EKS-MEG-00024

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MEG-00024

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Jak	326.7	9.8E-98	871	1142	272

Status

Unreviewed

Ensembl Protein

ENSMGAP00000012412

UniProt Accession

G1NGZ6;

Protein Name

Protein Synonyms/Alias

Gene Name

JAK1

Gene Synonyms/Alias

JAK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000011807	ENSMGAP00000012412	ENSMGAT00000013302

Organism

Meleagris gallopavo

Functional Description

Protein Length

1151

Protein Sequence
(FASTA)

MQYLNVKEDC KAMAFCAKMR STKKSEVNLE AQHQGLEILF YLQDKSPISY TSGEFTSEEL 60

CIEAAQKCSI SPLCHNLFAL FDENRKLWYA PNQVFKIDEK TSHRLYYRMR YYFTNWHGTS 120

ENEPSVWRHT PKKAKNSYDK KLAPEGTPIL DANSLEYIFA QGQYDLVKGL APIRDPKNDQ 180

EVHEIENECL GMAVLAISHY AIKKNVKLPE LPKDISYKHY IPETLNKTIR QRNFLTRIRI 240

NNVFKHFLKE FNNKTICDSS VSPRDLKVKY LSTMETLTKY YGAEIFETSS LLISSESEIN 300

RFNCGDGEII PLYEVIVTGN NGIQWRLKPN SVQTEKEKKK KSDGKIKKDE DRYKTRDLWN 360

NFSYFPEITH IVIKESTVSI NKQDNKKMEL KLSSHDEALS FASLIDGYFR LTADAHHYLC 420

TDVAPPLIEH NIKNGCHGPI CTEYAINKLR QEGNEAGMYV LRWSCTNFNH ILMTVTCLEG 480

PEMINNSVQY KNFQIEVKKG GYFLHGSNRS FASLKELMDH LKGQILRTDN ISFTLKRCCQ 540

PKPREISNLL VATKKAQECQ PAYHLGQLSF HRIRKEEIMQ GEHLGRGTRT QIYSGILNYK 600

DDENEGYQNE KEIKVLLKVL DPSHRDISLA FFEAASMMRQ VSHKHIVFLH GVCVRDLENI 660

MVEEFVEFGP LDLFMHRKSE LLTTPWKFNV AKQLASALSY LEDKDLVHGN VCTKNILLAR 720

EGIDTEYGPF IKLSDPGIPI TVLSRQECVE RIPWIAPECV EDSKNLSIAA DKWSFGTTLW 780

EICYNGETPL KDKTLAEKER FYEGHFMLIT PSCKELADLM KQCMNYDPHQ RPFFRAIMRD 840

INKLEEQNPD IVSEKKPVTE VDPTLFEKRF LKRIRDLGEG HFGKVELCRY DPEGDNTGEQ 900

VAVKSLKPES GGNHIADLKK EIEILRNLYH ENIVKYKGIC TEDGGNGIKL IMEFLPSGSL 960

KEYLPRNKNK INLKQLLRYA VQICKGMDYL GSRQYVHRDL AANVLVESEN RVKIGDFGLT 1020

KAIETDKEYY TVKDDLDSPV FWYAPECLIQ SKFYIASDVW SFGVTLYELL TYCDSESSPM 1080

TEFLKMIGPT QGQMTVARLV RVLQEEKRLP RPPNCPEEID QLMRKCWIFK HDKRTTFHNL 1140

IQGFETIMSK M 1151

Nucleotide Sequence
(FASTA)

ATGCAGTATC TAAACGTAAA AGAAGACTGC AAAGCCATGG CTTTCTGTGC AAAAATGAGG 60

AGCACAAAGA AGAGCGAAGT AAACCTGGAA GCTCAGCATC AGGGCTTAGA GATACTTTTC 120

TACCTGCAAG ATAAAAGCCC CATTTCTTAC ACCAGTGGCG AGTTTACCTC GGAGGAGCTG 180

TGCATTGAAG CTGCCCAGAA GTGCTCTATA TCTCCTCTGT GCCATAATCT CTTTGCACTG 240

TTTGATGAGA ACAGAAAGCT CTGGTATGCA CCAAACCAGG TCTTTAAGAT AGATGAAAAG 300

ACATCGCATC GGCTCTATTA TCGAATGAGA TACTACTTCA CAAACTGGCA TGGGACTAGT 360

GAAAACGAAC CCTCAGTGTG GAGGCATACC CCAAAGAAGG CAAAGAACTC TTACGACAAG 420

AAGCTGGCAC CGGAAGGAAC CCCAATCCTG GATGCAAACT CATTGGAATA CATCTTTGCA 480

CAGGGTCAGT ATGATTTAGT GAAGGGACTG GCACCAATCC GTGACCCTAA AAATGATCAA 540

GAAGTTCATG AAATTGAAAA TGAGTGTCTG GGAATGGCTG TGCTTGCAAT CTCTCATTAT 600

GCTATCAAGA AAAATGTGAA GCTGCCAGAG CTGCCCAAAG ATATCAGTTA TAAACATTAT 660

ATTCCTGAAA CTTTGAACAA GACTATCAGG CAGAGGAATT TCTTAACCAG GATTCGGATA 720

AACAACGTTT TCAAGCATTT CCTTAAAGAG TTCAACAATA AAACCATTTG TGACAGTAGT 780

GTGTCTCCAC GCGATCTGAA AGTTAAATAC TTATCAACAA TGGAGACTTT GACTAAATAT 840

TATGGAGCAG AAATTTTTGA GACTTCATCT CTGCTTATTT CATCTGAGAG TGAAATAAAT 900

AGATTTAACT GTGGAGACGG TGAGATCATT CCATTATATG AAGTCATCGT GACAGGAAAC 960

AATGGAATTC AGTGGAGGCT CAAGCCAAAT TCTGTACAGA CGGAGAAAGA GAAGAAGAAA 1020

AAATCTGATG GCAAAATCAA AAAGGATGAA GATAGATACA AAACCCGAGA TTTGTGGAAC 1080

AATTTTTCCT ATTTTCCTGA AATCACTCAC ATTGTCATCA AGGAGTCTAC GGTTAGCATT 1140

AACAAGCAGG ATAACAAAAA AATGGAATTA AAACTGTCCT CACATGATGA AGCTCTGTCA 1200

TTTGCATCAT TAATAGATGG ATACTTCAGA CTTACAGCAG ATGCCCACCA TTATCTCTGC 1260

ACAGATGTGG CTCCTCCACT GATTGAACAC AACATAAAAA ATGGTTGCCA TGGACCCATT 1320

TGCACTGAAT ATGCCATCAA CAAACTGCGA CAGGAAGGGA ATGAAGCAGG AATGTATGTA 1380

CTGAGGTGGA GCTGCACAAA CTTTAACCAC ATCCTCATGA CAGTGACTTG TCTTGAAGGC 1440

CCAGAGATGA TAAATAATTC AGTGCAGTAC AAGAACTTCC AGATTGAGGT GAAGAAAGGC 1500

GGGTACTTCC TACATGGCTC AAACAGGTCT TTTGCGTCCT TAAAAGAGTT GATGGATCAC 1560

CTGAAAGGAC AAATCCTTCG CACAGACAAC ATCAGCTTTA CGTTGAAGAG GTGCTGCCAA 1620

CCAAAGCCAA GAGAAATCTC CAACTTGTTG GTTGCAACCA AGAAGGCTCA GGAATGTCAG 1680

CCTGCTTACC ATCTAGGGCA GCTGAGCTTC CATCGAATCC GCAAAGAAGA AATAATGCAG 1740

GGTGAACACC TTGGAAGAGG GACGAGGACA CAGATTTACT CAGGGATTCT CAACTACAAA 1800

GATGATGAGA ATGAAGGATA TCAAAACGAA AAAGAGATTA AAGTACTCCT CAAAGTTTTG 1860

GACCCCAGTC ACAGAGACAT TTCTTTGGCC TTCTTTGAAG CAGCAAGCAT GATGAGGCAG 1920

GTTTCTCACA AGCACATCGT CTTTCTCCAT GGAGTCTGCG TCCGTGACTT AGAAAATATC 1980

ATGGTTGAAG AATTTGTTGA ATTTGGGCCT CTGGATTTGT TTATGCATCG GAAAAGTGAA 2040

CTCCTGACAA CTCCCTGGAA ATTCAATGTA GCCAAGCAAC TTGCAAGTGC GCTAAGCTAC 2100

CTGGAGGATA AGGATTTGGT ACATGGAAAC GTGTGTACTA AAAACATCCT ACTGGCAAGA 2160

GAGGGAATTG ACACCGAATA TGGGCCTTTC ATAAAGCTGA GCGACCCAGG AATCCCCATA 2220

ACTGTGCTGT CCAGGCAAGA ATGTGTGGAG CGAATCCCCT GGATTGCACC CGAATGTGTT 2280

GAAGACTCAA AAAATTTAAG CATTGCAGCA GATAAGTGGA GTTTTGGTAC AACACTGTGG 2340

GAAATCTGCT ATAATGGAGA AACACCACTG AAAGACAAGA CATTGGCAGA GAAGGAAAGG 2400

TTCTACGAAG GGCATTTCAT GTTGATAACA CCATCGTGCA AGGAACTAGC TGACCTGATG 2460

AAACAGTGCA TGAACTACGA CCCCCACCAG AGACCCTTCT TCAGAGCTAT CATGAGAGAC 2520

ATCAACAAAC TGGAGGAGCA AAACCCTGAT ATCGTCTCGG AGAAGAAGCC TGTCACAGAG 2580

GTCGATCCCA CACTCTTTGA AAAACGATTC TTGAAGAGAA TCCGTGATTT GGGAGAGGGC 2640

CACTTTGGGA AGGTTGAACT CTGCAGATAC GATCCAGAAG GTGACAATAC AGGAGAACAA 2700

GTGGCAGTTA AATCTCTGAA GCCAGAGAGT GGAGGGAATC ACATTGCTGA TCTCAAGAAG 2760

GAAATAGAAA TCTTGAGGAA TCTGTATCAT GAGAACATTG TCAAGTATAA GGGAATTTGC 2820

ACAGAAGATG GAGGAAATGG GATTAAACTC ATCATGGAAT TTCTTCCTTC TGGGAGCTTA 2880

AAGGAATATC TGCCACGAAA CAAGAACAAA ATCAATCTCA AGCAACTTCT CAGATACGCA 2940

GTTCAGATCT GCAAGGGGAT GGACTACTTG GGCTCCCGTC AGTACGTGCA CCGTGACTTA 3000

GCAGCAAATG TCCTTGTTGA AAGTGAGAAC AGAGTGAAAA TTGGAGATTT TGGTCTCACC 3060

AAAGCCATCG AGACTGATAA GGAGTACTAC ACTGTCAAAG ATGACCTCGA CAGCCCTGTA 3120

TTTTGGTATG CTCCAGAATG CTTGATTCAG AGTAAGTTTT ACATCGCCTC AGATGTGTGG 3180

TCGTTCGGGG TGACGCTGTA CGAACTGCTC ACCTACTGCG ATTCGGAGTC CAGCCCAATG 3240

ACAGAGTTCC TGAAGATGAT TGGCCCCACA CAGGGCCAGA TGACGGTAGC ACGGCTCGTG 3300

CGTGTCCTAC AAGAAGAGAA GCGTTTGCCA CGTCCACCCA ACTGCCCCGA GGAGATCGAC 3360

CAGCTGATGA GGAAATGCTG GATATTCAAG CACGATAAGC GGACAACCTT TCACAACCTG 3420

ATTCAAGGGT TTGAAACAAT TATGAGCAAG ATGTAA 3456

Domain Profile

S: 1     lkqiesLgkgtftkvfevredaegdsteeevalkvLk.esgedisrdfkreaeilsqlsh  59

         lk+i++Lg+g+f+kv+++r+d+egd+t+e+va+k Lk esg ++++d+k+e+eil++l+h

Q: 871   LKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKpESGGNHIADLKKEIEILRNLYH  930

         6899********************************************************

S: 60    ehivklkgvcvaegen..rlVmeyvesGsLdiyLrkkkealslsslldvakqlakameYL  117

         e+ivk+kg+c+++g n  +l+me+++sGsL++yL+++k++++l++ll +a q++k+m+YL

Q: 931   ENIVKYKGICTEDGGNgiKLIMEFLPSGSLKEYLPRNKNKINLKQLLRYAVQICKGMDYL  990

         ************************************************************

S: 118   edkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsripwl  176

         +++++vhrd+aa nvLve+e++      vk++d+gl+ka+++d eYy+v+++ ds+++w+

Q: 991   GSRQYVHRDLAA-NVLVESENR------VKIGDFGLTKAIETDkEYYTVKDDLDSPVFWY  1043

         **********98.9********......********************************

S: 177   apeclseaknlstasdvWsFgvtlyellt.cskgesp....lrsesle.......rklel  224

         apecl+++k +++asdvWsFgvtlyellt c++++sp    l++++++       r++++

Q: 1044  APECLIQSK-FYIASDVWSFGVTLYELLTyCDSESSPmtefLKMIGPTqgqmtvaRLVRV  1102

         *********.*******************************99999999***********

S: 225   leekerlpkpk.cpaelaelmtnclsyepsqrpsFraile  263

         l+e++rlp+p+ cp+e+ +lm++c+  + ++r++F+++++

Q: 1103  LQEEKRLPRPPnCPEEIDQLMRKCWIFKHDKRTTFHNLIQ  1142

         *************************************986

Domain Sequence
(FASTA)

LKRIRDLGEG HFGKVELCRY DPEGDNTGEQ VAVKSLKPES GGNHIADLKK EIEILRNLYH 60

ENIVKYKGIC TEDGGNGIKL IMEFLPSGSL KEYLPRNKNK INLKQLLRYA VQICKGMDYL 120

GSRQYVHRDL AANVLVESEN RVKIGDFGLT KAIETDKEYY TVKDDLDSPV FWYAPECLIQ 180

SKFYIASDVW SFGVTLYELL TYCDSESSPM TEFLKMIGPT QGQMTVARLV RVLQEEKRLP 240

RPPNCPEEID QLMRKCWIFK HDKRTTFHNL IQ 272

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005856	; C:cytoskeleton
GO:0016020	; C:membrane
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0019221	; P:cytokine-mediated signaling pathway
GO:0007167	; P:enzyme linked receptor protein signaling pathway
GO:0007243	; P:intracellular protein kinase cascade
GO:0018108	; P:peptidyl-tyrosine phosphorylation
GO:0046677	; P:response to antibiotic

KEGG

InterPros

IPR019749	; Band_41_domain.
IPR019748	; FERM_central.
IPR000299	; FERM_domain.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR020635	; Tyr_kinase_cat_dom.
IPR016251	; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR020776	; Tyr_kinase_non-rcpt_Jak1.

Pfam

PF07714

; Pkinase_Tyr; 2.

SMARTs

SM00295	; B41; 1.
SM00252	; SH2; 1.
SM00219	; TyrKc; 2.

Prosites

PS50057	; FERM_3; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS50001	; SH2; 1.

Prints

PR01823	; JANUSKINASE.
PR01824	; JANUSKINASE1.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013