EKS-MEG-00280

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MEG-00280

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PEK	358.9	1.6E-107	551	956	406

Status

Unreviewed

Ensembl Protein

ENSMGAP00000012643

UniProt Accession

G1NHI7;

Protein Name

Protein Synonyms/Alias

Gene Name

EIF2AK4

Gene Synonyms/Alias

EIF2AK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000012034	ENSMGAP00000012643	ENSMGAT00000013539

Organism

Meleagris gallopavo

Functional Description

Protein Length

1605

Protein Sequence
(FASTA)

VRQPPEINLV LHPQGLTGDD EVYAKVDLWV KCPHTYPDTV PEIQLKNPKG LSNEKINELK 60

SRLAELAKEC CGEVMIFELA GCVQSFLSEY NKPPSKSFHE EMLKNHKKEQ ERLAQEELRR 120

AQEVKRREEQ EQREILNEIQ RREEEKREER KKKEIAKQER LEIAALASQE NSHRRDTSGY 180

RVASSFNGNS LEHGVNNKQR PNSVGRSKRE RQFSVGNNEE SPGNYEVLNF STSGAGQLTV 240

HKGKCLGKDE QLGKSVYNAL ETHSGDFVLI YEWVLHWQKK MGKFLTAQEI EKIEKCKKQL 300

QGAETEFSSL TKLSHPNIVH FICMNLKERE DSVVVDILVE HVNGFSLSTY LHKETPVPIE 360

KLRHYVSQIL SALDYLHSNS VVHKVLCAST ILVDAEGNVK VTDYSISKRL ADICKADVFE 420

QTKVRFSEDS LPSKPGKKGD VWSLGLLLLS LSQGQVTKEY PVAVPNNLPA DFQDFLEKCV 480

CLEDKERWTP QQLLQHSFIN IPRMKVPVAE ENLDDSVGID CIETVVPSSQ ISSASFCTET 540

QRQFSRYYNE FEELKLLGKG AFGAVIKVRN KLDGCYYAVK RIRINTASKQ FRRIKGEVTL 600

LSRLNHENIV RYYNAWIEKH ESPVPIVSSS ETSEDKRTPT KAGLILTAEE TNDVEANAPP 660

PVLTSSVEWS TSCERSSSNK FSGADQESSD DDDDDGDGVF SHSFLPTTDS ESEIVFDNED 720

ENSKGHPPDE EGNEKNSHEE EDRTPVIQTV HYLYIQMEYC EKSTLRDTID RGLYEDTSRL 780

WRLFREILDG LAYIHEKGMI HRDLKPVNIF LDSNDHVKIG DFGLATDHPA NAAVSKQEEN 840

HSDSFANYDP SGNLTGMVGT ALYVSPEVQG NTKSTYNQKV DLFSLGIIFF EMSYHPMSTA 900

SERIFVLGQL RLPSILFPQD FDEVKHAKQR LVITWLLNHD PAARPTAVEL LKSEHLPPPQ 960

MEESELHEVL HHTLANVDGK AYRTMMSQIF SQRISPAIDY TYDSDTLKGS FSVWAAKIQQ 1020

HVCEIISRIF KRHGAIKLHT PLLMPRNKKL YEHNEASYLM DHSGMLVMLP YDLRIPFARF 1080

VARNNISNLK RYCIERVFRP RKLDRCHPKE LLECAFDIIT STGNSFLPLA ETIYAISEII 1140

QEFSVLQERN YSIYLNHTSL LKAILLHCGI PEDKLNQVYI ILCDAVTEKL TKREVEAKFC 1200

NLSLTSNSLS RLYRFIEQKG EASNVFPFLN TMIKQKPGVT QLLKHGMKDL EEIIGLLKQL 1260

GIKLQISINL GLVYKIQQHN GIIFQFVAYI KRRQRTVPEI LAAGGRYDHL IPQFRGPQAV 1320

GPVPSAVGVS IAIDKITAAV SSMEDTISVS SCDLLVVSVG QMSMGRAINI VQKLWTAGIP 1380

AEIMYDWSQS QEELQEYCRC SGITYVALVS DKEGSHVKVK SFEKDRQTEK RIFESDLVDH 1440

LVQKLKTKIC DERGSRETSD NLSVPNQKGS FANSSGAFES HGTLVVPNVS VIAPEKLSAS 1500

ARRRQEIQVQ TRLQTFISNL QQKTSEIEIL AVDLPKETLI HFLLLEFDGA RHAFDATVRQ 1560

LMSRWPKQRC SYLQAICDEI YSIKMEKRVP VLILYSYRDE CKVLF 1605

Nucleotide Sequence
(FASTA)

GTACGACAGC CTCCGGAAAT TAATTTAGTT CTGCATCCTC AGGGATTGAC TGGTGATGAT 60

GAGGTGTACG CCAAAGTTGA TCTCTGGGTC AAGTGCCCAC ATACTTACCC TGATACTGTT 120

CCTGAAATAC AACTGAAAAA TCCCAAAGGC TTGTCTAATG AGAAAATAAA TGAGTTAAAA 180

TCCAGACTAG CTGAACTGGC AAAAGAGTGC TGTGGAGAGG TGATGATATT TGAACTTGCA 240

GGCTGCGTAC AGTCATTTCT CAGCGAGTAT AATAAACCAC CTTCCAAGTC CTTTCATGAA 300

GAAATGCTAA AAAATCATAA AAAAGAGCAA GAAAGGCTGG CGCAGGAGGA ATTGCGTAGG 360

GCACAAGAAG TTAAGAGAAG AGAGGAGCAG GAGCAACGTG AAATCCTTAA TGAGATTCAG 420

AGACGGGAGG AAGAGAAAAG AGAAGAAAGA AAAAAGAAAG AGATTGCCAA ACAGGAACGT 480

CTGGAAATTG CTGCTCTGGC AAGTCAAGAA AATTCTCACA GGAGAGATAC ATCAGGGTAC 540

AGAGTTGCTT CCAGTTTTAA TGGGAACTCT TTGGAACATG GAGTGAATAA TAAACAACGC 600

CCAAATTCAG TTGGGCGTTC AAAGCGAGAA CGCCAGTTTT CTGTTGGTAA TAATGAAGAG 660

TCCCCTGGAA ATTATGAAGT TCTGAACTTC AGCACAAGTG GTGCTGGGCA ACTTACTGTG 720

CATAAAGGAA AATGTCTAGG CAAGGATGAA CAGCTTGGTA AATCAGTCTA CAATGCCTTG 780

GAAACTCACA GTGGAGACTT TGTTTTAATA TACGAGTGGG TTCTGCACTG GCAAAAAAAG 840

ATGGGAAAAT TTCTTACAGC ACAGGAAATA GAAAAAATAG AGAAGTGTAA GAAACAGCTT 900

CAGGGTGCAG AGACCGAGTT CAGCTCACTG ACAAAGCTAA GTCACCCAAA CATAGTACAT 960

TTCATATGTA TGAACTTGAA AGAACGGGAG GATTCAGTTG TGGTGGACAT TTTAGTGGAG 1020

CACGTAAACG GTTTCAGCCT TTCCACATAC TTGCACAAAG AGACTCCAGT TCCGATTGAG 1080

AAGTTGCGCC ATTATGTGAG CCAGATTTTG TCAGCTCTTG ACTACTTGCA CAGTAATTCA 1140

GTAGTGCACA AAGTTCTCTG TGCTTCCACT ATCCTGGTAG ATGCTGAAGG AAACGTTAAG 1200

GTGACGGACT ACAGCATTTC CAAACGCCTA GCGGATATCT GCAAAGCAGA TGTTTTTGAG 1260

CAAACCAAAG TTCGTTTTAG CGAGGATTCT CTTCCCAGCA AACCTGGAAA AAAAGGAGAT 1320

GTCTGGAGTC TGGGCTTGCT TCTGCTTTCA CTCAGCCAGG GCCAAGTAAC CAAGGAATAT 1380

CCAGTGGCTG TTCCTAATAA TTTACCTGCT GACTTCCAAG ACTTTCTGGA AAAATGTGTT 1440

TGCTTGGAAG ATAAGGAAAG ATGGACTCCT CAGCAACTGT TACAACACAG TTTTATAAAC 1500

ATTCCACGAA TGAAAGTACC TGTAGCAGAA GAAAATCTAG ATGATTCGGT AGGTATAGAT 1560

TGCATTGAGA CTGTTGTGCC CAGCAGCCAG ATATCCAGTG CTTCATTCTG CACGGAAACA 1620

CAGAGACAAT TTTCACGCTA CTACAATGAG TTTGAAGAGC TAAAATTACT TGGCAAAGGG 1680

GCTTTTGGAG CAGTCATCAA GGTGCGAAAT AAGCTTGATG GTTGCTATTA TGCTGTAAAA 1740

CGTATCCGCA TAAACACTGC CAGTAAGCAG TTTCGGAGGA TTAAGGGAGA AGTAACGTTA 1800

CTTTCCCGTT TAAACCATGA AAATATTGTG AGGTATTATA ATGCTTGGAT AGAAAAACAC 1860

GAAAGTCCTG TTCCCATTGT GTCATCATCT GAGACATCTG AAGACAAAAG AACACCCACC 1920

AAAGCAGGTC TCATCCTTAC GGCAGAGGAG ACAAACGATG TGGAAGCTAA TGCTCCTCCC 1980

CCGGTTCTGA CAAGTTCAGT TGAGTGGAGT ACTTCGTGTG AGAGATCCTC CAGCAACAAA 2040

TTCAGTGGAG CTGATCAGGA GTCCAGTGAT GATGACGATG ATGATGGTGA TGGGGTGTTC 2100

TCACATTCGT TTCTGCCAAC TACAGACTCT GAAAGTGAAA TAGTTTTTGA TAACGAGGAT 2160

GAGAACAGTA AAGGTCATCC TCCAGATGAA GAAGGCAATG AAAAGAATAG CCACGAAGAA 2220

GAAGACAGAA CACCAGTCAT TCAAACAGTG CATTATCTGT ACATCCAGAT GGAATACTGT 2280

GAAAAGAGCA CACTGAGGGA TACCATTGAC CGAGGGTTGT ATGAAGACAC CAGTCGGCTT 2340

TGGAGGCTTT TCCGAGAAAT TCTGGATGGG TTAGCTTACA TCCATGAGAA GGGAATGATC 2400

CACAGAGACC TGAAACCTGT GAACATTTTT TTAGATTCCA ATGATCACGT GAAAATTGGT 2460

GATTTTGGTT TAGCTACAGA TCATCCAGCA AATGCAGCAG TCTCTAAGCA AGAAGAAAAT 2520

CACTCGGATA GCTTTGCTAA CTATGACCCA TCAGGTAATT TGACGGGGAT GGTTGGCACT 2580

GCACTGTATG TCAGCCCAGA GGTCCAAGGA AACACAAAAT CTACATACAA TCAGAAAGTG 2640

GACCTGTTCA GTCTGGGTAT AATATTCTTT GAAATGTCCT ACCACCCCAT GAGTACTGCA 2700

TCGGAAAGGA TCTTTGTTCT TGGTCAGCTA AGATTACCCA GTATTTTATT TCCTCAAGAC 2760

TTCGATGAAG TCAAGCATGC AAAGCAGAGA TTGGTTATTA CGTGGCTCTT GAACCATGAC 2820

CCTGCAGCAA GACCAACAGC CGTGGAGCTC TTAAAAAGTG AACATCTTCC ACCACCACAA 2880

ATGGAAGAGT CTGAGCTTCA TGAAGTGCTC CACCATACCT TAGCCAATGT GGATGGCAAG 2940

GCCTACCGCA CTATGATGAG TCAGATATTT TCACAGCGTA TATCTCCAGC TATAGACTAC 3000

ACCTATGACA GTGATACACT GAAGGGCAGT TTTTCTGTTT GGGCAGCCAA GATCCAGCAG 3060

CACGTGTGCG AGATTATCAG TCGGATATTT AAAAGACACG GAGCCATCAA GCTGCATACT 3120

CCATTGCTAA TGCCTAGAAA TAAAAAACTG TATGAACATA ATGAAGCTTC CTATTTGATG 3180

GATCACAGTG GGATGCTGGT TATGCTTCCT TATGACCTCA GAATTCCTTT TGCAAGATTT 3240

GTAGCTAGAA ACAATATATC AAACTTGAAA AGATACTGCA TAGAGCGAGT TTTCAGACCT 3300

CGGAAGTTAG ACCGCTGTCA TCCCAAAGAA CTTCTGGAAT GTGCATTTGA CATTATTACA 3360

TCCACTGGAA ATAGCTTTTT GCCTTTAGCA GAAACAATTT ATGCAATTTC AGAAATCATT 3420

CAGGAGTTTT CAGTGCTACA GGAAAGAAAT TACAGTATCT ACTTGAACCA TACTTCCTTA 3480

CTGAAAGCTA TACTTTTGCA CTGTGGGATA CCAGAGGATA AACTCAATCA AGTTTACATC 3540

ATTCTCTGTG ATGCTGTGAC TGAAAAGCTA ACTAAAAGAG AAGTGGAAGC CAAATTCTGT 3600

AATCTCTCTC TCACGTCAAA TAGCCTTTCT CGACTCTACA GGTTCATTGA GCAGAAGGGA 3660

GAAGCAAGTA ATGTATTTCC ATTTTTAAAC ACAATGATAA AACAAAAGCC AGGTGTGACT 3720

CAGCTGCTGA AGCATGGTAT GAAGGATCTA GAGGAAATAA TCGGTCTGCT AAAGCAACTT 3780

GGAATAAAAC TTCAGATTTC CATAAATCTG GGACTAGTTT ACAAAATACA GCAACACAAC 3840

GGTATTATCT TCCAGTTCGT AGCATACATC AAAAGAAGGC AAAGAACTGT GCCTGAAATT 3900

CTTGCTGCAG GGGGCAGATA CGATCACCTG ATCCCACAAT TTAGAGGACC GCAGGCAGTA 3960

GGACCGGTGC CTTCAGCTGT TGGAGTCAGC ATAGCTATAG ATAAAATAAC TGCTGCTGTT 4020

TCCAGTATGG AGGATACTAT TTCTGTCAGC TCATGTGACC TGCTGGTTGT AAGTGTTGGT 4080

CAGATGTCAA TGGGGAGAGC TATCAATATT GTTCAGAAAC TCTGGACTGC AGGAATTCCA 4140

GCTGAAATAA TGTACGACTG GTCCCAGTCC CAGGAAGAAC TGCAGGAGTA TTGCAGATGT 4200

TCTGGGATTA CATATGTAGC TCTTGTATCA GACAAAGAAG GAAGTCATGT AAAGGTGAAA 4260

TCCTTTGAGA AAGACAGACA GACGGAGAAA AGGATTTTTG AATCTGACTT AGTAGATCAC 4320

CTGGTCCAGA AACTGAAAAC TAAAATCTGT GATGAAAGAG GTAGTAGAGA AACTTCAGAC 4380

AACCTCTCAG TACCAAACCA AAAGGGATCA TTTGCTAATA GTTCAGGTGC GTTTGAGTCG 4440

CATGGAACTC TTGTAGTGCC TAATGTCAGC GTTATAGCTC CTGAGAAGTT ATCTGCCAGT 4500

GCCAGACGTC GCCAAGAAAT TCAGGTTCAA ACAAGACTGC AGACATTCAT TTCTAACTTG 4560

CAACAGAAAA CAAGTGAAAT TGAGATTTTG GCAGTAGATC TGCCAAAAGA AACTCTGATA 4620

CACTTCTTAT TATTAGAGTT TGATGGAGCC AGACATGCCT TTGATGCTAC TGTGAGACAA 4680

CTGATGTCAC GATGGCCAAA ACAGAGATGT TCATACTTGC AAGCAATTTG TGATGAAATT 4740

TACAGTATCA AAATGGAGAA GAGGGTTCCT GTGCTCATCC TGTACAGTTA CCGAGATGAA 4800

TGCAAGGTTT TGTTTTAG 4818

Domain Profile

S: 1     feeikvlGkGgfgvVlkaknkldkkeyaikriklnkakkelekverevkaLaklehpniv  60

         fee+k+lGkG+fg+V+k++nkld+++ya+kri++n+a+k++++++ ev++L++l+h+niv

Q: 551   FEELKLLGKGAFGAVIKVRNKLDGCYYAVKRIRINTASKQFRRIKGEVTLLSRLNHENIV  610

         89**********************************************************

S: 61    rYfaawleekeesl........................tdsseveaeaeleesesseesd  96

         rY++aw+e++e+++                        +++++vea+a++    ss e++

Q: 611   RYYNAWIEKHESPVpivsssetsedkrtptkagliltaEETNDVEANAPPPVLTSSVEWS  670

         ************************************964488888888888888888888

S: 97    tk..........................................................  98

t+

Q: 671   TScersssnkfsgadqessddddddgdgvfshsflpttdseseivfdnedenskghppde  730

         888899999999999999999999999999999999999999999999999999999999

S: 99    .....................llyiqmelceketLkdwiderkllesrselvmrlfkqll  137

                              +lyiqme+cek+tL+d+id+  l+e++s+l+ rlf+++l

Q: 731   egneknsheeedrtpviqtvhYLYIQMEYCEKSTLRDTIDRG-LYEDTSRLW-RLFREIL  788

         9999999999********************************.9********.*******

S: 138   egleylHskgliHrdLkpsniFldsddqvKigDFgLatalaealkedvkqdaqske....  193

         +gl+y+H+kg+iHrdLkp+niFlds+d+vKigDFgLat+   +   + +++++s +

Q: 789   DGLAYIHEKGMIHRDLKPVNIFLDSNDHVKIGDFGLATDHPANAAVSKQEENHS-Dsfan  847

         ***************************************666555444444444.44777

S: 194   ....akhtgqvgtklymsPeql..eksqYnkkvDifsLGlilfeLly.pfstemervetl  246

             ++ tg+vgt+ly+sPe++  +ks+Yn+kvD+fsLG+i+fe++y p+st++er+ +l

Q: 848   ydpsGNLTGMVGTALYVSPEVQgnTKSTYNQKVDLFSLGIIFFEMSYhPMSTASERIFVL  907

         77777*****************999***********************************

S: 247   telrd..gkipedfdd.kvpkekkllqkllsrdpkeRpsasellksell  292

          +lr   + +p+dfd+ k+ k++ ++ +ll++dp+ Rp+a ellkse l

Q: 908   GQLRLpsILFPQDFDEvKHAKQRLVITWLLNHDPAARPTAVELLKSEHL  956

         **9987799************************************9865

Domain Sequence
(FASTA)

FEELKLLGKG AFGAVIKVRN KLDGCYYAVK RIRINTASKQ FRRIKGEVTL LSRLNHENIV 60

RYYNAWIEKH ESPVPIVSSS ETSEDKRTPT KAGLILTAEE TNDVEANAPP PVLTSSVEWS 120

TSCERSSSNK FSGADQESSD DDDDDGDGVF SHSFLPTTDS ESEIVFDNED ENSKGHPPDE 180

EGNEKNSHEE EDRTPVIQTV HYLYIQMEYC EKSTLRDTID RGLYEDTSRL WRLFREILDG 240

LAYIHEKGMI HRDLKPVNIF LDSNDHVKIG DFGLATDHPA NAAVSKQEEN HSDSFANYDP 300

SGNLTGMVGT ALYVSPEVQG NTKSTYNQKV DLFSLGIIFF EMSYHPMSTA SERIFVLGQL 360

RLPSILFPQD FDEVKHAKQR LVITWLLNHD PAARPTAVEL LKSEHL 406

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004694	; F:eukaryotic translation initiation factor 2alpha kinase activity
GO:0000049	; F:tRNA binding
GO:0009267	; P:cellular response to starvation
GO:0030968	; P:endoplasmic reticulum unfolded protein response
GO:0017148	; P:negative regulation of translation
GO:0043558	; P:regulation of translational initiation in response to stress

KEGG

mgp:100541758

;

InterPros

IPR004154	; Anticodon-bd.
IPR026920	; EIF2AK4.
IPR024435	; GCN2_anticodon-bd_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR006575	; RWD-domain.
IPR008271	; Ser/Thr_kinase_AS.
IPR016255	; Ser/Thr_kinase_GCN2.
IPR016135	; UBQ-conjugating_enzyme/RWD.

Pfam

PF12745	; HGTP_anticodon2; 1.
PF00069	; Pkinase; 3.
PF05773	; RWD; 1.

SMARTs

SM00591

; RWD; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50908	; RWD; 1.

Prints

Created Date

20-Feb-2013