology
GO:0005737; C:cytoplasm
GO:0009897; C:external side of plasma membrane
GO:0005615; C:extracellular space
GO:0016021; C:integral to membrane
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0005020; F:stem cell factor receptor activity
GO:0031532; P:actin cytoskeleton reorganization
GO:0000187; P:activation of MAPK activity
GO:0097067; P:cellular response to thyroid hormone stimulus
GO:0048066; P:developmental pigmentation
GO:0038093; P:Fc receptor signaling pathway
GO:0006687; P:glycosphingolipid metabolic process
GO:0007243; P:intracellular protein kinase cascade
GO:0002551; P:mast cell chemotaxis
GO:0043303; P:mast cell degranulation
GO:0043069; P:negative regulation of programmed cell death
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0008284; P:positive regulation of cell proliferation
GO:0010628; P:positive regulation of gene expression
GO:0043410; P:positive regulation of MAPK cascade
GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0042511; P:positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042523; P:positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0046777; P:protein autophosphorylation
GO:0048070; P:regulation of developmental pigmentation
GO:0009314; P:response to radiation
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
Pfam
PF07679; I-set; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 3.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
Created Date20-Feb-2013