EKS-MEG-00128
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MEG-00128
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/RSKb492.42.1E-148420677258
StatusUnreviewed
Ensembl ProteinENSMGAP00000012973
UniProt AccessionG1NI96;
Protein NameRibosomal protein S6 kinase
Protein Synonyms/Alias
Gene NameRPS6KA2
Gene Synonyms/Alias RPS6KA2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMGAG00000012309ENSMGAP00000012973ENSMGAT00000013874
OrganismMeleagris gallopavo
Functional Description
Protein Length738
Protein Sequence
(FASTA)
FKKREKLYTY VIYQCLFLRK EKNKTRITAK FKLKEEGIVK EIDISHHVKE GFEKADPSQF 60
ELFELLKVLG QGSYGKVFLV RKIKGSDAGQ LYAMKVLKKA TLKVRDRVRS KMERDILAEV 120
NHPFIVKLHY AFQTEGKLYL ILDFLRGGDL FTRLSKEVMF TEEDVKFYLA ELALALDHLH 180
GLGIIYRDLK PENILLDEEG HIKITDFGLS KEAIDHDKRA YSFCGTIEYM APEVVNRRGH 240
TQSADWWSFG VLMFEMLTGS LPFQGKDRKE TMALILKAKL GMPQFLSIEA QSLLRALFKR 300
NPSNRLGAGF DGVEEIKRHP FFITIDWNKL YRKEIKPPFK PAVGRPEDTF HFDPEFTSRT 360
PQTDSPGVPP SANAHHLFRG FSFVASNLVQ EPAQQDVHKI TVHPIVQQLH GNNIHFTDGY 420
EIKEDIGIGS YSVCKRCVHK ATETEFAVKI IDKSKRDPSE EIEILLRYGQ HPNIITLKDV 480
YDDGKYVYLV MELMRGGELL DRILQQKCFS EREASAVLCT ITRTVDYLHS QGVVHRDLKP 540
SNILYMDESG NPDSIRICDF GFAKQLRAEN GLLMTPCYTA NFVAPEVLKR QGYDAACDIW 600
SLGILLYTML AGFTPFANGP DDTPEEILAR IGSGKYALTG GNWDSVSDTA KDIVSKMLHV 660
DPHQRLTAVQ VLRHPWIVNR EYLSQNQLSR QDVHLVKGAM AATYFALNRT PQAPRLEPVL 720
SSNLAQRRGM KRLTSTRL 738
Nucleotide Sequence
(FASTA)
TTTAAGAAGA GAGAAAAACT TTACACGTAT GTTATATATC AATGTCTCTT CTTGAGGAAA 60
GAAAAAAACA AAACAAGAAT TACAGCAAAA TTCAAATTAA AAGAAGAAGG TATTGTGAAG 120
GAAATAGACA TCAGTCACCA TGTGAAGGAA GGTTTTGAAA AAGCAGATCC TTCTCAATTT 180
GAGCTGTTTG AGCTGCTGAA AGTATTAGGA CAAGGTTCAT ATGGAAAGGT ATTTCTAGTG 240
AGGAAGATCA AAGGATCTGA TGCGGGTCAA CTTTATGCCA TGAAGGTACT TAAGAAAGCA 300
ACTCTGAAAG TTCGGGATCG GGTACGGTCG AAAATGGAGA GAGATATTTT GGCAGAAGTG 360
AATCATCCTT TCATAGTCAA GCTTCATTAT GCATTTCAAA CAGAGGGGAA GTTGTATCTA 420
ATACTAGATT TCCTGCGGGG AGGGGACCTT TTCACAAGAC TCTCCAAAGA GGTGATGTTT 480
ACAGAAGAGG ATGTCAAGTT CTACTTAGCT GAGCTGGCCT TGGCTTTAGA CCACCTTCAT 540
GGGCTTGGAA TTATTTACAG GGATCTAAAA CCAGAAAACA TTCTTCTTGA TGAAGAGGGC 600
CACATTAAGA TAACAGATTT CGGTCTGAGT AAAGAAGCCA TCGACCATGA CAAGAGAGCG 660
TATTCGTTCT GTGGGACAAT AGAGTATATG GCCCCAGAGG TGGTCAACCG CAGAGGACAC 720
ACTCAGAGTG CTGACTGGTG GTCTTTTGGT GTGCTCATGT TTGAGATGCT GACGGGATCA 780
TTACCATTCC AGGGAAAAGA CAGAAAGGAG ACAATGGCTC TTATACTCAA AGCCAAGCTG 840
GGAATGCCAC AGTTCTTGAG CATAGAAGCC CAGAGCCTGC TGCGAGCCCT CTTCAAAAGG 900
AACCCATCTA ACAGATTAGG TGCTGGATTC GATGGAGTGG AAGAAATTAA ACGTCACCCT 960
TTCTTTATTA CTATAGACTG GAATAAACTG TACAGAAAAG AAATCAAGCC GCCTTTCAAG 1020
CCTGCAGTGG GACGGCCAGA AGACACTTTC CACTTTGATC CGGAGTTCAC ATCTCGGACC 1080
CCACAGACAG ATTCCCCAGG TGTTCCTCCA AGTGCCAATG CTCATCATCT TTTCAGAGGG 1140
TTCAGCTTTG TTGCCTCTAA CTTGGTGCAG GAGCCTGCAC AGCAGGATGT GCACAAAATC 1200
ACCGTTCATC CAATTGTGCA GCAATTACAT GGAAACAATA TTCACTTTAC AGATGGATAT 1260
GAGATCAAGG AGGACATAGG AATTGGCTCC TATTCAGTGT GCAAGAGGTG TGTTCATAAA 1320
GCAACAGAAA CCGAGTTTGC GGTGAAGATA ATTGACAAGA GCAAGAGAGA CCCCTCTGAA 1380
GAAATAGAGA TTCTCTTGCG ATACGGACAG CATCCAAACA TCATTACTCT TAAAGATGTC 1440
TATGATGATG GGAAATATGT GTACCTGGTG ATGGAGTTGA TGCGGGGAGG AGAGCTCCTG 1500
GACCGCATTC TTCAGCAGAA GTGTTTTTCA GAGCGAGAGG CCAGCGCTGT GCTGTGCACT 1560
ATCACCAGGA CTGTGGACTA CCTGCACTCC CAGGGGGTGG TGCACCGAGA TTTGAAGCCA 1620
AGTAATATCC TCTACATGGA TGAGTCAGGA AACCCAGACT CCATCAGGAT CTGTGACTTT 1680
GGCTTTGCCA AGCAACTGAG AGCAGAGAAC GGGCTGCTCA TGACTCCTTG CTACACGGCC 1740
AACTTTGTCG CCCCTGAGGT CCTTAAGCGC CAAGGTTATG ATGCAGCCTG TGACATCTGG 1800
AGCTTGGGGA TCCTGTTGTA CACCATGCTG GCAGGGTTCA CTCCTTTTGC AAATGGGCCA 1860
GATGACACCC CAGAGGAGAT TCTGGCCAGG ATTGGCAGTG GCAAATACGC ACTTACCGGA 1920
GGAAACTGGG ATTCAGTATC AGATACTGCA AAGGATATTG TGTCTAAGAT GCTTCACGTA 1980
GACCCTCATC AGCGTCTCAC AGCAGTTCAA GTGTTGAGAC ATCCATGGAT AGTGAACAGG 2040
GAGTATCTGT CTCAAAATCA ACTCAGCAGA CAGGATGTTC ACCTGGTGAA GGGTGCAATG 2100
GCAGCCACTT ACTTTGCTTT AAACCGAACA CCTCAGGCAC CAAGGCTGGA GCCTGTATTG 2160
TCCTCCAATC TGGCTCAGCG GAGGGGCATG AAAAGACTTA CCTCAACCAG ATTGTAG 2217
Domain Profile
S: 1     yevkedlGvGsysvckrcvhkatnqefavkiidkskrdtseeieillryeqhpnivtlkd  60
         ye+ked+G Gsysvckrcvhkat++efavkiidkskrd+seeieillry+qhpni+tlkd
Q: 420   YEIKEDIGIGSYSVCKRCVHKATETEFAVKIIDKSKRDPSEEIEILLRYGQHPNIITLKD  479
         789*********************************************************
S: 61    vyddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlk  120
         vyddgkyvylv+el++GGelldri+++k+fsereasa+l+t++++v+ylh+qGvvhrdlk
Q: 480   VYDDGKYVYLVMELMRGGELLDRILQQKCFSEREASAVLCTITRTVDYLHSQGVVHRDLK  539
         ************************************************************
S: 121   penilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdl  180
         p+nily+des+n++si+i+dfGfak++raengll+tpcyt+nfvapevlkrqGyd+acd+
Q: 540   PSNILYMDESGNPDSIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDI  599
         ************************************************************
S: 181   wslGvllytmlaGyvpfangpedtaeeilakikeGkfslsGeawdsvseeakdlvskllt  240
         wslG+llytmlaG++pfangp+dt+eeila+i++Gk++l G++wdsvs++akd+vsk+l+
Q: 600   WSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALTGGNWDSVSDTAKDIVSKMLH  659
         ************************************************************
S: 241   vdpakrlkleqllkhswl  258
         vdp++rl++ q+l+h+w+
Q: 660   VDPHQRLTAVQVLRHPWI  677
         *****************8
Domain Sequence
(FASTA)
YEIKEDIGIG SYSVCKRCVH KATETEFAVK IIDKSKRDPS EEIEILLRYG QHPNIITLKD 60
VYDDGKYVYL VMELMRGGEL LDRILQQKCF SEREASAVLC TITRTVDYLH SQGVVHRDLK 120
PSNILYMDES GNPDSIRICD FGFAKQLRAE NGLLMTPCYT ANFVAPEVLK RQGYDAACDI 180
WSLGILLYTM LAGFTPFANG PDDTPEEILA RIGSGKYALT GGNWDSVSDT AKDIVSKMLH 240
VDPHQRLTAV QVLRHPWI 258
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00154
EKS-ANC-00156
EKS-BOT-00161
EKS-CAJ-00165
EKS-CAF-00168
EKS-CAP-00161
EKS-DAR-00449
EKS-EQC-00163
EKS-GAG-00139
EKS-GOG-00162
EKS-HOS-00167
EKS-ICT-00156
EKS-LAC-00170
EKS-LOA-00159
EKS-MAM-00161
EKS-MOD-00158
EKS-MUM-00167
EKS-MUP-00165
EKS-ORC-00150
EKS-OTG-00167
EKS-PES-00142
EKS-POA-00158
EKS-RAN-00159
EKS-SAH-00153
EKS-SUS-00139
EKS-XET-00150
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005819; C:spindle
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004711; F:ribosomal protein S6 kinase activity
GO:0010659; P:cardiac muscle cell apoptotic process
GO:0071322; P:cellular response to carbohydrate stimulus
GO:0007243; P:intracellular protein kinase cascade
GO:0000089; P:mitotic metaphase
GO:0045786; P:negative regulation of cell cycle
GO:0008285; P:negative regulation of cell proliferation
GO:0018105; P:peptidyl-serine phosphorylation
GO:0043065; P:positive regulation of apoptotic process
GO:0010628; P:positive regulation of gene expression
GO:0070613; P:regulation of protein processing
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR016239; Ribosomal_S6_kinase_II.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
PF00433; Pkinase_C; 1.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 2.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 2.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00108; PROTEIN_KINASE_ST; 2.
Prints
Created Date20-Feb-2013