EKS-MEG-00082

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MEG-00082

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Tec	485.8	1.9E-146	264	513	250

Status

Unreviewed

Ensembl Protein

ENSMGAP00000012615

UniProt Accession

G3USQ2;

Protein Name

Protein Synonyms/Alias

Gene Name

TEC

Gene Synonyms/Alias

TEC;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000012004	ENSMGAP00000018730	ENSMGAT00000020363
ENSMGAG00000012004	ENSMGAP00000012615	ENSMGAT00000013511

Organism

Meleagris gallopavo

Functional Description

Protein Length

523

Protein Sequence
(FASTA)

GIKNNSNIMI KYHPKFWTEG IYQCCRQTEK LAPGCEKYNL FENSVVTLPL PMPEKSMRRP 60

PPPVPPAEEN DNEEEEIVVA MYDFQPTERH DLRLDKGEEY TVIEKNDIHW WKARDKHGHE 120

GYIPSNYVTG KKSNNLDQYE WYSRNLNRSK AEQLLRNEDK EGGFVVRDSS QPGLYTVSLY 180

TKFGGEGSSG IRHYHIKETV TSPKQYYLAE KHLFNSIPEI IEYHKHNAAG LVTRLRYPVT 240

PEKTTAPTTA GFSYEKWEIN PSELTFMREL GSGLFGVVRL GKWRAQYKVA IKAIREGAMY 300

EEDFIEEAKV MMKLTHPKLV QLYGVCTQQR PIYIVTEFME HGCLLNYLRQ KRGVLSKDVL 360

LTMCQDVCEG MEYLERNSFI HRDLAARNCL VNDLGVVKVS DFGMTRYVLD DQYTSSSGAK 420

FPVKWCPPEV FNYSRFSSKS DVWSFGVLMW EVFTEGKMPF EKSSNYDVVT MVSQGHRLYR 480

PKLACKQVYE VMMMCWQEKP EGRPTFEDLL HIIIDIAEGE DAF 523

Nucleotide Sequence
(FASTA)

GGAATAAAGA ACAACAGCAA TATAATGATA AAATATCATC CTAAATTCTG GACAGAAGGA 60

ATTTATCAGT GCTGCAGACA GACAGAAAAA TTAGCACCTG GCTGTGAAAA ATACAATCTT 120

TTTGAAAATA GTGTAGTAAC GCTGCCCTTG CCAATGCCAG AAAAAAGTAT GCGACGGCCA 180

CCACCACCTG TTCCTCCAGC TGAGGAAAAT GACAATGAAG AGGAGGAGAT AGTGGTTGCG 240

ATGTATGACT TCCAGCCTAC AGAACGTCAT GATTTAAGGT TAGATAAAGG TGAAGAATAT 300

ACAGTAATCG AGAAGAATGA CATTCACTGG TGGAAGGCAA GAGACAAACA TGGGCATGAA 360

GGATATATTC CAAGCAACTA TGTAACAGGA AAGAAGTCCA ACAACCTTGA TCAGTATGAG 420

TGGTACAGCA GGAACCTGAA TCGCAGCAAG GCAGAGCAAC TCCTTAGAAA TGAGGACAAA 480

GAAGGTGGTT TTGTGGTGAG AGATTCAAGT CAGCCTGGCC TGTATACAGT TTCCCTTTAT 540

ACAAAATTTG GAGGGGAAGG TTCATCAGGA ATAAGACACT ACCATATAAA AGAAACAGTG 600

ACATCACCAA AGCAATACTA CCTTGCAGAA AAACATCTCT TTAACTCCAT TCCAGAGATA 660

ATTGAGTATC ACAAACATAA TGCAGCAGGT CTTGTTACCA GGCTGCGTTA CCCTGTGACC 720

CCAGAGAAGA CAACAGCACC AACAACTGCA GGATTCAGCT ATGAGAAATG GGAAATTAAT 780

CCATCAGAGC TGACTTTCAT GAGAGAGCTG GGGAGTGGCC TATTTGGAGT AGTGCGCCTT 840

GGGAAATGGA GAGCGCAGTA CAAAGTGGCC ATCAAAGCAA TTCGGGAAGG CGCGATGTAT 900

GAAGAGGATT TTATTGAAGA AGCCAAAGTA ATGATGAAAC TAACACATCC TAAGTTAGTT 960

CAGCTGTATG GTGTGTGCAC ACAACAGAGA CCCATCTACA TTGTGACCGA GTTCATGGAG 1020

CATGGCTGCC TTCTGAATTA CCTAAGACAA AAACGTGGGG TTTTGAGTAA AGATGTCCTG 1080

CTCACTATGT GCCAAGACGT CTGTGAGGGA ATGGAATACC TGGAGAGGAA CAGCTTTATC 1140

CACAGAGACC TGGCTGCCAG GAACTGCTTG GTGAATGATT TGGGGGTGGT TAAAGTATCT 1200

GATTTTGGGA TGACAAGGTA TGTCCTTGAT GATCAGTACA CAAGTTCCTC GGGGGCTAAA 1260

TTTCCTGTGA AGTGGTGCCC ACCAGAAGTT TTCAATTACA GTCGATTCAG CAGCAAGTCA 1320

GATGTCTGGT CATTCGGTGT TTTAATGTGG GAAGTGTTTA CAGAAGGAAA AATGCCCTTC 1380

GAAAAAAGTT CCAACTATGA TGTGGTAACT ATGGTTAGCC AAGGACATCG CTTGTACCGC 1440

CCCAAGCTGG CCTGCAAGCA AGTATATGAA GTCATGATGA TGTGCTGGCA GGAGAAACCG 1500

GAGGGACGCC CAACTTTTGA AGACTTGCTC CATATAATCA TTGACATTGC AGAGGGTGAA 1560

GATGCTTTC 1569

Domain Profile

S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60

         lt+++elgsg fgvv+lgkwra+++vaikai+egam eedfieeakvmmkl+hpklvqly

Q: 264   LTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMYEEDFIEEAKVMMKLTHPKLVQLY  323

         79**********************************************************

S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120

         gvc++q+piyivte++e+gcllnylr+k++ l+k++ll mc+dvcegmeyler+sfihrd

Q: 324   GVCTQQRPIYIVTEFMEHGCLLNYLRQKRGVLSKDVLLTMCQDVCEGMEYLERNSFIHRD  383

         ************************************************************

S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180

         laarnclv++  vvkvsdfg++ryvlddqy+ss+gakfpvkw+ppev++ys++ssksdvw

Q: 384   LAARNCLVNDLGVVKVSDFGMTRYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVW  443

         ************************************************************

S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeer  240

         +fgvlmwevf+egk+p+ek sn++vv++vs+g+rlyrpkla k+vyevm+ cw+ekpe+r

Q: 444   SFGVLMWEVFTEGKMPFEKSSNYDVVTMVSQGHRLYRPKLACKQVYEVMMMCWQEKPEGR  503

         ************************************************************

S: 241   ptfkellsal  250

         ptf++ll+ +

Q: 504   PTFEDLLHII  513

         *******987

Domain Sequence
(FASTA)

LTFMRELGSG LFGVVRLGKW RAQYKVAIKA IREGAMYEED FIEEAKVMMK LTHPKLVQLY 60

GVCTQQRPIY IVTEFMEHGC LLNYLRQKRG VLSKDVLLTM CQDVCEGMEY LERNSFIHRD 120

LAARNCLVND LGVVKVSDFG MTRYVLDDQY TSSSGAKFPV KWCPPEVFNY SRFSSKSDVW 180

SFGVLMWEVF TEGKMPFEKS SNYDVVTMVS QGHRLYRPKL ACKQVYEVMM MCWQEKPEGR 240

PTFEDLLHII 250

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005856	; C:cytoskeleton
GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0005543	; F:phospholipid binding
GO:0050853	; P:B cell receptor signaling pathway
GO:0007229	; P:integrin-mediated signaling pathway
GO:0010543	; P:regulation of platelet activation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR001849	; Pleckstrin_homology.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF00169	; PH; 1.
PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00233	; PH; 1.
SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013