EKS-MEG-00314

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MEG-00314

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	294.8	4.4E-88	467	723	257

Status

Unreviewed

Ensembl Protein

ENSMGAP00000012744

UniProt Accession

G1NHS0;

Protein Name

Protein Synonyms/Alias

Gene Name

TNNI3K

Gene Synonyms/Alias

TNNI3K;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000012127	ENSMGAP00000012744	ENSMGAT00000013642

Organism

Meleagris gallopavo

Functional Description

Protein Length

837

Protein Sequence
(FASTA)

MGNYKSRPTQ TCTDEWKKKV SESYAIIIER LEDDLQIKDK ELAELKHVFS SDEAFCKVNL 60

NYRTDNGLSL LHLCCICEGN KSHIRTLMLK GLRPSRLTRN GFTALHLAAY KDNAELITAL 120

LHGGADVQQV GYGALTALHI ATIAGHHQAV DILLQHGAYV NVQDAVFFTP LHIAAYYGHE 180

QVTHLLLKFG ADVNASGEVG DRPLHLASAK GFLNITKLLM EEGSKADGAM TVNAQDNEDH 240

VPLHFCCRFG HHEIVKFLLH SSFEVQPHVV NIYGDTPLHL ACYSGKFDVV KEMIQLSGTE 300

SLTKENIFSE TAFHSACTYG KNIELVKFLL DQNVVSINHQ GRDGHTGLHC ACYHGHIRLV 360

QFLLDNGADM NLVACDPSRS SGEKDEQTCL MWAYEKGHDA IVTLLKHYKR PQDESPCNEY 420

SQPGGDGSYV SVPSPLGKIK SMTKEKADVL LLRAGLPSHF HLQLSEIEFH EIIGSGSFGK 480

VYKGRCRNKI VAIKRYRANT YCSKSDVDMF CREVSILCRL NHPCVIQFVG ACLDDPSQFA 540

IVTQYISGGS LFSLLHEQKR TLDLQSKLII AVDVAKGMEY LHNLTQPIIH RDLNSHNILL 600

YEDGHAVVAD FGESRFLQSL DEDNMTKQPG NLRWMAPEVF TQCTRYTIKA DVFSYALCLW 660

ELLTGEIPFA HLKPAAAAAD MAYHHIRPPI GYSIPKPICA LLMRGWNACP EGRPEFSEVV 720

TKLEECLCNI ELISPASSNS SGSLSPSSSS DCLVARGGPG RSHVAALRSR FELEYALNAR 780

AYAVWSQSTG QHLSQGLSLD DMRRNFQYPP IDKNGYVSDP MSTMRFHSCS SSFEESS 837

Nucleotide Sequence
(FASTA)

ATGGGAAATT ACAAATCTCG ACCAACCCAA ACCTGCACTG ATGAATGGAA GAAGAAAGTC 60

AGTGAATCGT ATGCTATAAT CATAGAGCGA TTAGAAGATG ACCTGCAAAT CAAAGACAAG 120

GAGCTGGCAG AACTGAAGCA CGTTTTTAGC TCTGATGAAG CCTTCTGCAA AGTCAATTTA 180

AATTACCGCA CAGATAATGG GCTCTCTCTT CTCCACTTAT GCTGCATATG TGAGGGTAAC 240

AAATCACATA TAAGAACTCT TATGCTAAAA GGACTGCGCC CATCCAGGTT AACAAGAAAT 300

GGATTTACTG CTCTGCACTT GGCAGCTTAC AAGGACAACG CAGAACTCAT AACGGCACTG 360

CTGCATGGCG GAGCTGACGT TCAGCAGGTT GGGTACGGAG CTCTGACAGC CCTTCACATT 420

GCCACCATAG CTGGGCATCA CCAGGCTGTT GATATTCTTT TGCAGCATGG AGCTTATGTG 480

AATGTTCAGG ATGCGGTTTT CTTCACCCCG TTGCACATTG CTGCATATTA TGGCCATGAA 540

CAGGTAACTC ATCTCTTGCT GAAGTTTGGA GCTGATGTGA ATGCAAGTGG GGAAGTTGGA 600

GACAGGCCTC TTCATTTAGC TTCTGCCAAA GGCTTTCTCA ACATTACAAA GCTCCTGATG 660

GAAGAAGGAA GCAAAGCTGA TGGTGCAATG ACAGTGAATG CTCAGGACAA CGAAGACCAC 720

GTTCCTCTGC ACTTCTGCTG TCGATTCGGG CACCATGAGA TTGTCAAGTT CTTACTGCAT 780

AGCAGCTTTG AAGTTCAGCC CCACGTGGTG AACATCTATG GAGACACACC GCTACACCTT 840

GCTTGTTACA GTGGGAAGTT TGACGTGGTC AAGGAAATGA TTCAACTCTC AGGAACAGAA 900

AGTCTCACTA AGGAGAACAT CTTCAGTGAA ACGGCTTTCC ACAGTGCTTG CACCTATGGA 960

AAGAACATAG AACTTGTAAA ATTCCTTCTC GACCAGAATG TCGTAAGCAT CAATCACCAG 1020

GGAAGAGATG GACATACAGG ACTGCACTGT GCTTGCTACC ATGGCCATAT TCGTCTGGTG 1080

CAGTTTTTGC TGGATAATGG AGCTGATATG AATCTGGTCG CTTGTGATCC CAGCAGGTCC 1140

AGTGGAGAAA AGGATGAGCA GACCTGCTTG ATGTGGGCTT ATGAGAAAGG TCATGATGCC 1200

ATTGTGACCC TTCTGAAGCA CTACAAAAGG CCTCAGGATG AATCACCCTG TAACGAATAC 1260

TCACAGCCTG GAGGAGATGG TTCCTACGTG TCAGTTCCAT CCCCTCTGGG AAAGATTAAA 1320

AGCATGACTA AAGAAAAGGC AGACGTGCTC CTCCTCCGTG CTGGTTTGCC ATCGCACTTC 1380

CATCTTCAGC TCTCTGAAAT AGAGTTCCAT GAGATCATTG GCTCAGGGTC TTTTGGAAAA 1440

GTATACAAGG GGCGATGCAG AAATAAAATC GTAGCAATTA AACGCTATCG AGCCAACACC 1500

TACTGCTCCA AGTCTGATGT GGACATGTTT TGCCGTGAAG TTTCCATTCT CTGTCGGCTG 1560

AATCATCCAT GTGTCATCCA GTTTGTTGGG GCGTGCCTGG ATGACCCAAG TCAGTTTGCT 1620

ATTGTCACTC AGTACATCTC TGGAGGATCG CTCTTCTCCC TGCTTCATGA ACAAAAGAGA 1680

ACTCTTGATC TGCAATCTAA GTTGATAATT GCTGTAGACG TTGCCAAAGG AATGGAGTAC 1740

CTCCACAACC TCACACAACC TATCATACAC CGTGATTTGA ACAGTCACAA TATTCTGCTG 1800

TATGAGGATG GACATGCAGT TGTTGCTGAT TTTGGAGAAT CGAGATTTTT GCAATCCCTG 1860

GATGAAGACA ACATGACAAA ACAGCCTGGG AACCTGCGCT GGATGGCCCC CGAGGTGTTC 1920

ACTCAGTGCA CGAGGTACAC CATCAAAGCA GACGTGTTCA GCTATGCTCT GTGTCTCTGG 1980

GAGCTGCTAA CAGGCGAAAT TCCATTTGCT CACCTAAAGC CAGCGGCGGC GGCGGCAGAC 2040

ATGGCGTACC ACCACATCCG CCCGCCCATC GGCTACTCCA TCCCCAAACC CATCTGCGCG 2100

CTGCTGATGC GGGGCTGGAA CGCCTGCCCG GAGGGTAGAC CAGAATTCTC AGAAGTGGTC 2160

ACAAAGTTAG AAGAATGTCT GTGCAACATT GAGTTGATCT CTCCAGCTTC CAGCAACAGC 2220

AGTGGTTCCC TGTCTCCCTC CTCGTCCTCA GACTGTCTCG TTGCACGTGG AGGACCTGGC 2280

CGCAGTCACG TCGCAGCTCT GCGCAGTCGC TTTGAGTTGG AATACGCTTT GAATGCAAGA 2340

GCTTACGCTG TCTGGTCACA GAGCACTGGG CAACACCTTT CTCAGGGTCT GTCTTTGGAT 2400

GACATGAGAA GAAACTTCCA GTACCCTCCA ATTGACAAAA ACGGTTACGT GTCGGATCCC 2460

ATGAGCACCA TGAGGTTTCA CTCCTGCAGC AGCAGCTTTG AGGAAAGCAG CTGA 2514

Domain Profile

S: 1     ieleeligsgafgkvykakwrkkevavKklreeaee.kekleklereakllsklshpnii  59

         ie++e+igsg+fgkvyk+++r+k va+K++r+++++ k+++++++re+++l++l+hp++i

Q: 467   IEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRANTYCsKSDVDMFCREVSILCRLNHPCVI  526

         5899****************************99998999********************

S: 60    ellGvcleepn.lllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhsea  118

         +++G+cl++p+ +++v++y++ggsL+++lhe +kr++dl+  + +a+++A+Gm+YLh+ +

Q: 527   QFVGACLDDPSqFAIVTQYISGGSLFSLLHE-QKRTLDLQSKLIIAVDVAKGMEYLHNLT  585

         ***********99******************.99*************************6

S: 119   pkkiihrdLksknvLlseekktlkicdFGtarelsk..stkmsaa.gtlawmaPEvl.ke  174

         + +iihrdL+s+n+Ll  e+ ++ ++dFG++r+l++  +++m+++ g+l+wmaPEv+ ++

Q: 586   Q-PIIHRDLNSHNILL-YEDGHAVVADFGESRFLQSldEDNMTKQpGNLRWMAPEVFtQC  643

         6.9*************.9*****************99877777777**************

S: 175   ekvseksDvwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkLmk  234

         ++++ k+Dv+Sy+++LWellt+e+P+++l+++a+a+++a++++r+pi+ s+p++++ L+

Q: 644   TRYTIKADVFSYALCLWELLTGEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPICALLM  703

         ************************************************************

S: 235   ecwnedpekRpsfseivksl  254

         + wn++pe Rp+fse+v++l

Q: 704   RGWNACPEGRPEFSEVVTKL  723

         ****************9875

Domain Sequence
(FASTA)

IEFHEIIGSG SFGKVYKGRC RNKIVAIKRY RANTYCSKSD VDMFCREVSI LCRLNHPCVI 60

QFVGACLDDP SQFAIVTQYI SGGSLFSLLH EQKRTLDLQS KLIIAVDVAK GMEYLHNLTQ 120

PIIHRDLNSH NILLYEDGHA VVADFGESRF LQSLDEDNMT KQPGNLRWMA PEVFTQCTRY 180

TIKADVFSYA LCLWELLTGE IPFAHLKPAA AAADMAYHHI RPPIGYSIPK PICALLMRGW 240

NACPEGRPEF SEVVTKL 257

Keyword

ANK repeat; Complete proteome; Reference proteome; Repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity

KEGG

InterPros

IPR002110	; Ankyrin_rpt.
IPR020683	; Ankyrin_rpt-contain_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.

Pfam

PF00023	; Ank; 1.
PF12796	; Ank_2; 3.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00248

; ANK; 10.

Prosites

PS50297	; ANK_REP_REGION; 1.
PS50088	; ANK_REPEAT; 6.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

PR01415

; ANKYRIN.

Created Date

20-Feb-2013