EKS-MEG-00399

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MEG-00399

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/RIPK	342.3	1.5E-102	27	292	266

Status

Unreviewed

Ensembl Protein

ENSMGAP00000012426

UniProt Accession

G1NH07;

Protein Name

Protein Synonyms/Alias

Gene Name

RIPK2

Gene Synonyms/Alias

RIPK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000011842	ENSMGAP00000012426	ENSMGAT00000013317

Organism

Meleagris gallopavo

Functional Description

Protein Length

574

Protein Sequence
(FASTA)

LTSVLYWEER GQKKATGSAI PTHKLPDLRF ISRGAYGTVS AARHADWRVP VALKCLQGPL 60

LDSDRNHLLK EAEILHKARF SYILPILGIC NEPDFLGIVT EYMANGSLNQ LLHGKDVYPD 120

IAWCLRYRIL YEIALGVNYL HNMNPPLLHH DLKTQNILLD DEFHVKIADF GMSKWRVISM 180

SQSRSETSLP EGGTIVYMPP EDYNPSQKTR ASVKHDIYSF AIIIWEVMSR KHPFEEVINP 240

LQIMYSVSQG QRLDLSETSL SMDIPHRALV IRLIESGWAQ NPDERPSFLK CLIDLEPVLR 300

TFDEIAILEA VILLKRSKSQ YESQCIHRSG KKAVVEKTSL NIPLNPQEET SASIHCDALP 360

LRSISPDTSR LKTPPQCNIL SSVNAGEKAE KTIDFIAINQ SIKKSADGNS CGLHSLSCQS 420

VDENLSVTQS AKPFVHPYSY LPSSEKNISV ASNSSSCVLQ TSPISSDFVL ETIQQNVAHQ 480

WIQSKREEII DQMTEACLNQ SLDALLSRFL LMKEDYELIS TKPTRTSKVR QLLDTSDNQG 540

EEFARIIIQK LKDNKQLGLQ PYPDIVFNSL RLHL 574

Nucleotide Sequence
(FASTA)

CTGACCTCTG TTCTCTACTG GGAGGAAAGA GGGCAGAAGA AAGCCACAGG CTCAGCCATA 60

CCCACGCATA AGCTGCCGGA CCTGCGCTTC ATCAGCCGCG GCGCCTACGG CACCGTGTCC 120

GCCGCCCGCC ACGCCGACTG GAGGGTCCCG GTGGCCCTCA AGTGTTTGCA AGGGCCGCTG 180

CTAGACAGTG ACAGAAACCA CCTTCTAAAG GAAGCAGAGA TATTACACAA AGCCAGGTTT 240

AGTTACATTC TGCCAATTTT GGGAATTTGC AATGAGCCTG ACTTTCTGGG GATTGTAACA 300

GAATACATGG CAAATGGATC GCTGAACCAG CTTTTACACG GGAAAGACGT GTATCCTGAC 360

ATTGCCTGGT GCCTGAGATA CCGCATTCTT TATGAAATTG CTTTGGGAGT GAACTATTTG 420

CACAACATGA ATCCTCCATT GTTGCACCAT GACTTGAAAA CCCAGAATAT TTTATTGGAT 480

GATGAGTTTC ATGTCAAGAT TGCAGATTTT GGCATGTCAA AATGGCGTGT CATATCCATG 540

TCACAGTCAC GCAGTGAAAC TTCCTTACCA GAAGGAGGGA CCATCGTCTA CATGCCCCCT 600

GAAGATTACA ATCCCAGTCA GAAAACTCGG GCAAGTGTGA AACATGATAT CTACAGTTTT 660

GCGATTATTA TATGGGAAGT GATGTCAAGG AAACACCCAT TTGAAGAAGT TATAAACCCC 720

TTGCAGATAA TGTATAGTGT GTCACAAGGA CAGCGACTAG ACTTAAGTGA AACAAGCTTA 780

TCAATGGACA TTCCACATCG AGCTCTTGTC ATAAGATTGA TAGAAAGTGG ATGGGCACAA 840

AACCCAGATG AAAGACCATC ATTCTTAAAA TGTTTAATAG ACCTTGAACC AGTCCTGAGA 900

ACATTTGATG AAATAGCTAT CCTGGAAGCA GTAATTTTGT TAAAGAGATC AAAGTCACAG 960

TATGAATCTC AGTGTATCCA CAGGAGTGGA AAAAAAGCAG TTGTGGAGAA AACATCTCTA 1020

AATATACCAC TGAATCCCCA AGAGGAAACA TCTGCTTCCA TACACTGTGA TGCACTTCCT 1080

CTTCGGAGTA TCTCTCCAGA TACATCACGA CTCAAAACTC CTCCCCAGTG TAATATCCTC 1140

TCATCAGTGA ATGCTGGTGA GAAAGCAGAA AAGACAATTG ACTTTATTGC TATAAATCAG 1200

AGCATCAAAA AGTCTGCTGA TGGAAATTCT TGTGGTCTAC ACTCTCTCAG CTGTCAGAGT 1260

GTGGATGAAA ATCTCTCTGT AACTCAAAGC GCCAAACCTT TTGTGCATCC ATACAGTTAC 1320

CTTCCCTCAT CTGAGAAGAA TATTTCAGTT GCCTCAAATT CTTCATCGTG TGTGCTGCAG 1380

ACATCACCAA TTTCCTCAGA TTTTGTTTTG GAAACCATAC AACAGAATGT AGCTCATCAA 1440

TGGATCCAAA GTAAGAGAGA AGAAATTATT GATCAGATGA CTGAAGCATG TTTGAATCAG 1500

TCACTGGATG CTCTTCTATC AAGATTTTTA CTCATGAAAG AAGACTATGA ACTTATAAGC 1560

ACCAAACCTA CAAGGACATC AAAAGTCCGA CAACTACTTG ATACCTCAGA TAACCAAGGA 1620

GAGGAATTTG CCAGAATTAT AATACAGAAG TTGAAAGATA ACAAACAGCT AGGACTTCAA 1680

CCCTATCCAG ACATTGTATT TAATTCTCTA AGACTGCATC TTTAA 1725

Domain Profile

S: 3     elelvgsGgfgkvfkarhrkwrvevavkslvlktdaldserkelleeakkmeklrfsyvl  62

         +l+++++G++g+v+ arh++wrv va k  +l++++lds+r++ll+ea++++k+rfsy+l

Q: 27    DLRFISRGAYGTVSAARHADWRVPVALK--CLQGPLLDSDRNHLLKEAEILHKARFSYIL  84

         7899************************..******************************

S: 63    kllGvikeeeklglvmeymenGsLeklLkseielp...wplkfRilkevvlgmnyLhslk  119

         ++lG+++e+++lg+v+eym+nGsL++lL+ +  +p   w l++Ril e++lg+nyLh+++

Q: 85    PILGICNEPDFLGIVTEYMANGSLNQLLHGKDVYPdiaWCLRYRILYEIALGVNYLHNMN  144

         ******************************98888888**********************

S: 120   PpllhkDLkpeniLlDnelhvkiaDfGlskf.meessqskevsssaegGtlaYlaPelle  178

         Ppllh+DLk++niLlD e+hvkiaDfG+sk+ + ++sqs++  s +egGt++Y++Pe ++

Q: 145   PPLLHHDLKTQNILLDDEFHVKIADFGMSKWrVISMSQSRSETSLPEGGTIVYMPPEDYN  204

         *******************************999**************************

S: 179   evnk.kaseksDvYsfaiviWavlakkepyeeeknslqiiivvkkgnRPeleevseelPr  237

         +++k +as k+D+Ysfai+iW+v+++k+p+ee++n lqi+++v++g+R +l+e   +l +

Q: 205   PSQKtRASVKHDIYSFAIIIWEVMSRKHPFEEVINPLQIMYSVSQGQRLDLSE--TSLSM  262

         **9999**********************************************9..55556

S: 238   evpq...lieLmkrcWeadpeeRPsFleie  264

         ++p+   +i+L++++W+++p+eRPsFl++

Q: 263   DIPHralVIRLIESGWAQNPDERPSFLKCL  292

         67777779*******************985

Domain Sequence
(FASTA)

DLRFISRGAY GTVSAARHAD WRVPVALKCL QGPLLDSDRN HLLKEAEILH KARFSYILPI 60

LGICNEPDFL GIVTEYMANG SLNQLLHGKD VYPDIAWCLR YRILYEIALG VNYLHNMNPP 120

LLHHDLKTQN ILLDDEFHVK IADFGMSKWR VISMSQSRSE TSLPEGGTIV YMPPEDYNPS 180

QKTRASVKHD IYSFAIIIWE VMSRKHPFEE VINPLQIMYS VSQGQRLDLS ETSLSMDIPH 240

RALVIRLIES GWAQNPDERP SFLKCL 266

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0002250	; P:adaptive immune response
GO:0007249	; P:I-kappaB kinase/NF-kappaB cascade
GO:0045087	; P:innate immune response
GO:0070427	; P:nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070431	; P:nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0046641	; P:positive regulation of alpha-beta T cell proliferation
GO:0043065	; P:positive regulation of apoptotic process
GO:0032722	; P:positive regulation of chemokine production
GO:0001961	; P:positive regulation of cytokine-mediated signaling pathway
GO:0070374	; P:positive regulation of ERK1 and ERK2 cascade
GO:0043123	; P:positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0033091	; P:positive regulation of immature T cell proliferation
GO:0032729	; P:positive regulation of interferon-gamma production
GO:0032743	; P:positive regulation of interleukin-2 production
GO:0032755	; P:positive regulation of interleukin-6 production
GO:0046330	; P:positive regulation of JNK cascade
GO:0051092	; P:positive regulation of NF-kappaB transcription factor activity
GO:0031398	; P:positive regulation of protein ubiquitination
GO:0045627	; P:positive regulation of T-helper 1 cell differentiation
GO:0002827	; P:positive regulation of T-helper 1 type immune response
GO:0032760	; P:positive regulation of tumor necrosis factor production
GO:0043330	; P:response to exogenous dsRNA
GO:0070555	; P:response to interleukin-1
GO:0070671	; P:response to interleukin-12
GO:0070673	; P:response to interleukin-18
GO:0042098	; P:T cell proliferation
GO:0050852	; P:T cell receptor signaling pathway
GO:0034134	; P:toll-like receptor 2 signaling pathway
GO:0034142	; P:toll-like receptor 4 signaling pathway

KEGG

InterPros

IPR001315	; CARD.
IPR011029	; DEATH-like.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017322	; Rcpt-int_Ser/Thr_kinase-2.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00619	; CARD; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS50209	; CARD; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013