EKS-MEG-00049

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MEG-00049

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	373.1	6.6E-112	364	656	293

Status

Unreviewed

Ensembl Protein

ENSMGAP00000012893

UniProt Accession

G1NI35;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK13

Gene Synonyms/Alias

CDK13;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000012248	ENSMGAP00000012893	ENSMGAT00000013792

Organism

Meleagris gallopavo

Functional Description

Protein Length

1150

Protein Sequence
(FASTA)

NRRSAKSRSR SPYSSRHSRS RSRHRLSRSR SRHSSISPST LTLKSSLAAE LNKNKKARAA 60

EAAKASAKAS NTSTPTKGNT DTAASAPQLN NVKDLKKVKI EHTPSPTSSV NLKNDKAKAK 120

VSLPETKGEN NLIADKNTKQ KATAVKEDKV TVVKQQPVTV KEKTKPTAPS VATKEKERTV 180

ALPASTLPPL PLPPTLPEDN ETDSLPTAAR KLGSVPKITL ANVIPVIQNH TCVVNVQLHL 240

TWTEPSSMET KTTTTTTKQK TKTKTKKQKP ISVSLESASS MLYSLRENIT VKSVKETEKK 300

LRHLLADLPL PPELPGGAEL GKSPEEKKPT VQLHNKRRPK ICGPRHGETK EKEIDWGKRC 360

VDKFDIIGII GEGTYGQVYK ARDKDTGELV ALKKVRLDNE KEGFPITAIR EIKILRQLNH 420

QSIINMKEIV TDKEDALDFK KDKGAFYLVF EYMDHDLMGL LESGLVHFNE NHIKSFMRQL 480

MEGLAYCHKK NFLHRDIKCS NILLNNRGQI KLADFGLARL YNSEESRPYT NKVITLWYRP 540

PELLLGEERY TPAIDVWSCG CILGELFTKK PIFQANQELA QLELISRICG SPCPAVWPDV 600

IKLAYFNTMK PKKQYRRKLR EEFAFIPPAA LDLFDYMLAL DPSKRCTAEQ ALQCEFLRDV 660

EPSKMPPPDL PLWQDCHELW SKKRRRQKQM GMTDDATATK VPRKDLSLGM DESRTNTPQG 720

MQTSSQLKTQ GNSSVALAKT STGQQLNQNE VAILLNLLQS KTSVSLAQFA QVLNIKVNPE 780

TQQQLNKINL PAGILSAGEK QSEQQQPPPP PPPPPEQESL KQPTVTQPPV PPAQLSQPKV 840

ETDAAQAAVQ SAFAVLLSQL IKAQQTKQKD LVLEEKENGS GQEDLARQAE MRLLNRTPEQ 900

ERPRILPPDQ RPPEPPEPPP LTDEDLDYRT ENQHLPITNS SGTDPHAGVK AALLQLLAQH 960

QAQATTEEPV QTSVDYQARD SYVAGPDYKD NFASSTFSSA HYGGSDGIGS GSSGALERRS 1020

FLGNTDIQPL DNYSTASSHS SVTGYGDIYL NTGPMLFSGD KDHRFEYSHG PISVLGNSRD 1080

ASVGPESTHS LPTKMHNYSY GSNLQENPGG ISHVHGQTWT SPAQGPGYSQ GYRGHISTSA 1140

VRGRGRGLPF 1150

Nucleotide Sequence
(FASTA)

AACAGGCGAT CAGCAAAATC TCGAAGCAGA AGTCCATATT CATCAAGGCA CTCAAGATCT 60

CGTAGCAGAC ACAGGTTGTC TAGATCGAGA AGTCGTCATT CAAGTATTTC TCCTAGTACA 120

TTAACTCTGA AGAGTAGCCT GGCTGCTGAG CTGAACAAAA ACAAAAAAGC AAGAGCAGCT 180

GAGGCAGCTA AAGCCAGTGC AAAAGCTTCC AACACTTCAA CGCCGACGAA GGGAAACACT 240

GACACTGCTG CAAGCGCACC TCAATTGAAC AATGTAAAGG ACCTGAAGAA AGTAAAAATT 300

GAGCATACAC CTTCTCCTAC GAGCAGCGTA AATTTGAAGA ATGACAAGGC AAAAGCAAAG 360

GTCTCACTTC CAGAAACTAA AGGAGAAAAT AATCTGATCG CAGACAAAAA TACTAAACAG 420

AAAGCTACAG CGGTAAAAGA GGACAAAGTA ACTGTTGTAA AACAGCAACC GGTCACTGTA 480

AAAGAGAAAA CCAAACCGAC TGCACCTAGC GTAGCAACAA AGGAGAAGGA GCGAACTGTT 540

GCACTACCAG CCTCCACACT GCCACCCTTG CCTTTGCCTC CCACGCTGCC TGAAGATAAT 600

GAAACTGATA GCTTACCCAC TGCTGCAAGG AAACTTGGGT CTGTACCCAA AATCACTCTA 660

GCAAATGTCA TTCCAGTTAT TCAGAATCAC ACCTGTGTGG TGAATGTGCA GTTGCATTTG 720

ACTTGGACAG AGCCATCCTC CATGGAAACA AAAACAACAA CAACAACAAC AAAACAAAAA 780

ACAAAAACAA AAACAAAAAA ACAAAAACCA ATATCTGTGA GTTTGGAATC TGCAAGTAGC 840

ATGCTGTATA GCTTGAGAGA GAATATTACA GTGAAGTCAG TTAAAGAAAC GGAGAAGAAA 900

CTTCGCCATC TGCTTGCAGA CTTGCCACTT CCACCTGAGT TGCCTGGAGG AGCTGAGTTA 960

GGCAAAAGTC CTGAAGAAAA GAAACCAACA GTTCAGTTAC ACAACAAGAG GAGACCAAAA 1020

ATATGTGGAC CACGACATGG TGAAACAAAA GAAAAAGAAA TAGACTGGGG AAAACGCTGT 1080

GTGGATAAAT TTGATATCAT TGGTATTATT GGTGAAGGCA CTTATGGACA AGTTTACAAA 1140

GCTAGGGATA AAGACACAGG AGAATTGGTG GCACTAAAGA AAGTACGATT GGATAATGAA 1200

AAGGAAGGGT TTCCAATTAC AGCTATTCGG GAGATTAAAA TTCTTCGACA GCTTAATCAC 1260

CAAAGCATTA TCAACATGAA GGAAATAGTG ACAGATAAGG AAGATGCTTT GGATTTCAAG 1320

AAGGACAAAG GTGCATTCTA TCTGGTATTT GAATATATGG ACCATGATTT GATGGGATTG 1380

CTGGAATCTG GTTTGGTTCA TTTTAATGAA AATCATATAA AATCATTTAT GAGACAGCTG 1440

ATGGAGGGTT TGGCCTACTG CCATAAGAAG AACTTTTTGC ACAGAGATAT AAAATGTTCA 1500

AATATTCTAC TAAATAATAG AGGGCAGATA AAGCTTGCAG ATTTTGGGCT TGCTCGGCTG 1560

TACAACTCGG AAGAAAGCCG ACCATATACC AACAAAGTTA TTACATTATG GTATCGGCCT 1620

CCTGAACTAC TGCTTGGAGA AGAAAGATAC ACGCCAGCTA TCGATGTCTG GAGCTGTGGC 1680

TGCATCCTGG GTGAACTTTT TACAAAAAAG CCAATATTTC AAGCAAATCA AGAACTTGCT 1740

CAGCTGGAAC TTATAAGCCG AATTTGTGGG AGCCCTTGTC CAGCAGTGTG GCCTGATGTT 1800

ATAAAATTAG CTTATTTCAA CACAATGAAA CCAAAGAAGC AGTATCGTCG AAAACTGAGA 1860

GAAGAGTTTG CATTCATCCC ACCAGCTGCA TTAGATTTGT TTGATTACAT GCTTGCTCTG 1920

GATCCCAGCA AGCGCTGCAC AGCTGAACAA GCTCTTCAGT GCGAGTTTCT GCGAGACGTG 1980

GAACCATCTA AAATGCCTCC CCCAGACCTT CCTTTGTGGC AGGATTGCCA CGAGCTGTGG 2040

AGTAAAAAAC GCAGAAGACA GAAGCAAATG GGCATGACTG ATGATGCAAC AGCGACTAAA 2100

GTCCCTAGGA AGGATCTGTC TCTAGGCATG GATGAGAGCA GAACCAACAC CCCACAAGGC 2160

ATGCAAACTT CTTCCCAACT CAAAACTCAG GGCAACTCTA GTGTAGCACT TGCAAAAACA 2220

AGCACTGGAC AGCAGTTAAA CCAGAATGAA GTGGCAATCC TGCTAAACCT CCTACAGTCT 2280

AAAACAAGTG TTAGTTTGGC GCAGTTTGCC CAAGTGTTGA ATATTAAGGT AAACCCAGAG 2340

ACTCAACAGC AACTAAATAA AATAAATCTT CCTGCTGGAA TTTTGTCAGC AGGTGAAAAA 2400

CAGTCAGAAC AGCAGCAGCC GCCGCCGCCT CCACCGCCAC CGCCGGAACA GGAGTCCCTA 2460

AAACAGCCGA CCGTCACGCA GCCTCCTGTA CCACCTGCTC AGCTGAGTCA GCCCAAAGTG 2520

GAAACTGACG CTGCCCAGGC AGCTGTACAG AGTGCATTTG CTGTTCTGTT GTCTCAGTTA 2580

ATAAAGGCTC AGCAAACAAA ACAAAAAGAT TTGGTGTTGG AGGAGAAGGA AAACGGATCA 2640

GGTCAAGAGG ACTTGGCTAG GCAGGCCGAG ATGAGACTCC TGAACCGAAC GCCGGAACAG 2700

GAACGCCCTC GGATCCTGCC TCCAGACCAG CGTCCCCCGG AGCCCCCAGA GCCCCCGCCT 2760

CTCACGGACG AAGACCTTGA TTATCGGACA GAGAACCAGC ATTTGCCTAT AACTAACTCT 2820

TCAGGAACAG ATCCTCATGC AGGAGTGAAA GCGGCGCTTC TGCAGCTGCT CGCTCAGCAT 2880

CAAGCTCAGG CAACAACGGA GGAGCCCGTA CAGACGAGCG TGGATTACCA GGCTAGAGAC 2940

TCCTATGTAG CAGGCCCAGA CTACAAGGAC AACTTTGCAT CATCTACCTT CTCCTCTGCT 3000

CACTATGGCG GTAGCGATGG CATAGGAAGC GGGTCATCGG GAGCGCTAGA ACGAAGGAGC 3060

TTCCTCGGAA ACACAGATAT TCAGCCTTTG GATAACTACA GTACTGCTTC ATCTCACTCC 3120

TCAGTAACTG GTTATGGAGA CATTTACCTC AACACTGGCC CCATGCTATT TAGCGGAGAT 3180

AAAGACCATA GGTTTGAATA CAGCCACGGC CCAATCTCAG TCCTGGGGAA CAGCAGGGAC 3240

GCTTCTGTGG GGCCAGAGAG TACTCATTCC TTGCCTACTA AGATGCACAA CTATAGCTAT 3300

GGAAGTAACT TACAGGAAAA CCCTGGTGGC ATCAGCCACG TGCATGGACA GACCTGGACA 3360

TCTCCTGCAC AAGGACCCGG CTACTCCCAA GGCTATAGGG GGCACATTAG TACATCTGCA 3420

GTGAGGGGGC GAGGCAGAGG ATTACCATTT TGA 3453

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         ++ +  igeGtyg+vyka+dk+tge+vAlKk+rl++ekeg+pita+rEi++l++l+h+ i

Q: 364   FDIIGIIGEGTYGQVYKARDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLNHQSI  423

         667889******************************************************

S: 61    vkLlevva.........kdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlle  111

         ++++e+v+         kdk  +yLvfe++++dL+ ll++    +++++++ks+++ql+e

Q: 424   INMKEIVTdkedaldfkKDKGAFYLVFEYMDHDLMGLLESGLV-HFNENHIKSFMRQLME  482

         ****************8899********************999.****************

S: 112   glaylHsnkilHRDlKpqNlLiskegklklaDfGlarafssplk.tytkevvTlwYraPe  170

         glay+H++++lHRD+K++N+L++++g++klaDfGlar ++s+++  yt++v+TlwYr+Pe

Q: 483   GLAYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYNSEESrPYTNKVITLWYRPPE  542

         ***************************************7766527**************

S: 171   lLlgakeYstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsk  230

         lLlg+++Y+ a+D+Ws+gcil el+t+kp+fq+++e  qle i++++g+p  +vwp+v k

Q: 543   LLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIK  602

         ************************************************************

S: 231   lpeykksfpkkkkk.klkekvkklkekaldllekllaldpkkRisakealqhky  283

         l  +++  pkk+++ kl+e++  +  +aldl++ +laldp+kR++a++alq ++

Q: 603   LAYFNTMKPKKQYRrKLREEFAFIPPAALDLFDYMLALDPSKRCTAEQALQCEF  656

         *****7777777777******9999**************************988

Domain Sequence
(FASTA)

FDIIGIIGEG TYGQVYKARD KDTGELVALK KVRLDNEKEG FPITAIREIK ILRQLNHQSI 60

INMKEIVTDK EDALDFKKDK GAFYLVFEYM DHDLMGLLES GLVHFNENHI KSFMRQLMEG 120

LAYCHKKNFL HRDIKCSNIL LNNRGQIKLA DFGLARLYNS EESRPYTNKV ITLWYRPPEL 180

LLGEERYTPA IDVWSCGCIL GELFTKKPIF QANQELAQLE LISRICGSPC PAVWPDVIKL 240

AYFNTMKPKK QYRRKLREEF AFIPPAALDL FDYMLALDPS KRCTAEQALQ CEF 293

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0019908	; C:nuclear cyclin-dependent protein kinase holoenzyme complex
GO:0016607	; C:nuclear speck
GO:0005524	; F:ATP binding
GO:0008353	; F:RNA polymerase II carboxy-terminal domain kinase activity
GO:0000380	; P:alternative mRNA splicing, via spliceosome
GO:0070816	; P:phosphorylation of RNA polymerase II C-terminal domain

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013