EKS-MEG-00239
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MEG-00239
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR499.81.2E-150685942258
StatusUnreviewed
Ensembl ProteinENSMGAP00000017960
UniProt AccessionG1NIB9;
Protein Name
Protein Synonyms/Alias
Gene NameEGFR
Gene Synonyms/Alias EGFR;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMGAG00000012330ENSMGAP00000013000ENSMGAT00000013902
ENSMGAG00000012330ENSMGAP00000017960ENSMGAT00000019827
ENSMGAG00000012330ENSMGAP00000017233ENSMGAT00000019681
OrganismMeleagris gallopavo
Functional Description
Protein Length1187
Protein Sequence
(FASTA)
CQGTNNKLTQ LGHVEDHFTS LQRMYNNCEV VLSNLEITYV EHNRDLSFLK TIQEVAGYVL 60
IALNMVDVIP LENLQIIRGN VLYDNSFALA VLSNYHMNKT QGLRELPMKR LSEILNGGVK 120
ISNNPKLCNM DTVLWNDIID TSRKPLTVLD FASNLSSCPK CHPNCTEDHC WGAGEQNCQT 180
LTKVICAQQC SGRCRGKVPS DCCHNQCAAG CTGPRESDCL ACRKFRDDAT CKDTCPPLVL 240
YNPTTYQMDV NPEGKYSFGA TCVRECPHNY VVTDHGSCVR SCNTDTYEVE ENGVRKCKKC 300
DGLCSKVCNG IGIGELKGIL SINATNIDSF KNCTKINGDV SILPVAFLGD AFTKTLPLDP 360
KKLDVFRTVK EISGFLLIQA WPDNATDLYA FENLEIIRGR TKQHGQYSLA VVNLKIQSLG 420
LRSLKEISDG DIAIMKNKNL CYADTMNWRS LFATQSQKTK IIQNRNKNDC TADRHVCDPL 480
CSDVGCWGPG PFHCFSCRFF SRQKECVKQC NILQGEPREF ERDSKCLPCH SECLVQNSTV 540
YNATCTGPGP DHCVKCAHFI DGPHCVKTCP AGVLGENDTL VWKYADANAV CQLCHPNCTR 600
GCKGPGLEGC PNGSKTPSIA AGVVGGLLCL VVVGLGIGLY LRRRHIVRKR TLRRLLQERE 660
LVEPLTPSGE APNQAHLRIL KETEFKKVKV LGSGAFGTVY KGLWIPEGEK VKIPVAIKEL 720
REATSPKANK EILDEAYVMA SVDNPHVCRL LGICLTSTVQ LITQLMPYGC LLDYIREHKD 780
NIGSQYLLNW CVQIAKGMNY LEERRLVHRD LAARNVLVKT PQHVKITDFG LAKLLGADEK 840
EYHAEGGKVP IKWMALESIL HRIYTHQSDV WSYGVTVWEL MTFGSKPYDG IPASEISSVL 900
EKGERLPQPP ICTIDVYMIM VKCWMIDADS RPKFRELIAE FSKMARDPPR YLVIQGDERM 960
HLPSPTDSKF YRTLMEEEDM EDIVDADEYL VPHQGFFNSP STSRTPLLSS LSATSNNSAT 1020
TCIDRNGQGH PVREDSFVQR YSSDPTGNFL EESIDDGFLP APEYVNQLMP KQPSTAMVQN 1080
PIYNNISLTA NSKLPMDSSY QNSHSTAVDN PEYLNTNQSP QAKTVFESSP YWIQSGNHQI 1140
NLDNPDYQQD FLPNETKPNG LLKVPAAENP EYLRVAAPKS EYIEASA 1187
Nucleotide Sequence
(FASTA)
TGTCAAGGGA CAAATAACAA GTTGACCCAG CTGGGGCATG TGGAAGATCA TTTCACCAGC 60
CTGCAGAGAA TGTACAACAA CTGTGAAGTG GTACTGAGTA ACCTGGAGAT TACCTACGTG 120
GAGCATAACC GTGATCTCTC CTTCCTTAAG ACCATACAGG AGGTTGCAGG CTATGTGCTC 180
ATTGCACTTA ACATGGTGGA CGTTATTCCC TTAGAAAACC TCCAGATCAT CCGAGGGAAT 240
GTGCTTTATG ACAACTCTTT TGCCCTGGCA GTTTTATCCA ATTACCACAT GAATAAAACC 300
CAGGGACTTC GAGAGCTGCC AATGAAACGA CTATCAGAAA TTCTCAATGG AGGTGTTAAA 360
ATCAGCAACA ACCCCAAACT ATGCAACATG GACACTGTTC TATGGAATGA CATCATTGAT 420
ACAAGCAGGA AGCCTCTCAC AGTACTTGAC TTTGCAAGCA ATCTTTCTTC TTGTCCAAAA 480
TGCCATCCAA ACTGCACAGA AGACCACTGC TGGGGTGCCG GTGAACAGAA CTGCCAGACT 540
TTAACAAAAG TCATCTGTGC CCAGCAATGC TCTGGCCGGT GCAGAGGAAA GGTGCCCAGT 600
GACTGCTGCC ACAATCAGTG TGCTGCAGGG TGCACGGGAC CTCGGGAGAG CGACTGCCTG 660
GCATGCCGCA AGTTTCGGGA TGATGCTACC TGCAAGGACA CGTGTCCCCC ACTGGTCCTC 720
TATAACCCGA CCACCTACCA AATGGATGTC AACCCCGAGG GAAAATACAG CTTTGGAGCC 780
ACTTGTGTGA GGGAATGTCC ACACAACTAT GTGGTGACAG ATCATGGCTC CTGCGTTCGC 840
TCATGCAATA CTGACACTTA CGAAGTGGAA GAAAACGGCG TTCGGAAGTG TAAAAAATGT 900
GATGGGCTGT GCAGCAAAGT GTGCAATGGC ATTGGAATAG GTGAACTTAA AGGGATACTA 960
TCCATAAACG CTACAAACAT CGACTCCTTC AAAAACTGTA CAAAGATCAA TGGGGATGTC 1020
AGCATTCTTC CTGTTGCGTT TCTAGGGGAT GCCTTCACAA AGACACTACC CCTTGACCCT 1080
AAGAAGCTGG ATGTCTTCAG AACAGTCAAA GAAATATCAG GATTTCTGTT GATTCAGGCC 1140
TGGCCTGATA ATGCTACTGA TCTCTATGCT TTTGAAAATC TGGAGATTAT CCGAGGCCGA 1200
ACCAAGCAGC ATGGCCAGTA TTCCCTTGCT GTTGTTAACT TGAAAATACA GTCCTTGGGG 1260
CTGCGCTCCC TCAAGGAAAT AAGTGATGGA GACATTGCCA TTATGAAGAA CAAGAACCTC 1320
TGCTACGCTG ACACCATGAA CTGGCGCAGC TTGTTTGCTA CTCAGAGTCA GAAAACAAAA 1380
ATAATACAGA ACAGAAATAA AAATGATTGT ACTGCTGACA GGCATGTGTG TGACCCGCTG 1440
TGCTCGGACG TGGGCTGCTG GGGCCCAGGG CCCTTCCACT GCTTTTCCTG CAGGTTTTTC 1500
AGTCGCCAGA AGGAGTGTGT GAAACAGTGC AACATCCTGC AAGGGGAGCC ACGTGAGTTT 1560
GAAAGGGACT CCAAATGCCT CCCCTGCCAC TCAGAGTGTC TGGTACAGAA CTCCACTGTA 1620
TACAACGCAA CCTGCACTGG ACCTGGCCCG GATCACTGTG TGAAGTGTGC CCATTTTATA 1680
GATGGTCCCC ACTGTGTGAA GACCTGCCCC GCGGGGGTGC TGGGTGAGAA TGACACCCTC 1740
GTCTGGAAGT ATGCAGATGC CAATGCTGTT TGCCAACTCT GCCATCCAAA CTGTACACGA 1800
GGGTGCAAAG GACCAGGTCT TGAAGGATGT CCAAATGGCT CCAAAACTCC ATCCATCGCG 1860
GCTGGTGTTG TCGGAGGACT CCTGTGCCTG GTTGTGGTTG GTTTGGGCAT TGGCCTTTAC 1920
CTGCGGCGAC GTCACATCGT GCGGAAGCGC ACCCTGCGCA GGCTGCTGCA AGAGAGAGAG 1980
CTTGTCGAAC CACTGACACC CAGTGGGGAG GCACCAAACC AGGCCCACCT GAGAATTTTA 2040
AAGGAAACAG AATTTAAAAA AGTCAAAGTT TTGGGCTCTG GAGCTTTTGG CACTGTTTAT 2100
AAGGGACTTT GGATCCCAGA AGGGGAAAAG GTTAAAATTC CTGTTGCTAT TAAAGAATTG 2160
AGAGAGGCTA CATCACCAAA AGCCAACAAG GAAATACTTG ACGAAGCCTA TGTGATGGCT 2220
AGTGTTGACA ATCCTCATGT GTGCCGCTTG CTGGGAATCT GCCTCACTTC CACTGTGCAG 2280
CTCATCACCC AGCTCATGCC TTATGGCTGC CTCCTTGACT ACATCCGAGA GCACAAGGAT 2340
AACATTGGCT CCCAGTACCT TCTCAACTGG TGTGTGCAGA TTGCAAAGGG AATGAACTAC 2400
CTGGAGGAAC GTCGCCTGGT GCACCGTGAC CTTGCTGCCA GGAATGTCCT TGTTAAGACT 2460
CCACAACACG TGAAAATCAC AGACTTCGGG CTGGCAAAGC TGCTTGGGGC AGATGAGAAG 2520
GAGTATCATG CAGAGGGAGG CAAGGTTCCT ATTAAATGGA TGGCATTGGA GTCAATTTTA 2580
CACCGAATTT ATACTCATCA AAGTGATGTC TGGAGTTATG GTGTGACAGT TTGGGAGTTG 2640
ATGACATTTG GGTCCAAGCC TTACGATGGG ATCCCTGCAA GTGAAATCTC CTCTGTCTTG 2700
GAGAAGGGCG AGCGTCTGCC TCAGCCACCT ATTTGTACCA TTGATGTGTA CATGATCATG 2760
GTCAAATGCT GGATGATTGA CGCAGACAGC CGTCCCAAGT TTCGTGAGCT GATTGCAGAG 2820
TTCTCCAAAA TGGCTCGTGA CCCTCCCCGC TATCTTGTCA TACAGGGAGA TGAAAGGATG 2880
CATTTGCCCA GCCCTACAGA TTCCAAGTTT TATCGCACCC TGATGGAGGA GGAGGACATG 2940
GAAGACATTG TGGATGCAGA TGAGTATCTT GTCCCACACC AGGGCTTTTT CAACAGCCCC 3000
TCTACATCTC GGACTCCTCT CCTGAGTTCA TTGAGCGCAA CTAGCAACAA TTCTGCTACA 3060
ACCTGCATTG ACAGAAATGG GCAGGGGCAC CCTGTGAGGG AAGACAGCTT TGTCCAGAGG 3120
TACAGCTCAG ACCCAACAGG TAATTTCTTG GAGGAGAGCA TAGATGATGG CTTCCTGCCT 3180
GCTCCAGAGT ATGTAAACCA ACTGATGCCC AAGCAACCAT CTACTGCCAT GGTCCAGAAT 3240
CCAATCTACA ACAACATCTC TCTCACAGCA AACTCAAAGC TCCCCATGGA CTCAAGCTAC 3300
CAGAATTCCC ACAGCACAGC TGTGGACAAC CCTGAATATC TCAACACTAA CCAGTCCCCA 3360
CAGGCCAAAA CAGTTTTCGA GAGCTCTCCT TACTGGATCC AGTCAGGCAA CCATCAAATA 3420
AATCTGGACA ATCCAGACTA CCAGCAGGAC TTTTTACCAA ATGAAACGAA ACCTAATGGT 3480
CTCTTGAAAG TTCCTGCAGC AGAAAACCCA GAGTACTTGA GGGTAGCAGC ACCAAAAAGT 3540
GAATACATTG AAGCTTCAGC ATGA 3564
Domain Profile
S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60
         +kk+kvlGsGafGtvykG+wipege+vkipvaik+l+e+t++kanke+ldea+v+as+d+
Q: 685   FKKVKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDN  744
         59**********************************************************
S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120
         ++++rllg+cl+st+ql+tql+p+Gclldy+rehkd++Gsq+llnwcvqiakGm+ylee+
Q: 745   PHVCRLLGICLTSTVQLITQLMPYGCLLDYIREHKDNIGSQYLLNWCVQIAKGMNYLEER  804
         ************************************************************
S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180
         rlvhrdlaarnvlvk+p+hvkitdfGlakll adeke++aeggkvpikw+alesil+r+y
Q: 805   RLVHRDLAARNVLVKTPQHVKITDFGLAKLLGADEKEYHAEGGKVPIKWMALESILHRIY  864
         ************************************************************
S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240
         thqsdvwsyGvtvwel+tfG+kpydgipa+ei+++lekGerl+qppictidvym++vkcw
Q: 865   THQSDVWSYGVTVWELMTFGSKPYDGIPASEISSVLEKGERLPQPPICTIDVYMIMVKCW  924
         ************************************************************
S: 241   midaesrpkfkelaeefs  258
         mida+srpkf+el++efs
Q: 925   MIDADSRPKFRELIAEFS  942
         ****************96
Domain Sequence
(FASTA)
FKKVKVLGSG AFGTVYKGLW IPEGEKVKIP VAIKELREAT SPKANKEILD EAYVMASVDN 60
PHVCRLLGIC LTSTVQLITQ LMPYGCLLDY IREHKDNIGS QYLLNWCVQI AKGMNYLEER 120
RLVHRDLAAR NVLVKTPQHV KITDFGLAKL LGADEKEYHA EGGKVPIKWM ALESILHRIY 180
THQSDVWSYG VTVWELMTFG SKPYDGIPAS EISSVLEKGE RLPQPPICTI DVYMIMVKCW 240
MIDADSRPKF RELIAEFS 258
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00280
EKS-ANC-00290
EKS-BOT-00297
EKS-CAE-00255
EKS-CAJ-00304
EKS-CAF-00304
EKS-CAP-00333
EKS-CII-00175
EKS-CIS-00072
EKS-DAR-00652
EKS-DRM-00152
EKS-EQC-00289
EKS-FEC-00283
EKS-GAM-00190
EKS-GAG-00251
EKS-GAA-00368
EKS-GOG-00295
EKS-HOS-00304
EKS-ICT-00280
EKS-LAC-00310
EKS-LOA-00308
EKS-MAM-00301
EKS-MOD-00292
EKS-MUM-00329
EKS-MUP-00295
EKS-MYL-00300
EKS-NOL-00274
EKS-OCP-00048
EKS-ORN-00388
EKS-ORA-00262
EKS-ORC-00280
EKS-ORL-00359
EKS-OTG-00304
EKS-PAT-00283
EKS-PES-00265
EKS-PEM-00164
EKS-POA-00289
EKS-PTV-00063
EKS-RAN-00314
EKS-SAH-00279
EKS-SUS-00262
EKS-TAG-00314
EKS-TAR-00390
EKS-TEN-00385
EKS-TUT-00065
EKS-XET-00371
EKS-XIM-00378
Gene Ontology
GO:0016323; C:basolateral plasma membrane
GO:0030139; C:endocytic vesicle
GO:0005768; C:endosome
GO:0016021; C:integral to membrane
GO:0045121; C:membrane raft
GO:0048471; C:perinuclear region of cytoplasm
GO:0005524; F:ATP binding
GO:0005006; F:epidermal growth factor-activated receptor activity
GO:0030235; F:nitric-oxide synthase regulator activity
GO:0004716; F:receptor signaling protein tyrosine kinase activity
GO:0008283; P:cell proliferation
GO:0016337; P:cell-cell adhesion
GO:0043066; P:negative regulation of apoptotic process
GO:0042177; P:negative regulation of protein catabolic process
GO:0035413; P:positive regulation of catenin import into nucleus
GO:0030335; P:positive regulation of cell migration
GO:0031659; P:positive regulation of cyclin-dependent protein kinase activity involved in G1/S
GO:0045739; P:positive regulation of DNA repair
GO:0045740; P:positive regulation of DNA replication
GO:0050679; P:positive regulation of epithelial cell proliferation
GO:0048146; P:positive regulation of fibroblast proliferation
GO:0043406; P:positive regulation of MAP kinase activity
GO:0045429; P:positive regulation of nitric oxide biosynthetic process
GO:0051897; P:positive regulation of protein kinase B signaling cascade
GO:0046777; P:protein autophosphorylation
GO:0050999; P:regulation of nitric-oxide synthase activity
GO:0050730; P:regulation of peptidyl-tyrosine phosphorylation
GO:0070141; P:response to UV-A
GO:0023014; P:signal transduction by phosphorylation
KEGG
InterPros
IPR000494; EGF_rcpt_L.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016245; Tyr_kinase_EGF/ERB/XmrK_rcpt.
Pfam
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00261; FU; 5.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013