EKS-MEG-00084
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MEG-00084
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Tec471.15.6E-142280530251
StatusUnreviewed
Ensembl ProteinENSMGAP00000012626
UniProt AccessionG1NHH0;
Protein Name
Protein Synonyms/Alias
Gene NameTXK
Gene Synonyms/Alias TXK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMGAG00000012022ENSMGAP00000012626ENSMGAT00000013522
OrganismMeleagris gallopavo
Functional Description
Protein Length536
Protein Sequence
(FASTA)
MFLFTDHTIQ SVFCCCCCCA VQKRIRAMRT KINVDSDTDL ETQYSASQSE DSHAPTWKCK 60
LLRCYRSRGI IQEIENKPLP PLPAEAFEDY TKKLKVIALY DFFARGPSDL TLKQSEEYII 120
LEQYDPHWWK ARDQYGNEGL IPSNYVTENT KSNLETYEWY CKNINRSQAE LLLRQKSKEG 180
SFVVRDSSQQ GILTLSVYSR SKGSHGGDIR HYQIKKNHLK QYYVAEKYLF SSIPELIQYH 240
QHNAAGLITR LRHPVRSIRC SSPATAGFSY EEWELNPSEL TFMKELGRGQ FGIVHLGKWK 300
ATIKVAIKKI NEGAMSEDDF MEEAKLMMKL SHPKLVQLYG VCTRQKPLYV VTEFLENGCL 360
LNYLRQWRGK LSRDMLLGMC LDVCEGMEYL ERNNFIHRDL AARNCLVNAE HTVKVSDFGM 420
ARYVIDDEYV SSSGAKFPIK WSSPEVFHFK KYSSKSDIWS FGVLMWEVFT EGKMPFESKS 480
NYEVVHEISA GNRLYRPHLA SHTVYKVMYS CWHEKPEGRP TFAELVETLT DIMEMG 536
Nucleotide Sequence
(FASTA)
ATGTTCTTGT TTACAGATCA CACCATCCAG TCTGTTTTCT GCTGCTGCTG CTGCTGTGCG 60
GTACAAAAAC GAATTAGAGC AATGAGAACA AAGATAAATG TGGACTCTGA CACTGACCTG 120
GAGACCCAGT ACTCAGCCTC TCAATCAGAA GATTCACATG CACCTACTTG GAAGTGTAAA 180
TTATTGAGGT GCTATAGAAG TAGGGGAATT ATACAAGAAA TAGAGAACAA GCCTTTACCT 240
CCTCTACCTG CTGAGGCTTT TGAAGACTAC ACAAAGAAAC TCAAAGTTAT TGCCCTATAT 300
GACTTTTTCG CTAGAGGACC CTCTGATTTA ACACTCAAGC AGTCGGAAGA ATACATTATC 360
CTTGAACAGT ATGATCCTCA CTGGTGGAAG GCTAGAGACC AGTATGGGAA TGAAGGTCTA 420
ATTCCTAGCA ATTATGTTAC TGAGAACACA AAAAGTAATT TAGAAACATA TGAGTGGTAT 480
TGCAAGAACA TCAACAGAAG CCAGGCAGAA CTACTTTTGC GACAGAAGTC CAAAGAAGGC 540
TCATTTGTTG TTAGAGATTC AAGCCAACAG GGAATCCTTA CGCTGTCTGT GTATTCACGA 600
TCTAAAGGAA GTCATGGTGG AGACATTCGA CATTATCAAA TTAAGAAAAA CCACTTGAAA 660
CAGTATTATG TAGCAGAAAA ATATCTATTC TCCTCTATTC CTGAGCTCAT TCAATATCAT 720
CAACACAATG CTGCAGGTCT TATCACCCGT CTCCGACATC CAGTCAGATC AATCAGATGT 780
TCTTCACCAG CAACAGCAGG ATTTAGTTAT GAGGAGTGGG AATTGAACCC CTCGGAACTG 840
ACGTTTATGA AAGAGCTTGG GCGTGGGCAA TTTGGAATTG TTCATCTGGG TAAATGGAAA 900
GCAACCATCA AGGTTGCCAT CAAAAAAATC AATGAAGGTG CGATGTCTGA AGACGATTTC 960
ATGGAGGAGG CCAAATTGAT GATGAAACTA TCCCACCCAA AGCTGGTCCA GCTGTATGGG 1020
GTGTGCACAC GTCAGAAGCC TCTCTACGTG GTGACTGAAT TCCTGGAGAA TGGTTGCCTG 1080
CTCAACTACC TGCGACAGTG GCGGGGGAAG CTCAGCAGAG ACATGCTGCT GGGAATGTGC 1140
CTGGATGTGT GTGAAGGGAT GGAGTATTTG GAGAGAAATA ACTTTATTCA CCGCGACTTA 1200
GCTGCAAGGA ACTGTTTAGT AAATGCTGAA CACACTGTTA AAGTATCTGA CTTCGGCATG 1260
GCAAGATACG TCATTGATGA TGAATATGTC AGCTCTTCAG GTGCCAAGTT TCCAATCAAG 1320
TGGTCATCTC CTGAAGTCTT TCATTTCAAA AAGTACAGCA GTAAATCTGA CATCTGGTCA 1380
TTTGGTGTAC TGATGTGGGA AGTTTTCACA GAAGGCAAAA TGCCTTTTGA AAGTAAATCA 1440
AATTATGAAG TTGTCCATGA GATTTCTGCA GGTAACCGAC TTTATCGGCC GCATTTGGCA 1500
TCACACACTG TGTACAAAGT CATGTACAGC TGCTGGCATG AGAAGCCTGA AGGACGTCCT 1560
ACTTTTGCAG AATTAGTAGA AACCCTCACA GATATAATGG AGATGGGATA A 1611
Domain Profile
S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60
         lt++kelg gqfg+v+lgkw+a i+vaik i+egamse+df+eeak mmklshpklvqly
Q: 280   LTFMKELGRGQFGIVHLGKWKATIKVAIKKINEGAMSEDDFMEEAKLMMKLSHPKLVQLY  339
         79**********************************************************
S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120
         gvc++qkp+y+vte+lengcllnylr+ ++kl++++ll mc dvcegmeyler++fihrd
Q: 340   GVCTRQKPLYVVTEFLENGCLLNYLRQWRGKLSRDMLLGMCLDVCEGMEYLERNNFIHRD  399
         ************************************************************
S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180
         laarnclv+ e++vkvsdfg+aryv+dd+yvss+gakfp+kws+pev++++kyssksd+w
Q: 400   LAARNCLVNAEHTVKVSDFGMARYVIDDEYVSSSGAKFPIKWSSPEVFHFKKYSSKSDIW  459
         ************************************************************
S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeer  240
         +fgvlmwevf+egk+p+e ksn+evv+++s g rlyrp+las++vy+vm+scw+ekpe+r
Q: 460   SFGVLMWEVFTEGKMPFESKSNYEVVHEISAGNRLYRPHLASHTVYKVMYSCWHEKPEGR  519
         ************************************************************
S: 241   ptfkellsale  251
         ptf+el+++l+
Q: 520   PTFAELVETLT  530
         *******9986
Domain Sequence
(FASTA)
LTFMKELGRG QFGIVHLGKW KATIKVAIKK INEGAMSEDD FMEEAKLMMK LSHPKLVQLY 60
GVCTRQKPLY VVTEFLENGC LLNYLRQWRG KLSRDMLLGM CLDVCEGMEY LERNNFIHRD 120
LAARNCLVNA EHTVKVSDFG MARYVIDDEY VSSSGAKFPI KWSSPEVFHF KKYSSKSDIW 180
SFGVLMWEVF TEGKMPFESK SNYEVVHEIS AGNRLYRPHL ASHTVYKVMY SCWHEKPEGR 240
PTFAELVETL T 251
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tursiops truncatus"; ?>
EKS-AIM-00100
EKS-BOT-00109
EKS-CAJ-00110
EKS-CAF-00110
EKS-CAP-00106
EKS-EQC-00106
EKS-ERE-00053
EKS-FEC-00104
EKS-GAG-00089
EKS-GOG-00109
EKS-HOS-00111
EKS-LAC-00111
EKS-LOA-00104
EKS-MAM-00104
EKS-MIM-00047
EKS-MOD-00108
EKS-MUM-00110
EKS-MUP-00112
EKS-MYL-00122
EKS-NOL-00101
EKS-ORC-00100
EKS-OTG-00110
EKS-PAT-00099
EKS-PES-00091
EKS-POA-00101
EKS-RAN-00106
EKS-SAH-00103
EKS-SUS-00096
EKS-TUT-00096
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
GO:0001012; F:RNA polymerase II regulatory region DNA binding
GO:0007202; P:activation of phospholipase C activity
GO:0002250; P:adaptive immune response
GO:0032729; P:positive regulation of interferon-gamma production
GO:0060335; P:positive regulation of interferon-gamma-mediated signaling pathway
GO:0046777; P:protein autophosphorylation
GO:0006357; P:regulation of transcription from RNA polymerase II promoter
GO:0050852; P:T cell receptor signaling pathway
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013