EKS-MEG-00238

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MEG-00238

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/IKK	272.1	4.5E-81	2	219	218

Status

Unreviewed

Ensembl Protein

ENSMGAP00000012469

UniProt Accession

G1NH45;

Protein Name

Protein Synonyms/Alias

Gene Name

CHUK

Gene Synonyms/Alias

CHUK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000011881	ENSMGAP00000012469	ENSMGAT00000013363

Organism

Meleagris gallopavo

Functional Description

Protein Length

675

Protein Sequence
(FASTA)

LSRLNHPNVV RACEVPEEMN FLVNDVPLLA MEYCSGGDLR KLLNKPENCC GLKESQILSL 60

LSDIGNAFSL YHVFGEDLEV PWRSASWKLI IHKIIDLGYA KDLDQGSLCT SFVGTLQYLA 120

PELFENKSYS VTVDYWSFGT MVFECIAGFR PFLHNLQPFT WHEKIKKKDP KHIFASEEMS 180

GEVRFSTHLP QPHSICSLIV EPMESWLQLM LNWDPEQRGG GLDPETNCPK CFLIMDHILN 240

LKIVHILNMT SAKIVSFLLH PEESLHSLQI RIEFETGIST GNQELLLETG ICLDPRKPAS 300

QCVIDGVRGW DSYMVYLFDK SKTVYDGPFA SRSLSECVNY IVQDSKIQLP IPQLRKVWAE 360

AVHYVIGLKE DYSRLFQGQR AAMLSLLRYN ANLIKMKNNM VSASQQLKAK LEFFHQSIRL 420

DLERYSDQMA YGISSEKMLK AWKEMEEKAS QCAQAEDIGY LDEQIMALHT EIVELQKSPY 480

ARRQGEVMES LEQKAIDLYK QLKTRPPDHA YSDSTDMVKI IVQTVQSQDR VLKELFGHLS 540

KLLGCKQKII DLLPKIEVAL NNIKEADNSV MQMQGKRQRE IWHLLKIACT QSSSRSLVSS 600

SLEGTASTPA ATWAPQGSSE YAPHPLSSMA TPGDGENFVD VIEENLNYLD RFSSMLQEAR 660

EEQNCLTNFD WSWLK 675

Nucleotide Sequence
(FASTA)

CTGTCTAGGT TGAACCATCC CAACGTAGTG AGAGCCTGCG AAGTTCCTGA GGAAATGAAC 60

TTCCTTGTGA ACGATGTGCC TCTTCTGGCA ATGGAATATT GCTCGGGGGG TGACCTCCGG 120

AAGCTGCTAA ACAAACCGGA AAACTGCTGT GGACTTAAGG AAAGCCAAAT ACTTTCTCTT 180

CTTAGTGACA TTGGTAATGC ATTCTCTCTC TATCATGTCT TCGGTGAAGA TTTGGAAGTG 240

CCATGGAGAA GTGCAAGTTG GAAACTGATC ATTCACAAAA TAATTGACCT GGGTTACGCC 300

AAGGATTTGG ATCAAGGAAG CTTGTGCACT TCATTTGTTG GAACACTGCA ATATTTGGCT 360

CCCGAACTCT TCGAGAATAA ATCCTATTCT GTCACTGTTG ATTACTGGAG CTTTGGAACG 420

ATGGTGTTTG AATGCATTGC AGGATTTCGG CCTTTCCTGC ACAATCTCCA GCCATTTACC 480

TGGCATGAAA AAATCAAGAA GAAGGATCCA AAACACATAT TTGCTTCTGA AGAGATGAGC 540

GGGGAGGTTC GCTTCAGTAC TCATTTGCCA CAGCCTCACA GCATCTGTAG TTTAATTGTA 600

GAACCGATGG AAAGTTGGTT GCAACTGATG CTGAATTGGG ACCCAGAACA GAGGGGTGGA 660

GGTTTAGATC CTGAAACCAA TTGTCCAAAG TGCTTCCTAA TTATGGATCA CATACTGAAT 720

TTGAAGATAG TGCACATCCT AAATATGACC TCTGCCAAGA TTGTTTCATT TCTCTTGCAT 780

CCTGAGGAAA GTCTTCATTC CCTTCAGATT CGAATTGAGT TTGAAACTGG AATAAGCACT 840

GGAAATCAGG AACTACTCTT GGAAACAGGA ATTTGCCTAG ACCCCCGGAA ACCTGCTTCC 900

CAGTGTGTTA TTGATGGCGT AAGGGGCTGG GATAGCTATA TGGTCTACTT GTTTGATAAA 960

AGCAAAACTG TCTATGATGG ACCCTTTGCT TCTCGGAGTC TGTCTGAATG TGTAAATTAT 1020

ATTGTACAGG ATAGTAAAAT CCAACTACCA ATTCCTCAGC TCCGCAAGGT ATGGGCAGAA 1080

GCAGTTCACT ACGTCATTGG GCTAAAAGAA GATTACAGCA GGCTTTTCCA GGGCCAGAGA 1140

GCTGCCATGC TGAGTCTCCT TCGGTATAAT GCCAACCTAA TCAAAATGAA AAACAATATG 1200

GTATCAGCAT CTCAGCAACT GAAAGCAAAG CTGGAATTCT TTCACCAGAG CATTCGCCTT 1260

GACCTGGAGA GATACAGCGA CCAGATGGCT TATGGCATAT CTTCAGAAAA GATGCTGAAA 1320

GCATGGAAGG AGATGGAAGA GAAGGCCTCT CAGTGTGCCC AGGCTGAAGA TATTGGATAT 1380

CTGGATGAAC AGATCATGGC TCTGCACACA GAGATTGTGG AGCTTCAGAA GAGTCCATAT 1440

GCAAGGCGCC AAGGAGAAGT CATGGAGAGC TTGGAACAGA AAGCCATAGA CCTGTACAAG 1500

CAATTAAAAA CAAGACCTCC AGATCATGCC TACAGTGACA GCACAGACAT GGTAAAGATT 1560

ATTGTGCAGA CAGTTCAGAG CCAAGACCGA GTACTGAAGG AGCTCTTTGG CCATCTCAGC 1620

AAGCTCTTGG GCTGTAAGCA GAAGATTATT GACTTGCTTC CAAAGATTGA AGTGGCTCTA 1680

AATAACATCA AAGAAGCTGA TAACTCAGTG ATGCAGATGC AGGGCAAAAG ACAAAGGGAG 1740

ATATGGCATT TGCTGAAAAT TGCTTGCACT CAAAGCTCTT CTCGTTCACT GGTAAGCTCC 1800

AGCCTAGAAG GGACAGCTTC AACTCCAGCA GCCACGTGGG CTCCTCAGGG CTCCTCAGAA 1860

TATGCACCTC ACCCTCTTTC ATCTATGGCA ACTCCTGGAG ATGGGGAAAA CTTTGTTGAC 1920

GTGATAGAGG AGAACTTGAA TTATCTTGAT CGCTTTAGCA GTATGTTGCA GGAGGCAAGA 1980

GAAGAGCAGA ACTGCTTGAC GAACTTCGAC TGGAGCTGGC TGAAGTAG 2028

Domain Profile

S: 52    rklnhknivklvdveeelnlasarlkvlvleyCsgGdlrkvLeepenayGLkesevlvvL  111

          +lnh+n+v++++v+ee+n++ +++++l++eyCsgGdlrk+L++pen++GLkes++l++L

Q: 2     SRLNHPNVVRACEVPEEMNFLVNDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLL  61

         69**********************************************************

S: 112   sdvvaglryLrenkivhRDlkPenivllkgedgksiykltDlGaareldddekvvslvGt  171

         sd+ +++   +   +   Dl    +   ++  +  i+k++DlG+a++ld++++++s+vGt

Q: 62    SDIGNAFSLYH---VFGEDLE---VPWRSASWKLIIHKIIDLGYAKDLDQGSLCTSFVGT  115

         ******99887...6778996...333444467799************************

S: 172   eeYlaPelyeqkkytatvDlWsiGvllyeaitGslPflpfegprrlykkitkkpakaiag  231

         ++YlaPel+e+k+y++tvD+Ws+G++++e+i+G++Pfl++ +p+++++ki+kk++k i++

Q: 116   LQYLAPELFENKSYSVTVDYWSFGTMVFECIAGFRPFLHNLQPFTWHEKIKKKDPKHIFA  175

         ************************************************************

S: 232   tekangevefssslPlsaslssglqeklekllanllevdeekrw  275

         +e+++gev+fs++lP++ s++s+++e +e++l+++l++d+e+r+

Q: 176   SEEMSGEVRFSTHLPQPHSICSLIVEPMESWLQLMLNWDPEQRG  219

         *****************************************986

Domain Sequence
(FASTA)

SRLNHPNVVR ACEVPEEMNF LVNDVPLLAM EYCSGGDLRK LLNKPENCCG LKESQILSLL 60

SDIGNAFSLY HVFGEDLEVP WRSASWKLII HKIIDLGYAK DLDQGSLCTS FVGTLQYLAP 120

ELFENKSYSV TVDYWSFGTM VFECIAGFRP FLHNLQPFTW HEKIKKKDPK HIFASEEMSG 180

EVRFSTHLPQ PHSICSLIVE PMESWLQLML NWDPEQRG 218

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0008384	; F:IkappaB kinase activity
GO:0007252	; P:I-kappaB phosphorylation
GO:0043123	; P:positive regulation of I-kappaB kinase/NF-kappaB cascade

KEGG

InterPros

IPR022007	; IKKbetaNEMObind.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.

Pfam

PF12179	; IKKbetaNEMObind; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS50011

; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013