EKS-MEG-00363
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MEG-00363
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Syk461.07.0E-139351599249
StatusUnreviewed
Ensembl ProteinENSMGAP00000013006
UniProt AccessionG1NIC4;
Protein NameTyrosine-protein kinase
Protein Synonyms/Alias
Gene NameSYK
Gene Synonyms/Alias SYK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMGAG00000012356ENSMGAP00000013006ENSMGAT00000013908
OrganismMeleagris gallopavo
Functional Description
Protein Length614
Protein Sequence
(FASTA)
MASNMASPAN HLPYFFGNIT REEAEEYLMQ GGMSDGLYLL RQSRNYLGGF ALSLAYGRKV 60
HHYTIERELS GTYAIAGGKS HASPAELINY HSEEADGLIC LLRKSFNRPP GIEPKTGPFE 120
DLKENLIREY VKQTWNLQGH ALEQAIISQK PQLEKLIATT AHEKMPWFHG RISREESEQR 180
ILIGSRNNGK FLLQADLNFS GSYPIIMASW RKLIYYQLVQ GETSEVSTGS PERFDVFLKF 240
LSHLKSYRKR TLMKKIAIPA AKFGRMENNV FDSRPLPGTP SKFQTPVGPP SDDQTPFNPY 300
VLQRGRGLIE AEKGDQREAL PMDTEVYESP YADPDEIKPK NVTLDRKLLT LEEGELGSGN 360
FGTVKKGFYK MKKGAKPVAV KILKNESNDP AIKDELLREA NVMQQLDNPY IVRMIGICEA 420
EAWMLVMEMA ELGPLNKFLQ KNRHITEKNI TELVHQVSMG MKYLEENNFV HRDLAARNVL 480
LVTQHYAKIS DFGLSKALSA DENYYKAQSH GKWPVKWYAP ECMNFYKFSS KSDVWSFGVL 540
MWEAFSYGQK PYKGMKGGEV AQMIERGERM ERPEACPVEV YDLMKLCWTY NVDDRPGFVS 600
VELRLRNYYY DISH 614
Nucleotide Sequence
(FASTA)
ATGGCTTCCA ACATGGCTAG CCCTGCTAAC CATCTGCCAT ACTTCTTTGG CAATATTACA 60
CGCGAGGAAG CTGAGGAGTA TCTGATGCAA GGAGGAATGA GTGATGGACT ATACCTGCTT 120
CGCCAAAGCC GGAATTACCT AGGGGGCTTT GCCTTATCCT TGGCCTATGG AAGGAAGGTT 180
CATCATTACA CAATTGAGAG AGAGCTGAGT GGGACATATG CTATTGCAGG AGGCAAATCA 240
CATGCAAGTC CTGCTGAACT CATTAACTAT CATTCAGAGG AAGCAGATGG CCTTATCTGT 300
CTACTGCGAA AATCTTTCAA TCGACCACCA GGCATTGAGC CCAAAACAGG GCCTTTTGAA 360
GATTTAAAAG AGAACCTCAT CAGAGAGTAT GTCAAACAAA CATGGAATCT GCAGGGTCAT 420
GCTCTTGAAC AAGCTATCAT TAGCCAAAAA CCTCAGCTGG AGAAACTGAT TGCCACTACA 480
GCCCATGAGA AGATGCCTTG GTTCCATGGG AGGATCTCTC GGGAGGAGTC AGAGCAGCGT 540
ATCCTCATTG GATCAAGAAA CAATGGAAAA TTTCTCTTGC AGGCGGATCT GAATTTTAGT 600
GGATCATATC CAATTATTAT GGCTTCTTGG AGAAAACTGA TTTATTACCA ACTTGTCCAA 660
GGTGAAACCT CAGAAGTGAG TACGGGTAGC CCTGAAAGGT TTGATGTCTT CTTAAAGTTT 720
TTGTCACACC TGAAAAGTTA CAGAAAAAGA ACACTTATGA AAAAGATTGC CATTCCAGCT 780
GCAAAATTTG GAAGAATGGA AAATAATGTT TTTGACAGCC GTCCTCTTCC TGGAACCCCT 840
TCTAAGTTCC AGACACCTGT TGGTCCCCCA TCTGATGACC AAACACCTTT TAATCCTTAT 900
GTACTGCAAA GGGGAAGAGG TCTAATAGAA GCAGAGAAAG GTGATCAGAG AGAGGCTTTA 960
CCCATGGACA CTGAGGTTTA TGAAAGTCCG TATGCTGATC CAGATGAAAT TAAACCAAAA 1020
AATGTCACTC TTGACAGAAA ATTGTTAACC CTAGAGGAAG GAGAACTTGG CTCTGGCAAC 1080
TTTGGCACTG TAAAGAAAGG GTTCTATAAG ATGAAAAAGG GGGCCAAGCC AGTGGCTGTA 1140
AAAATTCTTA AGAACGAGAG TAATGATCCA GCCATAAAGG ATGAGTTACT GAGAGAAGCA 1200
AATGTAATGC AGCAACTGGA CAACCCATAT ATTGTCCGAA TGATAGGTAT ATGTGAAGCA 1260
GAGGCCTGGA TGTTAGTAAT GGAAATGGCT GAACTTGGGC CACTGAACAA GTTTTTGCAA 1320
AAAAATCGGC ACATCACAGA AAAGAATATA ACAGAACTTG TACATCAGGT TTCCATGGGG 1380
ATGAAATATC TGGAGGAGAA TAACTTTGTA CATAGGGATC TGGCTGCGAG GAATGTGCTA 1440
TTAGTCACCC AACATTATGC CAAAATCAGT GACTTTGGAT TATCTAAGGC TCTTAGTGCT 1500
GATGAAAATT ATTACAAGGC ACAAAGTCAT GGAAAATGGC CAGTCAAGTG GTATGCTCCA 1560
GAATGTATGA ATTTCTACAA ATTTTCTAGC AAAAGTGATG TCTGGAGCTT TGGAGTTTTA 1620
ATGTGGGAAG CTTTCTCTTA TGGGCAAAAG CCCTATAAAG GAATGAAAGG CGGTGAAGTT 1680
GCACAGATGA TTGAAAGAGG AGAACGAATG GAACGTCCTG AAGCCTGTCC AGTGGAAGTC 1740
TATGACTTAA TGAAATTATG TTGGACGTAC AATGTTGATG ACCGACCAGG ATTCGTTTCC 1800
GTGGAGCTGC GATTACGGAA CTACTATTAC GACATTTCCC ACTAG 1845
Domain Profile
S: 2     vedkelGsGnfGsvkkGyyrmkkkrlevaikvlk.eadekadkdellreasvmqqldnky  60
         +e+ elGsGnfG+vkkG+y+mkk  + va+k+lk e++++a kdellrea+vmqqldn+y
Q: 351   LEEGELGSGNFGTVKKGFYKMKKGAKPVAVKILKnESNDPAIKDELLREANVMQQLDNPY  410
         6789******************************99************************
S: 61    ivrliGiakaealmlvmelaelGpllkylldkreeikaknvlelvhqvamGmkyleeknf  120
         ivr+iGi++aea+mlvme+aelGpl+k+l+++r+ i++kn+ elvhqv+mGmkylee+nf
Q: 411   IVRMIGICEAEAWMLVMEMAELGPLNKFLQKNRH-ITEKNITELVHQVSMGMKYLEENNF  469
         **********************************.*************************
S: 121   vhrdlaarnvllvarhyakisdfGlskalradesyykarsaGkwpvkwyapecinlrkfs  180
         vhrdlaarnvllv++hyakisdfGlskal ade+yyka+s+Gkwpvkwyapec+n++kfs
Q: 470   VHRDLAARNVLLVTQHYAKISDFGLSKALSADENYYKAQSHGKWPVKWYAPECMNFYKFS  529
         ************************************************************
S: 181   sksdvwsfGvtlweafsyGqkpykelkgsevlalvekGerlecpaecpaelyalmsscwk  240
         sksdvwsfGv++weafsyGqkpyk++kg ev +++e+Ger+e p+ cp e+y+lm+ cw+
Q: 530   SKSDVWSFGVLMWEAFSYGQKPYKGMKGGEVAQMIERGERMERPEACPVEVYDLMKLCWT  589
         ************************************************************
S: 241   ykvedrpdfl  250
         y+v+drp+f+
Q: 590   YNVDDRPGFV  599
         ********97
Domain Sequence
(FASTA)
LEEGELGSGN FGTVKKGFYK MKKGAKPVAV KILKNESNDP AIKDELLREA NVMQQLDNPY 60
IVRMIGICEA EAWMLVMEMA ELGPLNKFLQ KNRHITEKNI TELVHQVSMG MKYLEENNFV 120
HRDLAARNVL LVTQHYAKIS DFGLSKALSA DENYYKAQSH GKWPVKWYAP ECMNFYKFSS 180
KSDVWSFGVL MWEAFSYGQK PYKGMKGGEV AQMIERGERM ERPEACPVEV YDLMKLCWTY 240
NVDDRPGFV 249
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00408
EKS-ANC-00425
EKS-BOT-00438
EKS-CAJ-00443
EKS-CAF-00437
EKS-CAP-00471
EKS-DAR-00832
EKS-DRM-00206
EKS-EQC-00429
EKS-FEC-00419
EKS-GAM-00255
EKS-GAG-00369
EKS-GAA-00533
EKS-GOG-00430
EKS-HOS-00445
EKS-ICT-00420
EKS-LAC-00454
EKS-LOA-00446
EKS-MAM-00435
EKS-MOD-00428
EKS-MUM-00470
EKS-MYL-00431
EKS-NOL-00399
EKS-OCP-00105
EKS-ORN-00557
EKS-ORC-00411
EKS-ORL-00509
EKS-OTG-00442
EKS-PAT-00414
EKS-PES-00388
EKS-POA-00427
EKS-PTV-00147
EKS-RAN-00451
EKS-SUS-00387
EKS-TAG-00505
EKS-TAR-00547
EKS-TEN-00551
EKS-XET-00548
Gene Ontology
GO:0019815; C:B cell receptor complex
GO:0032009; C:early phagosome
GO:0042101; C:T cell receptor complex
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0004716; F:receptor signaling protein tyrosine kinase activity
GO:0007257; P:activation of JUN kinase activity
GO:0050853; P:B cell receptor signaling pathway
GO:0007167; P:enzyme linked receptor protein signaling pathway
GO:0045087; P:innate immune response
GO:0007229; P:integrin-mediated signaling pathway
GO:0007159; P:leukocyte cell-cell adhesion
GO:0019370; P:leukotriene biosynthetic process
GO:0002281; P:macrophage activation involved in immune response
GO:0002283; P:neutrophil activation involved in immune response
GO:0030593; P:neutrophil chemotaxis
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0046638; P:positive regulation of alpha-beta T cell differentiation
GO:0046641; P:positive regulation of alpha-beta T cell proliferation
GO:0045579; P:positive regulation of B cell differentiation
GO:0045780; P:positive regulation of bone resorption
GO:0050850; P:positive regulation of calcium-mediated signaling
GO:0033630; P:positive regulation of cell adhesion mediated by integrin
GO:0050715; P:positive regulation of cytokine secretion
GO:0045588; P:positive regulation of gamma-delta T cell differentiation
GO:0045425; P:positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process
GO:0045401; P:positive regulation of interleukin-3 biosynthetic process
GO:0043306; P:positive regulation of mast cell degranulation
GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation
GO:0046777; P:protein autophosphorylation
GO:0090237; P:regulation of arachidonic acid secretion
GO:0070372; P:regulation of ERK1 and ERK2 cascade
GO:0043313; P:regulation of neutrophil degranulation
GO:0050764; P:regulation of phagocytosis
GO:0090330; P:regulation of platelet aggregation
GO:0032928; P:regulation of superoxide anion generation
GO:0001820; P:serotonin secretion
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR023420; Kinase_SYK/ZAP-70_inter-SH2.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR012234; Tyr_kinase_non-rcpt_SYK/ZAP70.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
SMARTs
SM00252; SH2; 2.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 2.
Prints
PR00401; SH2DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013