EKS-MEG-00222

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MEG-00222

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	420.1	3.5E-126	195	482	288

Status

Unreviewed

Ensembl Protein

ENSMGAP00000013346

UniProt Accession

G1NJ60;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR2A

Gene Synonyms/Alias

ACVR2A;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMGAG00000012656	ENSMGAP00000013346	ENSMGAT00000014250
ENSMGAG00000012656	ENSMGAP00000017715	ENSMGAT00000020960

Organism

Meleagris gallopavo

Functional Description

Protein Length

516

Protein Sequence
(FASTA)

LLVCNLFFRV LLTVVCFSSL EGAILGRSET QECIYYNANW EKDKTNRSGI EPCYGDKDKR 60

RHCFATWKNI SGSIEIVKQG CWLDDINCYD RNDCIEKKDS PEVFFCCCEG NMCNERFFYF 120

PEMEVTQPTS NPVTPKPPLF NTLLYSLVPI MGIAVIVLFS FWMYRHHKLA YPPVLVPTQD 180

PGPPPPSPLM GLKPLQLLEI KARGRFGCVW KAQLLNEYVA VKIFPIQDKQ SWQNEYEIYS 240

LPGMKHDNIL QFIGAEKRGT SIDVDLWLIT AFHEKGSLTD FLKANVVSWN ELCHIAQTMA 300

RGLAYLHEDI PGLKDGHKPA ISHRDIKSKN VLLKNNLTAC IADFGLALKF EAGKSAGDTH 360

GQVGTRRYMA PEVLEGAINF QRDAFLRIDM YAMGLVLWEL ASRCTASDGP VDEYMLPFEE 420

EIGQHPSLED MQEVVVHKKK RPVLRECWQK HSGMAMLCET IEECWDHDAE ARLSAGCVEE 480

RIIQMQKLTN IITTEDIVTV VTMVTNVDFP PKESSL 516

Nucleotide Sequence
(FASTA)

CTGTTGGTGT GCAACTTGTT CTTCAGAGTG CTGCTAACTG TGGTGTGCTT TTCTTCCCTT 60

GAAGGTGCCA TTCTTGGCAG ATCAGAAACA CAAGAGTGCA TCTACTACAA CGCTAATTGG 120

GAGAAAGATA AAACAAATCG CAGCGGCATT GAGCCCTGTT ATGGAGATAA AGATAAAAGA 180

CGACACTGCT TTGCTACATG GAAGAATATT TCTGGATCAA TTGAAATTGT GAAACAAGGT 240

TGCTGGCTAG ATGACATCAA CTGTTATGAC AGGAATGATT GCATAGAGAA AAAAGACAGC 300

CCTGAAGTGT TCTTCTGTTG TTGTGAAGGC AACATGTGCA ATGAACGCTT CTTCTATTTT 360

CCAGAAATGG AGGTCACGCA GCCAACTTCC AACCCGGTCA CACCGAAGCC ACCTCTATTC 420

AACACCTTGC TTTATTCATT GGTGCCTATA ATGGGAATTG CAGTGATTGT GCTCTTTTCA 480

TTTTGGATGT ACAGACATCA CAAGCTAGCA TATCCTCCAG TACTTGTTCC AACCCAAGAT 540

CCTGGACCAC CACCGCCTTC ACCATTGATG GGTTTGAAGC CACTGCAGTT GCTAGAGATC 600

AAAGCCAGGG GACGATTTGG GTGTGTGTGG AAAGCTCAGC TGCTGAATGA ATATGTTGCA 660

GTCAAAATAT TCCCTATCCA GGACAAACAG TCGTGGCAGA ACGAATATGA AATTTACAGC 720

CTACCTGGAA TGAAGCATGA CAATATCTTA CAGTTCATCG GTGCAGAGAA ACGAGGCACT 780

AGCATTGATG TGGATCTCTG GTTAATTACA GCATTTCACG AAAAGGGTTC ATTAACTGAC 840

TTCCTCAAGG CTAACGTGGT TTCCTGGAAC GAGCTGTGTC ACATTGCTCA GACTATGGCT 900

CGAGGCTTGG CTTATCTCCA CGAGGATATT CCAGGGCTAA AGGATGGACA TAAACCCGCC 960

ATCTCACATA GGGACATCAA GAGCAAGAAT GTGCTGCTGA AAAACAACCT TACAGCCTGC 1020

ATTGCTGATT TCGGTCTAGC TTTAAAGTTT GAGGCTGGAA AATCTGCAGG AGATACACAT 1080

GGACAGGTTG GCACACGAAG GTATATGGCT CCTGAGGTCC TAGAAGGTGC TATAAACTTC 1140

CAAAGGGATG CGTTTTTGAG AATAGACATG TATGCCATGG GCTTGGTCCT CTGGGAGCTG 1200

GCATCACGCT GCACTGCCTC AGATGGCCCT GTAGATGAGT ACATGTTGCC ATTTGAAGAA 1260

GAAATTGGCC AGCATCCTTC CCTTGAAGAC ATGCAGGAAG TTGTGGTTCA TAAAAAGAAG 1320

AGACCTGTTC TAAGAGAATG TTGGCAAAAG CATTCTGGAA TGGCGATGCT CTGTGAGACC 1380

ATCGAGGAGT GCTGGGATCA CGACGCAGAA GCCAGGCTGT CGGCGGGGTG CGTAGAAGAA 1440

CGCATTATTC AGATGCAAAA ATTAACTAAC ATTATAACAA CAGAGGACAT TGTGACTGTG 1500

GTCACAATGG TGACAAATGT TGACTTTCCT CCCAAAGAAT CCAGTCTATG A 1551

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         l+lle+ ++Gr+g+Vwka+l +e+vAvKif+ +d++sw++E eiy+++ ++h+nilqfi+

Q: 195   LQLLEIKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEIYSLPGMKHDNILQFIG  254

         6899********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         a+k+ ++  ++l+l+t++hekgsL+d+Lk+++++++el+++a+++a+Gla+LHe+i+g k

Q: 255   AEKRGTSIDVDLWLITAFHEKGSLTDFLKANVVSWNELCHIAQTMARGLAYLHEDIPGLK  314

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         + +Kpai+HRD+kskN+l+k++lt+ciaD+GLalk+e+ k++ d  ++ qvGt+RYmaPE

Q: 315   DGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGD--THGQVGTRRYMAPE  372

         *****************************************888..79************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vle+a+n+++ +af r+D+Y++gLvlWE+asRc+++d+ v+ey+lpfee++g++Psle+m

Q: 373   VLEGAINFQR-DAFLRIDMYAMGLVLWELASRCTASDGPVDEYMLPFEEEIGQHPSLEDM  431

         *********9.9************************************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         +evvv+kk+rP ++e w+k++ +++l++++eecWd+d+eaRl+a +v++r+

Q: 432   QEVVVHKKKRPVLRECWQKHSGMAMLCETIEECWDHDAEARLSAGCVEERI  482

         ************************************************985

Domain Sequence
(FASTA)

LQLLEIKARG RFGCVWKAQL LNEYVAVKIF PIQDKQSWQN EYEIYSLPGM KHDNILQFIG 60

AEKRGTSIDV DLWLITAFHE KGSLTDFLKA NVVSWNELCH IAQTMARGLA YLHEDIPGLK 120

DGHKPAISHR DIKSKNVLLK NNLTACIADF GLALKFEAGK SAGDTHGQVG TRRYMAPEVL 180

EGAINFQRDA FLRIDMYAMG LVLWELASRC TASDGPVDEY MLPFEEEIGQ HPSLEDMQEV 240

VVHKKKRPVL RECWQKHSGM AMLCETIEEC WDHDAEARLS AGCVEERI 288

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0009986	; C:cell surface
GO:0005737	; C:cytoplasm
GO:0034673	; C:inhibin-betaglycan-ActRII complex
GO:0017002	; F:activin-activated receptor activity
GO:0005524	; F:ATP binding
GO:0015026	; F:coreceptor activity
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0030509	; P:BMP signaling pathway
GO:0032927	; P:positive regulation of activin receptor signaling pathway
GO:0030501	; P:positive regulation of bone mineralization
GO:0045648	; P:positive regulation of erythrocyte differentiation
GO:0045669	; P:positive regulation of osteoblast differentiation
GO:0010862	; P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0030510	; P:regulation of BMP signaling pathway
GO:0050999	; P:regulation of nitric-oxide synthase activity
GO:0023014	; P:signal transduction by phosphorylation

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR015768	; Activin_II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013